Association Between Food Specific IgG Antibodies with Clinical Activity in Patients with Inflammatory Bowel Disease: A Cross-Sectional Study

Parhusip Santi; Rengganis Iris; Simadibrata Marcellus; Abdullah Murdani; Shatri Hamzah; Evy Yunihastuti; Wibowo Heri

doi:doi:10.11648/j.ijg.20230701.15

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Association Between Food Specific IgG Antibodies with Clinical Activity in Patients with Inflammatory Bowel Disease: A Cross-Sectional Study

Parhusip Santi, Rengganis Iris, Simadibrata Marcellus, Abdullah Murdani, Shatri Hamzah, Evy Yunihastuti, Wibowo Heri

Published in International Journal of Gastroenterology (Volume 7, Issue 1)

Received: 11 November 2022 Accepted: 8 December 2022 Published: 31 May 2023

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Abstract

Background and aim: Inflammatory Bowel Disease (IBD) is an autoimmune disease that is influenced by food, an important factor in accelerating its clinical disease activity because of intestinal inflammation trough formation of antigen-antibody complex. Food-specific IgG examination can identify the types of person foods consumes that are maybe responsible for disease activity. It is useful in treating IBD without risking malnourishment as it is tailored to the individual immune profile. Methods: This is a cross-sectional study involving 113 patients diagnosed with IBD by colonoscopy. Examination of serum IgG specific for 220 types of foods was performed using ELISA and immuno-array techniques. Disease clinical activity was assessed using the Mayo Index and Crohn Disease Activity Index. Results: The highest proportion of dietary IgG in Chron’s disease was peas (100%), barley (97.9%), eggs (95.9%), milk (81.6%), and corn (75.5%); while in ulcerative colitis it was barley (98.4%), peas (96.8%), egg whites (92.2%), corn (82.8%), and prunes (78.1%). In ulcerative colitis, there was a weak negative correlation between cashew nuts IgG (r = -0.347, p=0.041) and chickpeas IgG (r =-0.473, p=0.017) with clinical disease activity; while in Chron’s disease, a weak positive correlation with disease activity was seen in barley (r = 0.261, p = 0.042). Conclusion: There was a weak negative correlation between cashew and chickpea-specific IgG antibodies with clinical activity of ulcerative colitis, and a weak positive correlation between barley-specific IgG antibodies and Chron’s disease clinical activity.

Published in	International Journal of Gastroenterology (Volume 7, Issue 1)
DOI	10.11648/j.ijg.20230701.15
Page(s)	32-39
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Food-Specific IgG Antibodies, Clinical Disease Activity, IBD

References

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[4]	Guan Q. A comprehensive review and update on the pathogenesis of inflammatory bowel disease. J Immunol Res. 2019.
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[7]	Eom T, Kim YS, Choi CH, et al. Current understanding of microbiota- and dietary-therapies for treating inflammatory bowel disease. J Microbiol. 2018; 56 (3): 189–98.
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[9]	Sakamoto N, Kono S, Wakai K, et al. Dietary risk factors for inflammatory bowel disease: A multicenter case-control study in Japan. Inflamm Bowel Dis. 2005; 11 (2): 154–63.
[10]	Jowett SL, Seal CJ, Pearce MS, et al. Influence of dietary factors on the clinical course of ulcerative colitis: A prospective cohort study. Gut. 2004; 53 (10): 1479–84.
[11]	Wang HY, Li Y, Li JJ, et al. Serological investigation of IgG and IgE antibodies against food antigens in patients with inflammatory bowel disease. World J Clin Cases. 2019; 7 (16): 2189–203.
[12]	Cai C, Shen J, Zhao D, et al. Serological investigation of food specific immunoglobulin G antibodies in patients with inflammatory bowel diseases. PLoS ONE. 2014; 9 (11): 1–8.
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[17]	Lamb CA, Kennedy NA, Raine T, et al. British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults. Gut. 2019 Dec; 68 (Suppl 3): s1–106.

