Research Article
Phytotherapeutic Effects of Ashanti Pepper and Horn of Plenty in Sleep Disorder Management Resulting from Stress-Induced Neurobehavioral Alterations
Akingbesote Babajide Oluwaseun*
,
Sule Ola Salawu,
Bashorun Bukola Justina
Issue:
Volume 10, Issue 1, February 2024
Pages:
1-9
Received:
6 December 2023
Accepted:
6 January 2024
Published:
2 April 2024
Abstract: This investigation explores the potential antidepressant effects arising from the inherent bioactive compounds found in Cnestis ferruguinea and Piper guineense. Both botanical entities contain flavonoids, phenolics, saponins, and tannins, which are known for their anxiolytic, antidepressant, and antioxidant properties. It is worth noting that Cnestis ferruguinea also contains terpenoids, which are recognized for their anxiolytic effects. Given the growing interest in nutritional interventions for neuropsychiatric conditions, our study meticulously examines the antioxidant capacities and anxiolytic properties of these phytochemicals, positioning them as potential regulators of brain health, particularly in the realm of sleep disorders. In response to the increasing demand for therapeutic alternatives with reduced side effects, our inquiry thoroughly examines the antioxidant and anxiolytic profiles of these botanical extracts. Of particular importance, Cnestis ferruguinea exhibits superior antioxidant potential compared to Piper guineense, thus warranting further investigation into its pharmacological utility. Subsequent analysis of the effects of Cnestis ferruguinea on sleep architecture, especially in the context of chronic stress, reveals promising results. The botanical extract significantly prolongs sleep duration in rats exposed to stress, suggesting a potential dual role in mitigating stress-induced neurobehavioral changes and depressive symptoms. Additionally, a noticeable decrease in immobility duration in the forced swim test, along with improvements in acetylcholinesterase levels following Cnestis ferruguinea treatment, provides mechanistic insights into its antidepressant effects. Our findings provide substantial evidence to support the pharmacotherapeutic potential of Cnestis ferruguinea, highlighted by its antioxidant abilities and anxiolytic effects. Further investigations should delve into the intricate molecular pathways underlying these effects, potentially paving the way for innovative botanical-based interventions in neuropsychiatric disorders, particularly those associated with stress-induced neurobehavioral changes and sleep disorders.
Abstract: This investigation explores the potential antidepressant effects arising from the inherent bioactive compounds found in Cnestis ferruguinea and Piper guineense. Both botanical entities contain flavonoids, phenolics, saponins, and tannins, which are known for their anxiolytic, antidepressant, and antioxidant properties. It is worth noting that Cnest...
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Research Article
A Comparative Study on the Antioxidant and Insecticidal Activities of Eucalyptus camaldulensis Essential Oil and Hydrosol
Issue:
Volume 10, Issue 1, February 2024
Pages:
10-17
Received:
30 March 2024
Accepted:
16 April 2024
Published:
10 May 2024
Abstract: The study investigates the hydrosol of Eucalyptus camaldulensis to assess its value and potential applications within the essential oil (EO) industry. Following steam distillation of E. camaldulensis leaves to extract essential oil, the resulting hydrosol underwent liquid-liquid extraction to yield a secondary essential oil (SEO). Comparative chemical analysis was performed using GC/MS. Comparative chemical analysis of the SEO and EO revealed distinct compositions, with 24 compounds identified in the SEO compared to 41 in the EO. Oxygenated compounds predominated in the SEO while non-oxygenated compounds were the most abundant in the EO (63.61%). Eucalyptol emerged as the primary constituent in both, with higher concentrations observed in the SEO (60.41%) than in the EO (28.53%). Additionally, antioxidant activity assessed using the DPPH assay demonstrated significant radical reduction in the SEO compared to the EO. In insecticidal tests targeting Callosobruchus maculatus, the SEO exhibited pronounced toxicity, with an IC50 value lower than that of the EO. This study showed the abundance of oxygenated compounds in E. camaldulensis hydrosol compared to pure essential oil, suggesting its potential as an antioxidant agent and for integrated pest management in agriculture. The research highlights the value of hydrosols in the EO industry and their potential applications in natural product formulations and pest control strategies.
Abstract: The study investigates the hydrosol of Eucalyptus camaldulensis to assess its value and potential applications within the essential oil (EO) industry. Following steam distillation of E. camaldulensis leaves to extract essential oil, the resulting hydrosol underwent liquid-liquid extraction to yield a secondary essential oil (SEO). Comparative chemi...
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