Revolutionary Study in Antibody and Bacterial Mediated Immunotoxin for Breast Cancer Treatment

Rajaganapathy Kaliyaperumal; Yuvaraj Govindarajan; Dillibabu

doi:doi:10.11648/j.bsi.20200504.12

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Revolutionary Study in Antibody and Bacterial Mediated Immunotoxin for Breast Cancer Treatment

Rajaganapathy Kaliyaperumal, Yuvaraj Govindarajan, Dillibabu

Published in Biomedical Statistics and Informatics (Volume 5, Issue 4)

Received: 3 November 2020 Accepted: 19 November 2020 Published: 31 December 2020

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Abstract

Many of this treatments for Breast cancer (BC-carcinoma), including surgery, radiation, and chemotherapy, haven't been effective in diminishing mortality rates, but bacterial mediated Antibody-immunotoxins has become one in all the best approaches to cancer treatment. Under these exceeding background, the present review, based on increasing mini report on bacterial mediated immunotoxins for breast cancer treatment. Various methodology suggest that, antibody therapies has been an central component in the association of malignant disease. Antibodies be capable of block the tumour growth factors or their specificity receptors and activate the immunological attack on the tumour microenvironment especially in breast cancer cells leads to tumor regression, and are used to deliver payloads such as radioisotopes, cytotoxic drugs or toxins. Immunotoxins are a new class of antitumour agents consisting of tumour selective ligands (generally mono clonal antibodies) linked to highly toxic protein molecules such as non-pathogenic bacterial species or programmed bacteria and take the advantage of the exquisite specificity of antibodies to selectively target drug delivery and the potency of toxins to kill the target cells. Currently, the attenuated bacteria as antitumor agents and vectors for gene directed enzyme prodrug or antibody conjugate therapy or immunotoxin have emerged as potential strategies.

Published in	Biomedical Statistics and Informatics (Volume 5, Issue 4)
DOI	10.11648/j.bsi.20200504.12
Page(s)	81-86
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Bacterial Mediated Immunotoxin, Breast Cancer, HER-2, Trastuzumab and Chimeric Toxins

References

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APA Style

Rajaganapathy Kaliyaperumal, Yuvaraj Govindarajan, Dillibabu. (2020). Revolutionary Study in Antibody and Bacterial Mediated Immunotoxin for Breast Cancer Treatment. Biomedical Statistics and Informatics, 5(4), 81-86. https://doi.org/10.11648/j.bsi.20200504.12

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ACS Style

Rajaganapathy Kaliyaperumal; Yuvaraj Govindarajan; Dillibabu. Revolutionary Study in Antibody and Bacterial Mediated Immunotoxin for Breast Cancer Treatment. Biomed. Stat. Inform. 2020, 5(4), 81-86. doi: 10.11648/j.bsi.20200504.12

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AMA Style

Rajaganapathy Kaliyaperumal, Yuvaraj Govindarajan, Dillibabu. Revolutionary Study in Antibody and Bacterial Mediated Immunotoxin for Breast Cancer Treatment. Biomed Stat Inform. 2020;5(4):81-86. doi: 10.11648/j.bsi.20200504.12

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@article{10.11648/j.bsi.20200504.12,
  author = {Rajaganapathy Kaliyaperumal and Yuvaraj Govindarajan and Dillibabu},
  title = {Revolutionary Study in Antibody and Bacterial Mediated Immunotoxin for Breast Cancer Treatment},
  journal = {Biomedical Statistics and Informatics},
  volume = {5},
  number = {4},
  pages = {81-86},
  doi = {10.11648/j.bsi.20200504.12},
  url = {https://doi.org/10.11648/j.bsi.20200504.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bsi.20200504.12},
  abstract = {Many of this treatments for Breast cancer (BC-carcinoma), including surgery, radiation, and chemotherapy, haven't been effective in diminishing mortality rates, but bacterial mediated Antibody-immunotoxins has become one in all the best approaches to cancer treatment. Under these exceeding background, the present review, based on increasing mini report on bacterial mediated immunotoxins for breast cancer treatment. Various methodology suggest that, antibody therapies has been an central component in the association of malignant disease. Antibodies be capable of block the tumour growth factors or their specificity receptors and activate the immunological attack on the tumour microenvironment especially in breast cancer cells leads to tumor regression, and are used to deliver payloads such as radioisotopes, cytotoxic drugs or toxins. Immunotoxins are a new class of antitumour agents consisting of tumour selective ligands (generally mono clonal antibodies) linked to highly toxic protein molecules such as non-pathogenic bacterial species or programmed bacteria and take the advantage of the exquisite specificity of antibodies to selectively target drug delivery and the potency of toxins to kill the target cells. Currently, the attenuated bacteria as antitumor agents and vectors for gene directed enzyme prodrug or antibody conjugate therapy or immunotoxin have emerged as potential strategies.},
 year = {2020}
}