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APA Style

Parhusip Santi, Rengganis Iris, Simadibrata Marcellus, Abdullah Murdani, Shatri Hamzah, et al. (2023). Association Between Food Specific IgG Antibodies with Clinical Activity in Patients with Inflammatory Bowel Disease: A Cross-Sectional Study. International Journal of Gastroenterology, 7(1), 32-39. https://doi.org/10.11648/j.ijg.20230701.15

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ACS Style

Parhusip Santi; Rengganis Iris; Simadibrata Marcellus; Abdullah Murdani; Shatri Hamzah, et al. Association Between Food Specific IgG Antibodies with Clinical Activity in Patients with Inflammatory Bowel Disease: A Cross-Sectional Study. Int. J. Gastroenterol. 2023, 7(1), 32-39. doi: 10.11648/j.ijg.20230701.15

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AMA Style

Parhusip Santi, Rengganis Iris, Simadibrata Marcellus, Abdullah Murdani, Shatri Hamzah, et al. Association Between Food Specific IgG Antibodies with Clinical Activity in Patients with Inflammatory Bowel Disease: A Cross-Sectional Study. Int J Gastroenterol. 2023;7(1):32-39. doi: 10.11648/j.ijg.20230701.15

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@article{10.11648/j.ijg.20230701.15,
  author = {Parhusip Santi and Rengganis Iris and Simadibrata Marcellus and Abdullah Murdani and Shatri Hamzah and Evy Yunihastuti and Wibowo Heri},
  title = {Association Between Food Specific IgG Antibodies with Clinical Activity in Patients with Inflammatory Bowel Disease: A Cross-Sectional Study},
  journal = {International Journal of Gastroenterology},
  volume = {7},
  number = {1},
  pages = {32-39},
  doi = {10.11648/j.ijg.20230701.15},
  url = {https://doi.org/10.11648/j.ijg.20230701.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijg.20230701.15},
  abstract = {Background and aim: Inflammatory Bowel Disease (IBD) is an autoimmune disease that is influenced by food, an important factor in accelerating its clinical disease activity because of intestinal inflammation trough formation of antigen-antibody complex. Food-specific IgG examination can identify the types of person foods consumes that are maybe responsible for disease activity. It is useful in treating IBD without risking malnourishment as it is tailored to the individual immune profile. Methods: This is a cross-sectional study involving 113 patients diagnosed with IBD by colonoscopy. Examination of serum IgG specific for 220 types of foods was performed using ELISA and immuno-array techniques. Disease clinical activity was assessed using the Mayo Index and Crohn Disease Activity Index. Results: The highest proportion of dietary IgG in Chron’s disease was peas (100%), barley (97.9%), eggs (95.9%), milk (81.6%), and corn (75.5%); while in ulcerative colitis it was barley (98.4%), peas (96.8%), egg whites (92.2%), corn (82.8%), and prunes (78.1%). In ulcerative colitis, there was a weak negative correlation between cashew nuts IgG (r = -0.347, p=0.041) and chickpeas IgG (r =-0.473, p=0.017) with clinical disease activity; while in Chron’s disease, a weak positive correlation with disease activity was seen in barley (r = 0.261, p = 0.042). Conclusion: There was a weak negative correlation between cashew and chickpea-specific IgG antibodies with clinical activity of ulcerative colitis, and a weak positive correlation between barley-specific IgG antibodies and Chron’s disease clinical activity.},
 year = {2023}
}

