Assessment of Some Immune System Related Parameters on <i>Helicobacter pylori</i> Infected Students in a Nigerian Tertiary Educational Institution

Dennis Oju Allagoa; Benjamin Onyema Eledo; Kingsley Excel Dunga; Sylvester Chibueze Izah

doi:doi:10.11648/j.ijg.20180202.11

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Assessment of Some Immune System Related Parameters on Helicobacter pylori Infected Students in a Nigerian Tertiary Educational Institution

Dennis Oju Allagoa, Benjamin Onyema Eledo, Kingsley Excel Dunga, Sylvester Chibueze Izah

Published in International Journal of Gastroenterology (Volume 2, Issue 2)

Received: 22 September 2018 Accepted: 5 October 2018 Published: 7 November 2018

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Abstract

This study evaluated the effect of Helicobacter pylori infection on total white blood cells and cluster of differentiation 4 (CD4) cells of students in a Nigerian tertiary educational institution. A total of 32 test subjects (comprising of 17 females and 15 males) and 30 control subjects (comprising of 16 females and 14 males) within the age of 18 – 32. The blood samples of the participants were analyzed for CD4 cells and total white blood cells counts using standard protocols. Results revealed that test and control subjects had mean values of 8.89 ×10⁹/L and 7.13 ×10⁹/L respectively (for females) and 9.12 ×10⁹/L and 7.25 ×10⁹/L respectively (for males) (total white blood cells), and 1369.76 cells/µl and 2169.55 cells/µl respectively for females and 1424.47 cells/µl and 2069.15 cells/µl respectively for males (CD4 counts). Significant variations (p<0.001) exist between test and control subjects for each of the immune system parameters under study. The significant increase in total white blood cells among the test subjects is a result of an immune response to an active infection and subsequent neutrophilia elicited by inflammation which is a major consequence of Helicobacter pylori infection. The decline in CD4 (though within normal range) may suggest that Helicobacter pylori infection may affect the immune system. However, caution should be exercised in the management of the infection especially among individual with other health challenges to avoid adverse health effects.

Published in	International Journal of Gastroenterology (Volume 2, Issue 2)
DOI	10.11648/j.ijg.20180202.11
Page(s)	24-27
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Cluster of Differentiation 4, Helicobacter Pylori, Immune System, Infections, White Blood Cells

References

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[2]	Xu, M-Y., Cao, B., Yuan, B-S., Yin, J., Liu, L. and Lu, Q-B. (2017). Association of anaemia with Helicobacter pylori infection: a retrospective study. Scientific Reports, 7,
[3]	Eledo BO, Allagoa DO, Onuoha EC, Okamgba OC, Ihedioha AU, Izah SC and Orutugu LA (2017). Effect of Helicobacter Pylori on Some Haemostatic Parameters among Students of a Tertiary Institution in Nigeria. Clinical Biotechnology and Microbiology, 1(5), 219-22
[4]	Yahya, R. Z., Rudainee, M.H.A., Alshammari, S. A., Alshammari, A., Ahmari, A. S. A., et al. (2017). Helicobacter pylori and Upper Gastrointestinal Diseases. EC Microbiology, SI.1, P23-P3
[5]	Tamokou, J., Guimtsop, Y. A. T., Ndebi, M. E. , Nzesseu, V .L. , Djokge, A. K. and Kuiate, J. (2017). Effect of Helicobacter pylori Infection on Selected Biochemical Parameters of Hypertensive Patients at Dschang District Hospital in Cameroon. International Journal of Tropical Disease and Health, 26(1): 1-8
[6]	Şenkaynağı, A. and Yıldız, M. (2017). The Relationship Among Helicobacter pylori Positivity, Acute Phase Reactants, Blood Groups and Tumor Markers in Urea Breathe Test. Middle Black Sea Journal of Health Science, 3(2):13-19
[7]	Xia, W., Zhang, X., Wang, J., Sun, C. and Wu, L. (2012). Survey of anaemia and Helicobacter pylori infection in adolescent girls in Suihua, China and enhancement of iron intervention effects by H. pylori eradication. Br J Nutr 108, 357–36
[8]	Rahmani, Y., Mohammadi, S., Babanejad, M., Rai, A., Zalei, B. and Shahmohammadi, A. (2017). Association of Helicobacter Pylori with Presence of Myocardial Infarction in Iran: A Systematic Review and Meta-Analysis. Ethiop J Health Sci. 27(4), 433–44
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[12]	Taye, B., Enquselassie, F., Tsegaye, A., Amberbir, A., Medhin, G., Fogarty, A., Robinson, K. and Davey, G. (2015). Effect of early and current Helicobacter pylori infection on the risk of anaemia in 5-year-old Ethiopian children. BMC Infectious Diseases, 15, 270
[13]	Eledo, B. O, Allagoa, D.O., Onuoha, E.C., Okamgba, E.C., Ihedioha, A.U. and Ugwu, I.M. (2018). Evaluation of Some Haematological Parameters Among Helicobacter pylori infected students in a Nigerian tertiary educational institution. Biotechnol Res 4(1):34-39
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[15]	Rostami-Nejad, M., Aldulaimi, D., Livett, H. and Rostami, K. (2015). Helicobacter pylori associated with iron deficiency anemia even in celiac disease patients; strongly evidence based but weakly reflected in practice. Gastroenterol Hepatol Bed Bench 8, 178–182
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[18]	Eledo, B. O, Allagoa, D. O, Ihedioha, A. U., Dunga, K. C. and Izah, S. C. (2017) Evaluation of some haematological parameters among post-menopausal women in Bayelsa state, Nigeria: a case study of patients attending Federal Medical Centre, Yenagoa. American Journal of Laboratory Medicine, 2(6), 132-13

