Antibiotic Susceptibility Pattern of <i>Pseudomonas aeruginosa</i> Isolates from Wound Infections in a Tertiary Care Centre in South Kerala, India

Suresh Babu

doi:doi:10.11648/j.ijidt.20180302.12

| Peer-Reviewed |

Antibiotic Susceptibility Pattern of Pseudomonas aeruginosa Isolates from Wound Infections in a Tertiary Care Centre in South Kerala, India

Suresh Babu

Received: 4 May 2018 Accepted: 14 June 2018 Published: 9 July 2018

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Multiple antibiotic resistance in bacterial populations is a pervasive and growing clinical problem, which is recognized as a threat to public health. Drug resistance to Pseudomonas sp. has spread to such a level irrespective of the type of patients, that, its pattern of distribution and antibiotic resistance needs to be studied in detail, especially in trauma patients. Of the Gram negative bacilli, Pseudomonas aeruginosa has been of particular interest, the incidence of which in wound infection has increased compared to a decade back. The objective of this study was to know the antibiotic susceptibility pattern of Pseudomonas aeruginosa isolates from wound infections. Out of the total of 1404 cases from which pus samples collected, 204 (14.5%) yielded Pseudomonas aeruginosa isolates. Among the antibiotics tested, Imipenem was the most sensitive drug, showing susceptibility in 81.3% of the isolates, followed by Piperacillin + tazobactam (76.4%), Meropenem (70.5%) and Piperacillin (67.6%). Fifteen (7.4%) multidrug resistant strains were reported out of the 204 isolations. Increase in resistance to aminoglycosides and fluoroquinolones in this study, prompted evaluation of antibiotic susceptibility pattern of Pseudomonas isolates from clinical samples at regular intervals.

DOI	10.11648/j.ijidt.20180302.12
Published in	International Journal of Infectious Diseases and Therapy (Volume 3, Issue 2, June 2018)
Page(s)	30-33
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Pseudomonas aeruginosa, Multiple Drug Resistance, Wound Infections, Gram Negative Bacilli