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TY  - JOUR
T1  - Association Between Food Specific IgG Antibodies with Clinical Activity in Patients with Inflammatory Bowel Disease: A Cross-Sectional Study
AU  - Parhusip Santi
AU  - Rengganis Iris
AU  - Simadibrata Marcellus
AU  - Abdullah Murdani
AU  - Shatri Hamzah
AU  - Evy Yunihastuti
AU  - Wibowo Heri
Y1  - 2023/05/31
PY  - 2023
N1  - https://doi.org/10.11648/j.ijg.20230701.15
DO  - 10.11648/j.ijg.20230701.15
T2  - International Journal of Gastroenterology
JF  - International Journal of Gastroenterology
JO  - International Journal of Gastroenterology
SP  - 32
EP  - 39
PB  - Science Publishing Group
SN  - 2640-169X
UR  - https://doi.org/10.11648/j.ijg.20230701.15
AB  - Background and aim: Inflammatory Bowel Disease (IBD) is an autoimmune disease that is influenced by food, an important factor in accelerating its clinical disease activity because of intestinal inflammation trough formation of antigen-antibody complex. Food-specific IgG examination can identify the types of person foods consumes that are maybe responsible for disease activity. It is useful in treating IBD without risking malnourishment as it is tailored to the individual immune profile. Methods: This is a cross-sectional study involving 113 patients diagnosed with IBD by colonoscopy. Examination of serum IgG specific for 220 types of foods was performed using ELISA and immuno-array techniques. Disease clinical activity was assessed using the Mayo Index and Crohn Disease Activity Index. Results: The highest proportion of dietary IgG in Chron’s disease was peas (100%), barley (97.9%), eggs (95.9%), milk (81.6%), and corn (75.5%); while in ulcerative colitis it was barley (98.4%), peas (96.8%), egg whites (92.2%), corn (82.8%), and prunes (78.1%). In ulcerative colitis, there was a weak negative correlation between cashew nuts IgG (r = -0.347, p=0.041) and chickpeas IgG (r =-0.473, p=0.017) with clinical disease activity; while in Chron’s disease, a weak positive correlation with disease activity was seen in barley (r = 0.261, p = 0.042). Conclusion: There was a weak negative correlation between cashew and chickpea-specific IgG antibodies with clinical activity of ulcerative colitis, and a weak positive correlation between barley-specific IgG antibodies and Chron’s disease clinical activity.
VL  - 7
IS  - 1
ER  -

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Author Information

Parhusip Santi

Clinical Allergy Immunology of Internal Department, Medical Faculty of Indonesian University, Jakarta, Indonesia
Rengganis Iris

Clinical Allergy Immunology of Internal Department, Medical Faculty of Indonesian University, Jakarta, Indonesia
Simadibrata Marcellus

Gastroenterology of Internal Department, Medical Faculty of Indonesian University, Jakarta, Indonesia
Abdullah Murdani

Gastroenterology of Internal Department, Medical Faculty of Indonesian University, Jakarta, Indonesia
Shatri Hamzah

Clinical Epidemiology of Internal Department, Medical Faculty of Indonesian University, Jakarta, Indonesia
Evy Yunihastuti

Clinical Allergy Immunology of Internal Department, Medical Faculty of Indonesian University, Jakarta, Indonesia
Wibowo Heri

Department of Parasitology, Medical Faculty of Indonesian University, Jakarta, Indonesia

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Plain Text BibTeX RIS

APA Style

Parhusip Santi, Rengganis Iris, Simadibrata Marcellus, Abdullah Murdani, Shatri Hamzah, et al. (2023). Association Between Food Specific IgG Antibodies with Clinical Activity in Patients with Inflammatory Bowel Disease: A Cross-Sectional Study. International Journal of Gastroenterology, 7(1), 32-39. https://doi.org/10.11648/j.ijg.20230701.15

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ACS Style

Parhusip Santi; Rengganis Iris; Simadibrata Marcellus; Abdullah Murdani; Shatri Hamzah, et al. Association Between Food Specific IgG Antibodies with Clinical Activity in Patients with Inflammatory Bowel Disease: A Cross-Sectional Study. Int. J. Gastroenterol. 2023, 7(1), 32-39. doi: 10.11648/j.ijg.20230701.15

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AMA Style

Parhusip Santi, Rengganis Iris, Simadibrata Marcellus, Abdullah Murdani, Shatri Hamzah, et al. Association Between Food Specific IgG Antibodies with Clinical Activity in Patients with Inflammatory Bowel Disease: A Cross-Sectional Study. Int J Gastroenterol. 2023;7(1):32-39. doi: 10.11648/j.ijg.20230701.15

