Expression of O6 Methyl Guanine Methyl Transferase (Mgmt) in Oral Squamous Cell Carcinoma Patients in Alexandria, Egypt (Smokers and Non-Smokers)

Hend Mohamed Helmy; Taissir Ali Omar; Sahar Mohamed ElSheikh; Ahmed Serag Habib

doi:doi:10.11648/j.ajls.20140204.15

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Expression of O6 Methyl Guanine Methyl Transferase (Mgmt) in Oral Squamous Cell Carcinoma Patients in Alexandria, Egypt (Smokers and Non-Smokers)

Hend Mohamed Helmy, Taissir Ali Omar, Sahar Mohamed ElSheikh, Ahmed Serag Habib

Received: 6 August 2014 Accepted: 16 August 2014 Published: 30 August 2014

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Abstract

Objectives: O6-methylguanine-DNA methyltransferase (MGMT) removes mutagenic, carcinogenic, and cytotoxic adducts from O6-methylguanine in DNA through a direct reversal mechanism. Decreased expression of MGMT has been reported in a variety of human malignant tumors. The purpose of this study was to clarify the correlation of MGMT expression levels in oral squamous cell carcinoma (OSCC) and cigarette smoking. Study Design: MGMT protein expression in 22 cases of oral squamous cell carcinoma by immunohistochemistry was investigated. Correlation with detailed tobacco history was then tested by statistical analysis. Results: All the non smoker OSCC cases showed positive immunoexpression. However 3 cases of the smoker patient revealed a weak positive immunostaining with only sporadic cells at the periphery. Conclusion: The results suggest that the absence of MGMT expression is related strongly to tobacco smoking and, thus, might be a significant event in oral carcinogenesis.

DOI	10.11648/j.ajls.20140204.15
Published in	American Journal of Life Sciences (Volume 2, Issue 4, August 2014)
Page(s)	217-223
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

O6-Methylguanine-DNA Methyltransferase, Tobacco, Oral Squamous Cell Carcinoma

References

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APA Style

Hend Mohamed Helmy, Taissir Ali Omar, Sahar Mohamed ElSheikh, Ahmed Serag Habib. (2014). Expression of O6 Methyl Guanine Methyl Transferase (Mgmt) in Oral Squamous Cell Carcinoma Patients in Alexandria, Egypt (Smokers and Non-Smokers). American Journal of Life Sciences, 2(4), 217-223. https://doi.org/10.11648/j.ajls.20140204.15

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ACS Style

Hend Mohamed Helmy; Taissir Ali Omar; Sahar Mohamed ElSheikh; Ahmed Serag Habib. Expression of O6 Methyl Guanine Methyl Transferase (Mgmt) in Oral Squamous Cell Carcinoma Patients in Alexandria, Egypt (Smokers and Non-Smokers). Am. J. Life Sci. 2014, 2(4), 217-223. doi: 10.11648/j.ajls.20140204.15

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AMA Style

Hend Mohamed Helmy, Taissir Ali Omar, Sahar Mohamed ElSheikh, Ahmed Serag Habib. Expression of O6 Methyl Guanine Methyl Transferase (Mgmt) in Oral Squamous Cell Carcinoma Patients in Alexandria, Egypt (Smokers and Non-Smokers). Am J Life Sci. 2014;2(4):217-223. doi: 10.11648/j.ajls.20140204.15

