Research Progress of Fatty Acid Synthase in Digestive Tract Tumors

Hou Jianzhang; Zhang Shuli; Yuan Jianlei; Li Hongyan; Hou Zhenjiang

doi:doi:10.11648/j.sjph.20221005.13

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Research Progress of Fatty Acid Synthase in Digestive Tract Tumors

Hou Jianzhang, Zhang Shuli, Yuan Jianlei, Li Hongyan, Hou Zhenjiang

Published in Science Journal of Public Health (Volume 10, Issue 5)

Received: 28 August 2022 Accepted: 5 October 2022 Published: 11 October 2022

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Abstract

Fatty acid synthase (FAS) is a key enzyme in the synthesis of endogenous fatty acids. It consists of two identical polypeptide chains connected in a head-to-tail manner to form a dimer, which constitutes the catalytic center of the enzyme. It is composed of seven enzymatic active domains, and catalyzes the synthesis of fatty acids by acetyl-CoA and malonyl-CoA. The main product of FAS is palmitic acid, which is not only one of the main components of the cell membrane structure, but also an important substrate for cell energy metabolism. It stores energy, synthesizes phospholipids, and participates in cell membrane structure, intracellular signal transduction and protein acylation and many other functions. In normal tissue cells, FAS is expressed at low activity, while FAS is highly expressed in many tumor tissue cells. The level of FAS activity in vivo is of great significance to fatty acid synthesis and body fat deposition. The application of FAS inhibitors can eliminate the proliferation and migration of tumor cells and become a new therapeutic target. In recent years, scholars at home and abroad have carried out a lot of research on FAS on fat synthesis, metabolic regulation and tumor tissue. This article reviews the structure, function, origin and distribution of FAS, as well as the research progress in digestive tract tumors, correctly understands the biological characteristics of FAS and its mechanism of action in tumors, and studies new FAS inhibitors, so as to provide insights into the digestive tract. The diagnosis of tumor provides a theoretical basis and new ideas for the successful prevention and treatment of tumors.

Published in	Science Journal of Public Health (Volume 10, Issue 5)
DOI	10.11648/j.sjph.20221005.13
Page(s)	214-222
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Fatty Acid Synthesis, Biological Characteristics, Gastrointestinal Cancer

References

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APA Style

Hou Jianzhang, Zhang Shuli, Yuan Jianlei, Li Hongyan, Hou Zhenjiang. (2022). Research Progress of Fatty Acid Synthase in Digestive Tract Tumors. Science Journal of Public Health, 10(5), 214-222. https://doi.org/10.11648/j.sjph.20221005.13

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ACS Style

Hou Jianzhang; Zhang Shuli; Yuan Jianlei; Li Hongyan; Hou Zhenjiang. Research Progress of Fatty Acid Synthase in Digestive Tract Tumors. Sci. J. Public Health 2022, 10(5), 214-222. doi: 10.11648/j.sjph.20221005.13

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AMA Style

Hou Jianzhang, Zhang Shuli, Yuan Jianlei, Li Hongyan, Hou Zhenjiang. Research Progress of Fatty Acid Synthase in Digestive Tract Tumors. Sci J Public Health. 2022;10(5):214-222. doi: 10.11648/j.sjph.20221005.13

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@article{10.11648/j.sjph.20221005.13,
  author = {Hou Jianzhang and Zhang Shuli and Yuan Jianlei and Li Hongyan and Hou Zhenjiang},
  title = {Research Progress of Fatty Acid Synthase in Digestive Tract Tumors},
  journal = {Science Journal of Public Health},
  volume = {10},
  number = {5},
  pages = {214-222},
  doi = {10.11648/j.sjph.20221005.13},
  url = {https://doi.org/10.11648/j.sjph.20221005.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20221005.13},
  abstract = {Fatty acid synthase (FAS) is a key enzyme in the synthesis of endogenous fatty acids. It consists of two identical polypeptide chains connected in a head-to-tail manner to form a dimer, which constitutes the catalytic center of the enzyme. It is composed of seven enzymatic active domains, and catalyzes the synthesis of fatty acids by acetyl-CoA and malonyl-CoA. The main product of FAS is palmitic acid, which is not only one of the main components of the cell membrane structure, but also an important substrate for cell energy metabolism. It stores energy, synthesizes phospholipids, and participates in cell membrane structure, intracellular signal transduction and protein acylation and many other functions. In normal tissue cells, FAS is expressed at low activity, while FAS is highly expressed in many tumor tissue cells. The level of FAS activity in vivo is of great significance to fatty acid synthesis and body fat deposition. The application of FAS inhibitors can eliminate the proliferation and migration of tumor cells and become a new therapeutic target. In recent years, scholars at home and abroad have carried out a lot of research on FAS on fat synthesis, metabolic regulation and tumor tissue. This article reviews the structure, function, origin and distribution of FAS, as well as the research progress in digestive tract tumors, correctly understands the biological characteristics of FAS and its mechanism of action in tumors, and studies new FAS inhibitors, so as to provide insights into the digestive tract. The diagnosis of tumor provides a theoretical basis and new ideas for the successful prevention and treatment of tumors.},
 year = {2022}
}

