Effects of Aged Garlic Extract on Rat’s Blood Cells Parameters After Whole-Body Exposure to Ionizing Radiation

Kouam Foubi Brice Bertrand; Chuisseu Djamen Dieudonné Pascal; Dzeufiet Djomeni Paul Désiré; Samba Ngano Odette; Mopia Myriam; Mouelle Sone; Tiedeu Alain Bertin; Gonsu Fotsin Joseph

doi:doi:10.11648/j.rst.20160202.14

Effects of Aged Garlic Extract on Rat’s Blood Cells Parameters After Whole-Body Exposure to Ionizing Radiation

Kouam Foubi Brice Bertrand, Chuisseu Djamen Dieudonné Pascal, Dzeufiet Djomeni Paul Désiré, Samba Ngano Odette, Mopia Myriam, Mouelle Sone, Tiedeu Alain Bertin, Gonsu Fotsin Joseph

Published in Radiation Science and Technology (Volume 2, Issue 2)

Received: 19 October 2016 Accepted: 8 November 2016 Published: 8 January 2017

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Abstract

Exposure to high amounts of ionizing radiation results in damage to the hematopoietic system characterized by the destruction of hematopoietic cells in bone marrow, thus reducing the production of blood cells. Infections and bleeding that result can be fatal. Aged garlic extract (AGE) has been demonstrated to possess several physiological activities in experimental animals thus, the present study aimed to evaluate the effect of AGE on the hematopoietic syndrome post whole-body exposure to ionizing radiations. Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E + Alpha Lipoïc Acid. Blood samples were collected the 8^th day post irradiation to investigate blood picture. Exposure of rats to gamma radiation caused a significant disturbance in the level of white blood cells count (WBCS), Lymphocytes (LY), mid-size population of monocytes, basophils, eosinophils, blasts, and other immature cells (MID),Granulocytes (GR), red blood cells count (RBCs), hemoglobin content (Hb), Mean Corpuscular Volume (MCV), hematocrit value (HTC), Mean corpuscular hemoglobin (MCH), Mean corpuscular hemoglobin concentration (MCHC) and platelets count (PLT). In rats exposed to radiation then treated with AGE, the results showed an improvement in all previous parameters. The results of the present investigation showed that AGE intake confers radiation protection to rat’s blood cells parameters after whole-body exposure to ionizing radiation.

Published in	Radiation Science and Technology (Volume 2, Issue 2)
DOI	10.11648/j.rst.20160202.14
Page(s)	30-35
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Irradiation, Ionizing Radiation, Oxidative Stress, AGE, Blood, Rats

References

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Kouam Foubi Brice Bertrand, Chuisseu Djamen Dieudonné Pascal, Dzeufiet Djomeni Paul Désiré, Samba Ngano Odette, Mopia Myriam, et al. (2017). Effects of Aged Garlic Extract on Rat’s Blood Cells Parameters After Whole-Body Exposure to Ionizing Radiation. Radiation Science and Technology, 2(2), 30-35. https://doi.org/10.11648/j.rst.20160202.14

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ACS Style

Kouam Foubi Brice Bertrand; Chuisseu Djamen Dieudonné Pascal; Dzeufiet Djomeni Paul Désiré; Samba Ngano Odette; Mopia Myriam, et al. Effects of Aged Garlic Extract on Rat’s Blood Cells Parameters After Whole-Body Exposure to Ionizing Radiation. Radiat. Sci. Technol. 2017, 2(2), 30-35. doi: 10.11648/j.rst.20160202.14

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AMA Style

Kouam Foubi Brice Bertrand, Chuisseu Djamen Dieudonné Pascal, Dzeufiet Djomeni Paul Désiré, Samba Ngano Odette, Mopia Myriam, et al. Effects of Aged Garlic Extract on Rat’s Blood Cells Parameters After Whole-Body Exposure to Ionizing Radiation. Radiat Sci Technol. 2017;2(2):30-35. doi: 10.11648/j.rst.20160202.14

