Facts from the Early Years of the History of Combinatorial Chemistry
Science Journal of Chemistry
Volume 6, Issue 6, December 2018, Pages: 123-130
Received: Nov. 22, 2018; Accepted: Dec. 14, 2018; Published: Jan. 10, 2019
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Author
Árpád Furka, Department of Organic Chemistry, Eötvös Loránd University, Budapest, Hungary
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Abstract
Looking into the combinatorial chemistry literature one can see that it is still mostly believed that the first combinatorial synthesis was invented by several groups exactly at the same time. In fact the principles of combinatorial chemistry, that is, synthesis of large number, even millions, of compounds and then by applying a proper deconvolution method identify the useful components, was invented, first described and notarized as early as 1982 by the Author of this article. The first publication of the synthetic method was in 1988. In February 1990 the manuscript of an article also describing the combinatorial split-mix synthesis was submitted to the International Journal of Peptide and Protein Research that appeared after a one and a half year delay. In this period four patent applications were filed, two conference lectures, two Nature papers and a book chapter were submitted then published. The editor in chief of the mentioned journal was among the authors of one patent application, one lecture, one Nature article and a book chapter. The evidences described below will hopefully convince the readers that the inventions in the patent submissions and in the mentioned publications were all 2-3 years earlier described in our 1988 publications and these publications were known by the authors.
Keywords
Combinatorial Chemistry, Split-Mix Synthesis, OBOC Libraries, Deconvolution, Peptides, Plagiarism
To cite this article
Árpád Furka, Facts from the Early Years of the History of Combinatorial Chemistry, Science Journal of Chemistry. Vol. 6, No. 6, 2018, pp. 123-130. doi: 10.11648/j.sjc.20180606.14
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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