Colonoscopy is an important tool for diagnosing and treating bowel injuries and reducing colorectal cancer incidence. Adequate bowel preparation is necessary to ensure the effectiveness of the procedure for detecting injuries. In this trial the aim was to compare effectiveness of lactitol, mannitol, and polyethylene glycol (PEG) oral solutions for bowel cleansing prior to colonoscopy. This is a randomized, blinded clinical trial. The primary endpoint was to evaluate the adequacy of colon cleansing according to the Boston Bowel Preparation Scale (BBPS). A total of 294 patients were randomized into three groups. The overall adequacy of bowel cleansing was achieved in 98.8% in the mannitol, followed by 93.5% in the lactitol and 92.3% in the PEG group. When comparing lactitol and mannitol, the efficacy to bowel preparation was greater in the mannitol group, but without statistical significance (P=0.164). The adequacy to bowel preparation was slightly better in the mannitol group than PEG (98.8% vs. 92.2%, respectively), but with P-value of 0.073. In adjusted analysis, the results were similar. The frequency of hypernatremia after bowel preparation was 25.3% in the mannitol group, followed by 7.3% and 5.2% in the PEG and lactitol, respectively. Considering tolerance for bowel preparation solution there was no difference between the mannitol and lactitol groups (P=0.07); but lactitol was better tolerated when compared to PEG (P=0.001). In conclusion, mannitol, lactitol and PEG are effective as intestinal cleansing solutions before colonoscopy, but adverse events, taste and tolerability must be considered before choosing.
| Published in | International Journal of Gastroenterology (Volume 4, Issue 2) |
| DOI | 10.11648/j.ijg.20200402.16 |
| Page(s) | 54-62 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Intestinal Preparation, Bowel Cleansing, Colonoscopy, Lactitol, Mannitol, Polyethylene Glycol
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APA Style
Lourianne Nascimento Cavalcante, Adriana Ribas, Alexandre Pithon Lins, Luciana Rodrigues Leal da Silva, Flora Maria Lorenzo Fortes, et al. (2020). A Randomized Clinical Trial Evaluating Mannitol, Lactitol, and Polyethylene Glycol Macrogol as Oral Solutions for Colonoscopy Preparation. International Journal of Gastroenterology, 4(2), 54-62. https://doi.org/10.11648/j.ijg.20200402.16
ACS Style
Lourianne Nascimento Cavalcante; Adriana Ribas; Alexandre Pithon Lins; Luciana Rodrigues Leal da Silva; Flora Maria Lorenzo Fortes, et al. A Randomized Clinical Trial Evaluating Mannitol, Lactitol, and Polyethylene Glycol Macrogol as Oral Solutions for Colonoscopy Preparation. Int. J. Gastroenterol. 2020, 4(2), 54-62. doi: 10.11648/j.ijg.20200402.16
AMA Style
Lourianne Nascimento Cavalcante, Adriana Ribas, Alexandre Pithon Lins, Luciana Rodrigues Leal da Silva, Flora Maria Lorenzo Fortes, et al. A Randomized Clinical Trial Evaluating Mannitol, Lactitol, and Polyethylene Glycol Macrogol as Oral Solutions for Colonoscopy Preparation. Int J Gastroenterol. 2020;4(2):54-62. doi: 10.11648/j.ijg.20200402.16
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Download@article{10.11648/j.ijg.20200402.16,
author = {Lourianne Nascimento Cavalcante and Adriana Ribas and Alexandre Pithon Lins and Luciana Rodrigues Leal da Silva and Flora Maria Lorenzo Fortes and Valdeck Sodre Bispo Jr and Marcus Vinicius Matos de Almeida and Maira Cintra de Oliveira and Camila Silveira and Marcos Clarencio Batista and Igelmar Barreto Paes},
title = {A Randomized Clinical Trial Evaluating Mannitol, Lactitol, and Polyethylene Glycol Macrogol as Oral Solutions for Colonoscopy Preparation},
journal = {International Journal of Gastroenterology},
volume = {4},
number = {2},
pages = {54-62},
doi = {10.11648/j.ijg.20200402.16},
url = {https://doi.org/10.11648/j.ijg.20200402.16},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijg.20200402.16},