References

[1]	Oguntibeju OO, Nwobu RA. Occurrence of P. aeruginosa in post operative wound infection. Pak J Med Sc 2004; 20:187-91.
[2]	Kolmos HJ, Svendsen RN, Nielsen SV. The surgical team as a resource of post - operative wound infections. J Hosp Infect 1997; 35:207-14.
[3]	Joshi KR, Onaghise EO, Oyaide SM. Aeruginosine typing of P. aeruginosa isolated at the university of Benin teaching Hospital, Benin. Afr J Clin Microbiol 1984; 1:13-8.
[4]	Ganjam Shrivastava, GS Bhatambare, A Lunavat, KB Patel, T Maheshwari. Pattern of microorganisms from burn wounds and their trends of susceptibility to antibiotics in tertiary care centre. Int J of Health System and Disaster Management 2016; 4(2):53-57.
[5]	Vivek Kulkami, Sagar Mohan Arati, YM Jayaraj, Channappa T Shivannavar, MR Joshi. Bacterial etiology and their biogram in burn wound infections at Kalaburgi region (India). Ind J Burns 2015; 23(1):65-70.
[6]	Richa Gupta, Abida Malik, Meher Rizvi, Moied Ahmed. Presence of metallo beta lactamases (MBL), ESBL Amp C positive non- fermenting gram negative bacilli among intensive care unit patients with special reference to molecular detection of bla CTX-M and bla Amp C genes. Ind J Med Res. 2016; 144(2):271-275.
[7]	Sapana G Mundhada, Prakash H Waghmare, Prachala G Rathod, Kishore V Ingole. Bacterial and fungal profile of burn wound infections in tertiary care centre. Ind J Burns. 2015; 23(1):71-75.
[8]	Santa Otta, Jayant Kumar Dash, Bichitrananda Swain. Aerobic bacteriology of burn wound infections. CHRISMED J Health Res 2015; 2(4):337-341.
[9]	Suryakala R Nair, Resmi Rajan, Sharada Devi Karunakaran, Lalithabai. A clinicomicrobiological study of diabetic foot ulcers from South Kerala. J of the Academy of Clinical Microbiologists. 2015; 17(2):94-99.
[10]	Obritsch MD, Fish DN, McLaren R, Jung R. National Surveillance of Antimicrobial Resistance in Pseudomonas aeruginosa isolates obtained from Intensive Care Unit Patients from 1993 to 2002. Antimicrob Agents Chem 2004; 48:4606-10.
[11]	Quinn JP, Studemeister AE, DiVincenzo CA, Lerner SA. Resistance to imipenem in Pseudomonas aeruginosa: Clinical experience and biochemical mechanisms. Rev Infect Dis 1988; 10:892-8.
[12]	Malini A, Deepa EK, Gokul BN, Prasad SR. Nonfermenting gram-negative bacilli infections in a tertiary care hospital in Kolar, Karnataka. J Lab Physicians 2009; 1:62-6.
[13]	Taneja N, Maharwal S, Sharma M. Imipenem resistance in nonfermenters causing nosocomial urinary tract infections. Indian J Med Sci 2003; 57:294-9.
[14]	Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility testing; Twentieth Informational Supplement (June 2010 update). M100-S20. Pennsylvania, USA: Clinical and Laboratory Standard Institute (CLSI) Document; 2010.
[15]	Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility testing; Twenty- Second Informational Supplement. M100-S22. Wayne, Pennsylvania, USA: Clinical and Laboratory Standards Institute (CLSI) Document; 2012.
[16]	National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial disk susceptibility tests. Approved standard M2 A7 NCCLS, Villanova, PA: 1995. p. 15.
[17]	ShampaAnupurba, AmitabhaBattacharjee, et al. Antimicrobial susceptibility of Pseudomonas aeruginosaisolated from wound infections. Indian J Dermatology 2006; 51(4):286-88.
[18]	NonikaRajkumari, NibuVargheese John, PurvaMathur, et al. Antimicrobial resistance in Pseudomonas sp. causing infections in trauma patients. A six year experience from a South Asian Country. J of Global Inf Dis 2014; 6(4):182-85.
[19]	Deepak Juyal, RajatPrakash, Shamanth A Shanakarnarayan, et al. Prevalence of non- fermenting gram negative bacilli and their vitro susceptibility in a tertiary care hospital of Uttarkhand: A study from foothills of Himalayas. Saudi J Health Sci 2013; 2(2):108-112.
[20]	Viren A Javiya, Samsuvra B Ghatak, Kamlesh R Patel et al. Antibiotic susceptibility patterns of Pseudomonas aeruginosa at a tertiary care hospital in Gujarat, India. Ind J Pharmacology 2008; 40(5):230-234.

Cite This Article

Plain Text BibTeX RIS

APA Style

Suresh Babu. (2018). Antibiotic Susceptibility Pattern of Pseudomonas aeruginosa Isolates from Wound Infections in a Tertiary Care Centre in South Kerala, India. International Journal of Infectious Diseases and Therapy, 3(2), 30-33. https://doi.org/10.11648/j.ijidt.20180302.12

Copy | Download

ACS Style

Suresh Babu. Antibiotic Susceptibility Pattern of Pseudomonas aeruginosa Isolates from Wound Infections in a Tertiary Care Centre in South Kerala, India. Int. J. Infect. Dis. Ther. 2018, 3(2), 30-33. doi: 10.11648/j.ijidt.20180302.12

Copy | Download

AMA Style

Suresh Babu. Antibiotic Susceptibility Pattern of Pseudomonas aeruginosa Isolates from Wound Infections in a Tertiary Care Centre in South Kerala, India. Int J Infect Dis Ther. 2018;3(2):30-33. doi: 10.11648/j.ijidt.20180302.12

