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Renal Involvement in Hospitalized Children with COVID-19
Mahmoud Alhandi Omar Helal,
Abubakr Imam,
Shaikha Nasser Al-Thani,
Wadha Al-Shafi,
Lujain Loay,
Farid Fatnassi,
Mahmoud Abdul Majid,
Malek Almoustafa,
Fatin A. Moussa,
Mohammed Sultan,
Moustafa Ezz,
Limia Altaj Sati Seed
Issue:
Volume 9, Issue 3, September 2023
Pages:
104-113
Received:
6 June 2023
Accepted:
21 June 2023
Published:
8 July 2023
Abstract: Background: Coronavirus disease 2019 (COVID-19), usually causes respiratory and gastrointestinal symptoms in children. While the clinical features range from upper respiratory tract infections to severe diseases. Kidney involvement in these children has been reported in different parts of the world, with different prevalence and acuity. To date, data are still accumulating to characterize kidney involvement in this disease and its impact on these children. Objective: We aimed to determine the prevalence of renal involvement in hospitalized children with COVID-19 in the state of Qatar and describe their clinical presentation and outcome. Methods: We retrospectively reviewed all children (age 0–14 years) with COVID-19 admitted to Hamad General Hospital, from March 1, 2020, to January 1, 2021. The diagnosis was confirmed by positive PCR results for the virus. We reviewed kidney involvement in these children at presentation, during hospitalization, and at 6 weeks follow-up. Results: A total of 2586 patients who were positive by PCR were reviewed, of which 584 were excluded due to missing data, and 1602 were completely asymptomatic at presentation. A total of 400 patients were then included in this study and were divided into two groups: patients without renal involvement (non-renal group) 282 patients (70.5%), and patients with renal involvement (renal group) 118 patients (29.5%). In the renal group, the median age was 16.7 months, and 90 patients (76.3%) were female. Fever was present in 107 patients (90.7%), and the median duration of hospitalization was 3.3 days. In this group, 84 patients (71.2%) presented with respiratory symptoms, and 34 patients (28.8%) presented with gastroenterological symptoms. The most frequent manifestation of renal involvement in these patients was microscopic hematuria, followed by leukocyturia, and acute kidney injury (AKI) was present in 14 patients (12%). During the reported period and follow-up of 6 weeks, children with AKI were at an early stage, and none of them required kidney replacement therapy. Conclusion: Kidney involvement in children with COVID-19 infection in our patients was noted in almost one-third of the patients and varied from urinary findings without any clinical symptoms to early-stage AKI. Electrolyte abnormalities with metabolic acidosis can present at presentation and require careful attention and management.
Abstract: Background: Coronavirus disease 2019 (COVID-19), usually causes respiratory and gastrointestinal symptoms in children. While the clinical features range from upper respiratory tract infections to severe diseases. Kidney involvement in these children has been reported in different parts of the world, with different prevalence and acuity. To date, da...
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Revolutionizing Anesthesia Using Esketamine for Congenital Diaphragmatic Hernia: A Case Report
Issue:
Volume 9, Issue 3, September 2023
Pages:
114-117
Received:
12 June 2023
Accepted:
28 June 2023
Published:
8 July 2023
Abstract: Congenital diaphragmatic hernia (CDH) is a rare developmental abnormality involving the partial formation of the diaphragm, which creates an opening that allows abdominal organs to extend into the chest cavity. Children with congenital diaphragmatic hernia often face complications such as lung infection, hypoxia, acid-base imbalance, and electrolyte disorders, due to the occurrence of abdominal organs within the chest cavity and underdeveloped lungs. The standard treatment for children with CDH involves reducing the herniated organs and repairing the diaphragmatic hernia following their birth. Anesthetic management during surgery can be challenging, particularly when addressing large hernias coupled with lung hypoplasia and congenital heart disease. Positive pressure ventilation with a mask during anesthesia induction may cause gastric distension, exacerbating the child's hypoxemia and further worsening circulation. Therefore, preserving spontaneous breathing during anesthesia induction is the ideal choice. We present a case involving the preservation of spontaneous breathing during the induction of anesthesia in a one-year-old child diagnosed with CDH. In this case, a novel approach using a combination of sevoflurane and esketamine is proposed to maintain stable hemodynamics without significant respiratory depression. The combination of sevoflurane and esketamine offers a promising solution for maintaining stable hemodynamics and preserving spontaneous breathing during anesthesia induction. Further research is required to validate the effectiveness of this approach and provide optimal dosing guidelines for different clinical scenarios.