Copy | Download

@article{10.11648/j.ijg.20230701.15,
  author = {Parhusip Santi and Rengganis Iris and Simadibrata Marcellus and Abdullah Murdani and Shatri Hamzah and Evy Yunihastuti and Wibowo Heri},
  title = {Association Between Food Specific IgG Antibodies with Clinical Activity in Patients with Inflammatory Bowel Disease: A Cross-Sectional Study},
  journal = {International Journal of Gastroenterology},
  volume = {7},
  number = {1},
  pages = {32-39},
  doi = {10.11648/j.ijg.20230701.15},
  url = {https://doi.org/10.11648/j.ijg.20230701.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijg.20230701.15},
  abstract = {Background and aim: Inflammatory Bowel Disease (IBD) is an autoimmune disease that is influenced by food, an important factor in accelerating its clinical disease activity because of intestinal inflammation trough formation of antigen-antibody complex. Food-specific IgG examination can identify the types of person foods consumes that are maybe responsible for disease activity. It is useful in treating IBD without risking malnourishment as it is tailored to the individual immune profile. Methods: This is a cross-sectional study involving 113 patients diagnosed with IBD by colonoscopy. Examination of serum IgG specific for 220 types of foods was performed using ELISA and immuno-array techniques. Disease clinical activity was assessed using the Mayo Index and Crohn Disease Activity Index. Results: The highest proportion of dietary IgG in Chron’s disease was peas (100%), barley (97.9%), eggs (95.9%), milk (81.6%), and corn (75.5%); while in ulcerative colitis it was barley (98.4%), peas (96.8%), egg whites (92.2%), corn (82.8%), and prunes (78.1%). In ulcerative colitis, there was a weak negative correlation between cashew nuts IgG (r = -0.347, p=0.041) and chickpeas IgG (r =-0.473, p=0.017) with clinical disease activity; while in Chron’s disease, a weak positive correlation with disease activity was seen in barley (r = 0.261, p = 0.042). Conclusion: There was a weak negative correlation between cashew and chickpea-specific IgG antibodies with clinical activity of ulcerative colitis, and a weak positive correlation between barley-specific IgG antibodies and Chron’s disease clinical activity.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Association Between Food Specific IgG Antibodies with Clinical Activity in Patients with Inflammatory Bowel Disease: A Cross-Sectional Study
AU  - Parhusip Santi
AU  - Rengganis Iris
AU  - Simadibrata Marcellus
AU  - Abdullah Murdani
AU  - Shatri Hamzah
AU  - Evy Yunihastuti
AU  - Wibowo Heri
Y1  - 2023/05/31
PY  - 2023
N1  - https://doi.org/10.11648/j.ijg.20230701.15
DO  - 10.11648/j.ijg.20230701.15
T2  - International Journal of Gastroenterology
JF  - International Journal of Gastroenterology
JO  - International Journal of Gastroenterology
SP  - 32
EP  - 39
PB  - Science Publishing Group
SN  - 2640-169X
UR  - https://doi.org/10.11648/j.ijg.20230701.15
AB  - Background and aim: Inflammatory Bowel Disease (IBD) is an autoimmune disease that is influenced by food, an important factor in accelerating its clinical disease activity because of intestinal inflammation trough formation of antigen-antibody complex. Food-specific IgG examination can identify the types of person foods consumes that are maybe responsible for disease activity. It is useful in treating IBD without risking malnourishment as it is tailored to the individual immune profile. Methods: This is a cross-sectional study involving 113 patients diagnosed with IBD by colonoscopy. Examination of serum IgG specific for 220 types of foods was performed using ELISA and immuno-array techniques. Disease clinical activity was assessed using the Mayo Index and Crohn Disease Activity Index. Results: The highest proportion of dietary IgG in Chron’s disease was peas (100%), barley (97.9%), eggs (95.9%), milk (81.6%), and corn (75.5%); while in ulcerative colitis it was barley (98.4%), peas (96.8%), egg whites (92.2%), corn (82.8%), and prunes (78.1%). In ulcerative colitis, there was a weak negative correlation between cashew nuts IgG (r = -0.347, p=0.041) and chickpeas IgG (r =-0.473, p=0.017) with clinical disease activity; while in Chron’s disease, a weak positive correlation with disease activity was seen in barley (r = 0.261, p = 0.042). Conclusion: There was a weak negative correlation between cashew and chickpea-specific IgG antibodies with clinical activity of ulcerative colitis, and a weak positive correlation between barley-specific IgG antibodies and Chron’s disease clinical activity.
VL  - 7
IS  - 1
ER  -

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