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TY  - JOUR
T1  - Revolutionary Study in Antibody and Bacterial Mediated Immunotoxin for Breast Cancer Treatment
AU  - Rajaganapathy Kaliyaperumal
AU  - Yuvaraj Govindarajan
AU  - Dillibabu
Y1  - 2020/12/31
PY  - 2020
N1  - https://doi.org/10.11648/j.bsi.20200504.12
DO  - 10.11648/j.bsi.20200504.12
T2  - Biomedical Statistics and Informatics
JF  - Biomedical Statistics and Informatics
JO  - Biomedical Statistics and Informatics
SP  - 81
EP  - 86
PB  - Science Publishing Group
SN  - 2578-8728
UR  - https://doi.org/10.11648/j.bsi.20200504.12
AB  - Many of this treatments for Breast cancer (BC-carcinoma), including surgery, radiation, and chemotherapy, haven't been effective in diminishing mortality rates, but bacterial mediated Antibody-immunotoxins has become one in all the best approaches to cancer treatment. Under these exceeding background, the present review, based on increasing mini report on bacterial mediated immunotoxins for breast cancer treatment. Various methodology suggest that, antibody therapies has been an central component in the association of malignant disease. Antibodies be capable of block the tumour growth factors or their specificity receptors and activate the immunological attack on the tumour microenvironment especially in breast cancer cells leads to tumor regression, and are used to deliver payloads such as radioisotopes, cytotoxic drugs or toxins. Immunotoxins are a new class of antitumour agents consisting of tumour selective ligands (generally mono clonal antibodies) linked to highly toxic protein molecules such as non-pathogenic bacterial species or programmed bacteria and take the advantage of the exquisite specificity of antibodies to selectively target drug delivery and the potency of toxins to kill the target cells. Currently, the attenuated bacteria as antitumor agents and vectors for gene directed enzyme prodrug or antibody conjugate therapy or immunotoxin have emerged as potential strategies.
VL  - 5
IS  - 4
ER  -

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Author Information

Rajaganapathy Kaliyaperumal

Chromosoft Research Centre, CRC Group, Chennai, Tamil Nadu, India
Yuvaraj Govindarajan

Chromosoft Research Centre, CRC Group, Chennai, Tamil Nadu, India
Dillibabu

Chromosoft Research Centre, CRC Group, Chennai, Tamil Nadu, India

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Plain Text BibTeX RIS

APA Style

Rajaganapathy Kaliyaperumal, Yuvaraj Govindarajan, Dillibabu. (2020). Revolutionary Study in Antibody and Bacterial Mediated Immunotoxin for Breast Cancer Treatment. Biomedical Statistics and Informatics, 5(4), 81-86. https://doi.org/10.11648/j.bsi.20200504.12

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ACS Style

Rajaganapathy Kaliyaperumal; Yuvaraj Govindarajan; Dillibabu. Revolutionary Study in Antibody and Bacterial Mediated Immunotoxin for Breast Cancer Treatment. Biomed. Stat. Inform. 2020, 5(4), 81-86. doi: 10.11648/j.bsi.20200504.12

