Medical Significance of CoQ10 and Its Enhanced Production Using Potential Producer Microorganisms

Mushimiyimana Henriette; Mukama Omar; Ndikubwimana Jean De Dieu; Mukasekuru Marie Rose; Xiao-Dong Gao; Bemena Léo

doi:doi:10.11648/j.ijfsb.20170202.14

| Peer-Reviewed

Medical Significance of CoQ10 and Its Enhanced Production Using Potential Producer Microorganisms

Mushimiyimana Henriette, Mukama Omar, Ndikubwimana Jean De Dieu, Mukasekuru Marie Rose, Xiao-Dong Gao, Bemena Léo

Published in International Journal of Food Science and Biotechnology (Volume 2, Issue 2)

Received: 20 March 2017 Accepted: 27 March 2017 Published: 15 April 2017

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Abstract

Coenzyme Q10 is a polyphilic molecule resembling to vitamin structure. In the cell, CoQ10 is produced from hydrophobic isoprenoid chain conjugation with benzoquinone ring. Naturally, various ubiquinone (UQ) can be produced by yeast and microorganisms and present in human as CoQ10. It plays a critical role in human health given its use as medicine, dietary supplement and in cosmetics. Currently, CoQ10 biosynthesis is highly studied due to its critical contribution in the electron transport chain and cellular respiration which produces energy in the form of ATP. It has antioxidant activity and highly used as supplement to human with various diseases depicting high need on the market. Its high scale production is based on engineering of natural producing strains through putative techniques of metabolic engineering including mutagenesis and/or metabolic pathways modification followed by fermentation strategies optimization. Escherichia coli and Saccharomyces cerevisiae are the most used and genetically optimized. However, to date, more other strains such as Sphingomonas sp., Agrobacterium sp., and Rhodobacter sphaeroides are entirely explored with significant improvement and utility since their CoQ are similar to that produced in humans. This review will first focus on strategies used to improve CoQ10 yield with the use of preferred genetic engineering of potent strain producers and culminate with pointing out the latest medical significance of CoQ10 in light of its deficiency towards advocating its use in mitigating mitochondrial associated dysfunction, neurodegenerative and cardiovascular diseases.

Published in	International Journal of Food Science and Biotechnology (Volume 2, Issue 2)
DOI	10.11648/j.ijfsb.20170202.14
Page(s)	56-66
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

CoQ10, Metabolic Engineering, Mevalonate and Non-Mevalonate Pathway, Potent, CoQ10 Producers, Medical Functions

References

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Mushimiyimana Henriette, Mukama Omar, Ndikubwimana Jean De Dieu, Mukasekuru Marie Rose, Xiao-Dong Gao, et al. (2017). Medical Significance of CoQ10 and Its Enhanced Production Using Potential Producer Microorganisms. International Journal of Food Science and Biotechnology, 2(2), 56-66. https://doi.org/10.11648/j.ijfsb.20170202.14

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Mushimiyimana Henriette; Mukama Omar; Ndikubwimana Jean De Dieu; Mukasekuru Marie Rose; Xiao-Dong Gao, et al. Medical Significance of CoQ10 and Its Enhanced Production Using Potential Producer Microorganisms. Int. J. Food Sci. Biotechnol. 2017, 2(2), 56-66. doi: 10.11648/j.ijfsb.20170202.14

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Mushimiyimana Henriette, Mukama Omar, Ndikubwimana Jean De Dieu, Mukasekuru Marie Rose, Xiao-Dong Gao, et al. Medical Significance of CoQ10 and Its Enhanced Production Using Potential Producer Microorganisms. Int J Food Sci Biotechnol. 2017;2(2):56-66. doi: 10.11648/j.ijfsb.20170202.14

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@article{10.11648/j.ijfsb.20170202.14,
  author = {Mushimiyimana Henriette and Mukama Omar and Ndikubwimana Jean De Dieu and Mukasekuru Marie Rose and Xiao-Dong Gao and Bemena Léo},
  title = {Medical Significance of CoQ10 and Its Enhanced Production Using Potential Producer Microorganisms},
  journal = {International Journal of Food Science and Biotechnology},
  volume = {2},
  number = {2},
  pages = {56-66},
  doi = {10.11648/j.ijfsb.20170202.14},
  url = {https://doi.org/10.11648/j.ijfsb.20170202.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijfsb.20170202.14},
  abstract = {Coenzyme Q10 is a polyphilic molecule resembling to vitamin structure. In the cell, CoQ10 is produced from hydrophobic isoprenoid chain conjugation with benzoquinone ring. Naturally, various ubiquinone (UQ) can be produced by yeast and microorganisms and present in human as CoQ10. It plays a critical role in human health given its use as medicine, dietary supplement and in cosmetics. Currently, CoQ10 biosynthesis is highly studied due to its critical contribution in the electron transport chain and cellular respiration which produces energy in the form of ATP. It has antioxidant activity and highly used as supplement to human with various diseases depicting high need on the market. Its high scale production is based on engineering of natural producing strains through putative techniques of metabolic engineering including mutagenesis and/or metabolic pathways modification followed by fermentation strategies optimization. Escherichia coli and Saccharomyces cerevisiae are the most used and genetically optimized. However, to date, more other strains such as Sphingomonas sp., Agrobacterium sp.,  and Rhodobacter sphaeroides are entirely explored with significant improvement and utility since their CoQ are similar to that produced in humans. This review will first focus on strategies used to improve CoQ10 yield with the use of preferred genetic engineering of potent strain producers and culminate with pointing out the latest medical significance of CoQ10 in light of its deficiency towards advocating its use in mitigating mitochondrial associated dysfunction, neurodegenerative and cardiovascular diseases.},
 year = {2017}
}

