Annona squamosa is a medicinal plant which has been used in alternative medicine from ancient times. Different parts of Annona squamosa such as fruits, seeds, leaves and barks have been used to treat many diseases. Some of the active constituents have been identified and investigated for biological actions while the rest are yet to be explored. Current understanding of pharmacological properties of Annona squamosa not only supports alternative medicine but also contributes to the development of potential drugs for certain diseases. Therefore, an updated review on pharmacological actions of Annona squamosa is in urgent need. The purpose of this review is to provide current understanding of important pharmacological properties of Annona squamosa. The information provided in this article could be used to proceed to the designation and development of new pharmacological agents prepared from Annona squamosa for commonly encountered diseases.
| Published in | International Journal of Pharmacy and Chemistry (Volume 3, Issue 6) |
| DOI | 10.11648/j.ijpc.20170306.14 |
| Page(s) | 86-93 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Annona squamosa, Pharmacological Activities, Custard Apple, Sugar Apple, Pharmacology
| [1] | SK Mwihia, MP Ngugi, and JM Maingi, Phytochemical and antioxidant screening of seed extracts of Kenya custard apple (Annona squamosa), Int J pharm Sci Inv, 6 (2007) 24-30. |
| [2] | P Taylor, M Arsenak, MJ Abad, A Fernandez, B Milano, R Gonto, MC Ruiz, et al., Screening of venezuelan medicinal plant extracts for cytostatic and cytotoxic activity against Tumor cell lines, Phytother Res, 27 (2013) 530-539. |
| [3] | Y Chen, Y Shi, C Ma, X Wang, Y Li, Y Miao, J Chen, and X Li, Antitumor activity of Annona squamosa, J Ethnopharmacol, 193(2016) 362-367. |
| [4] | RM Yang, WM Li, WJ Hu, WH Huang, CY Zhu, JG Yu, X Zhao, DY Cai, and NN Gao, Anticancer effect of total annonaceous acetogenins on hepatocarcinoma, Chin J Integr Med, 21 (2015) 682-688. |
| [5] | Y Chen, S Xu, JW Chen, Y Wang, X Xu, N Fan, and X Li, Antitumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds, J Ethnopharmacol. 142(2012) 462-466. |
| [6] | Y Miao, X Xu, F Yuan, Y Shi, Y Chen, J Chen, and X Li, Four cytotoxic annonaceous acetogenins from the seeds of Annona squamosa, Nat Prod Res 30 (2016): 1273-1279. |
| [7] | CC Liaw, YL Yang, M Chen, FR Chang, SL Chen, SH Wu, and YC Wu, Mono-tetrahydrofuran annonaceous acetogenins from Annona squamosa as cytotoxic agents and calcium ion chelators, J Nat Prod. 71 (2008) 764-771. |
| [8] | Y Chen, J Chem, Y Wang, S Xu, and X Li, Six cytotoxic annonaceous acetogenins from Annona squamosa seeds, Food Chem 135 (2012): 960-966. |
| [9] | HJ Yang, N Zhang, JW Chen, and MY Wang, Two new cytotoxic acetogenins from Annona squamosa, JAsian NatProd Res 11 (2009) 250-256. |
| [10] | Y Chen, JW Chen, and X Li, Cytotoxic bistetrahydrofuran annonaceous acetogenins from the seeds of Annona squamosa, Journal of Natural Products 74 (2011) 2477-2481. |
| [11] | H Xie, J Wei, M Liu, and R Yang, A new cytotoxic acetogenin from the seeds of Annona squamosa, Chen Cheml Lett, 14(2003) 588. |
| [12] | BV Pardhasaradhi, M Reddy, AM Kumari, AL Ali, and A Khar, Differential cytotoxic effects of Annona squamosa seed extracts on human tumor cell lines: role of reactive oxygen species and glutathione, J Biosci, 30 (2005): 237-244. |