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TY  - JOUR
T1  - Research Progress of Fatty Acid Synthase in Digestive Tract Tumors
AU  - Hou Jianzhang
AU  - Zhang Shuli
AU  - Yuan Jianlei
AU  - Li Hongyan
AU  - Hou Zhenjiang
Y1  - 2022/10/11
PY  - 2022
N1  - https://doi.org/10.11648/j.sjph.20221005.13
DO  - 10.11648/j.sjph.20221005.13
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 214
EP  - 222
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20221005.13
AB  - Fatty acid synthase (FAS) is a key enzyme in the synthesis of endogenous fatty acids. It consists of two identical polypeptide chains connected in a head-to-tail manner to form a dimer, which constitutes the catalytic center of the enzyme. It is composed of seven enzymatic active domains, and catalyzes the synthesis of fatty acids by acetyl-CoA and malonyl-CoA. The main product of FAS is palmitic acid, which is not only one of the main components of the cell membrane structure, but also an important substrate for cell energy metabolism. It stores energy, synthesizes phospholipids, and participates in cell membrane structure, intracellular signal transduction and protein acylation and many other functions. In normal tissue cells, FAS is expressed at low activity, while FAS is highly expressed in many tumor tissue cells. The level of FAS activity in vivo is of great significance to fatty acid synthesis and body fat deposition. The application of FAS inhibitors can eliminate the proliferation and migration of tumor cells and become a new therapeutic target. In recent years, scholars at home and abroad have carried out a lot of research on FAS on fat synthesis, metabolic regulation and tumor tissue. This article reviews the structure, function, origin and distribution of FAS, as well as the research progress in digestive tract tumors, correctly understands the biological characteristics of FAS and its mechanism of action in tumors, and studies new FAS inhibitors, so as to provide insights into the digestive tract. The diagnosis of tumor provides a theoretical basis and new ideas for the successful prevention and treatment of tumors.
VL  - 10
IS  - 5
ER  -

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Author Information

Hou Jianzhang

Department of Hepatobiliary and Pancreatic (Minimally Invasive) Surgery, Cangzhou People's Hospital, Cancer Hospital District, Cangzhou, China
Zhang Shuli

Department of Hepatobiliary and Pancreatic (Minimally Invasive) Surgery, Cangzhou People's Hospital, Cancer Hospital District, Cangzhou, China
Yuan Jianlei

Department of Hepatobiliary and Pancreatic (Minimally Invasive) Surgery, Cangzhou People's Hospital, Cancer Hospital District, Cangzhou, China
Li Hongyan

Department of Medical Technology, Cangzhou Medical College, Cangzhou, China
Hou Zhenjiang

Department of Medical Technology, Cangzhou Medical College, Cangzhou, China

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APA Style

Hou Jianzhang, Zhang Shuli, Yuan Jianlei, Li Hongyan, Hou Zhenjiang. (2022). Research Progress of Fatty Acid Synthase in Digestive Tract Tumors. Science Journal of Public Health, 10(5), 214-222. https://doi.org/10.11648/j.sjph.20221005.13

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ACS Style

Hou Jianzhang; Zhang Shuli; Yuan Jianlei; Li Hongyan; Hou Zhenjiang. Research Progress of Fatty Acid Synthase in Digestive Tract Tumors. Sci. J. Public Health 2022, 10(5), 214-222. doi: 10.11648/j.sjph.20221005.13

