Mutation of EGFR in Non-small Cell Lung Cancer, a Regional Study in Upper Egypt
Samir Shehata Mohammed Eid,
Ahmed Roshdi Hamed Ahmed,
Marwa Ismail Khalaf Abdelgawad,
Ahmed El-Sayed Mohamed,
Amany Osama Mohamed,
Dalia Osama Mohamed,
Mona Mahmoud Sayed,
Ebtesam Mahmoud Aly Elgezawy,
Heba Mohammed Saad-Eldeen
Issue:
Volume 8, Issue 1, March 2020
Pages:
1-7
Received:
2 December 2019
Accepted:
26 December 2019
Published:
7 January 2020
Abstract: Management of non-small cell lung cancer has been changed dramatically since detection of EGFR mutation. The rate of EGFR mutation in Upper Egypt is unknown. In this study; EGFR mutation in non-small cell lung cancer tissue was evaluated and correlated with clinicopathological features of the tumors. Tissue samples of non-small cell lung cancer that had been confirmed by histopathological and immunohistochemical examinations were evaluated for mutation of EGFR by StripAssay. Thirty four patients with non-small cell lung cancer; 21 males and 13 females with a mean age of 55.94 years were included in this study. The median tumor size was 6.0cm and more than half of the tumors were classified as T3. Fourteen patients had N2 nodal stage and 19 patients had either malignant pleural effusion or distant metastasis. The majority of the tumors were adenocarcinomas and half of them were grade II. The two year survival rate of the patients was 70.6% and the overall survival was 58.8%. EGFR mutation was recorded in 44.1% of the tumors; all of which were adenocarcinoma variant. The mutation was significantly more frequent in large sized tumors and it was relatively associated with poor survival. Mutation of EGFR was not associated with patients` age, sex, tumor grade, T stage, N stage or status of distant metastasis. The rate of EGFR gene mutation in non-small cell lung cancer in Upper Egypt is relatively high and target therapy based on these mutations could improve patients` outcome.
Abstract: Management of non-small cell lung cancer has been changed dramatically since detection of EGFR mutation. The rate of EGFR mutation in Upper Egypt is unknown. In this study; EGFR mutation in non-small cell lung cancer tissue was evaluated and correlated with clinicopathological features of the tumors. Tissue samples of non-small cell lung cancer tha...
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A Survey of the Cardiology Care Delivered to Cancer Patients in Nigeria
Alikor Chizindu Akubudike,
Weje Chituru Chioma
Issue:
Volume 8, Issue 1, March 2020
Pages:
8-12
Received:
21 November 2019
Accepted:
9 December 2019
Published:
17 January 2020
Abstract: BACKGROUND: The incidence of cardiovascular disease is on the rise and this is no less so amongst the population of individuals who are affected by cancer as improvement over the years in cancer treatment options have brought about improved outcomes in terms of overall patient survival and outcomes but has additionally also illuminated the side effects of these cancer treatment as patients live longer to manifest them thereby increasing morbidity and mortality. In Nigeria, there is paucity of data on cardio-oncology and this study will be the first documented study assessing the level of knowledge and the activity of cardiology care provided to oncology patients who develop cardiovascular disease in Nigeria and will therefore serve as a template towards the development of cardio-oncology services in Nigeria. METHODS: The survey was questionnaire-based involving cardiologist in Nigeria. They first part assessed the demographic characteristics of participants. The second part of the questionnaire assessed participants’ self-admitted expertise in the management of cardiovascular conditions complicating cancer treatment. RESULTS: There were more male (57.14%) than female (42.86%) respondents. More than two-thirds of respondents (71.4%, n=55) were aged 30-44 year. Cumulatively, the South-south and South-western regions accounted for over two-thirds of responses (72.43%, n=55). Over three-thirds of respondents (83.12%, n=) worked at teaching hospitals. Majority (89.5%, n=68) of ambulatory cancer patients in need of cardiology care received this service in a general cardiology clinic with only 10.5% (n=8) receiving care at a cardio-oncology centre. Majority of respondents (67.1%, n=51) dId not receive referrals from general practitioners or other specialists to evaluate cardiac problems in patients who had received cancer treatment. 80.5% of participants (n=62) said that they either did not know about the ESC position paper or knew about it but did not apply its suggestions to their practice. CONCLUSION: Most cancer patients requiring cardiovascular care are seen in the general cardiology clinic of Government owned hospitals in Nigeria. Although the knowledge of cardiologists in the management of cardiovascular complications of cancer patients is adequate, referral from General Practitioners is low. The ESC position paper on cardio-oncology is poorly known and utilized by cardiologist in the care of cancer patients with cardiovascular complications with the field of cardio-oncology generally regarded as a new topic in cardiology requiring more information on its dissemination and acceptance. This survey therefore makes obvious the dearth of knowledge regarding cardio-oncology that is prevalent in Nigeria. It is hoped that this will ignite a change in this aspect. There is therefore an urgent need to for all stakeholders to join force together towards the development of cardio-oncology skills and services in Nigeria.
Abstract: BACKGROUND: The incidence of cardiovascular disease is on the rise and this is no less so amongst the population of individuals who are affected by cancer as improvement over the years in cancer treatment options have brought about improved outcomes in terms of overall patient survival and outcomes but has additionally also illuminated the side eff...
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Early Mobilization in an Oncology Intensive Care Unit
Cristiani Caroline Carvalho,
Fernanda Cristina Chavaglia Marques,
Maria Luíza Alves Moreira,
Monyque Evelyn Barbosa Batista,
Isabella Fernandes Alves,
Patricia Regina dos Reis,
Daniela Santana Polati da Silveira
Issue:
Volume 8, Issue 1, March 2020
Pages:
13-19
Received:
23 August 2019
Accepted:
13 February 2020
Published:
17 March 2020
Abstract: Introduction: Quality of life and functionality of critically ill cancer patients are significantly affected after ICU admission, with changes due to immobility, hemodynamic instability, muscular atrophy, cognitive deficits, psychological difficulties, decreased cardiovascular functional capacity, neurological deleterious effects on the respiratory system. The physiotherapeutic intervention is effective in preventing and reducing the deleterious dysfunctions of immobility, as well as improving the quality of life of the patient during his / her stay in the ICU. Objective: To carry out a systematic review of literature seeking the benefits of early mobilization in intensive care patients. Methodology: Refers to a systematic literature review, approaching the PRISMA methodology, with two independent examiners who analyzed the quality of the study. We selected as inclusion criteria articles in Portuguese, English and Spanish that refer to the topic of early mobilization in intensive care oncology. Documents that do not associate with the proposed theme were excluded from the search. The articles were searched in the databases: VHL, PUBMED, COCHRANE, PEDRO and EBSCO. Results: For the elaboration of the study, 66 articles were found in the total, where only 8 articles were used because they refer to the use of early mobilization in intensive oncologic therapy. Final considerations: Early mobilization in the ICU is essential in the intervention of the multidisciplinary team on the cognitive, physical and functional aspects along with the kinesiotherapeutic progressivity adequate to the individual needs of each patient, providing significant benefits in the prevention of dysfunctions caused by the immobilism syndrome, resulting in the best quality of life for the patient.
Abstract: Introduction: Quality of life and functionality of critically ill cancer patients are significantly affected after ICU admission, with changes due to immobility, hemodynamic instability, muscular atrophy, cognitive deficits, psychological difficulties, decreased cardiovascular functional capacity, neurological deleterious effects on the respiratory...
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