Biomedical Sciences

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Antiurolithiatic Potential of Eleusine indica Linn. (GOOSE GRASS) Root Extract on Ethylene Glycol Induced Nephrolithiasis in Rattus norvegicus (ALBINO RATS)

Received: Aug. 22, 2017    Accepted: Sep. 14, 2017    Published: Oct. 23, 2017
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Abstract

The study was mainly aimed to determine the antiurolithiathic potential of different concentrations of E. indica root extract on ethylene glycol induced nephrolithiasis in Rattus norvergicus (albino rats). It specifically targeted the effects the plant extract will pose on serum parameters (creatinine, BUN and uric acid) nitrituria, proteinuria, calcium oxalate excretion, and the histopathology of kidney tubules and glomeruli of albino rats. In the study, root of E. indica was collected, dried and extracted using distilled water of 80°C-100°C. The actual experimental period lasted for 4 weeks. The study involved 5 test groups; negative control group (T-), positive control group or lithogenic group (T+), two prophylactic groups (T1 and T2) receiving different concentrations of E. indica root extract (T1- 500mg/kg and T2- 800mg/kg) and one curative group receiving 800mg/kg of E. indica root extract after being induced with kidney stones during the first 2 weeks of the experimental period. All the test groups received 0.75% ethylene glycol (stone inducing chemical) in water for 4 week ad libitum with the exception of the negative control. At the end of the study, there was elevated levels of serum creatinine, BUN and uric acid among the lithogenic group which was normalized in all the three treatment groups. There was no significant difference between the serum parameters of the E. indica treatment groups and that of negative control (P < 0.05). There was the presence of nitrituria, proteinuria, high pH and high levels of calcium oxalate excretion in the lithogenic group. But again all these parameters were normalized in the three E. indica treatment groups. E. indica root extract also maintained the normal structure of kidney glomeruli and tubules among T1 and T2 (prophylactic groups) and repaired kidney defects in T3 (curative group). E. indica root extract thus possess antiurolithiathic potentials and can be used to prevent and cure nephrolithiasis in albino rats.

DOI 10.11648/j.bs.20170305.13
Published in Biomedical Sciences ( Volume 3, Issue 5, September 2017 )
Page(s) 99-108
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Antiurolithiatic, Ethylene Glycol, Nitrituria, Proteinuria, Nephrolithiasis

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    Daniel Opoku Amoah, Maritan Bringas Joson, Marlon Cartera Pareja. (2017). Antiurolithiatic Potential of Eleusine indica Linn. (GOOSE GRASS) Root Extract on Ethylene Glycol Induced Nephrolithiasis in Rattus norvegicus (ALBINO RATS). Biomedical Sciences, 3(5), 99-108. https://doi.org/10.11648/j.bs.20170305.13

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    ACS Style

    Daniel Opoku Amoah; Maritan Bringas Joson; Marlon Cartera Pareja. Antiurolithiatic Potential of Eleusine indica Linn. (GOOSE GRASS) Root Extract on Ethylene Glycol Induced Nephrolithiasis in Rattus norvegicus (ALBINO RATS). Biomed. Sci. 2017, 3(5), 99-108. doi: 10.11648/j.bs.20170305.13

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    AMA Style

    Daniel Opoku Amoah, Maritan Bringas Joson, Marlon Cartera Pareja. Antiurolithiatic Potential of Eleusine indica Linn. (GOOSE GRASS) Root Extract on Ethylene Glycol Induced Nephrolithiasis in Rattus norvegicus (ALBINO RATS). Biomed Sci. 2017;3(5):99-108. doi: 10.11648/j.bs.20170305.13