Copy | Download

@article{10.11648/j.ijidt.20180302.12,
  author = {Suresh Babu},
  title = {Antibiotic Susceptibility Pattern of Pseudomonas aeruginosa Isolates from Wound Infections in a Tertiary Care Centre in South Kerala, India},
  journal = {International Journal of Infectious Diseases and Therapy},
  volume = {3},
  number = {2},
  pages = {30-33},
  doi = {10.11648/j.ijidt.20180302.12},
  url = {https://doi.org/10.11648/j.ijidt.20180302.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20180302.12},
  abstract = {Multiple antibiotic resistance in bacterial populations is a pervasive and growing clinical problem, which is recognized as a threat to public health. Drug resistance to Pseudomonas sp. has spread to such a level irrespective of the type of patients, that, its pattern of distribution and antibiotic resistance needs to be studied in detail, especially in trauma patients. Of the Gram negative bacilli, Pseudomonas aeruginosa has been of particular interest, the incidence of which in wound infection has increased compared to a decade back. The objective of this study was to know the antibiotic susceptibility pattern of Pseudomonas aeruginosa isolates from wound infections. Out of the total of 1404 cases from which pus samples collected, 204 (14.5%) yielded Pseudomonas aeruginosa isolates. Among the antibiotics tested, Imipenem was the most sensitive drug, showing susceptibility in 81.3% of the isolates, followed by Piperacillin + tazobactam (76.4%), Meropenem (70.5%) and Piperacillin (67.6%). Fifteen (7.4%) multidrug resistant strains were reported out of the 204 isolations. Increase in resistance to aminoglycosides and fluoroquinolones in this study, prompted evaluation of antibiotic susceptibility pattern of Pseudomonas isolates from clinical samples at regular intervals.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Antibiotic Susceptibility Pattern of Pseudomonas aeruginosa Isolates from Wound Infections in a Tertiary Care Centre in South Kerala, India
AU  - Suresh Babu
Y1  - 2018/07/09
PY  - 2018
N1  - https://doi.org/10.11648/j.ijidt.20180302.12
DO  - 10.11648/j.ijidt.20180302.12
T2  - International Journal of Infectious Diseases and Therapy
JF  - International Journal of Infectious Diseases and Therapy
JO  - International Journal of Infectious Diseases and Therapy
SP  - 30
EP  - 33
PB  - Science Publishing Group
SN  - 2578-966X
UR  - https://doi.org/10.11648/j.ijidt.20180302.12
AB  - Multiple antibiotic resistance in bacterial populations is a pervasive and growing clinical problem, which is recognized as a threat to public health. Drug resistance to Pseudomonas sp. has spread to such a level irrespective of the type of patients, that, its pattern of distribution and antibiotic resistance needs to be studied in detail, especially in trauma patients. Of the Gram negative bacilli, Pseudomonas aeruginosa has been of particular interest, the incidence of which in wound infection has increased compared to a decade back. The objective of this study was to know the antibiotic susceptibility pattern of Pseudomonas aeruginosa isolates from wound infections. Out of the total of 1404 cases from which pus samples collected, 204 (14.5%) yielded Pseudomonas aeruginosa isolates. Among the antibiotics tested, Imipenem was the most sensitive drug, showing susceptibility in 81.3% of the isolates, followed by Piperacillin + tazobactam (76.4%), Meropenem (70.5%) and Piperacillin (67.6%). Fifteen (7.4%) multidrug resistant strains were reported out of the 204 isolations. Increase in resistance to aminoglycosides and fluoroquinolones in this study, prompted evaluation of antibiotic susceptibility pattern of Pseudomonas isolates from clinical samples at regular intervals.
VL  - 3
IS  - 2
ER  -

Copy | Download

Author Information

Suresh Babu

Department of Microbiology, Dr SM CSI Medical College and Hospital, Trivandrum, India

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Suresh Babu. (2018). Antibiotic Susceptibility Pattern of Pseudomonas aeruginosa Isolates from Wound Infections in a Tertiary Care Centre in South Kerala, India. International Journal of Infectious Diseases and Therapy, 3(2), 30-33. https://doi.org/10.11648/j.ijidt.20180302.12

Copy | Download

ACS Style

Suresh Babu. Antibiotic Susceptibility Pattern of Pseudomonas aeruginosa Isolates from Wound Infections in a Tertiary Care Centre in South Kerala, India. Int. J. Infect. Dis. Ther. 2018, 3(2), 30-33. doi: 10.11648/j.ijidt.20180302.12