| [13] | BV Pardhasaradhi, M Reddy, AM Ali, AL Kumari, and A Khar, Antitumor activity of Annona squamosa seed extracts is through the generation of free radicals and induciton of apoptosis, Indian J biochem Biophys 41 (2004) 167-172. |
| [14] | YY Chen, CX Peng, Y Hu, C Bu, SC Guo, X Li, Y, Chen, and JW Chen, Studies on chemical constituents and anti-hepatoma effects of essential oil from Annona squamosa L. pericarp, Nat Prod Res, 31 (2017) 1308-1308. |
| [15] | YY Chen, YZ Cao, Li FQ, Zhu Xl, Peng CX, Lu JH, Chen JW, Li X, and Chen Y, Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract, Bioorg Med Chem Lett. 27 (2017) 1907-1910. |
| [16] | B Jou, and P Remanin, Antitumor constituents from Annona squamosa fruit pulp, Med Chem Res, 17 (2008) 345-355. |
| [17] | L Sun, H Zhu, L Gan, J Mo, F Feng, and C Zhou, Constituents from the bark of Annona squamosaand their anti-tumor activity, Zhongguo Zhong Yao Z Zhi. 37 (2012) 2100-2104. |
| [18] | K Suresh, S Manoharn, and D Blessy, Protective role of Annona squamosa linn bark extracts in DMBA induced genotoxicity, Kathmandu Univ Med J 6 (2008) 364-369. |
| [19] | K Suresh, S Manoharan, K Panjamurthy, and K Kavitha, Chemoprotective and antilipidperoxidative efficacy of Annona squamosa bark extracts in experimental oral carcinogenesis, Pak Jf Bio Sci, 9 (2006) 2600-2605. |
| [20] | DC Hopp, L Zeng, ZM Gu, JF Kozlowski, and JL McLaughlin, Novel mono-tetrahydrofuran ring acetogenins, from the bark of Annona squamosa, showing cytotoxic selectivities for the human pancreatic carcinoma cell line, PACA-2, J Nat Prod, 60 (1997): 581-586. |
| [21] | DC Hopp, L Zeng, Z Gu, and JL McLaughlin, Squamotacin: an annonaceous acetogenin with cytotoxic selectivity for the human prostate tumor cell line (PC-3), J Nat Prod,59 (1996) 97-99. |
| [22] | DC Hopp, FQ Alali, ZM Gu, and JL. McLaughlin, Three new bioactive bis-adjacent THF-ring acetogenins from the bark of Annona squamosa, Bioorg Med Chem 6 (1998) 569-575. |
| [23] | XH Li, YH Hui, JK Rupprecht, YM Liu, KV Wood, DL Smith, Chang, CJ, and JL McLaughlin, Bullatacin, bullatacinone, and squamone, a new bioactive acetogenin, from the bark of Annona squamosa, J Nat Prod, 53 (1990): 81-86. |
| [24] | D Nakano, K Ishitsuka, M Kamikawa, M Matsuda, R Tsuchihashi, M Okawa, H Okabe, K Tamura, and J Kinjo, Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma, J Nat Med, 67 (2013) 894-903. |
| [25] | NS Vila-Nova, SM Morais, MJ Facao, LM Machado, CM Becilaqua, IR Costa, NV Brasil, and HF Andrade Junior, Leishmanicidal activity and cytotoxicity of compounds from two Annonacea species cultivated in Northeastern Brazil, Rev Soc Bras Med Trop, 44 (2011) 567-571. |
| [26] | JH Thakkar, HK Solanki, P Tripathi, NJ Patel, and GK Jani, Evaluation of antimutagenic potential ofAnnona squamosa leaf extract, Elixir Human Phy. 31(2011) 1960-1965. |
| [27] | DS Wang, GH Rizwani, H Guo, M Ahmed, M Ahmed, SZ Hassan, A Hasan, ZS Chen, and RH Xu, Annona squamosa Linn: cytotoxic activity found in leaf extract against human tumor cell lines, Pak J Pharm Sci, 27(2014) 1559-1563. |
| [28] | NNC Pinto, JV Silva, LM Menegati, MCMR Guedes, LB Marques, TPD Silba, RCN Melo, et al., Cytotoxic and bacterial membrane destabilization induced by Annona squamosaL. Extracts, An Acad Bras Cienc, 14(2017) 1-21. |
| [29] | C Ma, Wang, Q, Y Shi, Y Li, X Wang, X Li, Y Chen, and J Chen, Three new anti-tumor annonaceous acetogenins from the seeds of Annona squamosa, Nat Prod Res 31 (2017) 2085-2090. |
