Diagnostic Approach to Soft Tissue Tumour of the Breast and Phyllodes Tumour in Ilorin, North Central with Review of Institutional Experience

Rasheed Mumini Wemimo; Afolayan Enoch Abiodun; Adegboye Adeyemi Taiwo

doi:doi:10.11648/j.wjmcr.20210203.11

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Diagnostic Approach to Soft Tissue Tumour of the Breast and Phyllodes Tumour in Ilorin, North Central with Review of Institutional Experience

Rasheed Mumini Wemimo, Afolayan Enoch Abiodun, Adegboye Adeyemi Taiwo

Published in World Journal of Medical Case Reports (Volume 2, Issue 3)

Received: 13 May 2021 Accepted: 7 June 2021 Published: 9 July 2021

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Abstract

Background: Primary soft tissue tumour (primary mesenchymal tumour) of the breast comprised of spectrum of neoplasm that arise from mammary stroma with comparable tumour biology of primary mesenchymal tumour at other sites. There are palpable diagnostic challenges which can be resolved by considering histomorphologic analysis that characterized each tumour entity regardless of the site and the use immunohistochemical markers. Methodology: This is an analytical hospital based retrospective study of patients with primary breast mesenchymal tumour and phyllodes diagnosed during 2014–2019 at the Department of Pathology, University of Ilorin Teaching Hospital. The histopathological diagnosis of primary mesenchymal tumour of the breast and phyllodes tumours with documented age and other inclusion criteria were used for the study but excluded patients with incomplete information. Result: This study analysed 39 patients with histological diagnosis of soft tissue tumour of the breast and phyllodes. The youngest patients was found to be 16 years of age while the oldest patients was 70 years with the mean age of 37.82±12.86. Benign phyllodes tumour accounted for 19 (48.7%), followed by borderline phyllodes 3 (7.7%) and 1 case of malignant phyllodes. Fibrosarcoma is the most common primary mesenchymal tumour of the breast which accounted for 6 (15.4%), followed by undifferentiated pleomorphic sarcoma 3 (7.7%) and 1 (2.5%) case of the following tumours, Neurofibroma, Granular cell tumour, Myofibroblastoma, Dermatofibroma, Low grade fibromyxoid sarcoma, Rhabdomyosarcoma and, Malignant phyllodes and Angiosarcoma. Conclusion: Primary mesenchymal tumour of the breast are rare or underdiagnosed, biopsy must be interpreted with caution in order to rule out their mimics that is phyllodes and metaplastic carcinoma with histomorphological analysis and complementary ancillary test.

Published in	World Journal of Medical Case Reports (Volume 2, Issue 3)
DOI	10.11648/j.wjmcr.20210203.11
Page(s)	29-34
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

PT (Phyllodes Tumour), UPS (Undifferentiated Pleomorphic Sarcoma), FA (Fibroadenoma), ER, (Oestrogen)

References

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APA Style

Rasheed Mumini Wemimo, Afolayan Enoch Abiodun, Adegboye Adeyemi Taiwo. (2021). Diagnostic Approach to Soft Tissue Tumour of the Breast and Phyllodes Tumour in Ilorin, North Central with Review of Institutional Experience. World Journal of Medical Case Reports, 2(3), 29-34. https://doi.org/10.11648/j.wjmcr.20210203.11

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ACS Style

Rasheed Mumini Wemimo; Afolayan Enoch Abiodun; Adegboye Adeyemi Taiwo. Diagnostic Approach to Soft Tissue Tumour of the Breast and Phyllodes Tumour in Ilorin, North Central with Review of Institutional Experience. World J. Med. Case Rep. 2021, 2(3), 29-34. doi: 10.11648/j.wjmcr.20210203.11

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AMA Style

Rasheed Mumini Wemimo, Afolayan Enoch Abiodun, Adegboye Adeyemi Taiwo. Diagnostic Approach to Soft Tissue Tumour of the Breast and Phyllodes Tumour in Ilorin, North Central with Review of Institutional Experience. World J Med Case Rep. 2021;2(3):29-34. doi: 10.11648/j.wjmcr.20210203.11