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AMA Style

Rajaganapathy Kaliyaperumal, Yuvaraj Govindarajan, Dillibabu. Revolutionary Study in Antibody and Bacterial Mediated Immunotoxin for Breast Cancer Treatment. Biomed Stat Inform. 2020;5(4):81-86. doi: 10.11648/j.bsi.20200504.12

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@article{10.11648/j.bsi.20200504.12,
  author = {Rajaganapathy Kaliyaperumal and Yuvaraj Govindarajan and Dillibabu},
  title = {Revolutionary Study in Antibody and Bacterial Mediated Immunotoxin for Breast Cancer Treatment},
  journal = {Biomedical Statistics and Informatics},
  volume = {5},
  number = {4},
  pages = {81-86},
  doi = {10.11648/j.bsi.20200504.12},
  url = {https://doi.org/10.11648/j.bsi.20200504.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bsi.20200504.12},
  abstract = {Many of this treatments for Breast cancer (BC-carcinoma), including surgery, radiation, and chemotherapy, haven't been effective in diminishing mortality rates, but bacterial mediated Antibody-immunotoxins has become one in all the best approaches to cancer treatment. Under these exceeding background, the present review, based on increasing mini report on bacterial mediated immunotoxins for breast cancer treatment. Various methodology suggest that, antibody therapies has been an central component in the association of malignant disease. Antibodies be capable of block the tumour growth factors or their specificity receptors and activate the immunological attack on the tumour microenvironment especially in breast cancer cells leads to tumor regression, and are used to deliver payloads such as radioisotopes, cytotoxic drugs or toxins. Immunotoxins are a new class of antitumour agents consisting of tumour selective ligands (generally mono clonal antibodies) linked to highly toxic protein molecules such as non-pathogenic bacterial species or programmed bacteria and take the advantage of the exquisite specificity of antibodies to selectively target drug delivery and the potency of toxins to kill the target cells. Currently, the attenuated bacteria as antitumor agents and vectors for gene directed enzyme prodrug or antibody conjugate therapy or immunotoxin have emerged as potential strategies.},
 year = {2020}
}

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TY  - JOUR
T1  - Revolutionary Study in Antibody and Bacterial Mediated Immunotoxin for Breast Cancer Treatment
AU  - Rajaganapathy Kaliyaperumal
AU  - Yuvaraj Govindarajan
AU  - Dillibabu
Y1  - 2020/12/31
PY  - 2020
N1  - https://doi.org/10.11648/j.bsi.20200504.12
DO  - 10.11648/j.bsi.20200504.12
T2  - Biomedical Statistics and Informatics
JF  - Biomedical Statistics and Informatics
JO  - Biomedical Statistics and Informatics
SP  - 81
EP  - 86
PB  - Science Publishing Group
SN  - 2578-8728
UR  - https://doi.org/10.11648/j.bsi.20200504.12
AB  - Many of this treatments for Breast cancer (BC-carcinoma), including surgery, radiation, and chemotherapy, haven't been effective in diminishing mortality rates, but bacterial mediated Antibody-immunotoxins has become one in all the best approaches to cancer treatment. Under these exceeding background, the present review, based on increasing mini report on bacterial mediated immunotoxins for breast cancer treatment. Various methodology suggest that, antibody therapies has been an central component in the association of malignant disease. Antibodies be capable of block the tumour growth factors or their specificity receptors and activate the immunological attack on the tumour microenvironment especially in breast cancer cells leads to tumor regression, and are used to deliver payloads such as radioisotopes, cytotoxic drugs or toxins. Immunotoxins are a new class of antitumour agents consisting of tumour selective ligands (generally mono clonal antibodies) linked to highly toxic protein molecules such as non-pathogenic bacterial species or programmed bacteria and take the advantage of the exquisite specificity of antibodies to selectively target drug delivery and the potency of toxins to kill the target cells. Currently, the attenuated bacteria as antitumor agents and vectors for gene directed enzyme prodrug or antibody conjugate therapy or immunotoxin have emerged as potential strategies.
VL  - 5
IS  - 4
ER  -

Copy | Download