Noninvasive Prediction of Esophageal Varices Grade (Size) in Sudanese Patients with Periportal Fibrosis

Mohammed Abdelrahim Hassan; Amin Mohammed Abass; Hyder Osman Mirghani; Elkhawad Osman; Mohammed Osman Elhassan Gadour

doi:doi:10.11648/j.ijg.20180202.12

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Noninvasive Prediction of Esophageal Varices Grade (Size) in Sudanese Patients with Periportal Fibrosis

Mohammed Abdelrahim Hassan, Amin Mohammed Abass, Hyder Osman Mirghani, Elkhawad Osman, Mohammed Osman Elhassan Gadour

Published in International Journal of Gastroenterology (Volume 2, Issue 2)

Received: 30 October 2018 Accepted: 13 November 2018 Published: 19 December 2018

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Abstract

Endoscopy is an effective tool for variceal grading, but it is costly, invasive, and not always at hand. The study aimed to assess platelets count and ultrasonographic parameters of portal hypertension as predictors of esophageal grade. This, cross-sectional hospital based study conducted among100 patients with Schistosomal portal hypertension at Ibn Sina Teaching Hospital, Khartoum, Sudan during the period from November 2011 – August 2012. Patients with liver cirrhosis, previous treatment for esophageal varices or on β blockers were not included. Information collected were: socio-demographic data, history of and onset of variceal bleeding, ascites, SchistosomaMansoni Score (SMS), the spleen size, liver span, portal and splenic veins diameter, variceal grade, and platelets count. The ethical committee of the Sudan Medical Specialization Board approved the research and the Statistical Package for Social Sciences (SPSS, version 20, New York) was used for data analysis. Participants (76% males), Mean age (43.9 ± 14 years), liver span, spleen size below the costal margin, and portal vein diameter were, 10.34± 2.01, 6 ± 3.9, and 1.5 cm ± 0.27 cm respectively. Platelets count, SMS, the extent of periportal fibrosis, and portal vein diameter were significant predictors of esophageal grade,(P-value <0.05), while spleen size, portal vein diameter, platelets/spleen index were not. The study concluded that, non-invasive assessment of ultrasonographic parameters (ShistosomaMansoni Score, portal vein diameter, degree of periportal fibrosis) and platelets count could aid the detection of patients with large esophageal varies for the implementation of the needed intervention. The limitation was the small sample size.

Published in	International Journal of Gastroenterology (Volume 2, Issue 2)
DOI	10.11648/j.ijg.20180202.12
Page(s)	28-33
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Predictors, Schistosomiasis, Esophageal Grade, Sudan

References

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[5]	Viallet A, Marleau D, Huet M, Martin FA, Villeneuve JP, Lavoie P. Haemodynamic evaluation of patients with intrahepatic portal hypertension.. Relationship between variceal and portohepatic gradient. Gastroentrol (1995); 69: 1297 -1300.
[6]	Rebouças G. Clinical aspects of hepatosplenic schistosomiasis: A contrast with cirrhosis. Yale J Biol Med. (1975); 48: 369–76.
[7]	Homeida M, Abdelgader AF, Cheever AW, Bennet JI, Arbab BM, Ibrahim SZ, Nash TE. Diagnose of pathologically confirmed symmer periportal fibrosis by ultrasonography. AM J Trop Med Hyg (1988); 38(1): 86-91.
[8]	Akande KO, Akere A, Otegbayo JA, Ola SO, Ousunmade D Accuracy of non-endoscopic predictors of oesophagealvarices in liver cirrhosis using platelet count, splenic size and portal vein diameter. Afr J Med Med Sci. (2016) ; 45(3): 243-251.
[9]	Chiodi D, Hernández N, Saona G, Sánchez A, Berrueta J, Mescia G, Pollio C, Robaina G. [Noninvasive diagnosis of esophageal varices in cirrhotic patients]. Acta Gastroenterol Latinoam. (2014); 44(2):108-13. [Article in Spanish].
[10]	Xu XD, Xu CF, Dai JJ, Qian JQ, Pin X. Ratio of platelet count/spleen diameter predicted the presence of esophageal varices in patients with schistosomiasis liver cirrhosis. Eur J Gastroenterol Hepatol. (2016); 28(5):588-91. doi: 10.1097/MEG.0000000000000584.
[11]	Agha A, Abdulhadi MM, Marenco S, Bella A, Alsaudi D, El-Haddad A, Inferrera S, Savarino V, Giannini EG. Use of the platelet count/spleen diameter ratio for the noninvasive diagnosis of esophageal varices in patients with schistosomiasis. Saudi J Gastroenterol. (2011); 17(5):307-11. doi: 10.4103/1319-3767.84483.
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[13]	Nada L, Samira el F, Bahija B, Adil I, Nourdine A Noninvasive predictors of presence and grade of esophageal varices in viral cirrhotic patients. Pan Afr Med J. (2015); 20:145. doi: 10.11604/pamj.2015.20.145.4320. eCollection 2015.
[14]	Mahassadi AK, Bathaix FY, Assi C, Bangoura AD, Allah-Kouadio E, Kissi HY, Touré A, Doffou S, Konaté I, Attia AK, Camara MB, Ndri-Yoman TA. Usefulness of Noninvasive Predictors of OesophagealVarices in Black African Cirrhotic Patients in Côte d'Ivoire (West Africa). Gastroenterol Res Pract. (2012); 2012:216390. doi: 10.1155/2012/216390. Epub (2012).
[15]	Farid M, Abdelwahab G, Thomas GS. Ultrasonographic prediction of oesophagealvarices in Schistosomias ismansoni. Am J Gastrol (1995); 88 (4): 560-563.
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[17]	Mirghani HO, Khamees H. Predictors of Bleeding of Esophageal Varices Among Patients with Portal Hypertension-Sudan. American Journal of Biomedical and Life Sciences (2016); 4(6): 103-106. doi: 10.11648/j.ajbls.20160406.14.
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APA Style