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TY  - JOUR
T1  - Medical Significance of CoQ10 and Its Enhanced Production Using Potential Producer Microorganisms
AU  - Mushimiyimana Henriette
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AU  - Ndikubwimana Jean De Dieu
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DO  - 10.11648/j.ijfsb.20170202.14
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JF  - International Journal of Food Science and Biotechnology
JO  - International Journal of Food Science and Biotechnology
SP  - 56
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PB  - Science Publishing Group
SN  - 2578-9643
UR  - https://doi.org/10.11648/j.ijfsb.20170202.14
AB  - Coenzyme Q10 is a polyphilic molecule resembling to vitamin structure. In the cell, CoQ10 is produced from hydrophobic isoprenoid chain conjugation with benzoquinone ring. Naturally, various ubiquinone (UQ) can be produced by yeast and microorganisms and present in human as CoQ10. It plays a critical role in human health given its use as medicine, dietary supplement and in cosmetics. Currently, CoQ10 biosynthesis is highly studied due to its critical contribution in the electron transport chain and cellular respiration which produces energy in the form of ATP. It has antioxidant activity and highly used as supplement to human with various diseases depicting high need on the market. Its high scale production is based on engineering of natural producing strains through putative techniques of metabolic engineering including mutagenesis and/or metabolic pathways modification followed by fermentation strategies optimization. Escherichia coli and Saccharomyces cerevisiae are the most used and genetically optimized. However, to date, more other strains such as Sphingomonas sp., Agrobacterium sp.,  and Rhodobacter sphaeroides are entirely explored with significant improvement and utility since their CoQ are similar to that produced in humans. This review will first focus on strategies used to improve CoQ10 yield with the use of preferred genetic engineering of potent strain producers and culminate with pointing out the latest medical significance of CoQ10 in light of its deficiency towards advocating its use in mitigating mitochondrial associated dysfunction, neurodegenerative and cardiovascular diseases.
VL  - 2
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Author Information

Mushimiyimana Henriette

Key Laboratory of Carbohydrate Chemistry and Biotechnology, School of Biotechnology, Jiangnan University, Wuxi, People’s Republic of China
Mukama Omar

Key Laboratory of Carbohydrate Chemistry and Biotechnology, School of Biotechnology, Jiangnan University, Wuxi, People’s Republic of China; Department of Applied Biology, College of Science and Technology, University of Rwanda, Kigali, Rwanda
Ndikubwimana Jean De Dieu

Key Laboratory of Carbohydrate Chemistry and Biotechnology, School of Biotechnology, Jiangnan University, Wuxi, People’s Republic of China
Mukasekuru Marie Rose

Key Laboratory of Carbohydrate Chemistry and Biotechnology, School of Biotechnology, Jiangnan University, Wuxi, People’s Republic of China; Department of Applied Biology, College of Science and Technology, University of Rwanda, Kigali, Rwanda
Xiao-Dong Gao

Key Laboratory of Carbohydrate Chemistry and Biotechnology, School of Biotechnology, Jiangnan University, Wuxi, People’s Republic of China
Bemena Léo

Key Laboratory of Carbohydrate Chemistry and Biotechnology, School of Biotechnology, Jiangnan University, Wuxi, People’s Republic of China

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Mushimiyimana Henriette, Mukama Omar, Ndikubwimana Jean De Dieu, Mukasekuru Marie Rose, Xiao-Dong Gao, et al. (2017). Medical Significance of CoQ10 and Its Enhanced Production Using Potential Producer Microorganisms. International Journal of Food Science and Biotechnology, 2(2), 56-66. https://doi.org/10.11648/j.ijfsb.20170202.14

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ACS Style

Mushimiyimana Henriette; Mukama Omar; Ndikubwimana Jean De Dieu; Mukasekuru Marie Rose; Xiao-Dong Gao, et al. Medical Significance of CoQ10 and Its Enhanced Production Using Potential Producer Microorganisms. Int. J. Food Sci. Biotechnol. 2017, 2(2), 56-66. doi: 10.11648/j.ijfsb.20170202.14