Abstract: Congenital diaphragmatic hernia (CDH) is a rare developmental abnormality involving the partial formation of the diaphragm, which creates an opening that allows abdominal organs to extend into the chest cavity. Children with congenital diaphragmatic hernia often face complications such as lung infection, hypoxia, acid-base imbalance, and electrolyt...
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Central Diabetes Insipidus (CDI) in Very Low Birth Weight Neonate: Case Report
Allam Fayez Mahmoud Abuhamda
Issue:
Volume 9, Issue 3, September 2023
Pages:
118-121
Received:
2 June 2023
Accepted:
19 June 2023
Published:
11 July 2023
Abstract: Diabetes Insipidus (DI) is rare, with an estimated incidence of 1 in 25,000 cases; less than 10% of cases are hereditary. CDI accounts for over 90% of DI cases and can appear at any age, depending on the cause. There is no indication that hereditary CDI causes are frequent. Central diabetes insipidus (CDI) is uncommon in neonates, particularly in very low-birth-weight newborns, and the great majority of cases are caused by disorders such as ischemia damage or bleeding brain injury. CDI is caused by a deficiency of antidiuretic hormone (ADH) as a result of posterior pituitary and/or hypothalamus dysfunction. We report a case of female, premature newborn, delivered in Sultan Qaboos Hospital in Salalah at 28 weeks gestational age, with a very low birth weight of 1001 grams. She also suffered polyuria and hypernatremia. The baby had hypernatremia and polyuria and low urine specific gravidity at the same time. Baby was early identified with central diabetes insipidus, we failed to control hypernatremia by fluid compensation but the case was effectively treated and controlled with oral desmopressin. Conclusion: Oral Desmopressin is effective and safe in the treatment of CDI but therapy necessitates frequent monitoring of hydration status, polyuria, serum sodium, and dosage calibration as needed.
Abstract: Diabetes Insipidus (DI) is rare, with an estimated incidence of 1 in 25,000 cases; less than 10% of cases are hereditary. CDI accounts for over 90% of DI cases and can appear at any age, depending on the cause. There is no indication that hereditary CDI causes are frequent. Central diabetes insipidus (CDI) is uncommon in neonates, particularly in v...
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Recurrent Acute Kidney Injury in a Child Due to CD46 Mutation Associated Hemolytic Uremic Syndrome: A Case Report and Review of Literature
Lipsa Priyadarshini,
Subal Kumar Pradhan
Issue:
Volume 9, Issue 3, September 2023
Pages:
122-125
Received:
20 June 2023
Accepted:
7 July 2023
Published:
20 July 2023
Abstract: Background: Atypical hemolytic uremic syndrome (aHUS) is a relatively rare disorder characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal dysfunction due to gene mutation of complement factors leading to dysregulated activation of the alternative complement pathway. Mutation of CD46 or membrane cofactor protein accounts for 5-20 percent of cases of atypical HUS. Clinical description: Here we report a 7-year-old boy with recurrent episodes of acute kidney injury and thrombocytopenia associated with diarrheal episode who was subsequently found to be having CD46 mutation. He was negative for anti-complement factor H (20AU/ml, ref 0-100 AU/ml). Renal ultrasonography showed normal kidney size with increased echogenicity. With a diagnosis of HUS with AKI and stage 1 hypertension, the patient was managed with amlodipine with monitoring of fluid and electrolyte status. The child underwent three sessions of hemodialysis. After one and half months of the episode, the patient got admitted for the third time with complaints of abdominal pain, hematuria, and oliguria. This episode was not associated with diarrhoea. His whole exome sequencing tested for mutation implicated in atypical HUS revealed a homozygous deletion (77bp) variant in Exon 14 of the CD46 gene. Patient was finally diagnosed with atypical HUS due to CD46 (MCP) mutation. Conclusion: HUS presenting in the context of a diarrhoeal episode should not always be assumed to be diarrhoea-associated HUS and in the recurrence of such episodes, screening for the genetic cause/complement mutation is crucial to establish underlying etiology and deciding therapeutic strategies.
Abstract: Background: Atypical hemolytic uremic syndrome (aHUS) is a relatively rare disorder characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal dysfunction due to gene mutation of complement factors leading to dysregulated activation of the alternative complement pathway. Mutation of CD46 or membrane cofactor protein accounts fo...