| [30] | RY Ibrahim, AI Hassan, and EK AI-adham, The anti-ulcerative colitis effects of Annona squamosa Linn. leaf aqueous extract in experimental animal model, Int J Clin Exp Med, 8 (2015): 21861-21870. |
| [31] | P Wu, M Wu, L Xu, H Xie, and X Wei, Anti-inflammatory cyclopeptides from exocarps of sugar-apples, Food Chem, 152(2014) 23-28. |
| [32] | C Saelee, V Thongrakard, and T Tencomnao, Effects of Thai medicinal herb extracts with anti-psoriatic activity on the expression on NF-kB signaling biomarkers in HaCaT keratinocytes, Molecules, 16 (2011) 3908-3932. |
| [33] | MJ Chavan, PS Wakte, and DB Shinde, Analgesic and anti-inflammatory activities of 18-acetoxy-ent-kaur-16-ene from Annona squamosa L. bark, Inflammopharm, 19 (2011) 111-115. |
| [34] | MJ Chavan, PS Wakte, and DB Shinde, Analgesic and anti-inflammatory activity of Caryophyllene oxide from Annona squamosa L. bark, Phytomedicine, 17 (2010) 149-151. |
| [35] | SH Yeh, FR chang, YC Wu, YL Yang, SK Zhuo, and TL Hwang, An anti-inflammatory ent-kaurane from the stems of Annona squamosa that inhibits various human neutrophil functions, Planta Med, 71 (2005) 904-909. |
| [36] | YL Yang, KF Hua, PH Chuang, SH Wu, KY Wu, FR Chang, and YC Wu, New cyclic peptides from the seeds of Annona squamosa L. and their anti-flammatory activities, J AgriFood Chem 56 (2007) 386-392. |
| [37] | A Dellai, I Maricic, V Kumar, S Arutyunyan, A Bouraoui, and A Nefzi, Parallel synthesis and anti-inflammatory activity of cyclic peptides cyclosquamosin D and Met-cherimolacyclopeptide B and their analogs, Bioorg Med Chem Lett, 20 (2010) 5653-5657. |
| [38] | AA Mariod, SI Abdelwahab, S Elkheir, YM Ahmed, PN Fauzi, and CS Chuen, Antioxidant activities of different parts from Annona squamosa, and Catunaregam nilotica metholic extract, Acta Sci Pol Technol Aliment, 11 (2012) 249-258. |
| [39] | N Kalidindi, NV Thimmaiah, NV Jagadeesh, R Nandeep, S Swetha, and B Kalidindi, Antifungal and antioxidant activities of organic and aqueous extracts of Annona squamosa Linn, leaves, J Food Drug Anal, 23 (2015): 795-802. |
| [40] | A Shirwaikar, K Rajendran, and CD Kumar, In vitro antioxidant studies of Annona squamosa Linn. Leaves, Indian J Exp Biol 42 (2004) 803-807. |
| [41] | R Baskar, V Rajeswari, and TS Kumar, In vitro antioxidant studies in leaves of Annona species. Indian J Exp Biol 45 (2007) 480-485. |
| [42] | GA El-Chaghaby, AF Ahmad, and ES Ramis, Evaluation of the antioxidant and antibacterial properties of various solvents extracts of Annona squamosa L. leaves, Arab J Chem, 7(2014) 227. |
| [43] | C Chandrashekar, and VR Kulkarni, Isolation, characterizations and free radical radical scavenging activity of Annona squamosa leaf, J Pharm Res, 4 (2011) 610-611. |
| [44] | S Panda, and A Kar, Protective effects of 5,7,4'-trihydroxy-6,3'dimethoxy-flavone 5-O-I-rhamnopyranoside, isolated from Annona squamosa leaves in thyrothoxicosis and in hepatic lipid peroxidation in rats, Bioorg Med Chem Lett, 25 (2015) 5726-5728. |
| [45] | S Panda, and A Kar, Antidiabetic and antioxidative effects of Annona squamosa leaves are possibly through quercetin-3-O-glucoside, Biofactors 31 (2007) 201-210. |
| [46] | UB Jagtap, and VA Bapat, Antioxidant activities of various solvent extracts of custard apple (Annona squamosa L.) fruit pulp, Nutrafood, 11 (2012): 137-144. |
