Background: Hypertension is a cardiovascular disease with high incidence. Syndrome of qi stagnation and blood stasis is a common symptom of traditional Chinese medicine in hypertension, manifested as dizziness, palpitation, chest tightness and so on. Buyang Huanwu Tang has the effect of activating blood circulation and regulating collaterals, removing blood stasis and regulating qi, which is widely used in clinical treatment of hypertension. Compared with Western medicine, Chinese medicine has different antihypertensive targets in the treatment of diseases, which can play a better antihypertensive effect. Purpose: To explore the molecular mechanism of buyang huanwu tang in the treatment of hypertension based on network pharmacology. Methods: the active components of buyang huanwu decoction were screened by TCMSP database. Prediction of relevant targets by Drugbank, GeneCards and OMIM databases; The PPI network control chart was constructed by using Cytoscape3.6.0 software. Enrichment analysis of GO and KEGG was carried out through DAVID database, and mapping was carried out by using Cytoscape. Results: a total of 97 active components, 34 disease targets and 59 pathways were screened. Conclusion: buyang huanwu decoction has the characteristics of multi-component, multi-target and multi-pathway in the treatment of hypertension. This study provides an idea for further research on the effect and mechanism of buyang huanwu decoction in the treatment of hypertension.
| Published in | Science Discovery (Volume 11, Issue 2) |
| DOI | 10.11648/j.sd.20231102.12 |
| Page(s) | 35-40 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2023. Published by Science Publishing Group |
Network Pharmacology, Buyang Huanwu Tang, Hypertension, Mechanism of Action
| [1] | Yang Qing, Yu Xiao-Jing, Su Qing, et al. Blockade of c-Src Within the Paraventricular Nucleus Attenuates Inflammatory Cytokines and Oxidative Stress in the Mechanism of the TLR4 Signal Pathway in Salt-Induced Hypertension [J]. Neuroscience bulletin, 2020, 36 (04): 385-395. |
| [2] | 刘莹, 韩雪梅. 从气虚血瘀论治高血压的疗效分析 [J]. 中国医药指南, 2019, 17 (27): 218-219. |
| [3] | Kim SK, Lee S, Lee MK, etal. A systems pharmacology approach to investigate the mechanism of Oryeong-san formula for the treatment of hypertension [J]. Journal of ethnopharmacology, 2019, 244: 112-129. |
| [4] | 何郁鹏, 文志梅. 补阳还五汤对H型高血压合并急性脑梗死患者同型半胱氨酸、血液流变学及神经功能的影响 [J]. 广州中医药大学学报, 2020, 37 (01): 25-30. |
| [5] | 庾剑鸿. 补阳还五汤对高血压患者血压控制达标率的影响 [J]. 中国现代药物应用, 2019, 13 (09): 135-136. |
| [6] | 林茂晖, 郑霖飞, 刘水源. 高血压脑出血保守治疗早期应用补阳还五汤的效果观察 [J]. 中外医学研究, 2020, 18 (11): 1-3. |
| [7] | 曲怡, 勇入琳, 李阳等. 补阳还五汤对高血压前期大鼠血管炎症保护机制研究[J]. 中华中医药学刊, 2017, 35 (02): 290-292. |
| [8] | 杨州帆, 吴鹏波, 刘其林, 等. CCND1 G/A位点基因多态性与肝细胞癌发生风险相关性的Meta分析[J]. 实用癌症杂志, 2020, 35 (01): 16-19+27. |
| [9] | Ngo KA, Kishimoto K, Davis-Turak J, et al. Dissecting the Regulatory Strategies of NF-κB RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics [J]. Cell Reports, 2020, 30 (8): 2758-2775. |
| [10] | Beilin Zhang, Ying Zhang, Fang Deng, et al. Ligustrazine prevents basilar artery remodeling in two-kidney-two-clip renovascular hypertension rats via suppressing PI3K/Akt signaling [J]. Microvascular Research, 2020, 128: 103938. |
| [11] | 冉希, 张天阳, 秦红霞等. 补阳还五汤对气虚血瘀型高血压脑出血恢复期患者血清PI3K/AKT信号通路的影响 [J]. 世界中医药, 2019, 14 (08): 2053-2057. |
| [12] | 曲怡, 刘路, 勇入琳等. 补阳还五汤对高血压模型大鼠肾脏组织RAS系统平衡作用机制研究 [J]. 中华中医药学刊, 2019, 37 (07): 1729-1733. |
| [13] | 崔赛, 商丽华. 冠状动脉粥样硬化性心脏病和甲状腺功能减低的综述 [J]. 系统医学, 2019, 4 (22): 196-198. |
| [14] | 王怀. 基于MCP-1/CCR2信号通路研究清达颗粒对自发性高血压大鼠心脏炎症的影响及作用机制 [D]. 福州:福建中医药大学, 2019. |
| [15] | 童晓云, 周敏, 余茂强等. 石决牡蛎汤通过p38MAPK通路改善自发性高血压大鼠血管重构的机制研究 [J]. 广州中医药大学学报, 2016, 33 (6): 846-851. |
APA Style
Xiaoqin Hu, Zhao Wei, Meng Dan, Tao Xin, Fu Rong, et al. (2023). To Explore the Mechanism of Buyang Huanwu Tang in the Treatment of Hypertension Based on Network Pharmacology. Science Discovery, 11(2), 35-40. https://doi.org/10.11648/j.sd.20231102.12
ACS Style
Xiaoqin Hu; Zhao Wei; Meng Dan; Tao Xin; Fu Rong, et al. To Explore the Mechanism of Buyang Huanwu Tang in the Treatment of Hypertension Based on Network Pharmacology. Sci. Discov. 2023, 11(2), 35-40. doi: 10.11648/j.sd.20231102.12
AMA Style