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@article{10.11648/j.wjmcr.20210203.11,
  author = {Rasheed Mumini Wemimo and Afolayan Enoch Abiodun and Adegboye Adeyemi Taiwo},
  title = {Diagnostic Approach to Soft Tissue Tumour of the Breast and Phyllodes Tumour in Ilorin, North Central with Review of Institutional Experience},
  journal = {World Journal of Medical Case Reports},
  volume = {2},
  number = {3},
  pages = {29-34},
  doi = {10.11648/j.wjmcr.20210203.11},
  url = {https://doi.org/10.11648/j.wjmcr.20210203.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjmcr.20210203.11},
  abstract = {Background: Primary soft tissue tumour (primary mesenchymal tumour) of the breast comprised of spectrum of neoplasm that arise from mammary stroma with comparable tumour biology of primary mesenchymal tumour at other sites. There are palpable diagnostic challenges which can be resolved by considering histomorphologic analysis that characterized each tumour entity regardless of the site and the use immunohistochemical markers. Methodology: This is an analytical hospital based retrospective study of patients with primary breast mesenchymal tumour and phyllodes diagnosed during 2014–2019 at the Department of Pathology, University of Ilorin Teaching Hospital. The histopathological diagnosis of primary mesenchymal tumour of the breast and phyllodes tumours with documented age and other inclusion criteria were used for the study but excluded patients with incomplete information. Result: This study analysed 39 patients with histological diagnosis of soft tissue tumour of the breast and phyllodes. The youngest patients was found to be 16 years of age while the oldest patients was 70 years with the mean age of 37.82±12.86. Benign phyllodes tumour accounted for 19 (48.7%), followed by borderline phyllodes 3 (7.7%) and 1 case of malignant phyllodes. Fibrosarcoma is the most common primary mesenchymal tumour of the breast which accounted for 6 (15.4%), followed by undifferentiated pleomorphic sarcoma 3 (7.7%) and 1 (2.5%) case of the following tumours, Neurofibroma, Granular cell tumour, Myofibroblastoma, Dermatofibroma, Low grade fibromyxoid sarcoma, Rhabdomyosarcoma and, Malignant phyllodes and Angiosarcoma. Conclusion: Primary mesenchymal tumour of the breast are rare or underdiagnosed, biopsy must be interpreted with caution in order to rule out their mimics that is phyllodes and metaplastic carcinoma with histomorphological analysis and complementary ancillary test.},
 year = {2021}
}

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TY  - JOUR
T1  - Diagnostic Approach to Soft Tissue Tumour of the Breast and Phyllodes Tumour in Ilorin, North Central with Review of Institutional Experience
AU  - Rasheed Mumini Wemimo
AU  - Afolayan Enoch Abiodun
AU  - Adegboye Adeyemi Taiwo
Y1  - 2021/07/09
PY  - 2021
N1  - https://doi.org/10.11648/j.wjmcr.20210203.11
DO  - 10.11648/j.wjmcr.20210203.11
T2  - World Journal of Medical Case Reports
JF  - World Journal of Medical Case Reports
JO  - World Journal of Medical Case Reports
SP  - 29
EP  - 34
PB  - Science Publishing Group
SN  - 2994-726X
UR  - https://doi.org/10.11648/j.wjmcr.20210203.11
AB  - Background: Primary soft tissue tumour (primary mesenchymal tumour) of the breast comprised of spectrum of neoplasm that arise from mammary stroma with comparable tumour biology of primary mesenchymal tumour at other sites. There are palpable diagnostic challenges which can be resolved by considering histomorphologic analysis that characterized each tumour entity regardless of the site and the use immunohistochemical markers. Methodology: This is an analytical hospital based retrospective study of patients with primary breast mesenchymal tumour and phyllodes diagnosed during 2014–2019 at the Department of Pathology, University of Ilorin Teaching Hospital. The histopathological diagnosis of primary mesenchymal tumour of the breast and phyllodes tumours with documented age and other inclusion criteria were used for the study but excluded patients with incomplete information. Result: This study analysed 39 patients with histological diagnosis of soft tissue tumour of the breast and phyllodes. The youngest patients was found to be 16 years of age while the oldest patients was 70 years with the mean age of 37.82±12.86. Benign phyllodes tumour accounted for 19 (48.7%), followed by borderline phyllodes 3 (7.7%) and 1 case of malignant phyllodes. Fibrosarcoma is the most common primary mesenchymal tumour of the breast which accounted for 6 (15.4%), followed by undifferentiated pleomorphic sarcoma 3 (7.7%) and 1 (2.5%) case of the following tumours, Neurofibroma, Granular cell tumour, Myofibroblastoma, Dermatofibroma, Low grade fibromyxoid sarcoma, Rhabdomyosarcoma and, Malignant phyllodes and Angiosarcoma. Conclusion: Primary mesenchymal tumour of the breast are rare or underdiagnosed, biopsy must be interpreted with caution in order to rule out their mimics that is phyllodes and metaplastic carcinoma with histomorphological analysis and complementary ancillary test.
VL  - 2
IS  - 3
ER  -

