Journal of Drug Design and Medicinal Chemistry

Volume 10, Issue 1, March 2024

  • Case Report

    Evaluating Efficacy of Newly Introduced Herbicides Against Coffee Weeds at Jimma, Southwest Ethiopia

    Tigist Bidira*, Tamiru Shimalis, Tekleeyesus Firde

    Issue: Volume 10, Issue 1, April 2024
    Pages: 1-7
    Received: 4 December 2023
    Accepted: 20 December 2023
    Published: 8 January 2024
    Downloads:
    Views:
    Abstract: Weed is the major limiting factor of coffee production in Ethiopia. Weeds cause 65% coffee yield reduction in the country. Now a day, the expensiveness of weed management has been a principle issue in economic analysis of coffee production in Ethiopia. Herbicide weeding is a best management option in coffee production. Which can offer an advantage ... Show More
  • Research Article

    Resveratrol: A Cell Growth Inhibitor Against Leishmania Tropica

    Kashif Iqbal*, Qaiser Aziz, Ayesha Sana

    Issue: Volume 10, Issue 1, April 2024
    Pages: 8-10
    Received: 8 December 2023
    Accepted: 6 January 2024
    Published: 23 January 2024
    Downloads:
    Views:
    Abstract: This study describes cell growth inhibition through invitro, invivo antileishmanial and cytotoxic effect of Resveratrol. Resveratrol was tested at range of concentration of 1 - 10 µg/ml for invitro analysis on L-tropica strain for 24 – 72 h, whereas Sodium Stibogluconate was reference drug. BALB/c mice were subjected to invivo test relative to nega... Show More
  • Research Article

    The Role of Color and Hue in Drug Design

    Zhao Mingrui*, Wang Yilin, Peng Peng, Li Hengxin, Li Zhaoxia

    Issue: Volume 10, Issue 1, April 2024
    Pages: 11-15
    Received: 27 December 2023
    Accepted: 9 January 2024
    Published: 1 February 2024
    Downloads:
    Views:
    Abstract: Purpose To explore the impact of color and hue in drug design and provide practical applications in drug development. Methods the association between color psychology and drug development, how color and hue can be used to influence people's perception and acceptance of drugs, and the practical application of color and hue in pharmaceutical formulat... Show More
  • Research Article

    Molecular Interaction Analysis of Phytochemicals as the Prospective Potential Multi-Target Inhibitors Related to Psoriasis and Other Autoimmune Disorders

    Biswajit Swain, Srinivas Maddi*

    Issue: Volume 10, Issue 1, April 2024
    Pages: 16-30
    Received: 2 January 2024
    Accepted: 20 January 2024
    Published: 1 February 2024
    Downloads:
    Views:
    Abstract: Psoriasis is an inflammatory skin disease in which the immune system's T cells are activated and trigger inflammation within the skin. Inflammatory markers, such as IL-23, IL-17, IL-6, TNF-α, NLRP-3, and 12R Lipoxygenase (12 R-Lox), play a crucial role in the inflammatory pathway. Anti-inflammatory drugs are used to modulate the immune response and... Show More
  • Research Article

    Identification of Potential Cytochrome p450c 17 Alpha Inhibitors for the Treatment of PCOS via Scaffold Hopping and Fragment-Based De-Novo Drug Design

    Comfort Azansuma Bandoma, Prince Yeboah, Kenneth Gyan, Shuraif Abdul Rafiu, Juliana Achiaa Adusei, Gideon Djan*

    Issue: Volume 10, Issue 1, April 2024
    Pages: 31-44
    Received: 28 November 2023
    Accepted: 12 December 2023
    Published: 5 February 2024
    Downloads:
    Views:
    Abstract: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting reproductive-aged women. It is characterized by hyperandrogenism, ovarian dysfunction, and metabolic abnormalities. Current treatment options have limitations and many women remain undiagnosed or untreated. Cytochrome P450c 17 alpha (CYP17A1) plays a key role in androgen bios... Show More