Risk Factors for Undiagnosed Hyperuricemia and Gout: Influence of Personal Characteristics, Life Style and Cardio-Metabolic Status: A Cross Sectional Study
Christopher Edet Ekpenyong,
Inyang Udoinyang Clement,
Caleb Effiong Edet
Issue:
Volume 5, Issue 2, April 2019
Pages:
27-38
Received:
20 February 2019
Accepted:
25 March 2019
Published:
23 May 2019
Abstract: Despite the increasing prevalence of hyperuricemia in the general population and its association with many diseases, serum uric acid (SUA) level has not been routinely determined in the evaluation and management of patients, especially those with metabolic disorders. This cross-sectional study used standard methods to assess the influence of personal characteristics, lifestyle and cardio-metabolic status on SUA levels of patients who visited a primary care center in Southern Nigeria. Forty-nine point seven percent of participants were hyperuricemic. Significant association and higher odds for hyperuricemia were found among participants who were married (Odd Ratio (OR)=2.24,95%Confidence interval (C.I) 1.947-5.303), dehydrated (OR=1.46,C.I 0.845-2.535), currently consuming alcohol (OR=5.199, C.I 4.249-69.623), with poor dietary habits (OR=1.23,C.I0.982-7.2356), physically inactive (OR=2.760,C.I 0.294-25.881), night clubbing (OR=3.09,C.I3.22-12.982), frequently drinking soft/sweet drinks (OR=3.42,C.I 2.01-10.29), abnormal anthropometric profile (OR=1.27,CI 1.094-1.485) for BMI and OR=1.52,C.I 0.874-2.656) for waist circumference) and metabolic disorders including hypertension (OR=1.60,C.I 1.280-2.008), T2DM (OR=1.27,C.I 1.089-1.474), dyslipidemia and musculoskeletal disorders (OR=3.26,C.I1.633-6.492). Demographic factors, poor lifestyle habits, abnormal adiposity and metabolic aberrations drive hyperuricemia and therefore underline the need for SUA evaluation and management among those with these characteristics to prevent associated diseases.
Abstract: Despite the increasing prevalence of hyperuricemia in the general population and its association with many diseases, serum uric acid (SUA) level has not been routinely determined in the evaluation and management of patients, especially those with metabolic disorders. This cross-sectional study used standard methods to assess the influence of person...
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Paediatric Abdominal Surgical Emergencies in Enugu, South East Nigeria: Any Change in Pattern and Outcome
Chukwubuike Kevin Emeka,
Nduagubam Obinna Chukwuebuka,
Ndu Ikenna Kingsley,
Odetunde Oluwatoyin Arinola,
Ekenze Sebastin Okwuchukwu,
Eze Thaddeus Chikaodili
Issue:
Volume 5, Issue 2, April 2019
Pages:
39-42
Received:
7 May 2019
Accepted:
10 June 2019
Published:
26 June 2019
Abstract: Background: Paediatric abdominal surgical emergencies (PASE) constitute a significant workload of the paediatric surgeon. The objective of this study was to characterize the pattern of PASE in a tertiary hospital in Enugu and determine any change in pattern and outcome. Methodology: This was a retrospective study of children aged 1 day to 16 years who presented with abdominal surgical emergencies to Enugu State University Teaching Hospital (ESUTH), Enugu. Result: There were 152 patients recruited for the study. There were 122 males and 30 females. The mean age at presentation was 6 years while the mean duration of symptoms before presentation to the hospital was 3.5 days. Thirty eight (25%) patients presented within 48 hours of the onset of their symptoms while 114 patients (75%) presented after 48 hours. The emergencies were intussusception 56 (36.8%), typhoid intestinal perforation 30 (19.7%), obstructed hernia 20 (13.2%), appendicitis 17 (11.2%), abdominal trauma 10 (6.6%), neonatal intestinal obstruction 6 (4%), ruptured appendix 6 (3.9%), Hirschsprung’s disease 4 (2.6%), adhesive bowel obstruction 2 (1.3%), and Gastroschisis 1 (0.7%). The mean hospital stay was 6.7 days. Thirty four patients (22.4%) who had surgery developed post-operative complication. The most common complication was surgical site infection and this occurred most in patients who had typhoid intestinal perforation (P = 0.017). There were 12 (7.9%) deaths. Conclusion: In this series, intussusception was the most common paediatric abdominal surgical emergency seen in Enugu unlike in the past when it used to be typhoid intestinal perforation. Mortality was less in the current study. This illustrates a change in pattern and outcome.
Abstract: Background: Paediatric abdominal surgical emergencies (PASE) constitute a significant workload of the paediatric surgeon. The objective of this study was to characterize the pattern of PASE in a tertiary hospital in Enugu and determine any change in pattern and outcome. Methodology: This was a retrospective study of children aged 1 day to 16 years ...
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