| [47] | E Nandhakumar, and P Indumathi, In vitro antioxidant activities of methanol and aqueous extract of Annona squamosa (L.) fruit pulp, J Acupunct Meridian Stud, 6 (2013) 142-148. |
| [48] | W Tu, J Zhu, S bi, D Hen, L Song, L Wang, J Zi, and R Yu, Isolation and characterization and bioactivities of a new polysaccharide from Annona squamosa and its sulfated derivative, Carbohydr Polym, 152(2016) 287-296. |
| [49] | V Kothari, and S Seshadri, Antioxidant activity of seed extracts of Annona squamosa and Carica papaya, Nut Food Sci, 40 (2010) 403-408. |
| [50] | DMM Luzia, and N Jorge, Soursop (Annona muricata L.) and sugar apple (Annona squamosa L.): Antioxidant activity, fatty acids profile and determination of tocopherols, Nut Food Sci, 42 (2012) 434-441. |
| [51] | N Pandey, and D Barve, Antioxidant activity of ethanolic extract of Annona squamosa Linn bark, Inter Res Pharm Biomed Sci, 2 (2011) 1692-1697. |
| [52] | S Panda, and A Khar, Possible amelioration of hyperthyroidism by the leaf extract of Annona squamosa, Current Sci, 84 (2003) 1402-1404. |
| [53] | RK Gupta, AN Kesari, PS Murthy, R Chandra, V Tandon, and G Watal, Hypoglycemic and antidiabetic effect of ethanolic extract of leaves of Annona squamosa L. in experimental animals, J Ethnopharmacol, 99 (2005) 75-81. |
| [54] | A Shirwaikar, K Rajendran, and C Kumar, Oral antidiabetic activity of Annona squamosa leaf alcohol extract in NIDDM rats, J Pharm Biol, 42 (2004) 30-35. |
| [55] | A Shiwaikar, K Rajendran, C Dinesh Kumar, and R Bodla, Antidiabetic activity of aqueous leaf extract of Annona squamosa in Streptozotocin-nicotinamide type 2 diabetic rats, J Ethnopharmacol, 91 (2004) 171-175. |
| [56] | M Mohd, KS Alam, A Mohd, M Abhiskek, and A Aftab, Antidiabetic activity of the aqueous extract of Annona squamosa in streptozotocin induced-hyperglycemic rats, Pharma Res, 2(2009) 59-63. |
| [57] | R Sangala, S Burra, J Gopu, DR Kodati, and Dubai A, Evaluation of antidiabetic activity of Annona squamosa Linn seed in Alloxan-induced diabetic rats, Int J Preclin Res, 2 (2011) 100-106. |
| [58] | RS Tomar, and SS Sisodia, Antidiabetic activity of Annona squamosa L. in experimental induced diabetic rats, Inter JPharm Biol Arch, 3 (2012) 1492-1495. |
| [59] | Ranjana, and YB Tripathi, Insulin secreting and alpha-glucosidase inhibitory activity of hexane extract of Annona squamosa Linn. in streptozotocin (STZ) induced diabetic rats, Indian J Exp Biol, 52 (2014) 623-629. |
| [60] | YY Ren, ZY Zhu, HQ Sun, and LJ Chen, Sturcutural characterization and inhibition on ɑ-glucosidase activity of acidic polysaccharide from Annona squamosa, Carbohydr Polym, 174(2017) 1-12. |
| [61] | JA Davis, S Sharma, S mittra, S Sujatha, A Kanaujia, Gl Katiyar, C Shukla, BS Lakshmi, VS Bansal, and PK Bhatnagar, Antihyperglycemic effect of Annona squamosa hexane extract in type 2 diabetes animal model: PTP1B inhibition, a possible mechanism of action?, Indian J Pharmacol, 44 (2012 326-332. |
| [62] | RA Gupta, AN Kesari, S Diwakar, A Tyagi, V Tandon, R Chandra, and G Watal, In vivo evaluation of anti-oxidant and anti-lipidimic potential of Annona squamosa aqueous extract in Type 2 diabetic models, J Ethnopharmacol, 118 (2008) 21-25. |
| [63] | R Kaur, M Afzal, I Kazmi, I Ahamd, Z Ahmed, B Ali, S Ahmad, and F Anwar, Polypharmacy (herbal and synthetic drug combination): a novel approach in the treatment of type-2 and its complications in rats, J Nat Med, 67 (2013) 662-671. |
