Background: Central diabetes insipidus (CDI) is a rare hypothalamic-pituitary disease due to the deficiency of arginine vasopressin (AVP) synthesis of which more than one third of etiologies are unidentified. Autoimmunity is associated with one third of patients with apparently idiopathic CDI. The most common antibody detected in auto immune CDI is autoantibodies to AVP-secreting cells (AVPcAb). Stiff-person syndrome (SPS) is a rare neurological disorder with features of an autoimmune disease. It is characterized by fluctuating muscle rigidity in the trunk and limbs and a heightened sensitivity to stimuli. It is well known that SPS is associated with multiple auto immune endocrinopathy including auto immune diabetes and auto immune thyroid disease. The association between SPS and CDI is not well documented in the literature. Case information: We report a case of 51 year old female who developed CDI while being treated for SPS unmasked by high dose steroids. Result: Anti amphiphysin is the only antibody detected in our patient. Animal studies showed a high expression of amphiphysin in anterior and posterior pituitary gland, data in human are still vague .One theory is that anti-amphiphysin antibodies attack the amphiphysin molecules in the AVP secreting cells and inhibit release of AVP. Conclusion: This antibody could hint towards the autoimmune cause of CDI.
| Published in | American Journal of Internal Medicine (Volume 7, Issue 6) |
| DOI | 10.11648/j.ajim.20190706.13 |
| Page(s) | 151-153 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Central Diabetes Insipidus, Stiff Person Syndrome, Anti Amphyphysin Antibodies
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APA Style
Fatima Zarzour, Abir Bou Khalil, Sami Toufic Azar. (2019). Central Diabetes Insipidus in a Patient with Stiff Person Syndrome. American Journal of Internal Medicine, 7(6), 151-153. https://doi.org/10.11648/j.ajim.20190706.13
ACS Style
Fatima Zarzour; Abir Bou Khalil; Sami Toufic Azar. Central Diabetes Insipidus in a Patient with Stiff Person Syndrome. Am. J. Intern. Med. 2019, 7(6), 151-153. doi: 10.11648/j.ajim.20190706.13
AMA Style
Fatima Zarzour, Abir Bou Khalil, Sami Toufic Azar. Central Diabetes Insipidus in a Patient with Stiff Person Syndrome. Am J Intern Med. 2019;7(6):151-153. doi: 10.11648/j.ajim.20190706.13
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Download@article{10.11648/j.ajim.20190706.13,
author = {Fatima Zarzour and Abir Bou Khalil and Sami Toufic Azar},
title = {Central Diabetes Insipidus in a Patient with Stiff Person Syndrome},
journal = {American Journal of Internal Medicine},
volume = {7},
number = {6},
pages = {151-153},
doi = {10.11648/j.ajim.20190706.13},
url = {https://doi.org/10.11648/j.ajim.20190706.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20190706.13},
abstract = {Background: Central diabetes insipidus (CDI) is a rare hypothalamic-pituitary disease due to the deficiency of arginine vasopressin (AVP) synthesis of which more than one third of etiologies are unidentified. Autoimmunity is associated with one third of patients with apparently idiopathic CDI. The most common antibody detected in auto immune CDI is autoantibodies to AVP-secreting cells (AVPcAb). Stiff-person syndrome (SPS) is a rare neurological disorder with features of an autoimmune disease. It is characterized by fluctuating muscle rigidity in the trunk and limbs and a heightened sensitivity to stimuli. It is well known that SPS is associated with multiple auto immune endocrinopathy including auto immune diabetes and auto immune thyroid disease. The association between SPS and CDI is not well documented in the literature. Case information: We report a case of 51 year old female who developed CDI while being treated for SPS unmasked by high dose steroids. Result: Anti amphiphysin is the only antibody detected in our patient. Animal studies showed a high expression of amphiphysin in anterior and posterior pituitary gland, data in human are still vague .One theory is that anti-amphiphysin antibodies attack the amphiphysin molecules in the AVP secreting cells and inhibit release of AVP. Conclusion: This antibody could hint towards the autoimmune cause of CDI.},
year = {2019}
}
TY - JOUR T1 - Central Diabetes Insipidus in a Patient with Stiff Person Syndrome AU - Fatima Zarzour AU - Abir Bou Khalil AU - Sami Toufic Azar Y1 - 2019/11/19 PY - 2019 N1 - https://doi.org/10.11648/j.ajim.20190706.13 DO - 10.11648/j.ajim.20190706.13 T2 - American Journal of Internal Medicine JF - American Journal of Internal Medicine JO - American Journal of Internal Medicine SP - 151 EP - 153 PB - Science Publishing Group SN - 2330-4324 UR - https://doi.org/10.11648/j.ajim.20190706.13 AB - Background: Central diabetes insipidus (CDI) is a rare hypothalamic-pituitary disease due to the deficiency of arginine vasopressin (AVP) synthesis of which more than one third of etiologies are unidentified. Autoimmunity is associated with one third of patients with apparently idiopathic CDI. The most common antibody detected in auto immune CDI is autoantibodies to AVP-secreting cells (AVPcAb). Stiff-person syndrome (SPS) is a rare neurological disorder with features of an autoimmune disease. It is characterized by fluctuating muscle rigidity in the trunk and limbs and a heightened sensitivity to stimuli. It is well known that SPS is associated with multiple auto immune endocrinopathy including auto immune diabetes and auto immune thyroid disease. The association between SPS and CDI is not well documented in the literature. Case information: We report a case of 51 year old female who developed CDI while being treated for SPS unmasked by high dose steroids. Result: Anti amphiphysin is the only antibody detected in our patient. Animal studies showed a high expression of amphiphysin in anterior and posterior pituitary gland, data in human are still vague .One theory is that anti-amphiphysin antibodies attack the amphiphysin molecules in the AVP secreting cells and inhibit release of AVP. Conclusion: This antibody could hint towards the autoimmune cause of CDI. VL - 7 IS - 6 ER -
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