Copy | Download

AMA Style

Suresh Babu. Antibiotic Susceptibility Pattern of Pseudomonas aeruginosa Isolates from Wound Infections in a Tertiary Care Centre in South Kerala, India. Int J Infect Dis Ther. 2018;3(2):30-33. doi: 10.11648/j.ijidt.20180302.12

Copy | Download

@article{10.11648/j.ijidt.20180302.12,
  author = {Suresh Babu},
  title = {Antibiotic Susceptibility Pattern of Pseudomonas aeruginosa Isolates from Wound Infections in a Tertiary Care Centre in South Kerala, India},
  journal = {International Journal of Infectious Diseases and Therapy},
  volume = {3},
  number = {2},
  pages = {30-33},
  doi = {10.11648/j.ijidt.20180302.12},
  url = {https://doi.org/10.11648/j.ijidt.20180302.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20180302.12},
  abstract = {Multiple antibiotic resistance in bacterial populations is a pervasive and growing clinical problem, which is recognized as a threat to public health. Drug resistance to Pseudomonas sp. has spread to such a level irrespective of the type of patients, that, its pattern of distribution and antibiotic resistance needs to be studied in detail, especially in trauma patients. Of the Gram negative bacilli, Pseudomonas aeruginosa has been of particular interest, the incidence of which in wound infection has increased compared to a decade back. The objective of this study was to know the antibiotic susceptibility pattern of Pseudomonas aeruginosa isolates from wound infections. Out of the total of 1404 cases from which pus samples collected, 204 (14.5%) yielded Pseudomonas aeruginosa isolates. Among the antibiotics tested, Imipenem was the most sensitive drug, showing susceptibility in 81.3% of the isolates, followed by Piperacillin + tazobactam (76.4%), Meropenem (70.5%) and Piperacillin (67.6%). Fifteen (7.4%) multidrug resistant strains were reported out of the 204 isolations. Increase in resistance to aminoglycosides and fluoroquinolones in this study, prompted evaluation of antibiotic susceptibility pattern of Pseudomonas isolates from clinical samples at regular intervals.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Antibiotic Susceptibility Pattern of Pseudomonas aeruginosa Isolates from Wound Infections in a Tertiary Care Centre in South Kerala, India
AU  - Suresh Babu
Y1  - 2018/07/09
PY  - 2018
N1  - https://doi.org/10.11648/j.ijidt.20180302.12
DO  - 10.11648/j.ijidt.20180302.12
T2  - International Journal of Infectious Diseases and Therapy
JF  - International Journal of Infectious Diseases and Therapy
JO  - International Journal of Infectious Diseases and Therapy
SP  - 30
EP  - 33
PB  - Science Publishing Group
SN  - 2578-966X
UR  - https://doi.org/10.11648/j.ijidt.20180302.12
AB  - Multiple antibiotic resistance in bacterial populations is a pervasive and growing clinical problem, which is recognized as a threat to public health. Drug resistance to Pseudomonas sp. has spread to such a level irrespective of the type of patients, that, its pattern of distribution and antibiotic resistance needs to be studied in detail, especially in trauma patients. Of the Gram negative bacilli, Pseudomonas aeruginosa has been of particular interest, the incidence of which in wound infection has increased compared to a decade back. The objective of this study was to know the antibiotic susceptibility pattern of Pseudomonas aeruginosa isolates from wound infections. Out of the total of 1404 cases from which pus samples collected, 204 (14.5%) yielded Pseudomonas aeruginosa isolates. Among the antibiotics tested, Imipenem was the most sensitive drug, showing susceptibility in 81.3% of the isolates, followed by Piperacillin + tazobactam (76.4%), Meropenem (70.5%) and Piperacillin (67.6%). Fifteen (7.4%) multidrug resistant strains were reported out of the 204 isolations. Increase in resistance to aminoglycosides and fluoroquinolones in this study, prompted evaluation of antibiotic susceptibility pattern of Pseudomonas isolates from clinical samples at regular intervals.
VL  - 3
IS  - 2
ER  -

Copy | Download