FGF-2, MMP-8 and Integrin α2β1 Expression in Periodontal ligament Remodelling Tension Area with Nanopowder <i>Stichopus hermanii</i> Application to Prevent Orthodontic Relapsing

Noengki Prameswari; Puguh Bayu Prabowo

doi:doi:10.11648/j.ijmsa.20170606.13

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FGF-2, MMP-8 and Integrin α2β1 Expression in Periodontal ligament Remodelling Tension Area with Nanopowder Stichopus hermanii Application to Prevent Orthodontic Relapsing

Noengki Prameswari, Puguh Bayu Prabowo

Published in International Journal of Materials Science and Applications (Volume 6, Issue 6)

Received: 19 October 2017 Accepted: 23 October 2017 Published: 16 November 2017

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Abstract

Background: Orthodontic relapse tendency occurs 33–90 per cent after at least 10 years post-treatment. Orthodontic Relapsing is the return, following orthodontic correction, at the end of treatment. Relapse, a return to the original teeth position, caused by periodontal, occlusal, soft tissue factor and growth. Nanopowder Stichopus hermanii have various active ingredient such as protein, collagen, flavonoid, chondroitin sulphate, cell growth factor, EPA DHA, that might have role to FGF-2, MMP-8, Integrin α2β1 in periodontal ligament remodelling tension area in reducing orthodontic relapsing. Objectives: The aim of this study is to investigate application of Nanopowder Stichopus hermanii to prevent relaps orthodontic by periodontal ligament remodelling tension area through FGF-2, MMP-8, and Integrin α2β1 parameter. Material and Method: The experiment was held by Post Test Only Group design. Twenty four male Cavia Cobaya were divided into three groups. K(-) group as negative control group (without treatment), K(+) group as positive control group which were applied with relaps orthodontic forces, and the other groups P, were applied with relaps orthodontic forces and nanopowder Stichopus hermanii 3%. After treatment the cavia cobaya were sacrificed. FGF-2, MMP-8, and Integrin α2β1 expression is examined with immunohistochemistry. Results: Application nanopowder Stichopus hermanii can reduce relaps until 30%. This study showed FGF-2 expresssion are 13,9±2,6; 6,5±1,4; 21±4,6; MMP-8 expression means and SD in K(-), K(+), P are 3.75±1.49; 14.88±2.64; 9.13±1 and Integrin α2β1 expression are 5.25±1.28; 12.88±1.36; 16.50±2.33. There was significantly differences in group P compare to K(-) and K(+). Conclusion: Application of Nanopowder Stichopus hermanii have role in periodontal ligament remodeling tension area through increasing FGF-2, decreasing MMP-8, increasing Integrin α2β1 and Collagen type 1 parameter to prevent relaps orthodontic until 30%.

Published in	International Journal of Materials Science and Applications (Volume 6, Issue 6)
DOI	10.11648/j.ijmsa.20170606.13
Page(s)	284-289
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Nanopowder Stichopus hermanii, FGF-2, MMP-8, Integrin α2β1, Relaps Orthodontic

References

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APA Style

Noengki Prameswari, Puguh Bayu Prabowo. (2017). FGF-2, MMP-8 and Integrin α2β1 Expression in Periodontal ligament Remodelling Tension Area with Nanopowder Stichopus hermanii Application to Prevent Orthodontic Relapsing. International Journal of Materials Science and Applications, 6(6), 284-289. https://doi.org/10.11648/j.ijmsa.20170606.13

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ACS Style

Noengki Prameswari; Puguh Bayu Prabowo. FGF-2, MMP-8 and Integrin α2β1 Expression in Periodontal ligament Remodelling Tension Area with Nanopowder Stichopus hermanii Application to Prevent Orthodontic Relapsing. Int. J. Mater. Sci. Appl. 2017, 6(6), 284-289. doi: 10.11648/j.ijmsa.20170606.13

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AMA Style

Noengki Prameswari, Puguh Bayu Prabowo. FGF-2, MMP-8 and Integrin α2β1 Expression in Periodontal ligament Remodelling Tension Area with Nanopowder Stichopus hermanii Application to Prevent Orthodontic Relapsing. Int J Mater Sci Appl. 2017;6(6):284-289. doi: 10.11648/j.ijmsa.20170606.13