| [64] | QL Dang, WK Kim, CM Nguyen, YH Choi, GJ Choi, KS Jang, MS Park, CH Lim, NH Luu, and JC Kim, Nematicidal and antifungal activities of annonaceous acetogenins from Annona squamosa against various plant pathogens, J AgriFood Chem, 59 (2011) 11160-11167. |
| [65] | A Dholvitayakhun, N Trachoo, U Sakee, and TP Cushnie, Potential applications for Annona squamosa leaf extract in the treatment and prevention of foodborne bacterial disease, Nat Prod Commun, 8 (2013) 385-388. |
| [66] | P Shokeen, K Ray, M Bala, and V Tandon, Preliminary studies on activity of Ocimum sanctum, Drynaria quercifolia, and Annona squamosaagainst Neisseria gonorrhoeae, Sex Transm Dis, 32 (2005) 106-111. |
| [67] | LP Padhi, SK Panda, SN Satapathy, and SK Dutta, In vitro evaluation of antibacterial potential of Annona squamosa L. and Annona reticulata L. from similipal biosphere reserve, Orissa, India., J AgriTech, 7 (2011) 133-142. |
| [68] | M Yusha'u, DW taura, B bello, and N Abdullahi, Screening of Annona squamosa extracts for antibacterial activity against some respiratory tract isolates, Int Res J Phar Pharmacol, 1 (2011) 237-241. |
| [69] | KS Shanker, S Kanjilal, BV Rao, KW Kishore, S Misra, and RB Prasad, Isolation and antimicrobial evaluation of isomeric hydroxy ketones in leaf cuticular waxes of Annona squamosa, Phytochem Anal, 18 (2007) 7-12. |
| [70] | MM Rahman, S Parvin, M Ekramul Haque, ME Islam, and MA Mosaddik, Antimicrobial and cytotoxic constituents from the seeds of Annona squamosa, Fitoterapia, 76 (2005) 484-489. |
| [71] | HM Kotkar, HM, PS Mendki, SV Sadan, SR Jha, SM Upasani, and VL Maheshwari, Antimicrobial and pesticidal activity of partially purified flavonoids of Annona squamosa, Pest Manag Sci, 58 (2002) 33-37. |
| [72] | JBS Kachhawa, N Sharma, S Tyagi, and KK Sharma, Screening of stem bark methanol extract of Annona squamosa for antibacterial activity, Inter J CurrPharm Res, 4 (2012) 48-50. |
| [73] | YC Wu, YC hung, FR Chang, M Cosentino, HK Wang, and KH Lee, Identification of ent-16 beta, 17-dihydroxykauran-19-oic acid as an anti-HIV principle and isolation of the new diterpenoids annosquamosins A and B from Annona squamosa, J Nat Prod, 59 (1996) 635-637. |
| [74] | A Bagavan, AA Rahuman, NK Kaushik, and D Sahal, In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum, Parasitol Res, 108 (2011) 15-22. |
| [75] | A EI-Tahir, GM Satti, and SA Khalid, Antiplasmodial activity of selected Sudanese medicinal plants with emphasis on Maytenus senegalensis (lam.) Exell, J Ethnopharmacol, 64 (1999) 227-233. |
| [76] | N Singh, NK Kaushik, D Mohanakrishnan, SK Tiwari, and D Sahal, Antiplasmodial activity of medicinal plants from Chhotanagpur plateau, Jharkhand, India, J Ethnopharmacol 13(2015) 152-162. |
| [77] | T Johns, A Windust, T Jurgens, and SM Mansor, Antimalarial alkaloids isolated from Annona squamosa, Phytopharm, 1 (2011) 49-53. |
| [78] | C Kamaraj, NK Kaushik, D Mohanakrishnan, G Elango, A Bagavan, AA Zahir, AA Rahuman, and D Sahal, Antiplasmodial potential of medicinal plant extracts from Malaiyur and Javadhu hills of South India, Parasitol Res, 111 (2012) 703-715. |
| [79] | BK Soni, DK Yadav, N Bano, P Pathak, M Dixit, R Maurya, M Sahai, SK Jain, and S Misra-Bhattacharya, N-Methyl-6,7-dimethoxyisoquinolone in Annona squamosa twigs is the major immune modifier to elicit polarized Th1 immune response in BA:B/C mice, Fitoterapia 83 (2012) 110-116. |
