Efficacy and Safety of Hybrid Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Head-to-Head Randomized Clinical Trials
Qiu Ju Lyu,
Qiang Hong Pu
Issue:
Volume 8, Issue 5, September 2022
Pages:
48-56
Received:
7 September 2022
Accepted:
29 September 2022
Published:
11 October 2022
DOI:
10.11648/j.ijpc.20220805.11
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Abstract: Background: The efficacy and safety of hybrid therapy as the empirical first-line therapy was still unclear in Helicobacter pylori (H. pylori) infection, so the efficacy and safety of hybrid therapy was evaluated which was compared to the other eradication therapies in guidelines. Methods: PubMed, Embase, Cochrane Central Register of Controlled Trials, Wanfang and Chinese BioMedical Literature database (CBM) were searched up to February 2020. Head-to-head randomized controlled trials were included that assessed efficacy and safety of hybrid therapy compared with other therapies (standard triple therapy, concomitant therapy, bismuth quadruple therapy or sequential therapy). Statistical analysis was performed with RevMan software 5.3. Results: Ten studies (2941 participants) as first-line treatment for H. pylori were identified. In the same proton pump inhibitors and duration, H. pylori eradication rate of hybrid therapy was higher than that of standard triple therapy (pooled eradication rates, 94.2% vs 85.4%; OR, 2.68; 95%CI: [1.42–5.06], P<0.05). However, there were no significant differences of eradication rates between hybrid therapy and sequential therapy (pooled eradication rates, 82.7% vs 84.9%; OR, 0.97; 95%CI: [0.85–1.11], P>0.05), concomitant therapy (pooled eradication rates, 83.5% vs 84.1%; OR, 0.96; 95%CI: [0.66–1.40], P>0.05), or bismuth quadruple therapy (pooled eradication rates, 95.2% vs 94.0%; OR, 1.28; 95%CI: [0.70–2.34], P>0.05). No significant differences in overall adverse events were found among hybrid therapy and standard triple therapy, sequential therapy, concomitant therapy or bismuth quadruple therapy. Conclusions: Hybrid therapy could be a suitable alternative to sequential therapy, concomitant therapy and bismuth quadruple therapy in first-line regimens. Hybrid therapy should be then recommended as empirical first-line regimen in H. pylori eradication.
Abstract: Background: The efficacy and safety of hybrid therapy as the empirical first-line therapy was still unclear in Helicobacter pylori (H. pylori) infection, so the efficacy and safety of hybrid therapy was evaluated which was compared to the other eradication therapies in guidelines. Methods: PubMed, Embase, Cochrane Central Register of Controlled Tri...
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Magnesium Enhances the Antidiabetic Activity of Lippia multiflora Aqueous Extract on Glycemia, Lipid Profile and Cardiovascular Parameters in Streptozotocin-diabetic Rats
Yapo Fulgence Allo,
Brou Andre Konan,
Ziehi Fidele Kpahe,
Yao Jacques Datte
Issue:
Volume 8, Issue 5, September 2022
Pages:
57-66
Received:
29 September 2022
Accepted:
14 October 2022
Published:
28 October 2022
DOI:
10.11648/j.ijpc.20220805.12
Downloads:
Views:
Abstract: Background & Aims: According to studies, magnesium would have beneficial effects in the treatment of diabetes which prompted studies on the supplementation of medicinal substances with magnesium for the treatment of this disease. This work is situated in this context. It was conducted to investigate the effects of Lippia multiflora leaves aqueous extract supplemented with magnesium (LiMAE-Mg) on blood glucose, lipid profile and cardiovascular parameters in streptozotocin-diabetic rats and compared with diabetic and drug-treated rats. Methods: Diabetes was induced in adult male Wistar rats by intraperitoneal administration of streptozotocin (10 mg/kg). 7 groups of 5 STZ-diabetic rats were treated daily for 10 days with Glucophage (Glu 10 mg/kg), Lippia multiflora leaves aqueous extract (LiMAE 200, 400 and 600 mg/kg) and LiMAE-Mg (200, 400 and 600 mg/kg). One group of untreated diabetic rats (uDR) and one group of healthy rats (HeR) were the controls. After 10 days of treatment, some biological parameters were measured in 12 hr-fasted rats. Results: Diabetic rats had elevated levels of blood glucose (379.76%), glycosylated hemoglobin (HbA1c), LDL-cholesterol, total cholesterol, triglycerides and cardiovascular parameters and decreased levels of blood insulin and HDL-cholesterol. Like Glu 10 mg/kg, LiMAE and LiMAE-Mg significantly (p < 0.05) reduced the disturbances caused by STZ in a dose-dependent manner. When diabetic rats were treated separately with LiMAE-Mg and LiMAE, a significant reduction in blood glucose (9.72 to 73.76%), HbA1c, LDL-cholesterol, total cholesterol, triglycerides and cardiovascular parameters and an elevation in blood insulin and HDL-cholesterol were observed. However, the effects induced by LiMAE-Mg were greater at p < 0.05 than those of LiMAE, the extract of Lippia multiflora without magnesium. Conclusion: Supplementation with magnesium significantly increased the antidiabetic effects of Lippia multiflora leaves aqueous extract in streptozotocin-diabetic rats. However, future studies should be carried out on body weight, transaminases of regulatory organs, redox status and hematological parameters. Ultimately, these works will make it possible to better appreciate the beneficial effect of supplementation with magnesium of this medicinal plant extract in diabetic.
Abstract: Background & Aims: According to studies, magnesium would have beneficial effects in the treatment of diabetes which prompted studies on the supplementation of medicinal substances with magnesium for the treatment of this disease. This work is situated in this context. It was conducted to investigate the effects of Lippia multiflora leaves aqueous e...
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