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@article{10.11648/j.ijmsa.20170606.13,
  author = {Noengki Prameswari and Puguh Bayu Prabowo},
  title = {FGF-2, MMP-8 and Integrin α2β1 Expression in Periodontal ligament Remodelling Tension Area with Nanopowder Stichopus hermanii Application to Prevent Orthodontic Relapsing},
  journal = {International Journal of Materials Science and Applications},
  volume = {6},
  number = {6},
  pages = {284-289},
  doi = {10.11648/j.ijmsa.20170606.13},
  url = {https://doi.org/10.11648/j.ijmsa.20170606.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmsa.20170606.13},
  abstract = {Background: Orthodontic relapse tendency occurs 33–90 per cent after at least 10 years post-treatment. Orthodontic Relapsing is the return, following orthodontic correction, at the end of treatment. Relapse, a return to the original teeth position, caused by periodontal, occlusal, soft tissue factor and growth. Nanopowder Stichopus hermanii have various active ingredient such as protein, collagen, flavonoid, chondroitin sulphate, cell growth factor, EPA DHA, that might have role to FGF-2, MMP-8, Integrin α2β1 in periodontal ligament remodelling tension area in reducing orthodontic relapsing. Objectives: The aim of this study is to investigate application of Nanopowder Stichopus hermanii to prevent relaps orthodontic by periodontal ligament remodelling tension area through FGF-2, MMP-8, and Integrin α2β1 parameter. Material and Method: The experiment was held by Post Test Only Group design. Twenty four male Cavia Cobaya were divided into three groups. K(-) group as negative control group (without treatment), K(+) group as positive control group which were applied with relaps orthodontic forces, and the other groups P, were applied with relaps orthodontic forces and nanopowder Stichopus hermanii 3%. After treatment the cavia cobaya were sacrificed. FGF-2, MMP-8, and Integrin α2β1 expression is examined with immunohistochemistry. Results: Application nanopowder Stichopus hermanii can reduce relaps until 30%. This study showed FGF-2 expresssion are 13,9±2,6; 6,5±1,4; 21±4,6; MMP-8 expression means and SD in K(-), K(+), P are 3.75±1.49; 14.88±2.64; 9.13±1 and Integrin α2β1 expression are 5.25±1.28; 12.88±1.36; 16.50±2.33. There was significantly differences in group P compare to K(-) and K(+). Conclusion: Application of Nanopowder Stichopus hermanii have role in periodontal ligament remodeling tension area through increasing FGF-2, decreasing MMP-8, increasing Integrin α2β1 and Collagen type 1 parameter to prevent relaps orthodontic until 30%.},
 year = {2017}
}

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TY - JOUR
T1 - FGF-2, MMP-8 and Integrin α2β1 Expression in Periodontal ligament Remodelling Tension Area with Nanopowder Stichopus hermanii Application to Prevent Orthodontic Relapsing
AU - Noengki Prameswari
AU - Puguh Bayu Prabowo
Y1 - 2017/11/16
PY - 2017
N1 - https://doi.org/10.11648/j.ijmsa.20170606.13
DO - 10.11648/j.ijmsa.20170606.13
T2 - International Journal of Materials Science and Applications
JF - International Journal of Materials Science and Applications
JO - International Journal of Materials Science and Applications
SP - 284
EP - 289
PB - Science Publishing Group
SN - 2327-2643
UR - https://doi.org/10.11648/j.ijmsa.20170606.13
AB - Background: Orthodontic relapse tendency occurs 33–90 per cent after at least 10 years post-treatment. Orthodontic Relapsing is the return, following orthodontic correction, at the end of treatment. Relapse, a return to the original teeth position, caused by periodontal, occlusal, soft tissue factor and growth. Nanopowder Stichopus hermanii have various active ingredient such as protein, collagen, flavonoid, chondroitin sulphate, cell growth factor, EPA DHA, that might have role to FGF-2, MMP-8, Integrin α2β1 in periodontal ligament remodelling tension area in reducing orthodontic relapsing. Objectives: The aim of this study is to investigate application of Nanopowder Stichopus hermanii to prevent relaps orthodontic by periodontal ligament remodelling tension area through FGF-2, MMP-8, and Integrin α2β1 parameter. Material and Method: The experiment was held by Post Test Only Group design. Twenty four male Cavia Cobaya were divided into three groups. K(-) group as negative control group (without treatment), K(+) group as positive control group which were applied with relaps orthodontic forces, and the other groups P, were applied with relaps orthodontic forces and nanopowder Stichopus hermanii 3%. After treatment the cavia cobaya were sacrificed. FGF-2, MMP-8, and Integrin α2β1 expression is examined with immunohistochemistry. Results: Application nanopowder Stichopus hermanii can reduce relaps until 30%. This study showed FGF-2 expresssion are 13,9±2,6; 6,5±1,4; 21±4,6; MMP-8 expression means and SD in K(-), K(+), P are 3.75±1.49; 14.88±2.64; 9.13±1 and Integrin α2β1 expression are 5.25±1.28; 12.88±1.36; 16.50±2.33. There was significantly differences in group P compare to K(-) and K(+). Conclusion: Application of Nanopowder Stichopus hermanii have role in periodontal ligament remodeling tension area through increasing FGF-2, decreasing MMP-8, increasing Integrin α2β1 and Collagen type 1 parameter to prevent relaps orthodontic until 30%.
VL - 6
IS - 6
ER -