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AMA Style

Hou Jianzhang, Zhang Shuli, Yuan Jianlei, Li Hongyan, Hou Zhenjiang. Research Progress of Fatty Acid Synthase in Digestive Tract Tumors. Sci J Public Health. 2022;10(5):214-222. doi: 10.11648/j.sjph.20221005.13

Copy | Download

@article{10.11648/j.sjph.20221005.13,
  author = {Hou Jianzhang and Zhang Shuli and Yuan Jianlei and Li Hongyan and Hou Zhenjiang},
  title = {Research Progress of Fatty Acid Synthase in Digestive Tract Tumors},
  journal = {Science Journal of Public Health},
  volume = {10},
  number = {5},
  pages = {214-222},
  doi = {10.11648/j.sjph.20221005.13},
  url = {https://doi.org/10.11648/j.sjph.20221005.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20221005.13},
  abstract = {Fatty acid synthase (FAS) is a key enzyme in the synthesis of endogenous fatty acids. It consists of two identical polypeptide chains connected in a head-to-tail manner to form a dimer, which constitutes the catalytic center of the enzyme. It is composed of seven enzymatic active domains, and catalyzes the synthesis of fatty acids by acetyl-CoA and malonyl-CoA. The main product of FAS is palmitic acid, which is not only one of the main components of the cell membrane structure, but also an important substrate for cell energy metabolism. It stores energy, synthesizes phospholipids, and participates in cell membrane structure, intracellular signal transduction and protein acylation and many other functions. In normal tissue cells, FAS is expressed at low activity, while FAS is highly expressed in many tumor tissue cells. The level of FAS activity in vivo is of great significance to fatty acid synthesis and body fat deposition. The application of FAS inhibitors can eliminate the proliferation and migration of tumor cells and become a new therapeutic target. In recent years, scholars at home and abroad have carried out a lot of research on FAS on fat synthesis, metabolic regulation and tumor tissue. This article reviews the structure, function, origin and distribution of FAS, as well as the research progress in digestive tract tumors, correctly understands the biological characteristics of FAS and its mechanism of action in tumors, and studies new FAS inhibitors, so as to provide insights into the digestive tract. The diagnosis of tumor provides a theoretical basis and new ideas for the successful prevention and treatment of tumors.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Research Progress of Fatty Acid Synthase in Digestive Tract Tumors
AU  - Hou Jianzhang
AU  - Zhang Shuli
AU  - Yuan Jianlei
AU  - Li Hongyan
AU  - Hou Zhenjiang
Y1  - 2022/10/11
PY  - 2022
N1  - https://doi.org/10.11648/j.sjph.20221005.13
DO  - 10.11648/j.sjph.20221005.13
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 214
EP  - 222
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20221005.13
AB  - Fatty acid synthase (FAS) is a key enzyme in the synthesis of endogenous fatty acids. It consists of two identical polypeptide chains connected in a head-to-tail manner to form a dimer, which constitutes the catalytic center of the enzyme. It is composed of seven enzymatic active domains, and catalyzes the synthesis of fatty acids by acetyl-CoA and malonyl-CoA. The main product of FAS is palmitic acid, which is not only one of the main components of the cell membrane structure, but also an important substrate for cell energy metabolism. It stores energy, synthesizes phospholipids, and participates in cell membrane structure, intracellular signal transduction and protein acylation and many other functions. In normal tissue cells, FAS is expressed at low activity, while FAS is highly expressed in many tumor tissue cells. The level of FAS activity in vivo is of great significance to fatty acid synthesis and body fat deposition. The application of FAS inhibitors can eliminate the proliferation and migration of tumor cells and become a new therapeutic target. In recent years, scholars at home and abroad have carried out a lot of research on FAS on fat synthesis, metabolic regulation and tumor tissue. This article reviews the structure, function, origin and distribution of FAS, as well as the research progress in digestive tract tumors, correctly understands the biological characteristics of FAS and its mechanism of action in tumors, and studies new FAS inhibitors, so as to provide insights into the digestive tract. The diagnosis of tumor provides a theoretical basis and new ideas for the successful prevention and treatment of tumors.
VL  - 10
IS  - 5
ER  -

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