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AMA Style

Mushimiyimana Henriette, Mukama Omar, Ndikubwimana Jean De Dieu, Mukasekuru Marie Rose, Xiao-Dong Gao, et al. Medical Significance of CoQ10 and Its Enhanced Production Using Potential Producer Microorganisms. Int J Food Sci Biotechnol. 2017;2(2):56-66. doi: 10.11648/j.ijfsb.20170202.14

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@article{10.11648/j.ijfsb.20170202.14,
  author = {Mushimiyimana Henriette and Mukama Omar and Ndikubwimana Jean De Dieu and Mukasekuru Marie Rose and Xiao-Dong Gao and Bemena Léo},
  title = {Medical Significance of CoQ10 and Its Enhanced Production Using Potential Producer Microorganisms},
  journal = {International Journal of Food Science and Biotechnology},
  volume = {2},
  number = {2},
  pages = {56-66},
  doi = {10.11648/j.ijfsb.20170202.14},
  url = {https://doi.org/10.11648/j.ijfsb.20170202.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijfsb.20170202.14},
  abstract = {Coenzyme Q10 is a polyphilic molecule resembling to vitamin structure. In the cell, CoQ10 is produced from hydrophobic isoprenoid chain conjugation with benzoquinone ring. Naturally, various ubiquinone (UQ) can be produced by yeast and microorganisms and present in human as CoQ10. It plays a critical role in human health given its use as medicine, dietary supplement and in cosmetics. Currently, CoQ10 biosynthesis is highly studied due to its critical contribution in the electron transport chain and cellular respiration which produces energy in the form of ATP. It has antioxidant activity and highly used as supplement to human with various diseases depicting high need on the market. Its high scale production is based on engineering of natural producing strains through putative techniques of metabolic engineering including mutagenesis and/or metabolic pathways modification followed by fermentation strategies optimization. Escherichia coli and Saccharomyces cerevisiae are the most used and genetically optimized. However, to date, more other strains such as Sphingomonas sp., Agrobacterium sp.,  and Rhodobacter sphaeroides are entirely explored with significant improvement and utility since their CoQ are similar to that produced in humans. This review will first focus on strategies used to improve CoQ10 yield with the use of preferred genetic engineering of potent strain producers and culminate with pointing out the latest medical significance of CoQ10 in light of its deficiency towards advocating its use in mitigating mitochondrial associated dysfunction, neurodegenerative and cardiovascular diseases.},
 year = {2017}
}

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TY  - JOUR
T1  - Medical Significance of CoQ10 and Its Enhanced Production Using Potential Producer Microorganisms
AU  - Mushimiyimana Henriette
AU  - Mukama Omar
AU  - Ndikubwimana Jean De Dieu
AU  - Mukasekuru Marie Rose
AU  - Xiao-Dong Gao
AU  - Bemena Léo
Y1  - 2017/04/15
PY  - 2017
N1  - https://doi.org/10.11648/j.ijfsb.20170202.14
DO  - 10.11648/j.ijfsb.20170202.14
T2  - International Journal of Food Science and Biotechnology
JF  - International Journal of Food Science and Biotechnology
JO  - International Journal of Food Science and Biotechnology
SP  - 56
EP  - 66
PB  - Science Publishing Group
SN  - 2578-9643
UR  - https://doi.org/10.11648/j.ijfsb.20170202.14
AB  - Coenzyme Q10 is a polyphilic molecule resembling to vitamin structure. In the cell, CoQ10 is produced from hydrophobic isoprenoid chain conjugation with benzoquinone ring. Naturally, various ubiquinone (UQ) can be produced by yeast and microorganisms and present in human as CoQ10. It plays a critical role in human health given its use as medicine, dietary supplement and in cosmetics. Currently, CoQ10 biosynthesis is highly studied due to its critical contribution in the electron transport chain and cellular respiration which produces energy in the form of ATP. It has antioxidant activity and highly used as supplement to human with various diseases depicting high need on the market. Its high scale production is based on engineering of natural producing strains through putative techniques of metabolic engineering including mutagenesis and/or metabolic pathways modification followed by fermentation strategies optimization. Escherichia coli and Saccharomyces cerevisiae are the most used and genetically optimized. However, to date, more other strains such as Sphingomonas sp., Agrobacterium sp.,  and Rhodobacter sphaeroides are entirely explored with significant improvement and utility since their CoQ are similar to that produced in humans. This review will first focus on strategies used to improve CoQ10 yield with the use of preferred genetic engineering of potent strain producers and culminate with pointing out the latest medical significance of CoQ10 in light of its deficiency towards advocating its use in mitigating mitochondrial associated dysfunction, neurodegenerative and cardiovascular diseases.
VL  - 2
IS  - 2
ER  -

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