International Journal of Homeopathy & Natural Medicines

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Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats

Received: Mar. 08, 2019    Accepted: Apr. 13, 2019    Published: May 20, 2019
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Abstract

Milk protein-derived bioactive peptides could be used in human nutrition in both newborns and adults, since they are claimed to be health-improving components that can be used to reduce the risk of disease or to enhance certain physiological functions. This study investigated the effect of oral intake of milk protein concentrate (MPC) and milk protein concentrate hydrolysate (MPCH) on body weight, organ relative weight, and hematological parameters in alloxan-induced diabetes rats. The animals were divided into six major groups after stabilization of diabetes for one week. Diabetic and non-diabetic rats groups were received intra-gastric dose of MPC or MPCH (150mg/kg B.W) for six weeks. Feed treatment by MPC and MPCH significantly (P<0.05) increased the final body weight of normal rats and improved the body weight of diabetic rats and significantly protective (P<0.05) the liver, kidney, heart and lung of normal rats and reduced the fallers of these organs in diabetic rats. The diabetes groups treated by MPCH showed improvement in RBC, Hb, Ht and PLT values. Meanwhile WBC not affected. The oral intake of MPCH protected the normal range of Lymphocytes and S. Nutrophils in healthy and diabetic rats. The oral intake of MPCH caused significant (P<0.05) decrease of Monocytes in diabetic and non-diabetic rats, while the oral intake of MPC had no affected on Monocytes of diabetic and non-diabetic rats. MPC and MPCH reduced the harmful effect of T2D on body weight, organs weights of rats, and improvement most hematological parameters of normal and diabetes rats.

DOI 10.11648/j.ijhnm.20190501.14
Published in International Journal of Homeopathy & Natural Medicines ( Volume 5, Issue 1, June 2019 )
Page(s) 18-29
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Milk Protein, Protein Hydrolysate, Bioactive Peptides, T2 Diabetes

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  • APA Style

    Mahmoud Ibrahim El-Sayed, Sameh Awad, Mokhtar Yousef, Abdelmonem Wahba, Aisha El Attar, et al. (2019). Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats. International Journal of Homeopathy & Natural Medicines, 5(1), 18-29. https://doi.org/10.11648/j.ijhnm.20190501.14

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    ACS Style

    Mahmoud Ibrahim El-Sayed; Sameh Awad; Mokhtar Yousef; Abdelmonem Wahba; Aisha El Attar, et al. Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats. Int. J. Homeopathy Nat. Med. 2019, 5(1), 18-29. doi: 10.11648/j.ijhnm.20190501.14

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    AMA Style

    Mahmoud Ibrahim El-Sayed, Sameh Awad, Mokhtar Yousef, Abdelmonem Wahba, Aisha El Attar, et al. Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats. Int J Homeopathy Nat Med. 2019;5(1):18-29. doi: 10.11648/j.ijhnm.20190501.14

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  • @article{10.11648/j.ijhnm.20190501.14,
      author = {Mahmoud Ibrahim El-Sayed and Sameh Awad and Mokhtar Yousef and Abdelmonem Wahba and Aisha El Attar and Mostafa Zedan},
      title = {Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats},
      journal = {International Journal of Homeopathy & Natural Medicines},
      volume = {5},
      number = {1},
      pages = {18-29},
      doi = {10.11648/j.ijhnm.20190501.14},
      url = {https://doi.org/10.11648/j.ijhnm.20190501.14},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijhnm.20190501.14},
      abstract = {Milk protein-derived bioactive peptides could be used in human nutrition in both newborns and adults, since they are claimed to be health-improving components that can be used to reduce the risk of disease or to enhance certain physiological functions. This study investigated the effect of oral intake of milk protein concentrate (MPC) and milk protein concentrate hydrolysate (MPCH) on body weight, organ relative weight, and hematological parameters in alloxan-induced diabetes rats. The animals were divided into six major groups after stabilization of diabetes for one week. Diabetic and non-diabetic rats groups were received intra-gastric dose of MPC or MPCH (150mg/kg B.W) for six weeks. Feed treatment by MPC and MPCH significantly (PPP<0.05) decrease of Monocytes in diabetic and non-diabetic rats, while the oral intake of MPC had no affected on Monocytes of diabetic and non-diabetic rats. MPC and MPCH reduced the harmful effect of T2D on body weight, organs weights of rats, and improvement most hematological parameters of normal and diabetes rats.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Effect of Milk Protein Hydrolysate on Some Hematological Parameters of Type II Diabetic Rats
    AU  - Mahmoud Ibrahim El-Sayed
    AU  - Sameh Awad
    AU  - Mokhtar Yousef
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    JF  - International Journal of Homeopathy & Natural Medicines
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    UR  - https://doi.org/10.11648/j.ijhnm.20190501.14
    AB  - Milk protein-derived bioactive peptides could be used in human nutrition in both newborns and adults, since they are claimed to be health-improving components that can be used to reduce the risk of disease or to enhance certain physiological functions. This study investigated the effect of oral intake of milk protein concentrate (MPC) and milk protein concentrate hydrolysate (MPCH) on body weight, organ relative weight, and hematological parameters in alloxan-induced diabetes rats. The animals were divided into six major groups after stabilization of diabetes for one week. Diabetic and non-diabetic rats groups were received intra-gastric dose of MPC or MPCH (150mg/kg B.W) for six weeks. Feed treatment by MPC and MPCH significantly (PPP<0.05) decrease of Monocytes in diabetic and non-diabetic rats, while the oral intake of MPC had no affected on Monocytes of diabetic and non-diabetic rats. MPC and MPCH reduced the harmful effect of T2D on body weight, organs weights of rats, and improvement most hematological parameters of normal and diabetes rats.
    VL  - 5
    IS  - 1
    ER  - 

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Author Information
  • Department of Dairy Technology Research, Food Technology Research Institute, ARC, Giza, Egypt

  • Department of Dairy Science and Technology, Faculty of Agriculture, Alexandria University, Alexandria, Egypt

  • Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt

  • Department of Dairy Science and Technology, Faculty of Agriculture, Alexandria University, Alexandria, Egypt

  • Department of Dairy Science and Technology, Faculty of Agriculture, Alexandria University, Alexandria, Egypt

  • Department of Dairy Technology Research, Food Technology Research Institute, ARC, Giza, Egypt

  • Section