The Role of Hesperetin in the Management of Diabetes Mellitus and Its Complications

J. Revathy; S. Sheik Abdullah

doi:doi:10.11648/j.jctr.20170501.11

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The Role of Hesperetin in the Management of Diabetes Mellitus and Its Complications

J. Revathy, S. Sheik Abdullah

Published in Journal of Cancer Treatment and Research (Volume 5, Issue 1)

Received: 31 October 2016 Accepted: 14 March 2017 Published: 17 March 2017

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Abstract

Diabetes mellitus is a chronic metabolic disease which is a serious global problem. Many antidiabetic therapies focus on improving insulin sensitivity, increasing insulin production, and/or decreasing the level of blood glucose. Hesperetin is a flavanoid commonly found in many herbal medicines and food. Hesperetin seem to demonstrate adequate properties. Animal studies were carried out for 45days and at the end of 45^th day blood samples were collected and various biochemical parameters were measured using autoanalyser. They can inhibit enzymes involved in glucose metabolism, prevent the development of insulin resistance and normalize plasma glucose and insulin levels. This synthetic drug apart from producing a hypoglycemic effect has also been found to manifest hypolipidemic and anti-obesity activity. Hesperetin is also promising agents in the prevention of diabetic complications. They have strong antioxidant activity and inhibit the formation of advanced glycation end products, implicated in the pathogenesis of diabetic nephropathy, embryopathy, and neuropathy or impaired wound healing. Until now very few clinical studies have been concerned with the application of Hesperetin in treating diabetes. Our experimental findings with respect to the mechanism of action of synthetic compound in Streptozotocin induced diabetic rats suggest that it enhances insulin secretion by the islets of langerhans and enhances glucose utilization. However, due to their great therapeutic potential, these compounds deserve special attention.

Published in	Journal of Cancer Treatment and Research (Volume 5, Issue 1)
DOI	10.11648/j.jctr.20170501.11
Page(s)	1-6
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Hesperetin, Insulin, Hypoglycemic Effect, Hypolipidemic Activity

References

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APA Style

J. Revathy, S. Sheik Abdullah. (2017). The Role of Hesperetin in the Management of Diabetes Mellitus and Its Complications. Journal of Cancer Treatment and Research, 5(1), 1-6. https://doi.org/10.11648/j.jctr.20170501.11

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ACS Style

J. Revathy; S. Sheik Abdullah. The Role of Hesperetin in the Management of Diabetes Mellitus and Its Complications. J. Cancer Treat. Res. 2017, 5(1), 1-6. doi: 10.11648/j.jctr.20170501.11

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AMA Style

J. Revathy, S. Sheik Abdullah. The Role of Hesperetin in the Management of Diabetes Mellitus and Its Complications. J Cancer Treat Res. 2017;5(1):1-6. doi: 10.11648/j.jctr.20170501.11

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@article{10.11648/j.jctr.20170501.11,
  author = {J. Revathy and S. Sheik Abdullah},
  title = {The Role of Hesperetin in the Management of Diabetes Mellitus and Its Complications},
  journal = {Journal of Cancer Treatment and Research},
  volume = {5},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.jctr.20170501.11},
  url = {https://doi.org/10.11648/j.jctr.20170501.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20170501.11},
  abstract = {Diabetes mellitus is a chronic metabolic disease which is a serious global problem. Many antidiabetic therapies focus on improving insulin sensitivity, increasing insulin production, and/or decreasing the level of blood glucose. Hesperetin is a flavanoid commonly found in many herbal medicines and food. Hesperetin seem to demonstrate adequate properties. Animal studies were carried out for 45days and at the end of 45th day blood samples were collected and various biochemical parameters were measured using autoanalyser. They can inhibit enzymes involved in glucose metabolism, prevent the development of insulin resistance and normalize plasma glucose and insulin levels. This synthetic drug apart from producing a hypoglycemic effect has also been found to manifest hypolipidemic and anti-obesity activity. Hesperetin is also promising agents in the prevention of diabetic complications. They have strong antioxidant activity and inhibit the formation of advanced glycation end products, implicated in the pathogenesis of diabetic nephropathy, embryopathy, and neuropathy or impaired wound healing. Until now very few clinical studies have been concerned with the application of Hesperetin in treating diabetes. Our experimental findings with respect to the mechanism of action of synthetic compound in Streptozotocin induced diabetic rats suggest that it enhances insulin secretion by the islets of langerhans and enhances glucose utilization. However, due to their great therapeutic potential, these compounds deserve special attention.},
 year = {2017}
}