Mohammed Abdelrahim Hassan, Amin Mohammed Abass, Hyder Osman Mirghani, Elkhawad Osman, Mohammed Osman Elhassan Gadour. (2018). Noninvasive Prediction of Esophageal Varices Grade (Size) in Sudanese Patients with Periportal Fibrosis. International Journal of Gastroenterology, 2(2), 28-33. https://doi.org/10.11648/j.ijg.20180202.12

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ACS Style

Mohammed Abdelrahim Hassan; Amin Mohammed Abass; Hyder Osman Mirghani; Elkhawad Osman; Mohammed Osman Elhassan Gadour. Noninvasive Prediction of Esophageal Varices Grade (Size) in Sudanese Patients with Periportal Fibrosis. Int. J. Gastroenterol. 2018, 2(2), 28-33. doi: 10.11648/j.ijg.20180202.12

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AMA Style

Mohammed Abdelrahim Hassan, Amin Mohammed Abass, Hyder Osman Mirghani, Elkhawad Osman, Mohammed Osman Elhassan Gadour. Noninvasive Prediction of Esophageal Varices Grade (Size) in Sudanese Patients with Periportal Fibrosis. Int J Gastroenterol. 2018;2(2):28-33. doi: 10.11648/j.ijg.20180202.12

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@article{10.11648/j.ijg.20180202.12,
  author = {Mohammed Abdelrahim Hassan and Amin Mohammed Abass and Hyder Osman Mirghani and Elkhawad Osman and Mohammed Osman Elhassan Gadour},
  title = {Noninvasive Prediction of Esophageal Varices Grade (Size) in Sudanese Patients with Periportal Fibrosis},
  journal = {International Journal of Gastroenterology},
  volume = {2},
  number = {2},
  pages = {28-33},
  doi = {10.11648/j.ijg.20180202.12},
  url = {https://doi.org/10.11648/j.ijg.20180202.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijg.20180202.12},
  abstract = {Endoscopy is an effective tool for variceal grading, but it is costly, invasive, and not always at hand. The study aimed to assess platelets count and ultrasonographic parameters of portal hypertension as predictors of esophageal grade. This, cross-sectional hospital based study conducted among100 patients with Schistosomal portal hypertension at Ibn Sina Teaching Hospital, Khartoum, Sudan during the period from November 2011 – August 2012. Patients with liver cirrhosis, previous treatment for esophageal varices or on β blockers were not included. Information collected were: socio-demographic data, history of and onset of variceal bleeding, ascites, SchistosomaMansoni Score (SMS), the spleen size, liver span, portal and splenic veins diameter, variceal grade, and platelets count. The ethical committee of the Sudan Medical Specialization Board approved the research and the Statistical Package for Social Sciences (SPSS, version 20, New York) was used for data analysis. Participants (76% males), Mean age (43.9 ± 14 years), liver span, spleen size below the costal margin, and portal vein diameter were, 10.34± 2.01, 6 ± 3.9, and 1.5 cm ± 0.27 cm respectively. Platelets count, SMS, the extent of periportal fibrosis, and portal vein diameter were significant predictors of esophageal grade,(P-value <0.05), while spleen size, portal vein diameter, platelets/spleen index were not. The study concluded that, non-invasive assessment of ultrasonographic parameters (ShistosomaMansoni Score, portal vein diameter, degree of periportal fibrosis) and platelets count could aid the detection of patients with large esophageal varies for the implementation of the needed intervention. The limitation was the small sample size.},
 year = {2018}
}

