Role of Endocrine System and Hypothalamic Neuropeptides in Hyperphagia Associated Obesity

Mubashir Abbas; Abdul Rehman; Zulfia Hussain; Junaid Ali Khan

doi:doi:10.11648/j.jfmhc.20210701.13

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Role of Endocrine System and Hypothalamic Neuropeptides in Hyperphagia Associated Obesity

Mubashir Abbas, Abdul Rehman, Zulfia Hussain, Junaid Ali Khan

Published in Journal of Family Medicine and Health Care (Volume 7, Issue 1)

Received: 3 January 2021 Accepted: 14 January 2021 Published: 10 March 2021

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Abstract

Activities occurring in an animal’s body are performed and regulated via certain chemicals. These chemical on the basis of multiple factors are divided into various classes. Hormones forma major class of such chemicals. Hormones are integral part of animal’s body that are involved in the mediation of a variety of vital functions. Hormonal secretions are precisely regulated in order to mediate relevant function as needed. They are important maintainers of a variety of homeostatic mechanisms including food intake, digestion, absorption and utilization. Like all other parts of animal’s body, adipose tissue is also under the influence of chemical messengers. Some of the endocrine messengers are Leptin, Insulin and Ghrelin hormone while neural chemicals include orexigenic hypothalamic neuropeptides (like Neuropeptide Y). While performing normal assigned function these chemical substances strive to maintain a balance between body energy need and energy intake. If concentration or functionality of any of them is disturbed due to certain change for sufficient time period then they fail to perform their duty resulting gradual increase in body mass index. Deficiency or hypersecretion, structural deformity and functional impairment are some of the aspects that contribute towards hormonal abnormalities. Present review is based on a concise discussion about obesogenic role of Leptin, Insulin and Ghrelin hormones and hypothalamic neuropeptides.

Published in	Journal of Family Medicine and Health Care (Volume 7, Issue 1)
DOI	10.11648/j.jfmhc.20210701.13
Page(s)	14-18
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Hyperphagia, Leptin, Insulin, Ghrelin, Adipocity, Endocrine Hormones, Hypothalamic Neuropeptides

References

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APA Style

Mubashir Abbas, Abdul Rehman, Zulfia Hussain, Junaid Ali Khan. (2021). Role of Endocrine System and Hypothalamic Neuropeptides in Hyperphagia Associated Obesity. Journal of Family Medicine and Health Care, 7(1), 14-18. https://doi.org/10.11648/j.jfmhc.20210701.13

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ACS Style

Mubashir Abbas; Abdul Rehman; Zulfia Hussain; Junaid Ali Khan. Role of Endocrine System and Hypothalamic Neuropeptides in Hyperphagia Associated Obesity. J. Fam. Med. Health Care 2021, 7(1), 14-18. doi: 10.11648/j.jfmhc.20210701.13

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AMA Style

Mubashir Abbas, Abdul Rehman, Zulfia Hussain, Junaid Ali Khan. Role of Endocrine System and Hypothalamic Neuropeptides in Hyperphagia Associated Obesity. J Fam Med Health Care. 2021;7(1):14-18. doi: 10.11648/j.jfmhc.20210701.13

