American Journal of Pediatrics

Special Issue

Chronic Kidney Disease in Children

  • Submission Deadline: Feb. 20, 2020
  • Status: Submission Closed
  • Lead Guest Editor: Ilkhamdzhan Karimdzhanov
About This Special Issue
Chronic kidney disease (CKD) has been suggested to affect 15–74.7 children per mil-lion globally. Although CKD is relatively rare in children as compared with adults, hypertension (HTN), obesity and metabolic syndrome, uric acid disturbances is highly prevalent. The prevalence of HTN, obesity and metabolic syndrome is tenfold higher than in the general pediatric population and known to increase as children progress through the stages of CKD, so that by the time they are on dialysis. CKD HTN, obesity, metabolic syndrome and uric acid metabolism are intrinsically linked. Thus, decreased kidney function may be directly related to increased BP, overweight and metabolic syndrome. There are now many studies demonstrating an interaction between CKD and HTN, overweight and metabolic syndrome likely hastening the progression of CKD toward end-stage renal disease. Addressing HTN, overweight and obesity may well prevent or abrogate this decline in renal function and have, therefore, become imperative in the management of CKD. As well as being an associated feature and complication of CKD, and independent risk factors for CKD progression, HTN, obesity, metabolic syndrome and disturbances of uric acid metabolism also contributes to cardiovascular mortality in these children.
Adopting best practices for monitoring and controlling body weight, BP are crucial to improve the management of obesity, HTN, and prevent future end-organ damage. However, diagnosing and managing HTN and obesity in pediatric CKD patients remains a challenge. When obesity and HTN are diagnosed, antihypertensive drugs, including angiotensin converting enzyme (ACE) inhibitors, antiobesity medications such as orlistat might offer renoprotection and delay the progression of CKD, especially in proteinuric states. Dietary restriction and monitoring is also a factor in managing obesity and HTN, but has proved difficult to control in the pediatric population.
To study the role of hypertension, obesity, metabolic syndrome and uric acid disturbances in progression of chronic kidney disease in children.
Aims and Scope:
  1. Chronic kidney diseases
  2. Hypertension
  3. Overweight
  4. Obesity
  5. Metabolic syndrome
  6. Uric acid
Lead Guest Editor
  • Ilkhamdzhan Karimdzhanov

    Tashkent Medical Academy, Tashkent, Uzbekistan

Guest Editors
  • Lola Rachmanova

    Tashkent Medical Academy, Tashkent, Uzbekistan

  • Turdicul Bobomuratov

    Tashkent Medical Academy, Tashkent, Uzbekistan

  • Gulshan Iskanova

    Tashkent Medical Academy, Tashkent, Uzbekistan

  • Anvar Tursunbaev

    Tashkent Medical Academy, Tashkent, Uzbekistan

  • Umida Zokirova

    Tashkent Medical Academy, Tashkent, Uzbekistan

  • Gulnoza Yusupova

    Tashkent Medical Academy, Tashkent, Uzbekistan

Published Articles
  • Takayasu’s Arteritis with Renovascular Damage: A Case Report

    Ilkhamdzhan Karimdzhanov , Dilorom Atayeva Rakhimjanovna , Alovkhon Suleymanov , Gulshan Iskanova , Sanjar Egamberdiyev

    Issue: Volume 6, Issue 2, June 2020
    Pages: 152-158
    Received: Feb. 19, 2020
    Accepted: Mar. 09, 2020
    Published: Mar. 31, 2020
    DOI: 10.11648/j.ajp.20200602.26
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    Abstract: Takayasu’s arteritis characterizes with severe damage of medium- and large-sized arteries. The pathophysiological progression of full-thickness inflammation of the vessel wall and subsequent fibrosis usually occurs with vascular stenosis and/or occlusion, causing ischemia of the corresponding organs, which is associated with high mortality. the sup... Show More
  • Arterial Hypertension in Children with Chronic Kidney Diseases

    Karimdzhanov Ilkhamdzhan , Rakhmanova Lola , Iskanova Gulshan , Israilova Nigora , Yusupova Gulnoza , Karimova Umida

    Issue: Volume 6, Issue 2, June 2020
    Pages: 109-116
    Received: Feb. 18, 2020
    Accepted: Mar. 04, 2020
    Published: Mar. 10, 2020
    DOI: 10.11648/j.ajp.20200602.18
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    Abstract: Arrterial hypertension (HTN) is one of the most common sequelae of chronic kidney disease (CKD) in children. In children with chronic kidney disease (CKD) HTN is several times higher than in the general pediatric population. With progression of CKD, HTN increases, reaching 45-60% in dialysis patients. The regulation of hypertension in children is m... Show More
  • Lupus Nephritis in Children: 21-Year Experience of a Single Center in Belarus

    Ina Kazyra , Alexander Sukalo

    Issue: Volume 6, Issue 1, March 2020
    Pages: 31-36
    Received: Jan. 15, 2020
    Accepted: Feb. 10, 2020
    Published: Feb. 18, 2020
    DOI: 10.11648/j.ajp.20200601.15
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    Abstract: The article presents a historical and prospective analysis of the clinical and paraclinical data of a cohort of children suffering from systemic lupus erythematosus (SLE) with kidney damage, observed in a single center for 21 year. The case histories of 62 patients (51 girls and 11 boys) with a diagnosis of SLE and lupus nephritis (LN) who were mon... Show More
  • New Biomarkers in the Diagnosis of Kidney Injury in Children with Hereditary Nephritis and Tubulopaties

    Hanna Bialkevich , Ina Kazyra , Alexander Sukalo

    Issue: Volume 6, Issue 1, March 2020
    Pages: 37-41
    Received: Jan. 15, 2020
    Accepted: Feb. 07, 2020
    Published: Feb. 18, 2020
    DOI: 10.11648/j.ajp.20200601.16
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    Abstract: The search of non-invasive methods of diagnosis of kidney disease, new biomarkers of injury and its level is very important at present time. Such markers are KIM-1 (kidney injury molecule - 1), TGF-β1 (transforming growth factor - β1), RBP (retinol-binding protein) and β2-MG (β2 – microglobulin). β2-MG and RBP are low molecular weight proteins whic... Show More