Xiaoqin Hu, Zhao Wei, Meng Dan, Tao Xin, Fu Rong, et al. To Explore the Mechanism of Buyang Huanwu Tang in the Treatment of Hypertension Based on Network Pharmacology. Sci Discov. 2023;11(2):35-40. doi: 10.11648/j.sd.20231102.12
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Download@article{10.11648/j.sd.20231102.12,
author = {Xiaoqin Hu and Zhao Wei and Meng Dan and Tao Xin and Fu Rong and Xuexia Zeng and Meilin Tao and Xuewen Zeng},
title = {To Explore the Mechanism of Buyang Huanwu Tang in the Treatment of Hypertension Based on Network Pharmacology},
journal = {Science Discovery},
volume = {11},
number = {2},
pages = {35-40},
doi = {10.11648/j.sd.20231102.12},
url = {https://doi.org/10.11648/j.sd.20231102.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20231102.12},
abstract = {Background: Hypertension is a cardiovascular disease with high incidence. Syndrome of qi stagnation and blood stasis is a common symptom of traditional Chinese medicine in hypertension, manifested as dizziness, palpitation, chest tightness and so on. Buyang Huanwu Tang has the effect of activating blood circulation and regulating collaterals, removing blood stasis and regulating qi, which is widely used in clinical treatment of hypertension. Compared with Western medicine, Chinese medicine has different antihypertensive targets in the treatment of diseases, which can play a better antihypertensive effect. Purpose: To explore the molecular mechanism of buyang huanwu tang in the treatment of hypertension based on network pharmacology. Methods: the active components of buyang huanwu decoction were screened by TCMSP database. Prediction of relevant targets by Drugbank, GeneCards and OMIM databases; The PPI network control chart was constructed by using Cytoscape3.6.0 software. Enrichment analysis of GO and KEGG was carried out through DAVID database, and mapping was carried out by using Cytoscape. Results: a total of 97 active components, 34 disease targets and 59 pathways were screened. Conclusion: buyang huanwu decoction has the characteristics of multi-component, multi-target and multi-pathway in the treatment of hypertension. This study provides an idea for further research on the effect and mechanism of buyang huanwu decoction in the treatment of hypertension.},
year = {2023}
}
TY - JOUR T1 - To Explore the Mechanism of Buyang Huanwu Tang in the Treatment of Hypertension Based on Network Pharmacology AU - Xiaoqin Hu AU - Zhao Wei AU - Meng Dan AU - Tao Xin AU - Fu Rong AU - Xuexia Zeng AU - Meilin Tao AU - Xuewen Zeng Y1 - 2023/03/31 PY - 2023 N1 - https://doi.org/10.11648/j.sd.20231102.12 DO - 10.11648/j.sd.20231102.12 T2 - Science Discovery JF - Science Discovery JO - Science Discovery SP - 35 EP - 40 PB - Science Publishing Group SN - 2331-0650 UR - https://doi.org/10.11648/j.sd.20231102.12 AB - Background: Hypertension is a cardiovascular disease with high incidence. Syndrome of qi stagnation and blood stasis is a common symptom of traditional Chinese medicine in hypertension, manifested as dizziness, palpitation, chest tightness and so on. Buyang Huanwu Tang has the effect of activating blood circulation and regulating collaterals, removing blood stasis and regulating qi, which is widely used in clinical treatment of hypertension. Compared with Western medicine, Chinese medicine has different antihypertensive targets in the treatment of diseases, which can play a better antihypertensive effect. Purpose: To explore the molecular mechanism of buyang huanwu tang in the treatment of hypertension based on network pharmacology. Methods: the active components of buyang huanwu decoction were screened by TCMSP database. Prediction of relevant targets by Drugbank, GeneCards and OMIM databases; The PPI network control chart was constructed by using Cytoscape3.6.0 software. Enrichment analysis of GO and KEGG was carried out through DAVID database, and mapping was carried out by using Cytoscape. Results: a total of 97 active components, 34 disease targets and 59 pathways were screened. Conclusion: buyang huanwu decoction has the characteristics of multi-component, multi-target and multi-pathway in the treatment of hypertension. This study provides an idea for further research on the effect and mechanism of buyang huanwu decoction in the treatment of hypertension. VL - 11 IS - 2 ER -
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