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Author Information

Noengki Prameswari

Orthodontics Department, Dentistry Faculty, Hang Tuah University, Surabaya, Indonesia
Puguh Bayu Prabowo

Dental Material Department, Dentistry Faculty, Hang Tuah University, Surabaya, Indonesia

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Noengki Prameswari, Puguh Bayu Prabowo. (2017). FGF-2, MMP-8 and Integrin α2β1 Expression in Periodontal ligament Remodelling Tension Area with Nanopowder Stichopus hermanii Application to Prevent Orthodontic Relapsing. International Journal of Materials Science and Applications, 6(6), 284-289. https://doi.org/10.11648/j.ijmsa.20170606.13

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ACS Style

Noengki Prameswari; Puguh Bayu Prabowo. FGF-2, MMP-8 and Integrin α2β1 Expression in Periodontal ligament Remodelling Tension Area with Nanopowder Stichopus hermanii Application to Prevent Orthodontic Relapsing. Int. J. Mater. Sci. Appl. 2017, 6(6), 284-289. doi: 10.11648/j.ijmsa.20170606.13

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AMA Style

Noengki Prameswari, Puguh Bayu Prabowo. FGF-2, MMP-8 and Integrin α2β1 Expression in Periodontal ligament Remodelling Tension Area with Nanopowder Stichopus hermanii Application to Prevent Orthodontic Relapsing. Int J Mater Sci Appl. 2017;6(6):284-289. doi: 10.11648/j.ijmsa.20170606.13

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@article{10.11648/j.ijmsa.20170606.13,
  author = {Noengki Prameswari and Puguh Bayu Prabowo},
  title = {FGF-2, MMP-8 and Integrin α2β1 Expression in Periodontal ligament Remodelling Tension Area with Nanopowder Stichopus hermanii Application to Prevent Orthodontic Relapsing},
  journal = {International Journal of Materials Science and Applications},
  volume = {6},
  number = {6},
  pages = {284-289},
  doi = {10.11648/j.ijmsa.20170606.13},
  url = {https://doi.org/10.11648/j.ijmsa.20170606.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmsa.20170606.13},
  abstract = {Background: Orthodontic relapse tendency occurs 33–90 per cent after at least 10 years post-treatment. Orthodontic Relapsing is the return, following orthodontic correction, at the end of treatment. Relapse, a return to the original teeth position, caused by periodontal, occlusal, soft tissue factor and growth. Nanopowder Stichopus hermanii have various active ingredient such as protein, collagen, flavonoid, chondroitin sulphate, cell growth factor, EPA DHA, that might have role to FGF-2, MMP-8, Integrin α2β1 in periodontal ligament remodelling tension area in reducing orthodontic relapsing. Objectives: The aim of this study is to investigate application of Nanopowder Stichopus hermanii to prevent relaps orthodontic by periodontal ligament remodelling tension area through FGF-2, MMP-8, and Integrin α2β1 parameter. Material and Method: The experiment was held by Post Test Only Group design. Twenty four male Cavia Cobaya were divided into three groups. K(-) group as negative control group (without treatment), K(+) group as positive control group which were applied with relaps orthodontic forces, and the other groups P, were applied with relaps orthodontic forces and nanopowder Stichopus hermanii 3%. After treatment the cavia cobaya were sacrificed. FGF-2, MMP-8, and Integrin α2β1 expression is examined with immunohistochemistry. Results: Application nanopowder Stichopus hermanii can reduce relaps until 30%. This study showed FGF-2 expresssion are 13,9±2,6; 6,5±1,4; 21±4,6; MMP-8 expression means and SD in K(-), K(+), P are 3.75±1.49; 14.88±2.64; 9.13±1 and Integrin α2β1 expression are 5.25±1.28; 12.88±1.36; 16.50±2.33. There was significantly differences in group P compare to K(-) and K(+). Conclusion: Application of Nanopowder Stichopus hermanii have role in periodontal ligament remodeling tension area through increasing FGF-2, decreasing MMP-8, increasing Integrin α2β1 and Collagen type 1 parameter to prevent relaps orthodontic until 30%.},
 year = {2017}
}

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