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Ameliorative Role of Jania Rubens Alga Against Toxicity of Heavy Metal Polluted Water in Male Rats

Received: Nov. 17, 2018    Accepted: Dec. 04, 2018    Published: Jan. 03, 2019
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Abstract

Elimination of heavy metals from contaminated water is a significant issue. Algae can be used as the detoxifying agent of these metals. This study was achieved to assess the efficacy of red marine alga (Jania Rubens) opposed to the initial modifications that may be concerning the toxicity of heavy metal-polluted water on male rats. 45 male Wistar rats were separated into 3 groups (15 rat/ group): Group I (control); Group II (Heavy metal group) and Group III (Treated group). There were significant increases in the levels of SGPT, SGOT, ALP, creatinine, urea, UA, malondialdehyde (MDA), glutathione peroxidase (GPx), protein carbonyl (PC) and significant decrease of body weights& levels of blood hemoglobin, total protein, albumin, catalase, SOD, and GSH in the heavy metal group in comparison with control. Meanwhile, the administration of treated water to rats restores all parameters to normal level in the treated group. Highly significant increase in Metallothionein (MT) levels in hepatic and renal tissue of heavy metal group compared to control, that restored to normal in the treated group. Also, Ni, Cd and Pb metals accumulated in liver, kidney and brain tissues were measured in all studied groups. Our results suggested the ameliorative effect of red marine algae treated water opposed to the toxicity of heavy metals in liver, kidney and brain tissues.

DOI 10.11648/j.stpp.20180202.13
Published in Science, Technology & Public Policy ( Volume 2, Issue 2, December 2018 )
Page(s) 38-46
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Heavy Metals, Water Treatment, Red Marine Algae, Metallothionein, Oxidative Stress

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Cite This Article
  • APA Style

    Soha Mohamed Hamdy, Amany Mohamed Shaban, Yasmeen Saeid Abdel Aziz, Atef Mohamed Mahmoud, Leqaa Abdel Aziz Moemen, et al. (2019). Ameliorative Role of Jania Rubens Alga Against Toxicity of Heavy Metal Polluted Water in Male Rats. Science, Technology & Public Policy, 2(2), 38-46. https://doi.org/10.11648/j.stpp.20180202.13

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    ACS Style

    Soha Mohamed Hamdy; Amany Mohamed Shaban; Yasmeen Saeid Abdel Aziz; Atef Mohamed Mahmoud; Leqaa Abdel Aziz Moemen, et al. Ameliorative Role of Jania Rubens Alga Against Toxicity of Heavy Metal Polluted Water in Male Rats. Sci. Technol. Public Policy 2019, 2(2), 38-46. doi: 10.11648/j.stpp.20180202.13

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    AMA Style

    Soha Mohamed Hamdy, Amany Mohamed Shaban, Yasmeen Saeid Abdel Aziz, Atef Mohamed Mahmoud, Leqaa Abdel Aziz Moemen, et al. Ameliorative Role of Jania Rubens Alga Against Toxicity of Heavy Metal Polluted Water in Male Rats. Sci Technol Public Policy. 2019;2(2):38-46. doi: 10.11648/j.stpp.20180202.13