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@article{10.11648/j.ajls.20140204.15,
  author = {Hend Mohamed Helmy and Taissir Ali Omar and Sahar Mohamed ElSheikh and Ahmed Serag Habib},
  title = {Expression of O6 Methyl Guanine Methyl Transferase (Mgmt) in Oral Squamous Cell Carcinoma Patients in Alexandria, Egypt (Smokers and Non-Smokers)},
  journal = {American Journal of Life Sciences},
  volume = {2},
  number = {4},
  pages = {217-223},
  doi = {10.11648/j.ajls.20140204.15},
  url = {https://doi.org/10.11648/j.ajls.20140204.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20140204.15},
  abstract = {Objectives: O6-methylguanine-DNA methyltransferase (MGMT) removes mutagenic, carcinogenic, and cytotoxic adducts from O6-methylguanine in DNA through a direct reversal mechanism. Decreased expression of MGMT has been reported in a variety of human malignant tumors. The purpose of this study was to clarify the correlation of MGMT expression levels in oral squamous cell carcinoma (OSCC) and cigarette smoking. Study Design: MGMT protein expression in 22 cases of oral squamous cell carcinoma by immunohistochemistry was investigated. Correlation with detailed tobacco history was then tested by statistical analysis. Results: All the non smoker OSCC cases showed positive immunoexpression. However 3 cases of the smoker patient revealed a weak positive immunostaining with only sporadic cells at the periphery. Conclusion: The results suggest that the absence of MGMT expression is related strongly to tobacco smoking and, thus, might be a significant event in oral carcinogenesis.},
 year = {2014}
}

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TY  - JOUR
T1  - Expression of O6 Methyl Guanine Methyl Transferase (Mgmt) in Oral Squamous Cell Carcinoma Patients in Alexandria, Egypt (Smokers and Non-Smokers)
AU  - Hend Mohamed Helmy
AU  - Taissir Ali Omar
AU  - Sahar Mohamed ElSheikh
AU  - Ahmed Serag Habib
Y1  - 2014/08/30
PY  - 2014
N1  - https://doi.org/10.11648/j.ajls.20140204.15
DO  - 10.11648/j.ajls.20140204.15
T2  - American Journal of Life Sciences
JF  - American Journal of Life Sciences
JO  - American Journal of Life Sciences
SP  - 217
EP  - 223
PB  - Science Publishing Group
SN  - 2328-5737
UR  - https://doi.org/10.11648/j.ajls.20140204.15
AB  - Objectives: O6-methylguanine-DNA methyltransferase (MGMT) removes mutagenic, carcinogenic, and cytotoxic adducts from O6-methylguanine in DNA through a direct reversal mechanism. Decreased expression of MGMT has been reported in a variety of human malignant tumors. The purpose of this study was to clarify the correlation of MGMT expression levels in oral squamous cell carcinoma (OSCC) and cigarette smoking. Study Design: MGMT protein expression in 22 cases of oral squamous cell carcinoma by immunohistochemistry was investigated. Correlation with detailed tobacco history was then tested by statistical analysis. Results: All the non smoker OSCC cases showed positive immunoexpression. However 3 cases of the smoker patient revealed a weak positive immunostaining with only sporadic cells at the periphery. Conclusion: The results suggest that the absence of MGMT expression is related strongly to tobacco smoking and, thus, might be a significant event in oral carcinogenesis.
VL  - 2
IS  - 4
ER  -

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Author Information

Hend Mohamed Helmy

Department of Oral Pathology, Faculty of Dentistry, Alexandria University, Egypt
Taissir Ali Omar

Department of Oral Pathology, Faculty of Dentistry, Alexandria University, Egypt
Sahar Mohamed ElSheikh

Department of Oral Pathology, Faculty of Dentistry, Alexandria University, Egypt
Ahmed Serag Habib

Department of Cranio Maxillofacial and Plastic Surgery, Faculty of Dentistry, Alexandria University, Egypt

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Plain Text BibTeX RIS

APA Style

Hend Mohamed Helmy, Taissir Ali Omar, Sahar Mohamed ElSheikh, Ahmed Serag Habib. (2014). Expression of O6 Methyl Guanine Methyl Transferase (Mgmt) in Oral Squamous Cell Carcinoma Patients in Alexandria, Egypt (Smokers and Non-Smokers). American Journal of Life Sciences, 2(4), 217-223. https://doi.org/10.11648/j.ajls.20140204.15

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ACS Style

Hend Mohamed Helmy; Taissir Ali Omar; Sahar Mohamed ElSheikh; Ahmed Serag Habib. Expression of O6 Methyl Guanine Methyl Transferase (Mgmt) in Oral Squamous Cell Carcinoma Patients in Alexandria, Egypt (Smokers and Non-Smokers). Am. J. Life Sci. 2014, 2(4), 217-223. doi: 10.11648/j.ajls.20140204.15

