Impacts of a National Action Plan on Antimicrobial Use in China: A Multi-Center Retrospective Study

Lidao Bao; Gaowa Sharen; Sha Li; Xianhua Ren; Ruilian Ma

doi:doi:10.11648/j.sjph.20180603.12

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Impacts of a National Action Plan on Antimicrobial Use in China: A Multi-Center Retrospective Study

Lidao Bao, Gaowa Sharen, Sha Li, Xianhua Ren, Ruilian Ma

Received: 10 May 2018 Accepted: Published: 10 May 2018

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Abstract

This study retrospectively analyzed antimicrobial prescription and concomitant economic outcomes in 28 Chinese state-owned hospitals before and after the intervention introduced by the Action Plan. The outcomes of national intervention were evaluated by analyzing statistics collected before and after the Action Plan which came into effect as of July 1, 2011. The fourth quarters of 2010 and 2011 were set as the baseline and intervention periods, respectively. The percentage of patients receiving antimicrobial prescription, the intensity of antimicrobials prescribed, economic indexes related to antimicrobial prescribing, and antimicrobial prophylaxis in clean surgical procedures were investigated, respectively. First, during the intervention period, the percentage of patients receiving antimicrobial treatment dropped to 15.6% and 49.1% in outpatient and inpatient settings, respectively. The intensity of antimicrobial prescribed decreased to 50.29 DDD (defined daily dose) in outpatient setting. The defined daily doses (DDDs) per thousand patients per day decreased to 12914.33 DDDs in outpatient settings. The results were statistically significant as compared to those in the baseline period (P<0.001). Second, the expenses on antimicrobials significantly decreased (P<0.001). Finally, the percentage of patients receiving antimicrobial prophylaxis for clean surgical procedures decreased to 48.94% (P<0.001), while the infection rates did not differ significantly (P=0.581). This multi-center study suggests that the Action Plan launched by China’s government proved effective in state-owned medical institutions in promoting rational antimicrobial prescription.

DOI	10.11648/j.sjph.20180603.12
Published in	Science Journal of Public Health (Volume 6, Issue 3, May 2018)
Page(s)	75-81
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Antimicrobial Use, Multi-center Study, Action Plan

References

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APA Style

Lidao Bao, Gaowa Sharen, Sha Li, Xianhua Ren, Ruilian Ma. (2018). Impacts of a National Action Plan on Antimicrobial Use in China: A Multi-Center Retrospective Study. Science Journal of Public Health, 6(3), 75-81. https://doi.org/10.11648/j.sjph.20180603.12

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ACS Style

Lidao Bao; Gaowa Sharen; Sha Li; Xianhua Ren; Ruilian Ma. Impacts of a National Action Plan on Antimicrobial Use in China: A Multi-Center Retrospective Study. Sci. J. Public Health 2018, 6(3), 75-81. doi: 10.11648/j.sjph.20180603.12

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AMA Style

Lidao Bao, Gaowa Sharen, Sha Li, Xianhua Ren, Ruilian Ma. Impacts of a National Action Plan on Antimicrobial Use in China: A Multi-Center Retrospective Study. Sci J Public Health. 2018;6(3):75-81. doi: 10.11648/j.sjph.20180603.12

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@article{10.11648/j.sjph.20180603.12,
  author = {Lidao Bao and Gaowa Sharen and Sha Li and Xianhua Ren and Ruilian Ma},
  title = {Impacts of a National Action Plan on Antimicrobial Use in China: A Multi-Center Retrospective Study},
  journal = {Science Journal of Public Health},
  volume = {6},
  number = {3},
  pages = {75-81},
  doi = {10.11648/j.sjph.20180603.12},
  url = {https://doi.org/10.11648/j.sjph.20180603.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20180603.12},
  abstract = {This study retrospectively analyzed antimicrobial prescription and concomitant economic outcomes in 28 Chinese state-owned hospitals before and after the intervention introduced by the Action Plan. The outcomes of national intervention were evaluated by analyzing statistics collected before and after the Action Plan which came into effect as of July 1, 2011. The fourth quarters of 2010 and 2011 were set as the baseline and intervention periods, respectively. The percentage of patients receiving antimicrobial prescription, the intensity of antimicrobials prescribed, economic indexes related to antimicrobial prescribing, and antimicrobial prophylaxis in clean surgical procedures were investigated, respectively. First, during the intervention period, the percentage of patients receiving antimicrobial treatment dropped to 15.6% and 49.1% in outpatient and inpatient settings, respectively. The intensity of antimicrobial prescribed decreased to 50.29 DDD (defined daily dose) in outpatient setting. The defined daily doses (DDDs) per thousand patients per day decreased to 12914.33 DDDs in outpatient settings. The results were statistically significant as compared to those in the baseline period (P<0.001). Second, the expenses on antimicrobials significantly decreased (P<0.001). Finally, the percentage of patients receiving antimicrobial prophylaxis for clean surgical procedures decreased to 48.94% (P<0.001), while the infection rates did not differ significantly (P=0.581). This multi-center study suggests that the Action Plan launched by China’s government proved effective in state-owned medical institutions in promoting rational antimicrobial prescription.},
 year = {2018}
}

