American Journal of Applied Scientific Research

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Cell Clusters in Cancer Metastasis: A Mini Review

Received: Apr. 20, 2020    Accepted: May 07, 2020    Published: May 19, 2020
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Abstract

Evidence is accumulating that suggests that cancer cell clusters are more likely to lead to metastatic lesions than are single cells. This mini-review explores this issue by examining evidence that indicates that cell clusters possess altered genes and metabolism that promote metastasis. When clusters are disaggregated, the resulting single cells often lose the altered properties characteristic of when they were in clusters. When cluster disrupting agents were injected into mice, metastasis was reduced. Cluster disaggregating agents are described and mechanisms of action of these compounds are explored. Using these agents to target cell clusters might offer a useful therapeutic approach in the treatment of cancer. Cell clusters are also involved in thrombocytosis and biofilm infectivity as well as cancer spread and cluster disrupting agents might be very useful in treating some human conditions in addition to cancer spread. Assays that examine the effectiveness of cluster disrupting agents are also described.

DOI 10.11648/j.ajasr.20200602.13
Published in American Journal of Applied Scientific Research ( Volume 6, Issue 2, June 2020 )
Page(s) 43-45
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Clustered Cancer Cells, Cancer Metastasis, Cluster Disrupting Agents

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Cite This Article
  • APA Style

    Steven Oppenheimer. (2020). Cell Clusters in Cancer Metastasis: A Mini Review. American Journal of Applied Scientific Research, 6(2), 43-45. https://doi.org/10.11648/j.ajasr.20200602.13

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    ACS Style

    Steven Oppenheimer. Cell Clusters in Cancer Metastasis: A Mini Review. Am. J. Appl. Sci. Res. 2020, 6(2), 43-45. doi: 10.11648/j.ajasr.20200602.13

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    AMA Style

    Steven Oppenheimer. Cell Clusters in Cancer Metastasis: A Mini Review. Am J Appl Sci Res. 2020;6(2):43-45. doi: 10.11648/j.ajasr.20200602.13

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  • @article{10.11648/j.ajasr.20200602.13,
      author = {Steven Oppenheimer},
      title = {Cell Clusters in Cancer Metastasis: A Mini Review},
      journal = {American Journal of Applied Scientific Research},
      volume = {6},
      number = {2},
      pages = {43-45},
      doi = {10.11648/j.ajasr.20200602.13},
      url = {https://doi.org/10.11648/j.ajasr.20200602.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajasr.20200602.13},
      abstract = {Evidence is accumulating that suggests that cancer cell clusters are more likely to lead to metastatic lesions than are single cells. This mini-review explores this issue by examining evidence that indicates that cell clusters possess altered genes and metabolism that promote metastasis. When clusters are disaggregated, the resulting single cells often lose the altered properties characteristic of when they were in clusters. When cluster disrupting agents were injected into mice, metastasis was reduced. Cluster disaggregating agents are described and mechanisms of action of these compounds are explored. Using these agents to target cell clusters might offer a useful therapeutic approach in the treatment of cancer. Cell clusters are also involved in thrombocytosis and biofilm infectivity as well as cancer spread and cluster disrupting agents might be very useful in treating some human conditions in addition to cancer spread. Assays that examine the effectiveness of cluster disrupting agents are also described.},
     year = {2020}
    }
    

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    AB  - Evidence is accumulating that suggests that cancer cell clusters are more likely to lead to metastatic lesions than are single cells. This mini-review explores this issue by examining evidence that indicates that cell clusters possess altered genes and metabolism that promote metastasis. When clusters are disaggregated, the resulting single cells often lose the altered properties characteristic of when they were in clusters. When cluster disrupting agents were injected into mice, metastasis was reduced. Cluster disaggregating agents are described and mechanisms of action of these compounds are explored. Using these agents to target cell clusters might offer a useful therapeutic approach in the treatment of cancer. Cell clusters are also involved in thrombocytosis and biofilm infectivity as well as cancer spread and cluster disrupting agents might be very useful in treating some human conditions in addition to cancer spread. Assays that examine the effectiveness of cluster disrupting agents are also described.
    VL  - 6
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Author Information
  • Department of Biology and Center for Cancer and Developmental Biology, California State University, Northridge, California, United States

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