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The Importance of Prebiotics and Quality Nutrition Such as Iron and Vitamin C to Ensure the Psychomotor and Cognitive Behaviors in Toddlerhood
Shahabuddin Mahmud,
Shabnam Sharmin,
Md. Aynul Islam Khan,
Rifat Jahan,
Shah Muhammad Masuduzzaman,
Mushfiqur Rahman,
Biplob Kumer Saha,
Morshed Alam
Issue:
Volume 9, Issue 3, September 2023
Pages:
126-136
Received:
13 February 2023
Accepted:
27 March 2023
Published:
27 July 2023
Abstract: Prebiotics are a class of substances that the gut flora breaks down. Interest in their link to general human health has grown in recent years. Their breakdown products include short-chain fatty acids that are released into the bloodstream and can feed the intestinal microbiota, which has an impact on not only the gastrointestinal tracts but also other distant organs. Scientists are seeking to industrially create prebiotics since meals naturally contain small amounts of fructo and galacto-oligosaccharides. Prebiotics appear to be intriguing possibilities for boosting human health as a substitute or in conjunction with probiotics, given their safety, health benefits, and advantages in manufacture and storage over probiotics. For the brain and neurocognitive system to grow normally, proper nourishment is essential. Early neurodevelopmental optimization can have significant long-term effects on both mental health and quality of life. The central and peripheral nervous systems continue to adapt and grow throughout life, even though the first 1000 days of life are the most crucial for neurodevelopment. Development and functioning have always been reliant on a variety of elements, including proper nourishment. In this review, we discuss the growing roles of polar lipids and high quality protein in the cognitive, emotional, and neurological development of newborns and young children.
Abstract: Prebiotics are a class of substances that the gut flora breaks down. Interest in their link to general human health has grown in recent years. Their breakdown products include short-chain fatty acids that are released into the bloodstream and can feed the intestinal microbiota, which has an impact on not only the gastrointestinal tracts but also ot...
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Kwashiorkor in an Exclusive Breastfed Infant in a Sri Lanka
Manori Priyadarhani,
Jeewana Prasad,
Asanka Alexander,
Hemali De Silva,
Perly Gamage
Issue:
Volume 9, Issue 3, September 2023
Pages:
137-139
Received:
4 October 2022
Accepted:
1 November 2022
Published:
31 July 2023
Abstract: Protein energy malnutrition is a common problem in developing countries rather than developed countries. Protein energy malnutrition is mainly divided into two groups, such as acute protein energy malnutrition and chronic protein energy malnutrition. In acute protein energy malnutrition mainly decreased weight gain with normal linear growth resulting in wasting. But in chronic protein energy malnutrition both weight and height will be affected, and it may cause reduction of linear growth in leading to stunting. The World Health Organization (WHO) and UNICEF recommend in using weight for height to detect acute malnutrition and if a weight for height is less than -3 standard deviation it classified as severe acute malnutrition. WHO also recommended using mid upper arm circumference to assess severe acute malnutrition and cut off point taken as 110-115mm. Protein energy malnutrition can occur in any condition in which there is severe restraint of caloric intake. Additional reasons are increased requirements, poor absorption, impaired utilization, or excessive loss of nutrients. Severe acute malnutrition can be divided in to two, based on a clinical feature such as if present with pitting edema, and fatty liver called kwashiorkor, and if not, called marasmus. Our patient was five months old, an exclusively breast-fed child presented severe acute malnutrition with features of kwashiorkor from a very poor socio-economic background. We were able to manage the child with available resources without any complications.
Abstract: Protein energy malnutrition is a common problem in developing countries rather than developed countries. Protein energy malnutrition is mainly divided into two groups, such as acute protein energy malnutrition and chronic protein energy malnutrition. In acute protein energy malnutrition mainly decreased weight gain with normal linear growth resulti...
