Traditional herbal medicines make up a large part of drug use. This work addressed an area of public health, the fight against diabetes. The present study aimed to carry out qualitative and quantitative screening of the secondary metabolites of extracts from the leaves and flowers of plants such as Catharanthus roseus, Lippia multiflora and Phyllanthus amarus, and to evaluate the antioxidant activity in their aqueous and ethanolic extracts, their larval toxicity and then to predict the antidiabetic activity. The results showed that its plants have in their various extracts some secondary metabolites such as alkaloids, tannins, flavonoids, coumarins, terpenoids, phenolic compounds, steroids, etc responsible for several interesting pharmaceutical activities. These medicinal plants showed a higher quantity of polyphenols in the hydro-ethanolic extracts, with levels of 60.65±0.13; 44.40±1.43 and 67.11±0.39 mg.eq/g respectively for C. roseus, L. multiflora and P. amarus and also a higher antioxidant potential for L. multiflora and P. amarus than the standard Vitamin C, with IC50 equal to 0.53 and 0.52 mg/mL respectively. Extracts are not toxic against larvae. These results are an important indicator of the hypoglycemic and anti-diabetic activity and confirmed the potential for use of these plants by the population in the fight against diabetes.
| Published in | International Journal of Pharmacy and Chemistry (Volume 9, Issue 5) |
| DOI | 10.11648/j.ijpc.20230905.11 |
| Page(s) | 56-66 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2023. Published by Science Publishing Group |
Phytochemical Analysis, Anti-Diabetic, Antioxidant Potential, Hydro-Ethanolic Extracts
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APA Style
Simplice Koudjina, Alban Gouton Houngbeme, Israël Dossou Paulin Agbogba, Guy Yacolé Sylvain Atohoun, Joachim Djimon Gbenou. (2023). Phytochemical Analysis and Bioactivities Studies of Fresh Leaves and Flowers from C. roseus, L. multiflora and P. amarus, Beninese Medicinal Plants Used Against Diabetes. International Journal of Pharmacy and Chemistry, 9(5), 56-66. https://doi.org/10.11648/j.ijpc.20230905.11
ACS Style
Simplice Koudjina; Alban Gouton Houngbeme; Israël Dossou Paulin Agbogba; Guy Yacolé Sylvain Atohoun; Joachim Djimon Gbenou. Phytochemical Analysis and Bioactivities Studies of Fresh Leaves and Flowers from C. roseus, L. multiflora and P. amarus, Beninese Medicinal Plants Used Against Diabetes. Int. J. Pharm. Chem. 2023, 9(5), 56-66. doi: 10.11648/j.ijpc.20230905.11
AMA Style
Simplice Koudjina, Alban Gouton Houngbeme, Israël Dossou Paulin Agbogba, Guy Yacolé Sylvain Atohoun, Joachim Djimon Gbenou. Phytochemical Analysis and Bioactivities Studies of Fresh Leaves and Flowers from C. roseus, L. multiflora and P. amarus, Beninese Medicinal Plants Used Against Diabetes. Int J Pharm Chem. 2023;9(5):56-66. doi: 10.11648/j.ijpc.20230905.11
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Download@article{10.11648/j.ijpc.20230905.11,
author = {Simplice Koudjina and Alban Gouton Houngbeme and Israël Dossou Paulin Agbogba and Guy Yacolé Sylvain Atohoun and Joachim Djimon Gbenou},
title = {Phytochemical Analysis and Bioactivities Studies of Fresh Leaves and Flowers from C. roseus, L. multiflora and P. amarus, Beninese Medicinal Plants Used Against Diabetes},
journal = {International Journal of Pharmacy and Chemistry},
volume = {9},
number = {5},
pages = {56-66},
doi = {10.11648/j.ijpc.20230905.11},
url = {https://doi.org/10.11648/j.ijpc.20230905.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20230905.11},
abstract = {Traditional herbal medicines make up a large part of drug use. This work addressed an area of public health, the fight against diabetes. The present study aimed to carry out qualitative and quantitative screening of the secondary metabolites of extracts from the leaves and flowers of plants such as Catharanthus roseus, Lippia multiflora and Phyllanthus amarus, and to evaluate the antioxidant activity in their aqueous and ethanolic extracts, their larval toxicity and then to predict the antidiabetic activity. The results showed that its plants have in their various extracts some secondary metabolites such as alkaloids, tannins, flavonoids, coumarins, terpenoids, phenolic compounds, steroids, etc responsible for several interesting pharmaceutical activities. These medicinal plants showed a higher quantity of polyphenols in the hydro-ethanolic extracts, with levels of 60.65±0.13; 44.40±1.43 and 67.11±0.39 mg.eq/g respectively for C. roseus, L. multiflora and P. amarus and also a higher antioxidant potential for L. multiflora and P. amarus than the standard Vitamin C, with IC50 equal to 0.53 and 0.52 mg/mL respectively. Extracts are not toxic against larvae. These results are an important indicator of the hypoglycemic and anti-diabetic activity and confirmed the potential for use of these plants by the population in the fight against diabetes.},
year = {2023}
}
TY - JOUR T1 - Phytochemical Analysis and Bioactivities Studies of Fresh Leaves and Flowers from C. roseus, L. multiflora and P. amarus, Beninese Medicinal Plants Used Against Diabetes AU - Simplice Koudjina AU - Alban Gouton Houngbeme AU - Israël Dossou Paulin Agbogba AU - Guy Yacolé Sylvain Atohoun AU - Joachim Djimon Gbenou Y1 - 2023/10/08 PY - 2023 N1 - https://doi.org/10.11648/j.ijpc.20230905.11 DO - 10.11648/j.ijpc.20230905.11 T2 - International Journal of Pharmacy and Chemistry JF - International Journal of Pharmacy and Chemistry JO - International Journal of Pharmacy and Chemistry SP - 56 EP - 66 PB - Science Publishing Group SN - 2575-5749 UR - https://doi.org/10.11648/j.ijpc.20230905.11 AB - Traditional herbal medicines make up a large part of drug use. This work addressed an area of public health, the fight against diabetes. The present study aimed to carry out qualitative and quantitative screening of the secondary metabolites of extracts from the leaves and flowers of plants such as Catharanthus roseus, Lippia multiflora and Phyllanthus amarus, and to evaluate the antioxidant activity in their aqueous and ethanolic extracts, their larval toxicity and then to predict the antidiabetic activity. The results showed that its plants have in their various extracts some secondary metabolites such as alkaloids, tannins, flavonoids, coumarins, terpenoids, phenolic compounds, steroids, etc responsible for several interesting pharmaceutical activities. These medicinal plants showed a higher quantity of polyphenols in the hydro-ethanolic extracts, with levels of 60.65±0.13; 44.40±1.43 and 67.11±0.39 mg.eq/g respectively for C. roseus, L. multiflora and P. amarus and also a higher antioxidant potential for L. multiflora and P. amarus than the standard Vitamin C, with IC50 equal to 0.53 and 0.52 mg/mL respectively. Extracts are not toxic against larvae. These results are an important indicator of the hypoglycemic and anti-diabetic activity and confirmed the potential for use of these plants by the population in the fight against diabetes. VL - 9 IS - 5 ER -
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