The Anticancer Effects of Hexane Extract of Rainbow Trout (Oncorhynchus mykiss) Muscle Enriched with Vegetable Oil Brasica sp.
Poroshad Montazeri Shahtoori,
Mozhgan Emtyazjoo,
Shahin Bonakdar,
Mohammad Rabani
Issue:
Volume 3, Issue 4, July 2015
Pages:
63-67
Received:
25 May 2015
Accepted:
16 June 2015
Published:
3 July 2015
Abstract: Background: As Canola oil (Brasica sp.) has beneficial compositions of essential fatty acids like saturated fatty acids, mono unsaturated fatty acids (MUFA) and poly unsaturated fatty acids (PUFA), practically it use in many experimental purposes. There are considerable amounts of oleic acid which is mono unsaturated fatty acids in canola oil that caused a good resistance to thermal processes such as deep frying. Rainbow trout is the main fish species farmed in about 85% of the total rate allocated to producing aquaculture fish in Iran. Rainbow trout has found in food baskets of many people due to its high nutritional value. Methods: in this study the hexane extracts of fish muscle isolated with purity of 250, 50, 10, 5 and 0.5 μg/ml at regular intervals of 24, 48 and 72 hours to determine the effects of hexane extracts on parameters which are associated with the survival of skin cancer cells A431 by MTT method in vitro comparison. Results: The effect of various concentrations of hexane extracts from fish muscle showed that the extracts of muscle at varying time intervals in hexane extracts administration had different effects on mortality of A431 cancer cells. Increasing of hexane extracts had significantly decreased the carcinogenic cells. The concentrations of hexane extract in 250 μg/ml at 24 hours were killed 50 percent of skin cancer A431cell lines. The addition of Brasica sp. vegetable oil as a dietary supplement is required to fish diet rations. Conclusion: In the present study the hexane extract inhibit the growth of cancer cells where the extract can be used as an anticancer agent for the operation of this lineage.
Abstract: Background: As Canola oil (Brasica sp.) has beneficial compositions of essential fatty acids like saturated fatty acids, mono unsaturated fatty acids (MUFA) and poly unsaturated fatty acids (PUFA), practically it use in many experimental purposes. There are considerable amounts of oleic acid which is mono unsaturated fatty acids in canola oil that ...
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The Influence of Synthesis Methods Against Anti-Cancer Activity of Curcumin Analogous
Imanuel Berly Delvis Kapelle,
Tun Tedja Irawadi,
Meika Syahbana Rusli,
Djumali Mangunwidjaja,
Zainal Alim Mas’ud
Issue:
Volume 3, Issue 4, July 2015
Pages:
68-75
Received:
1 June 2015
Accepted:
18 June 2015
Published:
4 July 2015
Abstract: Activity anticancer of curcumin analogous influenced by the structure, substituent and geometric isomeric. The purpose of this research was to determine the influence of curcumin analog synthesis methods against anti-cancer activity. The value of IC50 tested in vitro against breast cancer cells T47D uses the MTT method for samples aks (1,5-bis-benzo[1.3]dioxol-5-yl-penta-1,4-dien-3-one) with a method of the process of microwave 257,798 µg/ml better than conventional method 555,276 µg/ml. The results IC50 for samples akas (5-benzo 1.3 dioxol-5-yl-1-phenyl-penta-2,4-dien-1-one) with a method of microwave 7,247 µg/ml better than conventional method 125,300 µg/ml. Microwave method produces a product with a lower melting point and provide the results of anti-cancer activity against breast cancer cells T47D.
Abstract: Activity anticancer of curcumin analogous influenced by the structure, substituent and geometric isomeric. The purpose of this research was to determine the influence of curcumin analog synthesis methods against anti-cancer activity. The value of IC50 tested in vitro against breast cancer cells T47D uses the MTT method for samples aks (1,5-bis-benz...
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Application of Oncolytic Viruses for Cure of Colorectal Cancer
Della Davis,
S. S. Lahiri
Issue:
Volume 3, Issue 4, July 2015
Pages:
76-93
Received:
8 June 2015
Accepted:
21 June 2015
Published:
14 July 2015
Abstract: Colorectal cancer is one of the most commonly diagnosed and lethal cancers worldwide. It is the resultant of multistep processes caused by the accumulation of genetic/epigenetic aberrations. The different therapeutic strategies like radiotherapy, chemotherapy and surgery, used individually or in different combinations, do not remove tumors or their progression all the time. Besides, these procedures involve surrounding cells and tissues. In case of surgery, which is possible only before metastasis, even a single cancer cell left out during surgery, cause further cancer. Focus has been laid in developing agents that could specifically target the cancer cells and leave out the remaining normal cells. This also attempt at total recovery. This was how the focus was laid on viral agents. Over the last two decades, due to various advancements in molecular biology, virotherapy has seen various developments. A special class of viruses called oncolytic viruses have been used as a therapeutic strategy against cancer. These agents have various inherent and engineered factors like enhanced tissue tropism, thereby providing high selectivity; armed with transgenes to deliver therapeutic genes and to perform tumor selective replication, all these factors proving them improved and evolved mechanisms, when compared with other cancer therapeutics. These oncolytic viruses provide greater protection in association with herbal remedies. The purpose of this paper is to provide a detailed account of some of the current observations, developments and insights made in the field of oncolytic virotherapy for targeting colorectal cancer cells. A panel of five oncolytic viruses i.e. adenovirus, herpes virus, reovirus, vaccinia virus and new castle disease virus that are under clinical studies for targeting colorectal cancer cells have been discussed.
Abstract: Colorectal cancer is one of the most commonly diagnosed and lethal cancers worldwide. It is the resultant of multistep processes caused by the accumulation of genetic/epigenetic aberrations. The different therapeutic strategies like radiotherapy, chemotherapy and surgery, used individually or in different combinations, do not remove tumors or their...
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