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Efficacy of Lactobacillus Reuteri in Improving Gut Barrier Function & Management of Infantile Colic
Sukhamoy Kangsha Banik,
Mahmuda Zaman,
Muhammad Rezaul Karim,
Mohammed Mahfuzur Rahman,
Ahmed Nazmul Anam,
Hasan Al Zami,
Farzana Rahman Chowdhury
Issue:
Volume 9, Issue 3, September 2023
Pages:
140-149
Received:
8 January 2023
Accepted:
10 July 2023
Published:
31 July 2023
Abstract: Infantile colic is a frustrating impasse that affects up to 20% of infants. Nevertheless, its pathogenesis is currently unknown, some hypotheses are food hypersensitivity or allergy, gut dysmotility, inflammation, and visceral pain. Probiotics use in treatment and prevention of infantile colic is a moderately new topic. Moreover, Probiotics strains exhibit a wide range of health benefits by modifying the intestinal microbiota and immunity. Lactobacillus reuteri is one of the utmost widely studied probiotic strains. It endorses gut health by stimulation of mucosal gut barrier functions, production of antimicrobial substances (such as reuterin and lactic acid) and influencing acquired and innate immune responses. Reuterin produced by L. reuteri is a potent anti-microbial compound capable of inhibiting a wide spectrum of pathogenic microorganisms. L. reuteri creates biofilms that stimulate tumor necrosis factor production by lipopolysaccharide (LPS)-activated monocytoid cells, apart from antimicrobial metabolite production. Interestingly, as a potential therapy for childhood, L. reuteri administration has emerged functional gastrointestinal disturbances as these disturbances are associated with gut microbiota perturbations in early life. The review précises the beneficial aspects of the probiotic L. reuteri strain in clinical practice with a special focus on its role in improving gut health and immunity including managing Infantile colic in infants and toddlers.
Abstract: Infantile colic is a frustrating impasse that affects up to 20% of infants. Nevertheless, its pathogenesis is currently unknown, some hypotheses are food hypersensitivity or allergy, gut dysmotility, inflammation, and visceral pain. Probiotics use in treatment and prevention of infantile colic is a moderately new topic. Moreover, Probiotics strains...
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Prevalence and Clinical Presentation of Congenital Anomalies in Neonates
Mizanur Rahman,
Mohammad Abdullah Al Mamun,
Monir Hossain
Issue:
Volume 9, Issue 3, September 2023
Pages:
150-153
Received:
8 September 2022
Accepted:
12 June 2023
Published:
17 August 2023
Abstract: Introduction: The impact of congenital anomalies on newborn mortality is determined by a number of factors, including the prevalence of congenital anomalies, the prevalence of other opposing causes of death, the superiority and accessibility of medical and surgical care, and the presence and efficacy of primary prevention policies. The aim of the study was to assess the prevalence and evaluate the clinical presentation of congenital anomalies in neonates. Material & Methods: This prospective observational study was conducted at the Pediatric Medicine and Pediatric Surgery department of Dhaka Shishu Hospital, Dhaka, Bangladesh during the period from April 2012 to September 2012. Eighty (80) newborns were included in the study using the purposive sampling method. A pre-designed questionnaire was completed for every neonate including H/O regular maternal antenatal care with the taking of TT and MMR vaccine, any maternal disease or fever with rash, taking any offending drug, use of abortifacient, exposure to radiation or industrial hazards, feeding habit including smoking or use of alcohol and clinical and anthropological examination. After collecting, the data were processed and analyzed using computer-aided statistical software SPSS (Statistical Package for Social Sciences) version 16.0 for Windows (SPSS Inc., Chicago, Illinois, USA). Ethical clearance was taken from the Ethical Review Committee (ERC) of BICH, Dhaka Shishu Hospital, Dhaka, Bangladesh. Results: Prevalence of congenital anomalies were found at 7.2%. The mean age was 4.04±3.43 days with a range from 1 to 16 days. Male infants were 52 (65.0%) and female infants were 28 (35.0%). The newborn mean weight was 2437.5±324.4 gm, and the mean length was 51.89±2.71 cm. Mean OFC was 35.19±1.21 cm (normal OFC just after birth 35 cm and normal increment in 1st month 2 cm). The mean gestational age was 35.59±2.33 weeks. The distribution of the studied patients according to their immediate outcome shows, that almost two-thirds (66.3%) of patients had been discharged with advice, DORB was 11 (13.7%) and expired 16 (20.0%). Conclusion: The hospital prevalence of birth defects is 7.2% in newborns. Birth defects are more frequent in mothers with diabetes mellitus, hypertension, consanguineous marriage, and those with irregular antenatal care.
Abstract: Introduction: The impact of congenital anomalies on newborn mortality is determined by a number of factors, including the prevalence of congenital anomalies, the prevalence of other opposing causes of death, the superiority and accessibility of medical and surgical care, and the presence and efficacy of primary prevention policies. The aim of the s...