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  • @article{10.11648/j.stpp.20180202.13,
      author = {Soha Mohamed Hamdy and Amany Mohamed Shaban and Yasmeen Saeid Abdel Aziz and Atef Mohamed Mahmoud and Leqaa Abdel Aziz Moemen and Wael Mohamed Ibrahim and Nahed Shafik Gad},
      title = {Ameliorative Role of Jania Rubens Alga Against Toxicity of Heavy Metal Polluted Water in Male Rats},
      journal = {Science, Technology & Public Policy},
      volume = {2},
      number = {2},
      pages = {38-46},
      doi = {10.11648/j.stpp.20180202.13},
      url = {https://doi.org/10.11648/j.stpp.20180202.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.stpp.20180202.13},
      abstract = {Elimination of heavy metals from contaminated water is a significant issue. Algae can be used as the detoxifying agent of these metals. This study was achieved to assess the efficacy of red marine alga (Jania Rubens) opposed to the initial modifications that may be concerning the toxicity of heavy metal-polluted water on male rats. 45 male Wistar rats were separated into 3 groups (15 rat/ group): Group I (control); Group II (Heavy metal group) and Group III (Treated group). There were significant increases in the levels of SGPT, SGOT, ALP, creatinine, urea, UA, malondialdehyde (MDA), glutathione peroxidase (GPx), protein carbonyl (PC) and significant decrease of body weights& levels of blood hemoglobin, total protein, albumin, catalase, SOD, and GSH in the heavy metal group in comparison with control. Meanwhile, the administration of treated water to rats restores all parameters to normal level in the treated group. Highly significant increase in Metallothionein (MT) levels in hepatic and renal tissue of heavy metal group compared to control, that restored to normal in the treated group. Also, Ni, Cd and Pb metals accumulated in liver, kidney and brain tissues were measured in all studied groups. Our results suggested the ameliorative effect of red marine algae treated water opposed to the toxicity of heavy metals in liver, kidney and brain tissues.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Ameliorative Role of Jania Rubens Alga Against Toxicity of Heavy Metal Polluted Water in Male Rats
    AU  - Soha Mohamed Hamdy
    AU  - Amany Mohamed Shaban
    AU  - Yasmeen Saeid Abdel Aziz
    AU  - Atef Mohamed Mahmoud
    AU  - Leqaa Abdel Aziz Moemen
    AU  - Wael Mohamed Ibrahim
    AU  - Nahed Shafik Gad
    Y1  - 2019/01/03
    PY  - 2019
    N1  - https://doi.org/10.11648/j.stpp.20180202.13
    DO  - 10.11648/j.stpp.20180202.13
    T2  - Science, Technology & Public Policy
    JF  - Science, Technology & Public Policy
    JO  - Science, Technology & Public Policy
    SP  - 38
    EP  - 46
    PB  - Science Publishing Group
    SN  - 2640-4621
    UR  - https://doi.org/10.11648/j.stpp.20180202.13
    AB  - Elimination of heavy metals from contaminated water is a significant issue. Algae can be used as the detoxifying agent of these metals. This study was achieved to assess the efficacy of red marine alga (Jania Rubens) opposed to the initial modifications that may be concerning the toxicity of heavy metal-polluted water on male rats. 45 male Wistar rats were separated into 3 groups (15 rat/ group): Group I (control); Group II (Heavy metal group) and Group III (Treated group). There were significant increases in the levels of SGPT, SGOT, ALP, creatinine, urea, UA, malondialdehyde (MDA), glutathione peroxidase (GPx), protein carbonyl (PC) and significant decrease of body weights& levels of blood hemoglobin, total protein, albumin, catalase, SOD, and GSH in the heavy metal group in comparison with control. Meanwhile, the administration of treated water to rats restores all parameters to normal level in the treated group. Highly significant increase in Metallothionein (MT) levels in hepatic and renal tissue of heavy metal group compared to control, that restored to normal in the treated group. Also, Ni, Cd and Pb metals accumulated in liver, kidney and brain tissues were measured in all studied groups. Our results suggested the ameliorative effect of red marine algae treated water opposed to the toxicity of heavy metals in liver, kidney and brain tissues.
    VL  - 2
    IS  - 2
    ER  - 

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Author Information
  • Chemistry Department, Faculty of Science, Fayoum University, El- Fayoum, Egypt

  • Chemistry Department, Faculty of Science, Fayoum University, El- Fayoum, Egypt

  • Pollution Department, National Institute of Oceanography and Fisheries, Cairo, Egypt

  • Medical Biochemistry Department, Research Institute of Ophthalmology, Cairo, Egypt

  • Medical Biochemistry Department, Research Institute of Ophthalmology, Cairo, Egypt

  • Botany Department, Faculty of Science, Damanhour University, Beheira, Egypt

  • Pollution Department, National Institute of Oceanography and Fisheries, Cairo, Egypt

  • Section