GC–MS Analysis and Investigation of Bioactive Potential of Essential Oil from Citrus aurantium var. amara
Vikas Jha,
Aneesh Risbud,
Sankalp Kasbe,
Shreya Thube,
Geetika Preman,
Sathi Maiti,
Himadri Yadav,
Farheen Khan,
Fatimabi Shaikh,
Tisha Jain
Issue:
Volume 8, Issue 3, May 2022
Pages:
24-34
Received:
31 May 2022
Accepted:
22 June 2022
Published:
30 June 2022
DOI:
10.11648/j.ijpc.20220803.11
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Abstract: The need for efficient plant-based remedies is becoming acknowledged across the world as the incidence of infectious diseases rises. Essential oils have been actively studied in the research for plant-derived biomolecules that can substitute synthetic medications and, to some extent, eliminate or lessen their side effects. The goal of this study was to explore the presence of phytochemicals in neroli essential oil as well as its many therapeutic properties. We aimed to present a thorough viewpoint on researching essential oil extracted from the bloom of the bitter orange tree as a suitable replacement for synthetic counterparts. The various components present in the essential oil were identified using GC-MS analysis. The oil's antimicrobial properties were tested against a variety of fungal strains. The antioxidant potential was assessed using the DPPH (2,2-diphenyl-1-picrylhydrazy) reagent in a free radical scavenging experiment. The oil exhibited a variable degree of anti-microbial nature against the bacterial and fungal strains. Furthermore, the antimalarial and antituberculosis property was also evaluated against Plasmodium falciparum and Mycobacterium tuberculosis respectively. Finally, a study for determining the cytotoxicity activity of the oil was studied on the Chinese Hamster Ovary (CHO) cell line. The study's findings revealed that neroli essential oil has natural components that can be used to cure a variety of ailments.
Abstract: The need for efficient plant-based remedies is becoming acknowledged across the world as the incidence of infectious diseases rises. Essential oils have been actively studied in the research for plant-derived biomolecules that can substitute synthetic medications and, to some extent, eliminate or lessen their side effects. The goal of this study wa...
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A Study on Garcinia kola Seeds in the Niger Delta, Nigeria
Victoria Bennett,
Ibrahim Olabayode Saliu
Issue:
Volume 8, Issue 3, May 2022
Pages:
35-38
Received:
14 June 2022
Accepted:
6 July 2022
Published:
20 July 2022
DOI:
10.11648/j.ijpc.20220803.12
Downloads:
Views:
Abstract: Garcinia kola also known as Bitter kola belongs to the family, Clusiaceae. Garcinia kola seeds have proven to possess enormous medicinal and pharmacological abilities. Locally, Gracinia kola seeds are used to cure abdominal pains, chest cold and cough. It is also used as snake repellant. Garcinia kola seeds are served as snack in the Niger Delta, Nigeria. This research is to investigate the proximate, mineral and bioactive compounds in Garcinia kola seeds in the Niger Delta, Nigeria. Samples of freshly harvested Garcinia kola seeds were purchased from Swali market, Yenagoa, Bayelsa State, Nigeria. Proximate analysis of Garcinia kola seeds showed 44.65%, 0.20%, 2.88%, 8.77%, 1.09% and 42.41% moisture, ash, protein, fat, fibre and carbohydrate contents respectively. Varying compositions were reported by various researchers. This may indicate that proximate composition of Garcinia kola seeds varies with season, environment and/ or condition or time of evaluation. Moisture content of Garcinia kola seeds in the Niger Delta, Nigeria was lower than the moisture content values reported in the literature. Moisture content plays an important role in the physical appearance, shelf-life and resistance to bacterial contamination of nuts. The higher the amount of moisture, the more susceptible the seed becomes to bacterial contamination, implying that Garcinia kola seeds in the Niger Delta may have longer shelf-life, hence more resistance to bacterial contamination. Mineral analysis showed 0.26%, 0.002%, 0.001%, 0.03%, and 0.18% K, Fe, Mn, Ca, P contents respectively. Gas chromatography-mass spectrometry (GC-MS) analysis of methanolic extract of the seeds of Garcinia kola showed fifteen bioactive components. Substantial amounts of Caryophyllene, 56.1% and Humulene, 87.7% were identified in the seeds of Garcinia kola, confirming its use in folk medicine in the Niger Delta, Nigeria. All the different components identified from the seeds have different biological activities – anti-microbial, anti-cancer, anti-inflammatory and anti-malaria activities. Therefore, this research authenticates the medicinal and pharmacological abilities of Garcinia kola seeds; hence, recommends isolation of these bioactives to replace synthetic antibiotics in the pharmaceutical industry.
Abstract: Garcinia kola also known as Bitter kola belongs to the family, Clusiaceae. Garcinia kola seeds have proven to possess enormous medicinal and pharmacological abilities. Locally, Gracinia kola seeds are used to cure abdominal pains, chest cold and cough. It is also used as snake repellant. Garcinia kola seeds are served as snack in the Niger Delta, N...
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