Fabrication and Properties of a Hybrid Biocompatible Nanofiber Mesh Constituted of Polycaprolactone and Self-Assembly Peptide
Issue:
Volume 12, Issue 1, March 2023
Pages:
1-8
Received:
4 December 2022
Accepted:
27 December 2022
Published:
10 January 2023
Abstract: Conventional therapeutic methods for organ and tissue deficiencies include surgical reconstruction, organ transplantation, medical devices treatment, synthetic prosthesis and so on, of which the application is limited when donors exhibit a low availability and impaired organs and tissues cannot well perform their functions. Tissue Engineering (TE) can harmonize with regional organs or tissues, ensure optimal degradation time for novel structure rebirth, facilitate cell adhesiveness, contribute to cell procreation and differentiation in tissue scaffolds, etc., making it an alternative option for treating pathological obstacles. Artificial polymers such as polycaprolactone (PCL) and nature materials such as peptides are adopted for the fabrication of nanofiber scaffolds. The study first engineered porous PCL scaffolds for examining the fiber morphology and the diameter alternations considering the change of single variable condition of the solution concentration, voltage and electrode distance, etc., thereby finding the basic conditions for producing nanofiber scaffolds with good formation. With the increase in solution concentration, the more obvious molecule entanglement can limit the jet stretching, thereby enlarging the fiber diameters. Voltage negatively impacts the fiber diameters, and elevated voltage can strengthen the electric intensity, thereby leading to a complete stretching of cone jets and making fiber diameters thinner. Besides, increased electrode distance is followed by expanded flight distance and decreased electrode intensity (constant voltage), as a result, fibers become narrower. Nanofiber substance exhibits the optimal performance under the condition of solution concentration: 6%, voltage: 50kV, and electrode distance: 150mm. Subsequently, nanofiber scaffolds were fabricated based on the respective preparation of PCL/P11-4 and PCL/P11-8 polymer solutions. Both P11-4 and P11-8 presented uneven distribution in PCL scaffolds, which involved various PCL nanofiber substances with abundant peptides. PCL nanofiber scaffolds saw the breakage of P11-4 and P11-8 fibers.
Abstract: Conventional therapeutic methods for organ and tissue deficiencies include surgical reconstruction, organ transplantation, medical devices treatment, synthetic prosthesis and so on, of which the application is limited when donors exhibit a low availability and impaired organs and tissues cannot well perform their functions. Tissue Engineering (TE) ...
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Prediction of Thermal Comfort from Operating Temperature and the Predicted Mean Vote / Predicted Percentage Dissatisfied (PMV/PPD) Indices in a Nubian Vault
Karim Toussakoe,
Emmanuel Ouedraogo,
Bouto Kossi Imbga,
Gilbert Nana,
Abdoulaye Compaore,
Florent Pelega Kieno,
Sie Kam
Issue:
Volume 12, Issue 1, March 2023
Pages:
9-16
Received:
11 February 2023
Accepted:
13 March 2023
Published:
28 March 2023
Abstract: The building and construction sector has a significant impact on the environment due to its high consumption of energy resources and increasing levels of emissions, and pollution. According to the United Nations Human Settlements Program (UN-HABITAT), the energy used by buildings and construction accounts for more than a third of the final energy consumed in the world and a quarter of greenhouse gas emissions. African countries such as Burkina Faso are concerned in this reality in the field of building. This is why the major issue in the tropic today is the construction of new buildings with high environmental quality and high energy performance. Today's construction choices will have an impact on future generations. The technique and materials of a building contribute to the health, safety and comfort of people. In the present work, the operating temperature and the PMV/PPD indices in a Nubian vault were determined. The operating temperature and the PMV/PPD indices are indicators of thermal comfort. Thus, the knowledge of these indicators allows to appreciate the state of comfort in the Nubian vault. It is in this perspective that the operating temperature will be determined by the adaptive method. The Fanger model is used for the determination of the PMV/PPD indexes. From the state of sensation obtained, acceptable ambient conditions can be defined for an individual in a tropical zone. As an alternative, the most suitable construction type and building materials could be recommended for each type of climate.
Abstract: The building and construction sector has a significant impact on the environment due to its high consumption of energy resources and increasing levels of emissions, and pollution. According to the United Nations Human Settlements Program (UN-HABITAT), the energy used by buildings and construction accounts for more than a third of the final energy c...
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