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TY  - JOUR
T1  - Noninvasive Prediction of Esophageal Varices Grade (Size) in Sudanese Patients with Periportal Fibrosis
AU  - Mohammed Abdelrahim Hassan
AU  - Amin Mohammed Abass
AU  - Hyder Osman Mirghani
AU  - Elkhawad Osman
AU  - Mohammed Osman Elhassan Gadour
Y1  - 2018/12/19
PY  - 2018
N1  - https://doi.org/10.11648/j.ijg.20180202.12
DO  - 10.11648/j.ijg.20180202.12
T2  - International Journal of Gastroenterology
JF  - International Journal of Gastroenterology
JO  - International Journal of Gastroenterology
SP  - 28
EP  - 33
PB  - Science Publishing Group
SN  - 2640-169X
UR  - https://doi.org/10.11648/j.ijg.20180202.12
AB  - Endoscopy is an effective tool for variceal grading, but it is costly, invasive, and not always at hand. The study aimed to assess platelets count and ultrasonographic parameters of portal hypertension as predictors of esophageal grade. This, cross-sectional hospital based study conducted among100 patients with Schistosomal portal hypertension at Ibn Sina Teaching Hospital, Khartoum, Sudan during the period from November 2011 – August 2012. Patients with liver cirrhosis, previous treatment for esophageal varices or on β blockers were not included. Information collected were: socio-demographic data, history of and onset of variceal bleeding, ascites, SchistosomaMansoni Score (SMS), the spleen size, liver span, portal and splenic veins diameter, variceal grade, and platelets count. The ethical committee of the Sudan Medical Specialization Board approved the research and the Statistical Package for Social Sciences (SPSS, version 20, New York) was used for data analysis. Participants (76% males), Mean age (43.9 ± 14 years), liver span, spleen size below the costal margin, and portal vein diameter were, 10.34± 2.01, 6 ± 3.9, and 1.5 cm ± 0.27 cm respectively. Platelets count, SMS, the extent of periportal fibrosis, and portal vein diameter were significant predictors of esophageal grade,(P-value <0.05), while spleen size, portal vein diameter, platelets/spleen index were not. The study concluded that, non-invasive assessment of ultrasonographic parameters (ShistosomaMansoni Score, portal vein diameter, degree of periportal fibrosis) and platelets count could aid the detection of patients with large esophageal varies for the implementation of the needed intervention. The limitation was the small sample size.
VL  - 2
IS  - 2
ER  -

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Author Information

Mohammed Abdelrahim Hassan

Sudan Medical Specialization Board, Khartoum, Sudan
Amin Mohammed Abass

Department of Gastroenterology and Hepatology, Ibn Sina Teaching Hospital, Khartoum, Sudan
Hyder Osman Mirghani

Department of Internal Medicine, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia
Elkhawad Osman

Depatment of Radiology, Ibn Sina Teaching Hospital, Khartoum, Sudan
Mohammed Osman Elhassan Gadour

Department of Internal Medicine, Faculty of Medicine, Omdurman Islamic University, Omdurman, Sudan

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Plain Text BibTeX RIS

APA Style

Mohammed Abdelrahim Hassan, Amin Mohammed Abass, Hyder Osman Mirghani, Elkhawad Osman, Mohammed Osman Elhassan Gadour. (2018). Noninvasive Prediction of Esophageal Varices Grade (Size) in Sudanese Patients with Periportal Fibrosis. International Journal of Gastroenterology, 2(2), 28-33. https://doi.org/10.11648/j.ijg.20180202.12

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ACS Style

Mohammed Abdelrahim Hassan; Amin Mohammed Abass; Hyder Osman Mirghani; Elkhawad Osman; Mohammed Osman Elhassan Gadour. Noninvasive Prediction of Esophageal Varices Grade (Size) in Sudanese Patients with Periportal Fibrosis. Int. J. Gastroenterol. 2018, 2(2), 28-33. doi: 10.11648/j.ijg.20180202.12

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AMA Style

Mohammed Abdelrahim Hassan, Amin Mohammed Abass, Hyder Osman Mirghani, Elkhawad Osman, Mohammed Osman Elhassan Gadour. Noninvasive Prediction of Esophageal Varices Grade (Size) in Sudanese Patients with Periportal Fibrosis. Int J Gastroenterol. 2018;2(2):28-33. doi: 10.11648/j.ijg.20180202.12

