Research Article
Detection of Multidrug Resistant Staphylococcus aureus at Morogoro Regional Referral Hospital, Tanzania
Gwimo Nancy,
Philbert Balichene Madoshi*
,
Katakweba Abdul S.,
Matee Mecky
Issue:
Volume 10, Issue 2, June 2024
Pages:
14-22
Received:
22 February 2024
Accepted:
21 March 2024
Published:
11 April 2024
DOI:
10.11648/j.bs.20241002.11
Downloads:
Views:
Abstract: Background: Hospital settings are associated with constant introduction of pathogens which can be transmitted among workers by patients, and visitors, resulting into potential nosocomial infections. This study compared the carriage and pattern of drug resistant S. aureus among patients and on equipment in hospital setting at Morogoro Regional Referral Hospital (MRRH). Methods: A cross sectional study was conducted by collecting samples from the anterior nares using sterile cotton swabs from patients. Furthermore samples were collected from inanimate surfaces, ward door handles; wheelchairs; and trolleys. The samples were incubated on mannitol salt agar plates aerobically at 37°C for 24 hours. Antimicrobial susceptibility testing was done using; erythromycin, azithromycin, ofloxacin, gentamicin, ciprofloxacin and cefoxitin. Clindamycin inducible resistance was tested by D test as per CLSI (2019). Data analysis was carried using SPSS where Chi – square was used to compare the association of occurrence of resistance and source of isolation. Results: Out of 200 samples, 54 tested positive for S. aureus were from human while the prevalence of S. aureus in inanimate objects was high in beds 10 (40%). The AMR was observed more in azithromycin (26.3%) than other antimicrobials. The D-Test showed inducible clindamycin-resistant phenotype in 57.1% of the MRSA isolates. The maternity ward had the highest risk of being exposed to S. aureus contamination [OR = 9.9 (95% CI, 2.0-19.30), p = 0.01] and tables [OR = 4.6 (95% CI, 1.22-1.89, p= 0.03)]. The recovery wards were least likely to be contaminated with the result of four times likely to be contaminate for both patients and surfaces [OR = 5.1 (95% CI, 1.3-8.6), p= 0.04] when compared with other wards. Conclusion: This study presents some important findings on MRSA which is a global concern, the authors encourages more researches are done in MRSA for efficient availability in the AMR database.
Abstract: Background: Hospital settings are associated with constant introduction of pathogens which can be transmitted among workers by patients, and visitors, resulting into potential nosocomial infections. This study compared the carriage and pattern of drug resistant S. aureus among patients and on equipment in hospital setting at Morogoro Regional Refer...
Show More
Research Article
Demographics and Pathomorphology of Ameloblastoma: A 9 Year Retrospective Review at a Tertiary Health Care Centre in North-Central Nigeria
Philip Ojile Akpa*,
Innocent Emmanuel,
Barka Vandi Kwaghe,
Ijeoma Ahunna Okwudire-Ejeh,
Ayuba Madachi Dauda,
Olugbenga Akindele Silas
Issue:
Volume 10, Issue 2, June 2024
Pages:
23-29
Received:
19 March 2024
Accepted:
1 April 2024
Published:
17 April 2024
DOI:
10.11648/j.bs.20241002.12
Downloads:
Views:
Abstract: Ameloblastoma is a benign but locally invasive neoplasm that arises from odontogenic epithelium of the dental lamina. It is classified into the conventional, unicystic, extraosseous/peripheral and metastasizing variants. It is the most common odontogenic tumour in Nigeria and other developing countries. It affects individuals of all ages, has a peak of occurrence in the fourth and fifth decades with no sex predilection. The Mandible is the most commonly affected site and the conventional variant is predominant. The aim of this study is to document the demographics and Pathomorphology of ameloblastoma diagnosed at the Jos University Teaching Hospital over the past nine years. There is no previous documentation of the pattern of this tumour in the North-central region of Nigeria making this study relevant. This is a retrospective observational review of all cases of ameloblastoma diagnosed histologically at the Jos University Teaching Hospital between January 1st 2015 to December 31st 2023. Materials utilized consisted of patient clinical case files, electronic histopathology result records, histopathology glass slides and formalin fixed paraffin embedded tissue blocks. The patient age, sex, anatomic location of tumour in the Jaw/face and pathomorphological features were recorded for all cases. The data obtained was analysed using Epi-info 7 (version 3.5.4) and Microsoft-Excel. Results were presented in tables and charts. Fifty one cases of ameloblastoma were diagnosed during the 9 years of review. Their ages ranged between 6 and 65 years with a mean age of 30.9±13.8 years and a peak of occurrence in the third decade. There were 29 males and 22 females with a male to female ratio (M:F) of 1.3:1. Ninety-two percent of cases occurred in the mandible and 8% in the maxilla. The conventional variant accounted for 72.5% of cases and the unicystic variant 27.5%. The follicular type accounted for 64.8% of cases of conventional ameloblastoma. Ameloblastoma occurred more commonly in males with a peak in the third decade. A vast majority of cases involved the mandible and the conventional type was predominant. This demographic pattern supports existing evidence that ameloblastoma occurs more commonly in males and in relatively younger patients in Africa.
Abstract: Ameloblastoma is a benign but locally invasive neoplasm that arises from odontogenic epithelium of the dental lamina. It is classified into the conventional, unicystic, extraosseous/peripheral and metastasizing variants. It is the most common odontogenic tumour in Nigeria and other developing countries. It affects individuals of all ages, has a pea...
Show More