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@article{10.11648/j.rst.20160202.14,
  author = {Kouam Foubi Brice Bertrand and Chuisseu Djamen Dieudonné Pascal and Dzeufiet Djomeni Paul Désiré and Samba Ngano Odette and Mopia Myriam and Mouelle Sone and Tiedeu Alain Bertin and Gonsu Fotsin Joseph},
  title = {Effects of Aged Garlic Extract on Rat’s Blood Cells Parameters After Whole-Body Exposure to Ionizing Radiation},
  journal = {Radiation Science and Technology},
  volume = {2},
  number = {2},
  pages = {30-35},
  doi = {10.11648/j.rst.20160202.14},
  url = {https://doi.org/10.11648/j.rst.20160202.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.rst.20160202.14},
  abstract = {Exposure to high amounts of ionizing radiation results in damage to the hematopoietic system characterized by the destruction of hematopoietic cells in bone marrow, thus reducing the production of blood cells. Infections and bleeding that result can be fatal. Aged garlic extract (AGE) has been demonstrated to possess several physiological activities in experimental animals thus, the present study aimed to evaluate the effect of AGE on the hematopoietic syndrome post whole-body exposure to ionizing radiations. Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E + Alpha Lipoïc Acid. Blood samples were collected the 8th day post irradiation to investigate blood picture. Exposure of rats to gamma radiation caused a significant disturbance in the level of white blood cells count (WBCS), Lymphocytes (LY), mid-size population of monocytes, basophils, eosinophils, blasts, and other immature cells (MID),Granulocytes (GR), red blood cells count (RBCs), hemoglobin content (Hb), Mean Corpuscular Volume (MCV), hematocrit value (HTC), Mean corpuscular hemoglobin (MCH), Mean corpuscular hemoglobin concentration (MCHC) and platelets count (PLT). In rats exposed to radiation then treated with AGE, the results showed an improvement in all previous parameters. The results of the present investigation showed that AGE intake confers radiation protection to rat’s blood cells parameters after whole-body exposure to ionizing radiation.},
 year = {2017}
}

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TY  - JOUR
T1  - Effects of Aged Garlic Extract on Rat’s Blood Cells Parameters After Whole-Body Exposure to Ionizing Radiation
AU  - Kouam Foubi Brice Bertrand
AU  - Chuisseu Djamen Dieudonné Pascal
AU  - Dzeufiet Djomeni Paul Désiré
AU  - Samba Ngano Odette
AU  - Mopia Myriam
AU  - Mouelle Sone
AU  - Tiedeu Alain Bertin
AU  - Gonsu Fotsin Joseph
Y1  - 2017/01/08
PY  - 2017
N1  - https://doi.org/10.11648/j.rst.20160202.14
DO  - 10.11648/j.rst.20160202.14
T2  - Radiation Science and Technology
JF  - Radiation Science and Technology
JO  - Radiation Science and Technology
SP  - 30
EP  - 35
PB  - Science Publishing Group
SN  - 2575-5943
UR  - https://doi.org/10.11648/j.rst.20160202.14
AB  - Exposure to high amounts of ionizing radiation results in damage to the hematopoietic system characterized by the destruction of hematopoietic cells in bone marrow, thus reducing the production of blood cells. Infections and bleeding that result can be fatal. Aged garlic extract (AGE) has been demonstrated to possess several physiological activities in experimental animals thus, the present study aimed to evaluate the effect of AGE on the hematopoietic syndrome post whole-body exposure to ionizing radiations. Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E + Alpha Lipoïc Acid. Blood samples were collected the 8th day post irradiation to investigate blood picture. Exposure of rats to gamma radiation caused a significant disturbance in the level of white blood cells count (WBCS), Lymphocytes (LY), mid-size population of monocytes, basophils, eosinophils, blasts, and other immature cells (MID),Granulocytes (GR), red blood cells count (RBCs), hemoglobin content (Hb), Mean Corpuscular Volume (MCV), hematocrit value (HTC), Mean corpuscular hemoglobin (MCH), Mean corpuscular hemoglobin concentration (MCHC) and platelets count (PLT). In rats exposed to radiation then treated with AGE, the results showed an improvement in all previous parameters. The results of the present investigation showed that AGE intake confers radiation protection to rat’s blood cells parameters after whole-body exposure to ionizing radiation.
VL  - 2
IS  - 2
ER  -

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Author Information

Kouam Foubi Brice Bertrand

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Chuisseu Djamen Dieudonné Pascal

Faculty of Health Sciences, Université des Montagnes, Bangangté, Bangangté, Cameroon
Dzeufiet Djomeni Paul Désiré

Faculty of Sciences, University of Yaoundé I, Yaoundé, Cameroon
Samba Ngano Odette

Faculty of Sciences, University of Dschang, Dschang, Cameroon
Mopia Myriam

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Mouelle Sone

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Tiedeu Alain Bertin

National Advanced School of Engineering, University of Yaoundé I, Yaoundé, Cameroon
Gonsu Fotsin Joseph

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon

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APA Style

Kouam Foubi Brice Bertrand, Chuisseu Djamen Dieudonné Pascal, Dzeufiet Djomeni Paul Désiré, Samba Ngano Odette, Mopia Myriam, et al. (2017). Effects of Aged Garlic Extract on Rat’s Blood Cells Parameters After Whole-Body Exposure to Ionizing Radiation. Radiation Science and Technology, 2(2), 30-35. https://doi.org/10.11648/j.rst.20160202.14

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ACS Style

Kouam Foubi Brice Bertrand; Chuisseu Djamen Dieudonné Pascal; Dzeufiet Djomeni Paul Désiré; Samba Ngano Odette; Mopia Myriam, et al. Effects of Aged Garlic Extract on Rat’s Blood Cells Parameters After Whole-Body Exposure to Ionizing Radiation. Radiat. Sci. Technol. 2017, 2(2), 30-35. doi: 10.11648/j.rst.20160202.14