| [80] | N Sultana, Lipoxygenase inhibition by novel fatty acid ester from Annona squamosa seeds, J Enzyme Inhib Med Chem, 23 (2008) 877-881. |
| [81] | DK Yadav, N Singh, K Dev, R sharma, M Sahai, G Palit, and R Maurya Anti-ulcer constituents of Annona squamosa twigs, Fitoterapia, 82 (2012) 666-675. |
| [82] | R Alluri, and AK Pasala, PK Sagi, Evaluation of gastric antiulcer and antioxidant activities in aqueous extracts of Annona squamosa and Achyranthes aspera in rats, Inter J of Phytopharm, 2 (2011) 66-69. |
| [83] | DS Raj, JJ Vennila, C Aiyavu, and K Panneerselvam, The hepatoprotective effect of alcoholic extract of Annona squamosa leaves on experimentally induced liver injury in Swiss albino mice, Interl J Inte Biol, 5 (2009) 182-186. |
| [84] | TS Uduman, MSR Sundarapandia, A Muthumanikkam, G Kalimuthu, SA Parameswari, TR V Srinivas, and G Karunakaran, Protective effect of methonolic extract of Annona squamosa Linn in isoniazid-rifampicin induced hepatoxicity in rats, Pak J Pharm Sci, 24 (2011) 129-134. |
| [85] | SD Mehta, and S Paliwal, Hepatoprotective activity of hydroalcohilic extract of Annona squamosa seeds, Int J Pharm Phyto Res, 9 (2017) 997-1000. |
| [86] | M Kaleem, P Medha, QU Ahmed, M Asif, and B Bano, Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats, Singapore Med J, 49 (2008) 800-804. |
| [87] | AB Deshmukh, and JK Patel, Aqueous extract of Annona squamosa(L.) ameliorates renal failure induced in 5/6 nephrectomy in rat, Indian j Pharmacol, 43 (2011) 718-721. |
| [88] | H Morita, T Iizuka, CY Choo, KL Chan, K Takeya, and J Kobayashi, Vasorelaxant activity of cyclic peptide, cyclosquamosin B, from Annona squamosa, Bioorg Med Chem Lett,16 (2006) 4609-4611. |
| [89] | RK Gupta, AN Kesari, G Watal, PS Murthy, R Chandra, and V Tandon, Nutritional and hypoglycemic effect of fruit pulp of Annona squamosa in normal healthy and alloxan-induced diabetic rabbits, Ann Nutr Metab, 49 (2005) 407-413. |
| [90] | YL Yang, Chang, FR, CC Wu, WY Wang, and YC Wu, New ent-kaurane diterpenoids with anti-platelet agregation activity from Annona squamosa, J Nat Prod, 65 (2002) 1462-1467. |
| [91] | A Mishra, JVV Dogra, JN Singh, and OP Jha, Post-coital antifertility activity of Annona squamosa and Ipomoea fistulosa, J Med Plant Res, 35(1979) 283-285. |
| [92] | SB Vohora, Ishwar Kumar, and AH Naqvi, Phytochemical, pharmacological, antibacterial and anti-ovulatory studies on Annona squamosa, Planta medica, 28(1975) 97-100. |
| [93] | DC Damasceno, GT Valpato, TC: Rodrigues, PF Sartori, EA Perin, IM Calderon, and MV Rudge, Effects of Annona squamosa extract on early pregnancy in rats, Phytomedicine, 9 (2002) 667-672. |
| [94] | RS Gupta, A Sharma, and JBS Kachhawa, Evaluation of reversible contraceptic activities of Annona squamosa (linn.) stem bark methanol extract in male rats, Plant Prod Res J, 14(2010) 28-31. |
| [95] | T Ponrasu, and L Suguna, Efficacy of Annona squamosaL in the synthesis of glycosaminoglycans and collagen during wound repari in Streptozotoxin induced diabetic rats, BioMed ResInter,2014, 10 pages, Article ID 124352. |
| [96] | T Ponrasu, and L Suguna, Efficacy of Annona squamosa on wound healing in streptozotocin-induced diabetic rats, Int Wound J, 9 (2012) 613-623. |
APA Style
Win Min Oo, Myat Mon Khine. (2017). Pharmacological Activities of Annona squamosa: Updated Review. International Journal of Pharmacy and Chemistry, 3(6), 86-93. https://doi.org/10.11648/j.ijpc.20170306.14
