Research Article
Evaluation of Multidisciplinary Medication Reconciliation in Elderly Chemotherapy Patients
Issue:
Volume 14, Issue 6, December 2025
Pages:
210-216
Received:
29 October 2025
Accepted:
13 November 2025
Published:
28 November 2025
Abstract: Objective To evaluate the application effect of medication reconciliation implemented by multidisciplinary team for elderly patients with chemotherapy. Methods 104 patients who underwent chemotherapy in the general surgery department of our hospital from December 2022 to December 2023 were selected. Medication reconciliation services were developed and provided according to a multidisciplinary team collaboration model, and the general situation of potentially inappropriate medication use was investigated and statistically analyzed. The incidence of adverse drug reaction(ADR)/adverse drug event(ADE) and patient satisfaction with medication reconciliation services in elderly chemotherapy patients were evaluated before and after the intervention. Results Among the 104 elderly patients with chemotherapy, the average types of long-term drugs before admission were (5.81±2.07), 62 patients (59.62%) brought drugs, 22 patients (21.15%) used traditional Chinese medicine. According to the analysis of possible drug use risk factors in the patients, 42 patients (40.38%) of the 104 patients had 86 potentially inappropriate drugs, involving 54 drugs in 8 categories. The top 3 drugs were cardiovascular system drugs, digestive system drugs and endocrine system drugs. After the intervention, pharmacists put forward 26 drug suggestions, and doctors accepted 22 of them (84.62%). After the intervention, the incidence of ADR/ADE was lower (P<0.05), and the patient satisfaction was higher (P<0.05). Conclusion Elderly patients have many diseases, many drug risk factors and multiple drugs, so we should pay more attention to medication reconciliation. The implementation of the nurse-pharmacist-physician coordinated medication reconciliation intervention program can find the hidden dangers of drug use in time, avoid the deviation of drug therapy, and improve the drug literacy of patients. This program is an effective way of medication management for elderly patients.
Abstract: Objective To evaluate the application effect of medication reconciliation implemented by multidisciplinary team for elderly patients with chemotherapy. Methods 104 patients who underwent chemotherapy in the general surgery department of our hospital from December 2022 to December 2023 were selected. Medication reconciliation services were developed...
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Research Article
Patterns of Drug Therapy Among Diabetic Hypertensive Patients - A Single Center Study in Bangladesh
Jahanara Laizu*,
Kinkar Ghosh
,
Al Reza Md Sayeed
Issue:
Volume 14, Issue 6, December 2025
Pages:
217-222
Received:
1 January 2025
Accepted:
17 February 2025
Published:
11 December 2025
DOI:
10.11648/j.cmr.20251406.12
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Abstract: Hypertension is extremely prevalent in patients with diabetes. Limited data exist on whether patterns of drug therapy among diabetic hypertensive patients are consistent with evidence-based practice guidelines. There are many variations in prescribing patterns of diabetic hypertensive patients needs much care while choosing drugs. We have very limited research-based information regarding the patterns of drug therapy among diabetic hypertensive patients. The aim of this study was to assess the patterns of drug therapy among diabetic hypertensive patients. This retrospective study was conducted in the Department of Pharmacology, Uttara Adhunik Medical College and Hospital, Dhaka, Bangladesh during the period from January 2000 to December 2020. In total 78 diabetic hypertensive patients treated in the mentioned hospital were enrolled in this study as study subjects. As per the inclusion criteria of this study, only those patients who got at least one anti-diabetic and one anti-hypertensive drug in treatment were included. Proper written consents were taken from all the participants before data collection. All data were processed, analyzed and disseminated by using MS Excel and SPSS version 23.0 program as per necessity. In this study, the male-female ratio of the participants was 1.3:1. The mean ±SD age (Year) and BMI (Body Mass Index) (Kg/m2) of our participants were 53.2 ±6.82 and 32.41 ±2.49 respectively. For our patients, 87% and 13% drugs were used through oral and parenteral routes respectively. In this study, among all of our participants, as antihypertensive drug therapy, in 49%, 36% and 15% cases mono, duel and triple antihypertensive drugs were used respectively. In this study, among all of our participants, as anti-diabetic drug therapy, in majority of the patients, mono-therapy was used whereas, in 24% cases double and in 10% cases triple drug therapy was used. Majority of the diabetic hypertensive patients are treated by mono antihypertensive and mono antidiabetic therapy. The treatment cost of insulin receiving patients are higher than that of other diabetic hypertensive patients.
Abstract: Hypertension is extremely prevalent in patients with diabetes. Limited data exist on whether patterns of drug therapy among diabetic hypertensive patients are consistent with evidence-based practice guidelines. There are many variations in prescribing patterns of diabetic hypertensive patients needs much care while choosing drugs. We have very limi...
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Case Report
Clinical and Genetic Analysis of a Chinese Patient Carrying a Novel POGZ Variant Associated with White-Sutton Syndrome
Issue:
Volume 14, Issue 6, December 2025
Pages:
223-228
Received:
6 November 2025
Accepted:
17 November 2025
Published:
17 December 2025
DOI:
10.11648/j.cmr.20251406.13
Downloads:
Views:
Abstract: Background: White-Sutton Syndrome (WSS) is a rare autosomal dominant neurodevelopmental disorder caused by pathogenic variants in the POGZ gene, which is essential for chromatin remodeling and neuronal development. Because of its broad phenotypic heterogeneity and lack of disease-specific features, early diagnosis and management remain challenging. Timely genetic testing can significantly aid in early diagnosis and intervention, improving patient outcomes. Objective: To describe the clinical and genetic findings of a Chinese pediatric patient with a novel POGZ mutation, summarize the diagnostic approach, and underscore the importance of early genetic testing and multidisciplinary management for the diagnosis and management of WSS. Method: A 4-month-old male infant presented with developmental delay and abnormal liver function. Comprehensive clinical, imaging, auditory, and ophthalmologic evaluations were performed. Whole-genome sequencing and Sanger validation were conducted, followed by multidisciplinary management including nutritional therapy and early rehabilitation. Result: The patient exhibited microcephaly, hypotonia, distinctive facial dysmorphism, auditory impairment, and retinitis pigmentosa. Brain MRI revealed hypoplasia of the corpus callosum. A novel heterozygous frameshift mutation c.2699_2700dup (p.Leu901TyrfsTer2) in POGZ was identified and classified as pathogenic according to ACMG criteria (PVS1 + PS2 + PM2 + PP4). The variant was not reported in existing genetic databases, representing a novel pathogenic mutation expanding the POGZ mutational spectrum. Despite multidisciplinary rehabilitation, neurodevelopmental progress remained limited. Conclusion: This report documents the first Chinese case of White-Sutton Syndrome caused by a novel POGZ frameshift mutation, emphasizing the importance of early genetic testing for accurate diagnosis and timely intervention. Genetic diagnosis combined with personalized rehabilitation may improve long-term neurodevelopmental outcomes for patients with WSS. This case study expands the mutation spectrum of the POGZ gene and provides valuable reference for the diagnosis, treatment, prognosis assessment, and genetic counseling of WSS patients.
Abstract: Background: White-Sutton Syndrome (WSS) is a rare autosomal dominant neurodevelopmental disorder caused by pathogenic variants in the POGZ gene, which is essential for chromatin remodeling and neuronal development. Because of its broad phenotypic heterogeneity and lack of disease-specific features, early diagnosis and management remain challenging....
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