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AMA Style

Kouam Foubi Brice Bertrand, Chuisseu Djamen Dieudonné Pascal, Dzeufiet Djomeni Paul Désiré, Samba Ngano Odette, Mopia Myriam, et al. Effects of Aged Garlic Extract on Rat’s Blood Cells Parameters After Whole-Body Exposure to Ionizing Radiation. Radiat Sci Technol. 2017;2(2):30-35. doi: 10.11648/j.rst.20160202.14

Copy | Download

@article{10.11648/j.rst.20160202.14,
  author = {Kouam Foubi Brice Bertrand and Chuisseu Djamen Dieudonné Pascal and Dzeufiet Djomeni Paul Désiré and Samba Ngano Odette and Mopia Myriam and Mouelle Sone and Tiedeu Alain Bertin and Gonsu Fotsin Joseph},
  title = {Effects of Aged Garlic Extract on Rat’s Blood Cells Parameters After Whole-Body Exposure to Ionizing Radiation},
  journal = {Radiation Science and Technology},
  volume = {2},
  number = {2},
  pages = {30-35},
  doi = {10.11648/j.rst.20160202.14},
  url = {https://doi.org/10.11648/j.rst.20160202.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.rst.20160202.14},
  abstract = {Exposure to high amounts of ionizing radiation results in damage to the hematopoietic system characterized by the destruction of hematopoietic cells in bone marrow, thus reducing the production of blood cells. Infections and bleeding that result can be fatal. Aged garlic extract (AGE) has been demonstrated to possess several physiological activities in experimental animals thus, the present study aimed to evaluate the effect of AGE on the hematopoietic syndrome post whole-body exposure to ionizing radiations. Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E + Alpha Lipoïc Acid. Blood samples were collected the 8th day post irradiation to investigate blood picture. Exposure of rats to gamma radiation caused a significant disturbance in the level of white blood cells count (WBCS), Lymphocytes (LY), mid-size population of monocytes, basophils, eosinophils, blasts, and other immature cells (MID),Granulocytes (GR), red blood cells count (RBCs), hemoglobin content (Hb), Mean Corpuscular Volume (MCV), hematocrit value (HTC), Mean corpuscular hemoglobin (MCH), Mean corpuscular hemoglobin concentration (MCHC) and platelets count (PLT). In rats exposed to radiation then treated with AGE, the results showed an improvement in all previous parameters. The results of the present investigation showed that AGE intake confers radiation protection to rat’s blood cells parameters after whole-body exposure to ionizing radiation.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Effects of Aged Garlic Extract on Rat’s Blood Cells Parameters After Whole-Body Exposure to Ionizing Radiation
AU  - Kouam Foubi Brice Bertrand
AU  - Chuisseu Djamen Dieudonné Pascal
AU  - Dzeufiet Djomeni Paul Désiré
AU  - Samba Ngano Odette
AU  - Mopia Myriam
AU  - Mouelle Sone
AU  - Tiedeu Alain Bertin
AU  - Gonsu Fotsin Joseph
Y1  - 2017/01/08
PY  - 2017
N1  - https://doi.org/10.11648/j.rst.20160202.14
DO  - 10.11648/j.rst.20160202.14
T2  - Radiation Science and Technology
JF  - Radiation Science and Technology
JO  - Radiation Science and Technology
SP  - 30
EP  - 35
PB  - Science Publishing Group
SN  - 2575-5943
UR  - https://doi.org/10.11648/j.rst.20160202.14
AB  - Exposure to high amounts of ionizing radiation results in damage to the hematopoietic system characterized by the destruction of hematopoietic cells in bone marrow, thus reducing the production of blood cells. Infections and bleeding that result can be fatal. Aged garlic extract (AGE) has been demonstrated to possess several physiological activities in experimental animals thus, the present study aimed to evaluate the effect of AGE on the hematopoietic syndrome post whole-body exposure to ionizing radiations. Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E + Alpha Lipoïc Acid. Blood samples were collected the 8th day post irradiation to investigate blood picture. Exposure of rats to gamma radiation caused a significant disturbance in the level of white blood cells count (WBCS), Lymphocytes (LY), mid-size population of monocytes, basophils, eosinophils, blasts, and other immature cells (MID),Granulocytes (GR), red blood cells count (RBCs), hemoglobin content (Hb), Mean Corpuscular Volume (MCV), hematocrit value (HTC), Mean corpuscular hemoglobin (MCH), Mean corpuscular hemoglobin concentration (MCHC) and platelets count (PLT). In rats exposed to radiation then treated with AGE, the results showed an improvement in all previous parameters. The results of the present investigation showed that AGE intake confers radiation protection to rat’s blood cells parameters after whole-body exposure to ionizing radiation.
VL  - 2
IS  - 2
ER  -

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