American Journal of Heterocyclic Chemistry

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Metal Complexes as Potential Antimicrobial Agent: A Review

Received: Jul. 11, 2017    Accepted: Aug. 08, 2017    Published: Jan. 08, 2018
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Abstract

Metal ions play many critical functions in humans. Deficiency of some metal ions can lead to disease like pernicious anemia resulting from iron deficiency, growth retardation arising from insufficient dietary zinc, and heart disease in infants owing to copper deficiency. Antibiotic resistance has been growing at an alarming rate and consequently the activity of antibiotics against Gram-negative and Gram-positive bacteria has dropped dramatically day by day. In this sense there is a strong need to synthesis new substances that not only have good spectrum of activity, but having new mechanisms of action. Inorganic compounds particularly metal complexes have played an important role in the development of new metal based drugs. A significantly rising interest in the design of metal complexes as drugs and diagnostic agents is currently observed in the area of scientific inquiry, specifically termed medicinal inorganic chemistry. In this review our main focused on research undertaken over the past few decades which has sought to possess preclinical pharmacological screenings like anti-bacterial, anti-fungal, anti-inflammatory, anti-cancer, DNA- interaction and anti-tumor action of synthetic metal complexes.

DOI 10.11648/j.ajhc.20180401.11
Published in American Journal of Heterocyclic Chemistry ( Volume 4, Issue 1, March 2018 )
Page(s) 1-21
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Metal Based Drugs, Antibacterial, Antifungal, Anti-inflammatory, Anti-Cancer, DNA-Interaction and Anti-tumor Activity

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    Md. Saddam Hossain, C. M. Zakaria, Md. Kudrat-E-Zahan. (2018). Metal Complexes as Potential Antimicrobial Agent: A Review. American Journal of Heterocyclic Chemistry, 4(1), 1-21. https://doi.org/10.11648/j.ajhc.20180401.11

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    ACS Style

    Md. Saddam Hossain; C. M. Zakaria; Md. Kudrat-E-Zahan. Metal Complexes as Potential Antimicrobial Agent: A Review. Am. J. Heterocycl. Chem. 2018, 4(1), 1-21. doi: 10.11648/j.ajhc.20180401.11

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    AMA Style

    Md. Saddam Hossain, C. M. Zakaria, Md. Kudrat-E-Zahan. Metal Complexes as Potential Antimicrobial Agent: A Review. Am J Heterocycl Chem. 2018;4(1):1-21. doi: 10.11648/j.ajhc.20180401.11

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  • @article{10.11648/j.ajhc.20180401.11,
      author = {Md. Saddam Hossain and C. M. Zakaria and Md. Kudrat-E-Zahan},
      title = {Metal Complexes as Potential Antimicrobial Agent: A Review},
      journal = {American Journal of Heterocyclic Chemistry},
      volume = {4},
      number = {1},
      pages = {1-21},
      doi = {10.11648/j.ajhc.20180401.11},
      url = {https://doi.org/10.11648/j.ajhc.20180401.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajhc.20180401.11},
      abstract = {Metal ions play many critical functions in humans. Deficiency of some metal ions can lead to disease like pernicious anemia resulting from iron deficiency, growth retardation arising from insufficient dietary zinc, and heart disease in infants owing to copper deficiency. Antibiotic resistance has been growing at an alarming rate and consequently the activity of antibiotics against Gram-negative and Gram-positive bacteria has dropped dramatically day by day. In this sense there is a strong need to synthesis new substances that not only have good spectrum of activity, but having new mechanisms of action. Inorganic compounds particularly metal complexes have played an important role in the development of new metal based drugs. A significantly rising interest in the design of metal complexes as drugs and diagnostic agents is currently observed in the area of scientific inquiry, specifically termed medicinal inorganic chemistry. In this review our main focused on research undertaken over the past few decades which has sought to possess preclinical pharmacological screenings like anti-bacterial, anti-fungal, anti-inflammatory, anti-cancer, DNA- interaction and anti-tumor action of synthetic metal complexes.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Metal Complexes as Potential Antimicrobial Agent: A Review
    AU  - Md. Saddam Hossain
    AU  - C. M. Zakaria
    AU  - Md. Kudrat-E-Zahan
    Y1  - 2018/01/08
    PY  - 2018
    N1  - https://doi.org/10.11648/j.ajhc.20180401.11
    DO  - 10.11648/j.ajhc.20180401.11
    T2  - American Journal of Heterocyclic Chemistry
    JF  - American Journal of Heterocyclic Chemistry
    JO  - American Journal of Heterocyclic Chemistry
    SP  - 1
    EP  - 21
    PB  - Science Publishing Group
    SN  - 2575-5722
    UR  - https://doi.org/10.11648/j.ajhc.20180401.11
    AB  - Metal ions play many critical functions in humans. Deficiency of some metal ions can lead to disease like pernicious anemia resulting from iron deficiency, growth retardation arising from insufficient dietary zinc, and heart disease in infants owing to copper deficiency. Antibiotic resistance has been growing at an alarming rate and consequently the activity of antibiotics against Gram-negative and Gram-positive bacteria has dropped dramatically day by day. In this sense there is a strong need to synthesis new substances that not only have good spectrum of activity, but having new mechanisms of action. Inorganic compounds particularly metal complexes have played an important role in the development of new metal based drugs. A significantly rising interest in the design of metal complexes as drugs and diagnostic agents is currently observed in the area of scientific inquiry, specifically termed medicinal inorganic chemistry. In this review our main focused on research undertaken over the past few decades which has sought to possess preclinical pharmacological screenings like anti-bacterial, anti-fungal, anti-inflammatory, anti-cancer, DNA- interaction and anti-tumor action of synthetic metal complexes.
    VL  - 4
    IS  - 1
    ER  - 

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Author Information
  • Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh

  • Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh

  • Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh

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