ACS Style
Win Min Oo; Myat Mon Khine. Pharmacological Activities of Annona squamosa: Updated Review. Int. J. Pharm. Chem. 2017, 3(6), 86-93. doi: 10.11648/j.ijpc.20170306.14
AMA Style
Win Min Oo, Myat Mon Khine. Pharmacological Activities of Annona squamosa: Updated Review. Int J Pharm Chem. 2017;3(6):86-93. doi: 10.11648/j.ijpc.20170306.14
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Download@article{10.11648/j.ijpc.20170306.14,
author = {Win Min Oo and Myat Mon Khine},
title = {Pharmacological Activities of Annona squamosa: Updated Review},
journal = {International Journal of Pharmacy and Chemistry},
volume = {3},
number = {6},
pages = {86-93},
doi = {10.11648/j.ijpc.20170306.14},
url = {https://doi.org/10.11648/j.ijpc.20170306.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20170306.14},
abstract = {Annona squamosa is a medicinal plant which has been used in alternative medicine from ancient times. Different parts of Annona squamosa such as fruits, seeds, leaves and barks have been used to treat many diseases. Some of the active constituents have been identified and investigated for biological actions while the rest are yet to be explored. Current understanding of pharmacological properties of Annona squamosa not only supports alternative medicine but also contributes to the development of potential drugs for certain diseases. Therefore, an updated review on pharmacological actions of Annona squamosa is in urgent need. The purpose of this review is to provide current understanding of important pharmacological properties of Annona squamosa. The information provided in this article could be used to proceed to the designation and development of new pharmacological agents prepared from Annona squamosa for commonly encountered diseases.},
year = {2017}
}
TY - JOUR T1 - Pharmacological Activities of Annona squamosa: Updated Review AU - Win Min Oo AU - Myat Mon Khine Y1 - 2017/11/25 PY - 2017 N1 - https://doi.org/10.11648/j.ijpc.20170306.14 DO - 10.11648/j.ijpc.20170306.14 T2 - International Journal of Pharmacy and Chemistry JF - International Journal of Pharmacy and Chemistry JO - International Journal of Pharmacy and Chemistry SP - 86 EP - 93 PB - Science Publishing Group SN - 2575-5749 UR - https://doi.org/10.11648/j.ijpc.20170306.14 AB - Annona squamosa is a medicinal plant which has been used in alternative medicine from ancient times. Different parts of Annona squamosa such as fruits, seeds, leaves and barks have been used to treat many diseases. Some of the active constituents have been identified and investigated for biological actions while the rest are yet to be explored. Current understanding of pharmacological properties of Annona squamosa not only supports alternative medicine but also contributes to the development of potential drugs for certain diseases. Therefore, an updated review on pharmacological actions of Annona squamosa is in urgent need. The purpose of this review is to provide current understanding of important pharmacological properties of Annona squamosa. The information provided in this article could be used to proceed to the designation and development of new pharmacological agents prepared from Annona squamosa for commonly encountered diseases. VL - 3 IS - 6 ER -
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