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APA Style

Dennis Oju Allagoa, Benjamin Onyema Eledo, Kingsley Excel Dunga, Sylvester Chibueze Izah. (2018). Assessment of Some Immune System Related Parameters on Helicobacter pylori Infected Students in a Nigerian Tertiary Educational Institution. International Journal of Gastroenterology, 2(2), 24-27. https://doi.org/10.11648/j.ijg.20180202.11

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ACS Style

Dennis Oju Allagoa; Benjamin Onyema Eledo; Kingsley Excel Dunga; Sylvester Chibueze Izah. Assessment of Some Immune System Related Parameters on Helicobacter pylori Infected Students in a Nigerian Tertiary Educational Institution. Int. J. Gastroenterol. 2018, 2(2), 24-27. doi: 10.11648/j.ijg.20180202.11

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AMA Style

Dennis Oju Allagoa, Benjamin Onyema Eledo, Kingsley Excel Dunga, Sylvester Chibueze Izah. Assessment of Some Immune System Related Parameters on Helicobacter pylori Infected Students in a Nigerian Tertiary Educational Institution. Int J Gastroenterol. 2018;2(2):24-27. doi: 10.11648/j.ijg.20180202.11

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@article{10.11648/j.ijg.20180202.11,
  author = {Dennis Oju Allagoa and Benjamin Onyema Eledo and Kingsley Excel Dunga and Sylvester Chibueze Izah},
  title = {Assessment of Some Immune System Related Parameters on Helicobacter pylori Infected Students in a Nigerian Tertiary Educational Institution},
  journal = {International Journal of Gastroenterology},
  volume = {2},
  number = {2},
  pages = {24-27},
  doi = {10.11648/j.ijg.20180202.11},
  url = {https://doi.org/10.11648/j.ijg.20180202.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijg.20180202.11},
  abstract = {This study evaluated the effect of Helicobacter pylori infection on total white blood cells and cluster of differentiation 4 (CD4) cells of students in a Nigerian tertiary educational institution. A total of 32 test subjects (comprising of 17 females and 15 males) and 30 control subjects (comprising of 16 females and 14 males) within the age of 18 – 32. The blood samples of the participants were analyzed for CD4 cells and total white blood cells counts using standard protocols. Results revealed that test and control subjects had mean values of 8.89 ×109/L and 7.13 ×109/L respectively (for females) and 9.12 ×109/L and 7.25 ×109/L respectively (for males) (total white blood cells), and 1369.76 cells/µl and 2169.55 cells/µl respectively for females and 1424.47 cells/µl and 2069.15 cells/µl respectively for males (CD4 counts). Significant variations (p<0.001) exist between test and control subjects for each of the immune system parameters under study. The significant increase in total white blood cells among the test subjects is a result of an immune response to an active infection and subsequent neutrophilia elicited by inflammation which is a major consequence of Helicobacter pylori infection. The decline in CD4 (though within normal range) may suggest that Helicobacter pylori infection may affect the immune system. However, caution should be exercised in the management of the infection especially among individual with other health challenges to avoid adverse health effects.},
 year = {2018}
}