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Author Information

Rasheed Mumini Wemimo

Department of Pathology, University of Ilorin Teaching Hospital, Ilorin, Nigeria
Afolayan Enoch Abiodun

Department of Pathology, University of Ilorin Teaching Hospital, Ilorin, Nigeria
Adegboye Adeyemi Taiwo

Mojitaiwo Data Services and Data Management Executives, Ilorin, Nigeria

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APA Style

Rasheed Mumini Wemimo, Afolayan Enoch Abiodun, Adegboye Adeyemi Taiwo. (2021). Diagnostic Approach to Soft Tissue Tumour of the Breast and Phyllodes Tumour in Ilorin, North Central with Review of Institutional Experience. World Journal of Medical Case Reports, 2(3), 29-34. https://doi.org/10.11648/j.wjmcr.20210203.11

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ACS Style

Rasheed Mumini Wemimo; Afolayan Enoch Abiodun; Adegboye Adeyemi Taiwo. Diagnostic Approach to Soft Tissue Tumour of the Breast and Phyllodes Tumour in Ilorin, North Central with Review of Institutional Experience. World J. Med. Case Rep. 2021, 2(3), 29-34. doi: 10.11648/j.wjmcr.20210203.11

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AMA Style

Rasheed Mumini Wemimo, Afolayan Enoch Abiodun, Adegboye Adeyemi Taiwo. Diagnostic Approach to Soft Tissue Tumour of the Breast and Phyllodes Tumour in Ilorin, North Central with Review of Institutional Experience. World J Med Case Rep. 2021;2(3):29-34. doi: 10.11648/j.wjmcr.20210203.11