abstract = {Colonoscopy is an important tool for diagnosing and treating bowel injuries and reducing colorectal cancer incidence. Adequate bowel preparation is necessary to ensure the effectiveness of the procedure for detecting injuries. In this trial the aim was to compare effectiveness of lactitol, mannitol, and polyethylene glycol (PEG) oral solutions for bowel cleansing prior to colonoscopy. This is a randomized, blinded clinical trial. The primary endpoint was to evaluate the adequacy of colon cleansing according to the Boston Bowel Preparation Scale (BBPS). A total of 294 patients were randomized into three groups. The overall adequacy of bowel cleansing was achieved in 98.8% in the mannitol, followed by 93.5% in the lactitol and 92.3% in the PEG group. When comparing lactitol and mannitol, the efficacy to bowel preparation was greater in the mannitol group, but without statistical significance (P=0.164). The adequacy to bowel preparation was slightly better in the mannitol group than PEG (98.8% vs. 92.2%, respectively), but with P-value of 0.073. In adjusted analysis, the results were similar. The frequency of hypernatremia after bowel preparation was 25.3% in the mannitol group, followed by 7.3% and 5.2% in the PEG and lactitol, respectively. Considering tolerance for bowel preparation solution there was no difference between the mannitol and lactitol groups (P=0.07); but lactitol was better tolerated when compared to PEG (P=0.001). In conclusion, mannitol, lactitol and PEG are effective as intestinal cleansing solutions before colonoscopy, but adverse events, taste and tolerability must be considered before choosing.},
year = {2020}
}
TY - JOUR T1 - A Randomized Clinical Trial Evaluating Mannitol, Lactitol, and Polyethylene Glycol Macrogol as Oral Solutions for Colonoscopy Preparation AU - Lourianne Nascimento Cavalcante AU - Adriana Ribas AU - Alexandre Pithon Lins AU - Luciana Rodrigues Leal da Silva AU - Flora Maria Lorenzo Fortes AU - Valdeck Sodre Bispo Jr AU - Marcus Vinicius Matos de Almeida AU - Maira Cintra de Oliveira AU - Camila Silveira AU - Marcos Clarencio Batista AU - Igelmar Barreto Paes Y1 - 2020/09/23 PY - 2020 N1 - https://doi.org/10.11648/j.ijg.20200402.16 DO - 10.11648/j.ijg.20200402.16 T2 - International Journal of Gastroenterology JF - International Journal of Gastroenterology JO - International Journal of Gastroenterology SP - 54 EP - 62 PB - Science Publishing Group SN - 2640-169X UR - https://doi.org/10.11648/j.ijg.20200402.16 AB - Colonoscopy is an important tool for diagnosing and treating bowel injuries and reducing colorectal cancer incidence. Adequate bowel preparation is necessary to ensure the effectiveness of the procedure for detecting injuries. In this trial the aim was to compare effectiveness of lactitol, mannitol, and polyethylene glycol (PEG) oral solutions for bowel cleansing prior to colonoscopy. This is a randomized, blinded clinical trial. The primary endpoint was to evaluate the adequacy of colon cleansing according to the Boston Bowel Preparation Scale (BBPS). A total of 294 patients were randomized into three groups. The overall adequacy of bowel cleansing was achieved in 98.8% in the mannitol, followed by 93.5% in the lactitol and 92.3% in the PEG group. When comparing lactitol and mannitol, the efficacy to bowel preparation was greater in the mannitol group, but without statistical significance (P=0.164). The adequacy to bowel preparation was slightly better in the mannitol group than PEG (98.8% vs. 92.2%, respectively), but with P-value of 0.073. In adjusted analysis, the results were similar. The frequency of hypernatremia after bowel preparation was 25.3% in the mannitol group, followed by 7.3% and 5.2% in the PEG and lactitol, respectively. Considering tolerance for bowel preparation solution there was no difference between the mannitol and lactitol groups (P=0.07); but lactitol was better tolerated when compared to PEG (P=0.001). In conclusion, mannitol, lactitol and PEG are effective as intestinal cleansing solutions before colonoscopy, but adverse events, taste and tolerability must be considered before choosing. VL - 4 IS - 2 ER -
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