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TY  - JOUR
T1  - Assessment of Some Immune System Related Parameters on Helicobacter pylori Infected Students in a Nigerian Tertiary Educational Institution
AU  - Dennis Oju Allagoa
AU  - Benjamin Onyema Eledo
AU  - Kingsley Excel Dunga
AU  - Sylvester Chibueze Izah
Y1  - 2018/11/07
PY  - 2018
N1  - https://doi.org/10.11648/j.ijg.20180202.11
DO  - 10.11648/j.ijg.20180202.11
T2  - International Journal of Gastroenterology
JF  - International Journal of Gastroenterology
JO  - International Journal of Gastroenterology
SP  - 24
EP  - 27
PB  - Science Publishing Group
SN  - 2640-169X
UR  - https://doi.org/10.11648/j.ijg.20180202.11
AB  - This study evaluated the effect of Helicobacter pylori infection on total white blood cells and cluster of differentiation 4 (CD4) cells of students in a Nigerian tertiary educational institution. A total of 32 test subjects (comprising of 17 females and 15 males) and 30 control subjects (comprising of 16 females and 14 males) within the age of 18 – 32. The blood samples of the participants were analyzed for CD4 cells and total white blood cells counts using standard protocols. Results revealed that test and control subjects had mean values of 8.89 ×109/L and 7.13 ×109/L respectively (for females) and 9.12 ×109/L and 7.25 ×109/L respectively (for males) (total white blood cells), and 1369.76 cells/µl and 2169.55 cells/µl respectively for females and 1424.47 cells/µl and 2069.15 cells/µl respectively for males (CD4 counts). Significant variations (p<0.001) exist between test and control subjects for each of the immune system parameters under study. The significant increase in total white blood cells among the test subjects is a result of an immune response to an active infection and subsequent neutrophilia elicited by inflammation which is a major consequence of Helicobacter pylori infection. The decline in CD4 (though within normal range) may suggest that Helicobacter pylori infection may affect the immune system. However, caution should be exercised in the management of the infection especially among individual with other health challenges to avoid adverse health effects.
VL  - 2
IS  - 2
ER  -

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Author Information

Dennis Oju Allagoa

Department of Gynecology and Obstetrics, Federal Medical Centre Yenagoa, Bayelsa state, Nigeria
Benjamin Onyema Eledo

Department of Medical Laboratory Science, Faculty of Health Sciences, Madonna University, Elele, Nigeria; Haematology and Blood Transfusion Department Federal Medical Centre, Yenagoa, Nigeria
Kingsley Excel Dunga

Department of Medical Laboratory Science, Faculty of Health Sciences, Madonna University, Elele, Nigeria
Sylvester Chibueze Izah

Department of Biological Sciences, Faculty of Science, Niger Delta University, Wilberforce Island, Nigeria

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APA Style

Dennis Oju Allagoa, Benjamin Onyema Eledo, Kingsley Excel Dunga, Sylvester Chibueze Izah. (2018). Assessment of Some Immune System Related Parameters on Helicobacter pylori Infected Students in a Nigerian Tertiary Educational Institution. International Journal of Gastroenterology, 2(2), 24-27. https://doi.org/10.11648/j.ijg.20180202.11

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ACS Style

Dennis Oju Allagoa; Benjamin Onyema Eledo; Kingsley Excel Dunga; Sylvester Chibueze Izah. Assessment of Some Immune System Related Parameters on Helicobacter pylori Infected Students in a Nigerian Tertiary Educational Institution. Int. J. Gastroenterol. 2018, 2(2), 24-27. doi: 10.11648/j.ijg.20180202.11