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AMA Style

Hend Mohamed Helmy, Taissir Ali Omar, Sahar Mohamed ElSheikh, Ahmed Serag Habib. Expression of O6 Methyl Guanine Methyl Transferase (Mgmt) in Oral Squamous Cell Carcinoma Patients in Alexandria, Egypt (Smokers and Non-Smokers). Am J Life Sci. 2014;2(4):217-223. doi: 10.11648/j.ajls.20140204.15

Copy | Download

@article{10.11648/j.ajls.20140204.15,
  author = {Hend Mohamed Helmy and Taissir Ali Omar and Sahar Mohamed ElSheikh and Ahmed Serag Habib},
  title = {Expression of O6 Methyl Guanine Methyl Transferase (Mgmt) in Oral Squamous Cell Carcinoma Patients in Alexandria, Egypt (Smokers and Non-Smokers)},
  journal = {American Journal of Life Sciences},
  volume = {2},
  number = {4},
  pages = {217-223},
  doi = {10.11648/j.ajls.20140204.15},
  url = {https://doi.org/10.11648/j.ajls.20140204.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20140204.15},
  abstract = {Objectives: O6-methylguanine-DNA methyltransferase (MGMT) removes mutagenic, carcinogenic, and cytotoxic adducts from O6-methylguanine in DNA through a direct reversal mechanism. Decreased expression of MGMT has been reported in a variety of human malignant tumors. The purpose of this study was to clarify the correlation of MGMT expression levels in oral squamous cell carcinoma (OSCC) and cigarette smoking. Study Design: MGMT protein expression in 22 cases of oral squamous cell carcinoma by immunohistochemistry was investigated. Correlation with detailed tobacco history was then tested by statistical analysis. Results: All the non smoker OSCC cases showed positive immunoexpression. However 3 cases of the smoker patient revealed a weak positive immunostaining with only sporadic cells at the periphery. Conclusion: The results suggest that the absence of MGMT expression is related strongly to tobacco smoking and, thus, might be a significant event in oral carcinogenesis.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - Expression of O6 Methyl Guanine Methyl Transferase (Mgmt) in Oral Squamous Cell Carcinoma Patients in Alexandria, Egypt (Smokers and Non-Smokers)
AU  - Hend Mohamed Helmy
AU  - Taissir Ali Omar
AU  - Sahar Mohamed ElSheikh
AU  - Ahmed Serag Habib
Y1  - 2014/08/30
PY  - 2014
N1  - https://doi.org/10.11648/j.ajls.20140204.15
DO  - 10.11648/j.ajls.20140204.15
T2  - American Journal of Life Sciences
JF  - American Journal of Life Sciences
JO  - American Journal of Life Sciences
SP  - 217
EP  - 223
PB  - Science Publishing Group
SN  - 2328-5737
UR  - https://doi.org/10.11648/j.ajls.20140204.15
AB  - Objectives: O6-methylguanine-DNA methyltransferase (MGMT) removes mutagenic, carcinogenic, and cytotoxic adducts from O6-methylguanine in DNA through a direct reversal mechanism. Decreased expression of MGMT has been reported in a variety of human malignant tumors. The purpose of this study was to clarify the correlation of MGMT expression levels in oral squamous cell carcinoma (OSCC) and cigarette smoking. Study Design: MGMT protein expression in 22 cases of oral squamous cell carcinoma by immunohistochemistry was investigated. Correlation with detailed tobacco history was then tested by statistical analysis. Results: All the non smoker OSCC cases showed positive immunoexpression. However 3 cases of the smoker patient revealed a weak positive immunostaining with only sporadic cells at the periphery. Conclusion: The results suggest that the absence of MGMT expression is related strongly to tobacco smoking and, thus, might be a significant event in oral carcinogenesis.
VL  - 2
IS  - 4
ER  -

Copy | Download