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TY - JOUR
T1 - The Role of Hesperetin in the Management of Diabetes Mellitus and Its Complications
AU - J. Revathy
AU - S. Sheik Abdullah
Y1 - 2017/03/17
PY - 2017
N1 - https://doi.org/10.11648/j.jctr.20170501.11
DO - 10.11648/j.jctr.20170501.11
T2 - Journal of Cancer Treatment and Research
JF - Journal of Cancer Treatment and Research
JO - Journal of Cancer Treatment and Research
SP - 1
EP - 6
PB - Science Publishing Group
SN - 2376-7790
UR - https://doi.org/10.11648/j.jctr.20170501.11
AB - Diabetes mellitus is a chronic metabolic disease which is a serious global problem. Many antidiabetic therapies focus on improving insulin sensitivity, increasing insulin production, and/or decreasing the level of blood glucose. Hesperetin is a flavanoid commonly found in many herbal medicines and food. Hesperetin seem to demonstrate adequate properties. Animal studies were carried out for 45days and at the end of 45th day blood samples were collected and various biochemical parameters were measured using autoanalyser. They can inhibit enzymes involved in glucose metabolism, prevent the development of insulin resistance and normalize plasma glucose and insulin levels. This synthetic drug apart from producing a hypoglycemic effect has also been found to manifest hypolipidemic and anti-obesity activity. Hesperetin is also promising agents in the prevention of diabetic complications. They have strong antioxidant activity and inhibit the formation of advanced glycation end products, implicated in the pathogenesis of diabetic nephropathy, embryopathy, and neuropathy or impaired wound healing. Until now very few clinical studies have been concerned with the application of Hesperetin in treating diabetes. Our experimental findings with respect to the mechanism of action of synthetic compound in Streptozotocin induced diabetic rats suggest that it enhances insulin secretion by the islets of langerhans and enhances glucose utilization. However, due to their great therapeutic potential, these compounds deserve special attention.
VL - 5
IS - 1
ER -

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Author Information

J. Revathy

Research and Development Centre, Bharathiyar University, Coimbatore, Tamilnadu, India
S. Sheik Abdullah

Biochemistry Faculty, Department of Chemistry and Biosciences, Sastra University, Srinivasa Ramanujan Centre, Kumbakonam, Tamilnadu India

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Plain Text BibTeX RIS

APA Style

J. Revathy, S. Sheik Abdullah. (2017). The Role of Hesperetin in the Management of Diabetes Mellitus and Its Complications. Journal of Cancer Treatment and Research, 5(1), 1-6. https://doi.org/10.11648/j.jctr.20170501.11

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ACS Style

J. Revathy; S. Sheik Abdullah. The Role of Hesperetin in the Management of Diabetes Mellitus and Its Complications. J. Cancer Treat. Res. 2017, 5(1), 1-6. doi: 10.11648/j.jctr.20170501.11

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AMA Style

J. Revathy, S. Sheik Abdullah. The Role of Hesperetin in the Management of Diabetes Mellitus and Its Complications. J Cancer Treat Res. 2017;5(1):1-6. doi: 10.11648/j.jctr.20170501.11

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@article{10.11648/j.jctr.20170501.11,
  author = {J. Revathy and S. Sheik Abdullah},
  title = {The Role of Hesperetin in the Management of Diabetes Mellitus and Its Complications},
  journal = {Journal of Cancer Treatment and Research},
  volume = {5},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.jctr.20170501.11},
  url = {https://doi.org/10.11648/j.jctr.20170501.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20170501.11},
  abstract = {Diabetes mellitus is a chronic metabolic disease which is a serious global problem. Many antidiabetic therapies focus on improving insulin sensitivity, increasing insulin production, and/or decreasing the level of blood glucose. Hesperetin is a flavanoid commonly found in many herbal medicines and food. Hesperetin seem to demonstrate adequate properties. Animal studies were carried out for 45days and at the end of 45th day blood samples were collected and various biochemical parameters were measured using autoanalyser. They can inhibit enzymes involved in glucose metabolism, prevent the development of insulin resistance and normalize plasma glucose and insulin levels. This synthetic drug apart from producing a hypoglycemic effect has also been found to manifest hypolipidemic and anti-obesity activity. Hesperetin is also promising agents in the prevention of diabetic complications. They have strong antioxidant activity and inhibit the formation of advanced glycation end products, implicated in the pathogenesis of diabetic nephropathy, embryopathy, and neuropathy or impaired wound healing. Until now very few clinical studies have been concerned with the application of Hesperetin in treating diabetes. Our experimental findings with respect to the mechanism of action of synthetic compound in Streptozotocin induced diabetic rats suggest that it enhances insulin secretion by the islets of langerhans and enhances glucose utilization. However, due to their great therapeutic potential, these compounds deserve special attention.},
 year = {2017}
}

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