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@article{10.11648/j.jfmhc.20210701.13,
  author = {Mubashir Abbas and Abdul Rehman and Zulfia Hussain and Junaid Ali Khan},
  title = {Role of Endocrine System and Hypothalamic Neuropeptides in Hyperphagia Associated Obesity},
  journal = {Journal of Family Medicine and Health Care},
  volume = {7},
  number = {1},
  pages = {14-18},
  doi = {10.11648/j.jfmhc.20210701.13},
  url = {https://doi.org/10.11648/j.jfmhc.20210701.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfmhc.20210701.13},
  abstract = {Activities occurring in an animal’s body are performed and regulated via certain chemicals. These chemical on the basis of multiple factors are divided into various classes. Hormones forma major class of such chemicals. Hormones are integral part of animal’s body that are involved in the mediation of a variety of vital functions. Hormonal secretions are precisely regulated in order to mediate relevant function as needed. They are important maintainers of a variety of homeostatic mechanisms including food intake, digestion, absorption and utilization. Like all other parts of animal’s body, adipose tissue is also under the influence of chemical messengers. Some of the endocrine messengers are Leptin, Insulin and Ghrelin hormone while neural chemicals include orexigenic hypothalamic neuropeptides (like Neuropeptide Y). While performing normal assigned function these chemical substances strive to maintain a balance between body energy need and energy intake. If concentration or functionality of any of them is disturbed due to certain change for sufficient time period then they fail to perform their duty resulting gradual increase in body mass index. Deficiency or hypersecretion, structural deformity and functional impairment are some of the aspects that contribute towards hormonal abnormalities. Present review is based on a concise discussion about obesogenic role of Leptin, Insulin and Ghrelin hormones and hypothalamic neuropeptides.},
 year = {2021}
}

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TY  - JOUR
T1  - Role of Endocrine System and Hypothalamic Neuropeptides in Hyperphagia Associated Obesity
AU  - Mubashir Abbas
AU  - Abdul Rehman
AU  - Zulfia Hussain
AU  - Junaid Ali Khan
Y1  - 2021/03/10
PY  - 2021
N1  - https://doi.org/10.11648/j.jfmhc.20210701.13
DO  - 10.11648/j.jfmhc.20210701.13
T2  - Journal of Family Medicine and Health Care
JF  - Journal of Family Medicine and Health Care
JO  - Journal of Family Medicine and Health Care
SP  - 14
EP  - 18
PB  - Science Publishing Group
SN  - 2469-8342
UR  - https://doi.org/10.11648/j.jfmhc.20210701.13
AB  - Activities occurring in an animal’s body are performed and regulated via certain chemicals. These chemical on the basis of multiple factors are divided into various classes. Hormones forma major class of such chemicals. Hormones are integral part of animal’s body that are involved in the mediation of a variety of vital functions. Hormonal secretions are precisely regulated in order to mediate relevant function as needed. They are important maintainers of a variety of homeostatic mechanisms including food intake, digestion, absorption and utilization. Like all other parts of animal’s body, adipose tissue is also under the influence of chemical messengers. Some of the endocrine messengers are Leptin, Insulin and Ghrelin hormone while neural chemicals include orexigenic hypothalamic neuropeptides (like Neuropeptide Y). While performing normal assigned function these chemical substances strive to maintain a balance between body energy need and energy intake. If concentration or functionality of any of them is disturbed due to certain change for sufficient time period then they fail to perform their duty resulting gradual increase in body mass index. Deficiency or hypersecretion, structural deformity and functional impairment are some of the aspects that contribute towards hormonal abnormalities. Present review is based on a concise discussion about obesogenic role of Leptin, Insulin and Ghrelin hormones and hypothalamic neuropeptides.
VL  - 7
IS  - 1
ER  -

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Author Information

Mubashir Abbas

Institute of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan
Abdul Rehman

Institute of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan
Zulfia Hussain

Institute of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan
Junaid Ali Khan

Institute of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan

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APA Style

Mubashir Abbas, Abdul Rehman, Zulfia Hussain, Junaid Ali Khan. (2021). Role of Endocrine System and Hypothalamic Neuropeptides in Hyperphagia Associated Obesity. Journal of Family Medicine and Health Care, 7(1), 14-18. https://doi.org/10.11648/j.jfmhc.20210701.13

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ACS Style

Mubashir Abbas; Abdul Rehman; Zulfia Hussain; Junaid Ali Khan. Role of Endocrine System and Hypothalamic Neuropeptides in Hyperphagia Associated Obesity. J. Fam. Med. Health Care 2021, 7(1), 14-18. doi: 10.11648/j.jfmhc.20210701.13

