Aim: To investigate the effects of co-ingestion of amino acids with fat on postchallenge glycemia and lipidemia. Methods: Nine healthy young Japanese women were enrolled. At each session, the subjects ingested one of three beverages containing fat cream (OFTT™ cream, 1 g/kg body weight, 0.35 g/kg as fat) and/or amino acid mixture (Amizet B™, 600 mg/kg body weight, 60 mg/kg as amino acids) in a randomized crossover design. The three beverages were as follows: fat cream (F trial), amino acid mixture (A trial), or both (FA trial). Venous blood samples were obtained before (0) and 0.5, 1, 2, and 3 h in the A trial, and at 0, 0.5, 1, 2, 4, and 6 h after ingestion in the F and FA trials. Results: Fat ingestion increased the secretion of incretins (GIP and GLP-1), but only a weak effect on insulin secretion was observed. Amino acids ingestion had only a weak effect on the secretion of incretins, but synergistically stimulated the insulin secretion induced by fat ingestion. Glucagon showed behavior similar to that of insulin. There were no significant effects of the co-ingestion of amino acids on lipid or lipoprotein metabolism compared to the ingestion of fat alone. All of these phenomena were observed without a change in blood glucose levels. Conclusion: Fat ingestion stimulated mainly the secretion of incretins via intestinal cells, whereas the amino acid ingestion stimulated mainly insulin secretion by directly acting on pancreatic β cells. The co-ingestion of amino acids with fat may improve postchallenge glucose metabolism, but it had little effect on postchallenge lipid or lipoprotein metabolism.
| Published in | International Journal of Nutrition and Food Sciences (Volume 11, Issue 6) |
| DOI | 10.11648/j.ijnfs.20221106.11 |
| Page(s) | 177-186 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Amino Acids, Postchallenge Glycemia, Postchallenge Lipidemia, Young Women, GIP, GLP-1, Insulin, Glucagon
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APA Style
Natsuko Ichikawa, Yukino Morita, Kayo Ootani, Michitaka Naito. (2022). Effects of Co-ingestion of Amino Acids with Fat on Postchallenge Glycemia and Lipidemia in Healthy Young Women. International Journal of Nutrition and Food Sciences, 11(6), 177-186. https://doi.org/10.11648/j.ijnfs.20221106.11
ACS Style
Natsuko Ichikawa; Yukino Morita; Kayo Ootani; Michitaka Naito. Effects of Co-ingestion of Amino Acids with Fat on Postchallenge Glycemia and Lipidemia in Healthy Young Women. Int. J. Nutr. Food Sci. 2022, 11(6), 177-186. doi: 10.11648/j.ijnfs.20221106.11
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Download@article{10.11648/j.ijnfs.20221106.11,
author = {Natsuko Ichikawa and Yukino Morita and Kayo Ootani and Michitaka Naito},
title = {Effects of Co-ingestion of Amino Acids with Fat on Postchallenge Glycemia and Lipidemia in Healthy Young Women},
journal = {International Journal of Nutrition and Food Sciences},
volume = {11},
number = {6},
pages = {177-186},
doi = {10.11648/j.ijnfs.20221106.11},
url = {https://doi.org/10.11648/j.ijnfs.20221106.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20221106.11},
abstract = {Aim: To investigate the effects of co-ingestion of amino acids with fat on postchallenge glycemia and lipidemia. Methods: Nine healthy young Japanese women were enrolled. At each session, the subjects ingested one of three beverages containing fat cream (OFTT™ cream, 1 g/kg body weight, 0.35 g/kg as fat) and/or amino acid mixture (Amizet B™, 600 mg/kg body weight, 60 mg/kg as amino acids) in a randomized crossover design. The three beverages were as follows: fat cream (F trial), amino acid mixture (A trial), or both (FA trial). Venous blood samples were obtained before (0) and 0.5, 1, 2, and 3 h in the A trial, and at 0, 0.5, 1, 2, 4, and 6 h after ingestion in the F and FA trials. Results: Fat ingestion increased the secretion of incretins (GIP and GLP-1), but only a weak effect on insulin secretion was observed. Amino acids ingestion had only a weak effect on the secretion of incretins, but synergistically stimulated the insulin secretion induced by fat ingestion. Glucagon showed behavior similar to that of insulin. There were no significant effects of the co-ingestion of amino acids on lipid or lipoprotein metabolism compared to the ingestion of fat alone. All of these phenomena were observed without a change in blood glucose levels. Conclusion: Fat ingestion stimulated mainly the secretion of incretins via intestinal cells, whereas the amino acid ingestion stimulated mainly insulin secretion by directly acting on pancreatic β cells. The co-ingestion of amino acids with fat may improve postchallenge glucose metabolism, but it had little effect on postchallenge lipid or lipoprotein metabolism.},
year = {2022}
}
TY - JOUR T1 - Effects of Co-ingestion of Amino Acids with Fat on Postchallenge Glycemia and Lipidemia in Healthy Young Women AU - Natsuko Ichikawa AU - Yukino Morita AU - Kayo Ootani AU - Michitaka Naito Y1 - 2022/11/11 PY - 2022 N1 - https://doi.org/10.11648/j.ijnfs.20221106.11 DO - 10.11648/j.ijnfs.20221106.11 T2 - International Journal of Nutrition and Food Sciences JF - International Journal of Nutrition and Food Sciences JO - International Journal of Nutrition and Food Sciences SP - 177 EP - 186 PB - Science Publishing Group SN - 2327-2716 UR - https://doi.org/10.11648/j.ijnfs.20221106.11 AB - Aim: To investigate the effects of co-ingestion of amino acids with fat on postchallenge glycemia and lipidemia. Methods: Nine healthy young Japanese women were enrolled. At each session, the subjects ingested one of three beverages containing fat cream (OFTT™ cream, 1 g/kg body weight, 0.35 g/kg as fat) and/or amino acid mixture (Amizet B™, 600 mg/kg body weight, 60 mg/kg as amino acids) in a randomized crossover design. The three beverages were as follows: fat cream (F trial), amino acid mixture (A trial), or both (FA trial). Venous blood samples were obtained before (0) and 0.5, 1, 2, and 3 h in the A trial, and at 0, 0.5, 1, 2, 4, and 6 h after ingestion in the F and FA trials. Results: Fat ingestion increased the secretion of incretins (GIP and GLP-1), but only a weak effect on insulin secretion was observed. Amino acids ingestion had only a weak effect on the secretion of incretins, but synergistically stimulated the insulin secretion induced by fat ingestion. Glucagon showed behavior similar to that of insulin. There were no significant effects of the co-ingestion of amino acids on lipid or lipoprotein metabolism compared to the ingestion of fat alone. All of these phenomena were observed without a change in blood glucose levels. Conclusion: Fat ingestion stimulated mainly the secretion of incretins via intestinal cells, whereas the amino acid ingestion stimulated mainly insulin secretion by directly acting on pancreatic β cells. The co-ingestion of amino acids with fat may improve postchallenge glucose metabolism, but it had little effect on postchallenge lipid or lipoprotein metabolism. VL - 11 IS - 6 ER -
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