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TY  - JOUR
T1  - Impacts of a National Action Plan on Antimicrobial Use in China: A Multi-Center Retrospective Study
AU  - Lidao Bao
AU  - Gaowa Sharen
AU  - Sha Li
AU  - Xianhua Ren
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DO  - 10.11648/j.sjph.20180603.12
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
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PB  - Science Publishing Group
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UR  - https://doi.org/10.11648/j.sjph.20180603.12
AB  - This study retrospectively analyzed antimicrobial prescription and concomitant economic outcomes in 28 Chinese state-owned hospitals before and after the intervention introduced by the Action Plan. The outcomes of national intervention were evaluated by analyzing statistics collected before and after the Action Plan which came into effect as of July 1, 2011. The fourth quarters of 2010 and 2011 were set as the baseline and intervention periods, respectively. The percentage of patients receiving antimicrobial prescription, the intensity of antimicrobials prescribed, economic indexes related to antimicrobial prescribing, and antimicrobial prophylaxis in clean surgical procedures were investigated, respectively. First, during the intervention period, the percentage of patients receiving antimicrobial treatment dropped to 15.6% and 49.1% in outpatient and inpatient settings, respectively. The intensity of antimicrobial prescribed decreased to 50.29 DDD (defined daily dose) in outpatient setting. The defined daily doses (DDDs) per thousand patients per day decreased to 12914.33 DDDs in outpatient settings. The results were statistically significant as compared to those in the baseline period (P<0.001). Second, the expenses on antimicrobials significantly decreased (P<0.001). Finally, the percentage of patients receiving antimicrobial prophylaxis for clean surgical procedures decreased to 48.94% (P<0.001), while the infection rates did not differ significantly (P=0.581). This multi-center study suggests that the Action Plan launched by China’s government proved effective in state-owned medical institutions in promoting rational antimicrobial prescription.
VL  - 6
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Author Information

Lidao Bao

Department of Pharmacy, Affiliated Hospital of Inner Mongolian Medical University, Hohhot, P. R. China
Gaowa Sharen

Department of Ultrasound, Affiliated Hospital of Inner Mongolian Medical University, Hohhot, P. R. China
Sha Li

Department of Pharmacy, Affiliated Hospital of Inner Mongolian Medical University, Hohhot, P. R. China
Xianhua Ren

Department of Pharmacy, Affiliated Hospital of Inner Mongolian Medical University, Hohhot, P. R. China
Ruilian Ma

Department of Pharmacy, Affiliated Hospital of Inner Mongolian Medical University, Hohhot, P. R. China

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APA Style

Lidao Bao, Gaowa Sharen, Sha Li, Xianhua Ren, Ruilian Ma. (2018). Impacts of a National Action Plan on Antimicrobial Use in China: A Multi-Center Retrospective Study. Science Journal of Public Health, 6(3), 75-81. https://doi.org/10.11648/j.sjph.20180603.12

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ACS Style

Lidao Bao; Gaowa Sharen; Sha Li; Xianhua Ren; Ruilian Ma. Impacts of a National Action Plan on Antimicrobial Use in China: A Multi-Center Retrospective Study. Sci. J. Public Health 2018, 6(3), 75-81. doi: 10.11648/j.sjph.20180603.12