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AMA Style

Mubashir Abbas, Abdul Rehman, Zulfia Hussain, Junaid Ali Khan. Role of Endocrine System and Hypothalamic Neuropeptides in Hyperphagia Associated Obesity. J Fam Med Health Care. 2021;7(1):14-18. doi: 10.11648/j.jfmhc.20210701.13

Copy | Download

@article{10.11648/j.jfmhc.20210701.13,
  author = {Mubashir Abbas and Abdul Rehman and Zulfia Hussain and Junaid Ali Khan},
  title = {Role of Endocrine System and Hypothalamic Neuropeptides in Hyperphagia Associated Obesity},
  journal = {Journal of Family Medicine and Health Care},
  volume = {7},
  number = {1},
  pages = {14-18},
  doi = {10.11648/j.jfmhc.20210701.13},
  url = {https://doi.org/10.11648/j.jfmhc.20210701.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfmhc.20210701.13},
  abstract = {Activities occurring in an animal’s body are performed and regulated via certain chemicals. These chemical on the basis of multiple factors are divided into various classes. Hormones forma major class of such chemicals. Hormones are integral part of animal’s body that are involved in the mediation of a variety of vital functions. Hormonal secretions are precisely regulated in order to mediate relevant function as needed. They are important maintainers of a variety of homeostatic mechanisms including food intake, digestion, absorption and utilization. Like all other parts of animal’s body, adipose tissue is also under the influence of chemical messengers. Some of the endocrine messengers are Leptin, Insulin and Ghrelin hormone while neural chemicals include orexigenic hypothalamic neuropeptides (like Neuropeptide Y). While performing normal assigned function these chemical substances strive to maintain a balance between body energy need and energy intake. If concentration or functionality of any of them is disturbed due to certain change for sufficient time period then they fail to perform their duty resulting gradual increase in body mass index. Deficiency or hypersecretion, structural deformity and functional impairment are some of the aspects that contribute towards hormonal abnormalities. Present review is based on a concise discussion about obesogenic role of Leptin, Insulin and Ghrelin hormones and hypothalamic neuropeptides.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Role of Endocrine System and Hypothalamic Neuropeptides in Hyperphagia Associated Obesity
AU  - Mubashir Abbas
AU  - Abdul Rehman
AU  - Zulfia Hussain
AU  - Junaid Ali Khan
Y1  - 2021/03/10
PY  - 2021
N1  - https://doi.org/10.11648/j.jfmhc.20210701.13
DO  - 10.11648/j.jfmhc.20210701.13
T2  - Journal of Family Medicine and Health Care
JF  - Journal of Family Medicine and Health Care
JO  - Journal of Family Medicine and Health Care
SP  - 14
EP  - 18
PB  - Science Publishing Group
SN  - 2469-8342
UR  - https://doi.org/10.11648/j.jfmhc.20210701.13
AB  - Activities occurring in an animal’s body are performed and regulated via certain chemicals. These chemical on the basis of multiple factors are divided into various classes. Hormones forma major class of such chemicals. Hormones are integral part of animal’s body that are involved in the mediation of a variety of vital functions. Hormonal secretions are precisely regulated in order to mediate relevant function as needed. They are important maintainers of a variety of homeostatic mechanisms including food intake, digestion, absorption and utilization. Like all other parts of animal’s body, adipose tissue is also under the influence of chemical messengers. Some of the endocrine messengers are Leptin, Insulin and Ghrelin hormone while neural chemicals include orexigenic hypothalamic neuropeptides (like Neuropeptide Y). While performing normal assigned function these chemical substances strive to maintain a balance between body energy need and energy intake. If concentration or functionality of any of them is disturbed due to certain change for sufficient time period then they fail to perform their duty resulting gradual increase in body mass index. Deficiency or hypersecretion, structural deformity and functional impairment are some of the aspects that contribute towards hormonal abnormalities. Present review is based on a concise discussion about obesogenic role of Leptin, Insulin and Ghrelin hormones and hypothalamic neuropeptides.
VL  - 7
IS  - 1
ER  -

Copy | Download