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AMA Style

Dennis Oju Allagoa, Benjamin Onyema Eledo, Kingsley Excel Dunga, Sylvester Chibueze Izah. Assessment of Some Immune System Related Parameters on Helicobacter pylori Infected Students in a Nigerian Tertiary Educational Institution. Int J Gastroenterol. 2018;2(2):24-27. doi: 10.11648/j.ijg.20180202.11

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@article{10.11648/j.ijg.20180202.11,
  author = {Dennis Oju Allagoa and Benjamin Onyema Eledo and Kingsley Excel Dunga and Sylvester Chibueze Izah},
  title = {Assessment of Some Immune System Related Parameters on Helicobacter pylori Infected Students in a Nigerian Tertiary Educational Institution},
  journal = {International Journal of Gastroenterology},
  volume = {2},
  number = {2},
  pages = {24-27},
  doi = {10.11648/j.ijg.20180202.11},
  url = {https://doi.org/10.11648/j.ijg.20180202.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijg.20180202.11},
  abstract = {This study evaluated the effect of Helicobacter pylori infection on total white blood cells and cluster of differentiation 4 (CD4) cells of students in a Nigerian tertiary educational institution. A total of 32 test subjects (comprising of 17 females and 15 males) and 30 control subjects (comprising of 16 females and 14 males) within the age of 18 – 32. The blood samples of the participants were analyzed for CD4 cells and total white blood cells counts using standard protocols. Results revealed that test and control subjects had mean values of 8.89 ×109/L and 7.13 ×109/L respectively (for females) and 9.12 ×109/L and 7.25 ×109/L respectively (for males) (total white blood cells), and 1369.76 cells/µl and 2169.55 cells/µl respectively for females and 1424.47 cells/µl and 2069.15 cells/µl respectively for males (CD4 counts). Significant variations (p<0.001) exist between test and control subjects for each of the immune system parameters under study. The significant increase in total white blood cells among the test subjects is a result of an immune response to an active infection and subsequent neutrophilia elicited by inflammation which is a major consequence of Helicobacter pylori infection. The decline in CD4 (though within normal range) may suggest that Helicobacter pylori infection may affect the immune system. However, caution should be exercised in the management of the infection especially among individual with other health challenges to avoid adverse health effects.},
 year = {2018}
}

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TY  - JOUR
T1  - Assessment of Some Immune System Related Parameters on Helicobacter pylori Infected Students in a Nigerian Tertiary Educational Institution
AU  - Dennis Oju Allagoa
AU  - Benjamin Onyema Eledo
AU  - Kingsley Excel Dunga
AU  - Sylvester Chibueze Izah
Y1  - 2018/11/07
PY  - 2018
N1  - https://doi.org/10.11648/j.ijg.20180202.11
DO  - 10.11648/j.ijg.20180202.11
T2  - International Journal of Gastroenterology
JF  - International Journal of Gastroenterology
JO  - International Journal of Gastroenterology
SP  - 24
EP  - 27
PB  - Science Publishing Group
SN  - 2640-169X
UR  - https://doi.org/10.11648/j.ijg.20180202.11
AB  - This study evaluated the effect of Helicobacter pylori infection on total white blood cells and cluster of differentiation 4 (CD4) cells of students in a Nigerian tertiary educational institution. A total of 32 test subjects (comprising of 17 females and 15 males) and 30 control subjects (comprising of 16 females and 14 males) within the age of 18 – 32. The blood samples of the participants were analyzed for CD4 cells and total white blood cells counts using standard protocols. Results revealed that test and control subjects had mean values of 8.89 ×109/L and 7.13 ×109/L respectively (for females) and 9.12 ×109/L and 7.25 ×109/L respectively (for males) (total white blood cells), and 1369.76 cells/µl and 2169.55 cells/µl respectively for females and 1424.47 cells/µl and 2069.15 cells/µl respectively for males (CD4 counts). Significant variations (p<0.001) exist between test and control subjects for each of the immune system parameters under study. The significant increase in total white blood cells among the test subjects is a result of an immune response to an active infection and subsequent neutrophilia elicited by inflammation which is a major consequence of Helicobacter pylori infection. The decline in CD4 (though within normal range) may suggest that Helicobacter pylori infection may affect the immune system. However, caution should be exercised in the management of the infection especially among individual with other health challenges to avoid adverse health effects.
VL  - 2
IS  - 2
ER  -

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