Copy | Download

@article{10.11648/j.wjmcr.20210203.11,
  author = {Rasheed Mumini Wemimo and Afolayan Enoch Abiodun and Adegboye Adeyemi Taiwo},
  title = {Diagnostic Approach to Soft Tissue Tumour of the Breast and Phyllodes Tumour in Ilorin, North Central with Review of Institutional Experience},
  journal = {World Journal of Medical Case Reports},
  volume = {2},
  number = {3},
  pages = {29-34},
  doi = {10.11648/j.wjmcr.20210203.11},
  url = {https://doi.org/10.11648/j.wjmcr.20210203.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjmcr.20210203.11},
  abstract = {Background: Primary soft tissue tumour (primary mesenchymal tumour) of the breast comprised of spectrum of neoplasm that arise from mammary stroma with comparable tumour biology of primary mesenchymal tumour at other sites. There are palpable diagnostic challenges which can be resolved by considering histomorphologic analysis that characterized each tumour entity regardless of the site and the use immunohistochemical markers. Methodology: This is an analytical hospital based retrospective study of patients with primary breast mesenchymal tumour and phyllodes diagnosed during 2014–2019 at the Department of Pathology, University of Ilorin Teaching Hospital. The histopathological diagnosis of primary mesenchymal tumour of the breast and phyllodes tumours with documented age and other inclusion criteria were used for the study but excluded patients with incomplete information. Result: This study analysed 39 patients with histological diagnosis of soft tissue tumour of the breast and phyllodes. The youngest patients was found to be 16 years of age while the oldest patients was 70 years with the mean age of 37.82±12.86. Benign phyllodes tumour accounted for 19 (48.7%), followed by borderline phyllodes 3 (7.7%) and 1 case of malignant phyllodes. Fibrosarcoma is the most common primary mesenchymal tumour of the breast which accounted for 6 (15.4%), followed by undifferentiated pleomorphic sarcoma 3 (7.7%) and 1 (2.5%) case of the following tumours, Neurofibroma, Granular cell tumour, Myofibroblastoma, Dermatofibroma, Low grade fibromyxoid sarcoma, Rhabdomyosarcoma and, Malignant phyllodes and Angiosarcoma. Conclusion: Primary mesenchymal tumour of the breast are rare or underdiagnosed, biopsy must be interpreted with caution in order to rule out their mimics that is phyllodes and metaplastic carcinoma with histomorphological analysis and complementary ancillary test.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Diagnostic Approach to Soft Tissue Tumour of the Breast and Phyllodes Tumour in Ilorin, North Central with Review of Institutional Experience
AU  - Rasheed Mumini Wemimo
AU  - Afolayan Enoch Abiodun
AU  - Adegboye Adeyemi Taiwo
Y1  - 2021/07/09
PY  - 2021
N1  - https://doi.org/10.11648/j.wjmcr.20210203.11
DO  - 10.11648/j.wjmcr.20210203.11
T2  - World Journal of Medical Case Reports
JF  - World Journal of Medical Case Reports
JO  - World Journal of Medical Case Reports
SP  - 29
EP  - 34
PB  - Science Publishing Group
SN  - 2994-726X
UR  - https://doi.org/10.11648/j.wjmcr.20210203.11
AB  - Background: Primary soft tissue tumour (primary mesenchymal tumour) of the breast comprised of spectrum of neoplasm that arise from mammary stroma with comparable tumour biology of primary mesenchymal tumour at other sites. There are palpable diagnostic challenges which can be resolved by considering histomorphologic analysis that characterized each tumour entity regardless of the site and the use immunohistochemical markers. Methodology: This is an analytical hospital based retrospective study of patients with primary breast mesenchymal tumour and phyllodes diagnosed during 2014–2019 at the Department of Pathology, University of Ilorin Teaching Hospital. The histopathological diagnosis of primary mesenchymal tumour of the breast and phyllodes tumours with documented age and other inclusion criteria were used for the study but excluded patients with incomplete information. Result: This study analysed 39 patients with histological diagnosis of soft tissue tumour of the breast and phyllodes. The youngest patients was found to be 16 years of age while the oldest patients was 70 years with the mean age of 37.82±12.86. Benign phyllodes tumour accounted for 19 (48.7%), followed by borderline phyllodes 3 (7.7%) and 1 case of malignant phyllodes. Fibrosarcoma is the most common primary mesenchymal tumour of the breast which accounted for 6 (15.4%), followed by undifferentiated pleomorphic sarcoma 3 (7.7%) and 1 (2.5%) case of the following tumours, Neurofibroma, Granular cell tumour, Myofibroblastoma, Dermatofibroma, Low grade fibromyxoid sarcoma, Rhabdomyosarcoma and, Malignant phyllodes and Angiosarcoma. Conclusion: Primary mesenchymal tumour of the breast are rare or underdiagnosed, biopsy must be interpreted with caution in order to rule out their mimics that is phyllodes and metaplastic carcinoma with histomorphological analysis and complementary ancillary test.
VL  - 2
IS  - 3
ER  -

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