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AMA Style

Lidao Bao, Gaowa Sharen, Sha Li, Xianhua Ren, Ruilian Ma. Impacts of a National Action Plan on Antimicrobial Use in China: A Multi-Center Retrospective Study. Sci J Public Health. 2018;6(3):75-81. doi: 10.11648/j.sjph.20180603.12

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@article{10.11648/j.sjph.20180603.12,
  author = {Lidao Bao and Gaowa Sharen and Sha Li and Xianhua Ren and Ruilian Ma},
  title = {Impacts of a National Action Plan on Antimicrobial Use in China: A Multi-Center Retrospective Study},
  journal = {Science Journal of Public Health},
  volume = {6},
  number = {3},
  pages = {75-81},
  doi = {10.11648/j.sjph.20180603.12},
  url = {https://doi.org/10.11648/j.sjph.20180603.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20180603.12},
  abstract = {This study retrospectively analyzed antimicrobial prescription and concomitant economic outcomes in 28 Chinese state-owned hospitals before and after the intervention introduced by the Action Plan. The outcomes of national intervention were evaluated by analyzing statistics collected before and after the Action Plan which came into effect as of July 1, 2011. The fourth quarters of 2010 and 2011 were set as the baseline and intervention periods, respectively. The percentage of patients receiving antimicrobial prescription, the intensity of antimicrobials prescribed, economic indexes related to antimicrobial prescribing, and antimicrobial prophylaxis in clean surgical procedures were investigated, respectively. First, during the intervention period, the percentage of patients receiving antimicrobial treatment dropped to 15.6% and 49.1% in outpatient and inpatient settings, respectively. The intensity of antimicrobial prescribed decreased to 50.29 DDD (defined daily dose) in outpatient setting. The defined daily doses (DDDs) per thousand patients per day decreased to 12914.33 DDDs in outpatient settings. The results were statistically significant as compared to those in the baseline period (P<0.001). Second, the expenses on antimicrobials significantly decreased (P<0.001). Finally, the percentage of patients receiving antimicrobial prophylaxis for clean surgical procedures decreased to 48.94% (P<0.001), while the infection rates did not differ significantly (P=0.581). This multi-center study suggests that the Action Plan launched by China’s government proved effective in state-owned medical institutions in promoting rational antimicrobial prescription.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Impacts of a National Action Plan on Antimicrobial Use in China: A Multi-Center Retrospective Study
AU  - Lidao Bao
AU  - Gaowa Sharen
AU  - Sha Li
AU  - Xianhua Ren
AU  - Ruilian Ma
Y1  - 2018/05/10
PY  - 2018
N1  - https://doi.org/10.11648/j.sjph.20180603.12
DO  - 10.11648/j.sjph.20180603.12
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 75
EP  - 81
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20180603.12
AB  - This study retrospectively analyzed antimicrobial prescription and concomitant economic outcomes in 28 Chinese state-owned hospitals before and after the intervention introduced by the Action Plan. The outcomes of national intervention were evaluated by analyzing statistics collected before and after the Action Plan which came into effect as of July 1, 2011. The fourth quarters of 2010 and 2011 were set as the baseline and intervention periods, respectively. The percentage of patients receiving antimicrobial prescription, the intensity of antimicrobials prescribed, economic indexes related to antimicrobial prescribing, and antimicrobial prophylaxis in clean surgical procedures were investigated, respectively. First, during the intervention period, the percentage of patients receiving antimicrobial treatment dropped to 15.6% and 49.1% in outpatient and inpatient settings, respectively. The intensity of antimicrobial prescribed decreased to 50.29 DDD (defined daily dose) in outpatient setting. The defined daily doses (DDDs) per thousand patients per day decreased to 12914.33 DDDs in outpatient settings. The results were statistically significant as compared to those in the baseline period (P<0.001). Second, the expenses on antimicrobials significantly decreased (P<0.001). Finally, the percentage of patients receiving antimicrobial prophylaxis for clean surgical procedures decreased to 48.94% (P<0.001), while the infection rates did not differ significantly (P=0.581). This multi-center study suggests that the Action Plan launched by China’s government proved effective in state-owned medical institutions in promoting rational antimicrobial prescription.
VL  - 6
IS  - 3
ER  -

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