Copy | Download

@article{10.11648/j.ijg.20180202.12,
  author = {Mohammed Abdelrahim Hassan and Amin Mohammed Abass and Hyder Osman Mirghani and Elkhawad Osman and Mohammed Osman Elhassan Gadour},
  title = {Noninvasive Prediction of Esophageal Varices Grade (Size) in Sudanese Patients with Periportal Fibrosis},
  journal = {International Journal of Gastroenterology},
  volume = {2},
  number = {2},
  pages = {28-33},
  doi = {10.11648/j.ijg.20180202.12},
  url = {https://doi.org/10.11648/j.ijg.20180202.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijg.20180202.12},
  abstract = {Endoscopy is an effective tool for variceal grading, but it is costly, invasive, and not always at hand. The study aimed to assess platelets count and ultrasonographic parameters of portal hypertension as predictors of esophageal grade. This, cross-sectional hospital based study conducted among100 patients with Schistosomal portal hypertension at Ibn Sina Teaching Hospital, Khartoum, Sudan during the period from November 2011 – August 2012. Patients with liver cirrhosis, previous treatment for esophageal varices or on β blockers were not included. Information collected were: socio-demographic data, history of and onset of variceal bleeding, ascites, SchistosomaMansoni Score (SMS), the spleen size, liver span, portal and splenic veins diameter, variceal grade, and platelets count. The ethical committee of the Sudan Medical Specialization Board approved the research and the Statistical Package for Social Sciences (SPSS, version 20, New York) was used for data analysis. Participants (76% males), Mean age (43.9 ± 14 years), liver span, spleen size below the costal margin, and portal vein diameter were, 10.34± 2.01, 6 ± 3.9, and 1.5 cm ± 0.27 cm respectively. Platelets count, SMS, the extent of periportal fibrosis, and portal vein diameter were significant predictors of esophageal grade,(P-value <0.05), while spleen size, portal vein diameter, platelets/spleen index were not. The study concluded that, non-invasive assessment of ultrasonographic parameters (ShistosomaMansoni Score, portal vein diameter, degree of periportal fibrosis) and platelets count could aid the detection of patients with large esophageal varies for the implementation of the needed intervention. The limitation was the small sample size.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Noninvasive Prediction of Esophageal Varices Grade (Size) in Sudanese Patients with Periportal Fibrosis
AU  - Mohammed Abdelrahim Hassan
AU  - Amin Mohammed Abass
AU  - Hyder Osman Mirghani
AU  - Elkhawad Osman
AU  - Mohammed Osman Elhassan Gadour
Y1  - 2018/12/19
PY  - 2018
N1  - https://doi.org/10.11648/j.ijg.20180202.12
DO  - 10.11648/j.ijg.20180202.12
T2  - International Journal of Gastroenterology
JF  - International Journal of Gastroenterology
JO  - International Journal of Gastroenterology
SP  - 28
EP  - 33
PB  - Science Publishing Group
SN  - 2640-169X
UR  - https://doi.org/10.11648/j.ijg.20180202.12
AB  - Endoscopy is an effective tool for variceal grading, but it is costly, invasive, and not always at hand. The study aimed to assess platelets count and ultrasonographic parameters of portal hypertension as predictors of esophageal grade. This, cross-sectional hospital based study conducted among100 patients with Schistosomal portal hypertension at Ibn Sina Teaching Hospital, Khartoum, Sudan during the period from November 2011 – August 2012. Patients with liver cirrhosis, previous treatment for esophageal varices or on β blockers were not included. Information collected were: socio-demographic data, history of and onset of variceal bleeding, ascites, SchistosomaMansoni Score (SMS), the spleen size, liver span, portal and splenic veins diameter, variceal grade, and platelets count. The ethical committee of the Sudan Medical Specialization Board approved the research and the Statistical Package for Social Sciences (SPSS, version 20, New York) was used for data analysis. Participants (76% males), Mean age (43.9 ± 14 years), liver span, spleen size below the costal margin, and portal vein diameter were, 10.34± 2.01, 6 ± 3.9, and 1.5 cm ± 0.27 cm respectively. Platelets count, SMS, the extent of periportal fibrosis, and portal vein diameter were significant predictors of esophageal grade,(P-value <0.05), while spleen size, portal vein diameter, platelets/spleen index were not. The study concluded that, non-invasive assessment of ultrasonographic parameters (ShistosomaMansoni Score, portal vein diameter, degree of periportal fibrosis) and platelets count could aid the detection of patients with large esophageal varies for the implementation of the needed intervention. The limitation was the small sample size.
VL  - 2
IS  - 2
ER  -

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