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  • @article{10.11648/j.bs.20170305.13,
      author = {Daniel Opoku Amoah and Maritan Bringas Joson and Marlon Cartera Pareja},
      title = {Antiurolithiatic Potential of Eleusine indica Linn. (GOOSE GRASS) Root Extract on Ethylene Glycol Induced Nephrolithiasis in Rattus norvegicus (ALBINO RATS)},
      journal = {Biomedical Sciences},
      volume = {3},
      number = {5},
      pages = {99-108},
      doi = {10.11648/j.bs.20170305.13},
      url = {https://doi.org/10.11648/j.bs.20170305.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.bs.20170305.13},
      abstract = {The study was mainly aimed to determine the antiurolithiathic potential of different concentrations of E. indica root extract on ethylene glycol induced nephrolithiasis in Rattus norvergicus (albino rats). It specifically targeted the effects the plant extract will pose on serum parameters (creatinine, BUN and uric acid) nitrituria, proteinuria, calcium oxalate excretion, and the histopathology of kidney tubules and glomeruli of albino rats. In the study, root of E. indica was collected, dried and extracted using distilled water of 80°C-100°C. The actual experimental period lasted for 4 weeks. The study involved 5 test groups; negative control group (T-), positive control group or lithogenic group (T+), two prophylactic groups (T1 and T2) receiving different concentrations of E. indica root extract (T1- 500mg/kg and T2- 800mg/kg) and one curative group receiving 800mg/kg of E. indica root extract after being induced with kidney stones during the first 2 weeks of the experimental period. All the test groups received 0.75% ethylene glycol (stone inducing chemical) in water for 4 week ad libitum with the exception of the negative control. At the end of the study, there was elevated levels of serum creatinine, BUN and uric acid among the lithogenic group which was normalized in all the three treatment groups. There was no significant difference between the serum parameters of the E. indica treatment groups and that of negative control (P E. indica treatment groups. E. indica root extract also maintained the normal structure of kidney glomeruli and tubules among T1 and T2 (prophylactic groups) and repaired kidney defects in T3 (curative group). E. indica root extract thus possess antiurolithiathic potentials and can be used to prevent and cure nephrolithiasis in albino rats.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Antiurolithiatic Potential of Eleusine indica Linn. (GOOSE GRASS) Root Extract on Ethylene Glycol Induced Nephrolithiasis in Rattus norvegicus (ALBINO RATS)
    AU  - Daniel Opoku Amoah
    AU  - Maritan Bringas Joson
    AU  - Marlon Cartera Pareja
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    JF  - Biomedical Sciences
    JO  - Biomedical Sciences
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    PB  - Science Publishing Group
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    UR  - https://doi.org/10.11648/j.bs.20170305.13
    AB  - The study was mainly aimed to determine the antiurolithiathic potential of different concentrations of E. indica root extract on ethylene glycol induced nephrolithiasis in Rattus norvergicus (albino rats). It specifically targeted the effects the plant extract will pose on serum parameters (creatinine, BUN and uric acid) nitrituria, proteinuria, calcium oxalate excretion, and the histopathology of kidney tubules and glomeruli of albino rats. In the study, root of E. indica was collected, dried and extracted using distilled water of 80°C-100°C. The actual experimental period lasted for 4 weeks. The study involved 5 test groups; negative control group (T-), positive control group or lithogenic group (T+), two prophylactic groups (T1 and T2) receiving different concentrations of E. indica root extract (T1- 500mg/kg and T2- 800mg/kg) and one curative group receiving 800mg/kg of E. indica root extract after being induced with kidney stones during the first 2 weeks of the experimental period. All the test groups received 0.75% ethylene glycol (stone inducing chemical) in water for 4 week ad libitum with the exception of the negative control. At the end of the study, there was elevated levels of serum creatinine, BUN and uric acid among the lithogenic group which was normalized in all the three treatment groups. There was no significant difference between the serum parameters of the E. indica treatment groups and that of negative control (P E. indica treatment groups. E. indica root extract also maintained the normal structure of kidney glomeruli and tubules among T1 and T2 (prophylactic groups) and repaired kidney defects in T3 (curative group). E. indica root extract thus possess antiurolithiathic potentials and can be used to prevent and cure nephrolithiasis in albino rats.
    VL  - 3
    IS  - 5
    ER  - 

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Author Information
  • Biological Sciences Department, College of Science, Computer Studies, De La Salle University-Dasmari?as, Cavite, Philippines

  • Biological Sciences Department, College of Science, Computer Studies, De La Salle University-Dasmari?as, Cavite, Philippines

  • Biological Sciences Department, College of Science, Computer Studies, De La Salle University-Dasmari?as, Cavite, Philippines

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