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Risk Factors for the Development of Epilepsy Among Children with Cerebral Palsy
Mohammad Mohsin,
Farjana Yesmin Khan,
Razia Sultana,
Ahmed Hosain,
Nusrat Shams,
Seikh Azimul Hoque
Issue:
Volume 9, Issue 3, September 2023
Pages:
154-163
Received:
25 March 2023
Accepted:
28 April 2023
Published:
22 August 2023
Abstract: Background: Cerebral palsy is the most common physical disability in children. Epilepsy is one of the most common and important co-morbidity among patients with cerebral palsy. Epilepsy is said to occur in 15–90% of children with CP. There is a paucity of studies among these individuals to determine the risk factors predicting the development of epilepsy. The aim of this study was to determine the risk factors predicting the development of epilepsy considering antenatal, natal, and postnatal characteristics associated impairments and cranial imaging findings in a patient with cerebral palsy. Methods: This case-control study was conducted in the Department of Pediatric Neurology at the National Institute of Neurosciences and Hospital, Dhaka, Bangladesh during the period from January 2020 to December 2020. In total 150 children with cerebral palsy were enrolled in this study who were divided into two groups. In CP with epilepsy, there were 50 patients were taken as the case group, and in CP without epilepsy, there was 100 age- sex-matched patients were taken as a control group. Informed consent was taken from all the parents. Demographic features, clinical findings, functional disability, psychological assessment, computerized tomography (CT) scan, and EEG findings in epilepsy cases were collected in a predesigned questionnaire and analyzed. Results: In this study, 56.0% had age at onset of epileptic seizure less than 12 months. The total mean age at the onset of epilepsy was 13.58 ± 14.47 months. Epilepsy was most common in spastic quadriplegic CP (54%). 38.0% had focal epileptiform activity on EEG. Clinically focal epilepsy was found in 36.0%, generalized epilepsy in 32.0%, syndromic epilepsy in 28.0%, and unknown epilepsy in 4.0%. Focal epilepsy is more common in spastic hemiplegia CP. Generalized and syndromic epilepsy is a more common spastic quadriplegic CP. After logistic regression analysis, a significant positive correlation was found between the history of neonatal seizure (OR, 6.769), 1st Seizure during the 1st year of life (OR, 3.660), family history of epilepsy (OR, 16.453), CT scan abnormalities (OR, 4.045), severe intellectual disability (OR, 6.042) and spastic quadriplegic CP (OR, 6.163) with the occurrence of epilepsy in cerebral palsy cases. A statistically significant positive correlation was not found between functional severities of CP by GMFCS, MACS and moderate intellectual disability as a risk factor to develop epilepsy in CP patients. Conclusion: Cerebral palsy is associated with higher incidence of epilepsy. This study determined the presence of history of neonatal seizure, 1st Seizure during the 1st year of life, family history of epilepsy, CT scan abnormalities, severe intellectual disability and spastic quadriplegic CP were the risk factors for the development of epilepsy in children with cerebral palsy.
Abstract: Background: Cerebral palsy is the most common physical disability in children. Epilepsy is one of the most common and important co-morbidity among patients with cerebral palsy. Epilepsy is said to occur in 15–90% of children with CP. There is a paucity of studies among these individuals to determine the risk factors predicting the development of ep...
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Effect of Periconceptional Life Style Factors on Occurrence of Birth Defect
Nusrat Shams,
Monir Hossain,
Mahfuza Shirin,
Husnea Ara Khan,
Mohammad Mohsin
Issue:
Volume 9, Issue 3, September 2023
Pages:
164-170
Received:
10 June 2023
Accepted:
4 July 2023
Published:
22 August 2023
Abstract: Globally, birth defects (BDs) affect approximately 3-5% of infants and can arise during intrauterine life, remaining present at birth regardless of whether they are immediately recognized. These defects can be caused by a variety of factors, including chromosomal anomalies, multifactorial etiology, single gene disorders, and environmental influences; however, the cause remains unknown in many cases. Among the various causes, periconceptional factors play a crucial role in influencing the critical period of organogenesis. Therefore, the aim of this case-control study conducted at the Pediatric Surgery and Medicine Department in Dhaka Shishu (Children) Hospital, Bangladesh, from January 2012 to December 2013 was to assess the impact of periconceptional lifestyle factors on the occurrence of birth defects. The study included 280 infants aged 0-364 days, with an equal number of cases presenting structural birth defects and controls without any birth defects. Detailed examinations and relevant investigations were conducted for each subject, and data analysis was performed using SPSS 16.0 version through univariate, bivariate, and multivariate analyses, with results presented in tables and graphs. The study revealed significant associations between birth defects and several lifestyle factors, including advanced parental age (>30 years), parental illiteracy, maternal low BMI, low socio-economic condition, rural residency, paternal insecticide exposure, prolonged sunlight exposure, parental tobacco exposure in various forms, use of coal stove for cooking, and inadequate dietary intake of meat, fish, milk, egg, and pulses. These findings emphasize the importance of preventive measures through pre-conceptional and periconceptional care to modify these lifestyle factors and reduce the incidence of birth defects.
