Exploratory Clinical Safety and Efficacy Study of Adoptive Transfer of Tumor Infiltration Lymphocytes in Patients with Refractory Malignant Ascites
Tiecheng Wu,
Ping Lin,
Xiumei Rong,
Zhenying Geng,
Feifei Huo,
Dazhao Xu,
Libin Xu,
Jun Ren
Issue:
Volume 6, Issue 3, September 2022
Pages:
40-45
Received:
7 August 2022
Accepted:
14 September 2022
Published:
27 September 2022
DOI:
10.11648/j.ijcm.20220603.11
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Abstract: Objective: To study the safety and clinical efficacy of intraperitoneal transfer of autologous tumor infiltrating lymphocytes (TIL) in the treatment of recurrent and refractory malignant ascites. Methods: A single-arm, open-label study, 9 patients with previously unsatisfied ascites treated had been enrolled to receive both intraperitoneal and intravenous or intraperitoneal alone transfer of TILs in Beijing Zhongguancun Hospital, Chinese Academy of Sciences from December 2019 to October 2021, and the complete record including efficacy and adverse reactions of the treatment were observed. Results: Of those nine patients, including 1 case of liver cancer, 1 case of esophageal cancer, 1 case of lung cancer and 1 case of ovarian cancer, 2 cases of rectal cancer and 3 cases of gastric cancer, all with multiple site metastases. Six patients (66.7%) were diagnosed with omental, mesenteric or peritoneal metastases by CT. Both pleural effusion and ascites were found in 8 cases (88.9%). The median maximum fluid depth of peritoneal effusion was 7.8 cm (3.9-12cm) and the median maximum fluid depth of pleural effusion was 6.2cm (0.1-12.8cm) measured by ultrasonography. All patients received other treatments before TILs transfer: intraperitoneal chemotherapy in 7 cases (77.8%), peritoneal drainage in 6 cases (66.7%), and systemic chemotherapy in 4 cases (44.4%). TIL transfer was performed 19 times, including 11 times of intraperitoneal and 8 times of intravenous transfer. One patient had fever (39.3°C) and chills during intravenous transfer, which was relieved after intravenous injection of dexamethasone. Median survival time of patients at post- adoptive transfer was 12.3 weeks (0.5-29.2 weeks), and one patient was still alive at 29.2 weeks. Conclusion: Most patients with malignant ascites have multiple metastases and pleural effusion. Combined with supportive treatment, multidisciplinary comprehensive treatment can still be carried out. After proper screening for patients, the success rate of preparing TILs from malignant ascites was high, and the completion rate of transfer was high. The adverse reactions of intraperitoneal and intravenous transfer were minimal. Further study of treatment efficacy is warranted.
Abstract: Objective: To study the safety and clinical efficacy of intraperitoneal transfer of autologous tumor infiltrating lymphocytes (TIL) in the treatment of recurrent and refractory malignant ascites. Methods: A single-arm, open-label study, 9 patients with previously unsatisfied ascites treated had been enrolled to receive both intraperitoneal and intr...
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Research Hotspots and Development Trend Analysis of Standardized Training of Chinese Medicine Resident Doctors
Zhichun Zhang,
Lu Miao,
Mei Wang,
Liyuan Lv,
Shaodan Tian
Issue:
Volume 6, Issue 3, September 2022
Pages:
46-51
Received:
31 August 2022
Accepted:
20 September 2022
Published:
29 September 2022
DOI:
10.11648/j.ijcm.20220603.12
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Abstract: Objective: To explore the research hotspots and trends of the standardized training of TCM resident doctors in the past 11 years through the bibliometric analysis of the research on the standardized training of TCM resident doctors (abbreviated as resident training). Based on the China Knowledge Network (CNKI) database, the research used bibliometric research methods through CiteSpace to visually analyze the annual distribution, institutions, authors, and keywords of articles published from 2011 to 2021 and analyze the frequency and aggregation of keywords. The analytical results were discussed. Results: 1) A total of 470 articles on residential training in traditional Chinese medicine were included. The results showed that Beijing Traditional Chinese Medicine Hospital affiliated with Capital Medical University, was the institution with the most publications, and Wang Yan and Liu Yonghui were the authors with the most publications. 2) The research hotspots of TCM residency training mainly include primary teaching, case-based teaching and seminar teaching and other teaching mode research, TCM clinical thinking, clinical skills and doctor-patient communication ability and other post competency training research, teaching reform, dual-track integration and "5 + 3" integration and other talent training models research, TCM inheritance, residential training quality, residency employment and scientific research capabilities and other problems in TCM residential training, TCM innovative talent training and TCM international integration exploration and practice research. 3) From the exploration of standardized training mode—the exploration of teaching reforms and teaching methods — The research on the competency of resident doctors was the trend of the research on residential training of traditional Chinese medicine. Conclusion The critical research directions of TCM residency training should focus on the teaching and training mode of TCM residents, the problems existing in TCM residency training, the cultivation of innovative TCM talents and the internationalization of TCM.
Abstract: Objective: To explore the research hotspots and trends of the standardized training of TCM resident doctors in the past 11 years through the bibliometric analysis of the research on the standardized training of TCM resident doctors (abbreviated as resident training). Based on the China Knowledge Network (CNKI) database, the research used bibliometr...
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