The Diagnostic Role of p53 and Ki 67 Immunohistochemistry in Evaluation of Urinary Bladder Carcinomas in Egyptian Patients
International Journal of Chinese Medicine
Volume 3, Issue 1, March 2019, Pages: 1-6
Received: Apr. 23, 2019; Accepted: May 30, 2019; Published: Jun. 10, 2019
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Sahar Ali Mohamed, Department of Pathology, General Organization of Teaching Hospitals and Institutes (GOTHI), Cairo, Egypt
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Background: Urothelial carcinomas (UC) are the most common cancers of urinary bladder responsible for a significant proportion of cancer morbidity and mortality. In Egypt, bladder cancer is the second most common malignancy. We did the present investigation to exhibit the clinicohistopathological highlights and to associate the p53 and Ki 67 immunoexpression with grade and stage of bladder carcinomas. Materials and Methods: sixty-two cases of bladder neoplasm were investigated. Grading and staging was done. An immunohistochemical assay for p53 and Ki 67 was performed in altogether cases, with relation to clinicopathological parameter. Results: There was a significant association of p53 and Ki 67 overexpression in high grade with the epithelial type (P=0.0001) & (P=.0.01) respectively. While there was a statistically significant association of high expression of P53 in PT1 compared to PTa and PT2 (p=0.000001). There was a significant correlation between Ki 67 in staging pT1 (pTa + pT1/pT2, P = 0.000001; pTa/ pT1, P = 0.000001; pT1/pT2, P = 0.000002). Conclusion: The role of p53 and Ki 67 immunohistochemical relativities in the differential diagnosis and prognosis of urinary bladder carcinomas in step with the pathological stage and histologic grade of the neoplasm, will be understood due to unique biology and pathogenic features of these tumors. Thus, this study supports the opinion that combined use of p53 and Ki 67 immunostaining markers may help as further prognostic clue alongside with histologic grading and staging in bladder carcinomas.
Urinary Carcinomas, p53, Ki 67, Urothelial, Prognosis, Stage, Grade
To cite this article
Sahar Ali Mohamed, The Diagnostic Role of p53 and Ki 67 Immunohistochemistry in Evaluation of Urinary Bladder Carcinomas in Egyptian Patients, International Journal of Chinese Medicine. Vol. 3, No. 1, 2019, pp. 1-6. doi: 10.11648/j.ijcm.20190301.11
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