Abstract: Globally, birth defects (BDs) affect approximately 3-5% of infants and can arise during intrauterine life, remaining present at birth regardless of whether they are immediately recognized. These defects can be caused by a variety of factors, including chromosomal anomalies, multifactorial etiology, single gene disorders, and environmental influence...
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Comparison of Clinical and Laboratory Characteristics of COVID-19 and Respiratory Diseases of Other Etiology in Hospitalized Children
Huseynova Ilhama Yelmar,
Hasanov Alekber Qazanfar,
Mammadova Fakhriya Makhmud,
Gafarov Ismayıl Adil
Issue:
Volume 9, Issue 3, September 2023
Pages:
171-179
Received:
24 July 2023
Accepted:
10 August 2023
Published:
22 August 2023
Abstract: Today, respiratory diseases are one of the most widespread pathologies of children, causing maximum morbidity. The aim of our study was to determine and analyze differences in clinical and laboratory data and outcomes among children hospitalized with respiratory diseases of COVID-19 and other etiologies. For this purpose, 164 patients under the age of 17 were involved in the study. Patients were divided into two groups: Group I included 89 (54.3%) patients diagnosed with CKD (upper respiratory tract diseases of various etiologies), Group II included 75 (45.7%) patients diagnosed with COVID-19 (PCR positive) pneumonia. During the clinical examination, intoxication, indigestion, auscultatory changes in the lungs, loss of sense of smell, muscle pains, etc., upper respiratory tract damage syndrome, catarrhal symptoms, rhinitis, hyperemia of yawning at various levels during CRX were more manifested during the clinical examination. In both comparison groups of sick children, the main leading symptoms in general were fever 122 (74.4%), cough 133 (81.1%). An increase in the concentration of pro-inflammatory cytokines (IL-1β, IL-6, Il-18) was observed in the blood of patients during both pathologies. Cytokine levels were more prominent increased during COVID-19 compared to ARDs. This indicates the severity of the inflammatory process during COVID-19. The study of the level of pro-inflammatory cytokines in the blood serum of COVID-19 patients allows to determine the progress and severity of the inflammatory process.
Abstract: Today, respiratory diseases are one of the most widespread pathologies of children, causing maximum morbidity. The aim of our study was to determine and analyze differences in clinical and laboratory data and outcomes among children hospitalized with respiratory diseases of COVID-19 and other etiologies. For this purpose, 164 patients under the age...
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Top 100 Most Cited Articles on Acne Vulgaris
Malini Sivasaththivel,
John Su,
Anousha Yazdabadi
Issue:
Volume 9, Issue 3, September 2023
Pages:
180-185
Received:
14 November 2022
Accepted:
14 December 2022
Published:
28 August 2023
Abstract: Background: Acne vulgaris is a common skin condition presentation seen by dermatologists for which clinicians are well armed to manage. Bibliometric analysis scientifically assesses the impact of published research in any given field and identifies clinical issues of current interest. Objective: The aim of the study was to elucidate the 100 most cited journal articles on the topic of acnze vulgaris and their influence on understanding the pathophysiology and management of this presentation. Methods: The search term ‘Acne vulgaris’ was used within the Scopus database to determine the top 100 most cited articles on acne vulgaris with only articles with a primary focus on acne vulgaris being included in the study. Year of publication, subject matter, journal of publication, authorship and impact factor were ascertained. Results: The number of citations ranged from 131 to 713. Over half of the articles were published after 2000. The USA, UK and Germany were the countries that contributed most to the top 100. Review articles were the most highly cited article category. Discussion Treatment was the focus of the most cited articles within the top 100, with many reviewing therapies such as photodynamic therapy and laser therapy. Established effective therapies for moderate to severe acne like isotretinoin were less commonly reviewed. Conclusion: New therapies such as phototherapy, photodynamic therapy and laser are the primary focus of current research suggesting the evolution of new directions in understanding and managing acne vulgaris.
Abstract: Background: Acne vulgaris is a common skin condition presentation seen by dermatologists for which clinicians are well armed to manage. Bibliometric analysis scientifically assesses the impact of published research in any given field and identifies clinical issues of current interest. Objective: The aim of the study was to elucidate the 100 most ci...
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