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Advantages of Customized Titanium Meshes in Oral Bone Regeneration: A Literature Review and Two Cases Presentation Using Customized Meshes

Received: 4 November 2025     Accepted: 19 November 2025     Published: 17 December 2025
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Abstract

Bone grafting before dental implants are placed is one of the most common procedures nowadays in dentistry. The reality is that CBCT and also CAD-CAM technology have changed all what has to be related to it. Customized titanium meshes (CTMs) have become a reliable option for guided bone regeneration (GBR), allowing precise anatomical reconstruction of alveolar defects through CAD/CAM technology. Their rigidity, biocompatibility, and design flexibility provide superior mechanical stability and soft-tissue management compared with conventional collagen membranes or PTR membranes. This review analyzes the biological, technical, and clinical advantages of CTMs, summarizing current evidence on their predictability, technical considerations, and limitations. Additionally, it explores the role of digital planning and 3D printing in optimizing surgical outcomes, minimizing intraoperative adjustments, and improving patient-specific adaptation. CTMs have demonstrated high success rates in maintaining space for bone regeneration, reducing complications such as mesh exposure, and achieving satisfactory aesthetic and functional results. The review also discusses potential complications, handling protocols, and long-term clinical follow-up. Furthermore, it presents two cases in which Element® Customized Ti-Meshes were used, showing excellent integration and bone volume stability. After successful osteointegration of the bone graft, dental implants were placed, achieving predictable and stable restorative outcomes.

Published in International Journal of Clinical Oral and Maxillofacial Surgery (Volume 11, Issue 2)
DOI 10.11648/j.ijcoms.20251102.14
Page(s) 82-88
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2025. Published by Science Publishing Group

Keywords

Customized Titanium Mesh, Bone Regeneration, CAD/CAM, Implant Dentistry, Biomaterials

References
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[2] Chiapasco M, Zaniboni M, Boisco M. (2006). Augmentation procedures for the rehabilitation of deficient edentulous ridges with oral implants. Clin Oral Implants Res, 17(Suppl 2), 136-159.
[3] Rakhmatia YD, Ayukawa Y, Furuhashi A, Koyano K. (2013). Current barrier membranes: Titanium mesh and other membranes for GBR. J Prosthodont Res, 57(1), 3-14.
[4] Buser D, Martin W, Belser UC. (2004). Optimizing esthetics for implant restorations in the anterior maxilla: Anatomic and surgical considerations. Int J Oral Maxillofac Implants, 19(Suppl), 43-61.
[5] Rocchietta I, Fontana F, Simion M. (2008). Clinical outcomes of vertical bone augmentation using titanium-reinforced e-PTFE membranes. Clin Oral Implants Res, 19(4), 380-386.
[6] De Stavola L, Tunkel J. (2013). A new approach for GBR in vertical defects using titanium-reinforced d-PTFE membranes. Int J Periodontics Restorative Dent, 33(3), 355-361.
[7] Cerea M, Dolcini G. (2018). Custom-made titanium mesh for alveolar bone reconstruction. Int J Periodontics Restorative Dent, 38(2), 231-239.
[8] Gherlone EF, Capparè P, Vinci R, Ferrini F, Gastaldi G. (2021). Evaluation of customized CAD/CAM titanium meshes for alveolar ridge augmentation: A multicenter prospective study. Materials, 14(5), 1208.
[9] González-García R, Monje A, Moreno C. (2021). Digital workflow for customized titanium mesh in complex alveolar defects. Clin Oral Implants Res, 32(3), 325-334.
[10] Urban IA, Lozada JL, Jovanovic SA, Nagursky H, Nagy K. (2011). Vertical ridge augmentation with titanium-reinforced d-PTFE membranes and a combination of particulate autogenous bone and anorganic bovine bone mineral. Clin Oral Implants Res, 22(2), 210-217.
[11] Chiapasco M, Casentini P, Zaniboni M. (2009). Bone augmentation procedures in implant dentistry. Int J Oral Maxillofac Implants, 24(Suppl), 237-259.
[12] Watzinger F, et al. (2020). Three-dimensional printing of patient-specific meshes for bone regeneration. J Craniomaxillofac Surg, 48(9), 844-851.
[13] Rasia-dal Polo M, Poli PP, Rancitelli D, Beretta M, Maiorana C. (2017). Alveolar ridge reconstruction with titanium mesh. Clin Implant Dent Relat Res, 19(2), 195-203.
[14] Her S, Kang T, Fien MJ. (2012). Titanium mesh as an alternative for GBR procedures: A retrospective study. Clin Implant Dent Relat Res, 14(3), 464-471.
[15] Stimmelmayr M, Güth JF, Erdelt K, Edelhoff D, Beuer F. (2020). CAD/CAM-fabricated titanium meshes for alveolar ridge augmentation. Int J Comput Dent, 23(1), 27-40.
[16] Xing Z, Chen L, Chen X, Xu H. (2019). Efficacy of customized titanium meshes for alveolar bone augmentation: A systematic review. J Oral Rehabil, 46(9), 777-787.
[17] Cucchi, A., Vignudelli, E., Napolitano, A., Franco, S., Corinaldesi, G., & Marchetti, C. (2021). Vertical and horizontal ridge augmentation using customized CAD/CAM titanium mesh with versus without resorbable membranes: A randomized clinical trial. Clinical Oral Implants Research, 32(11), 1251-1264.
[18] Molina, A., Sanz-Sánchez, I., & Sanz-Martín, I. (2022). Efficacy and predictability of CAD/CAM titanium meshes for bone regeneration: A systematic review. International Journal of Oral and Maxillofacial Surgery, 51(11), 1407-1418.
[19] Bianchi, A. E., Dolcini, G. A., & Colombo, M. (2023). Design and clinical application of a novel CAD/CAM titanium mesh with geometric retention for bone regeneration: A technical note. The International Journal of Periodontics & Restorative Dentistry, 43(1), 33-40.
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  • APA Style

    Fajo, I. M., Lloret, A. M. (2025). Advantages of Customized Titanium Meshes in Oral Bone Regeneration: A Literature Review and Two Cases Presentation Using Customized Meshes. International Journal of Clinical Oral and Maxillofacial Surgery, 11(2), 82-88. https://doi.org/10.11648/j.ijcoms.20251102.14

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    ACS Style

    Fajo, I. M.; Lloret, A. M. Advantages of Customized Titanium Meshes in Oral Bone Regeneration: A Literature Review and Two Cases Presentation Using Customized Meshes. Int. J. Clin. Oral Maxillofac. Surg. 2025, 11(2), 82-88. doi: 10.11648/j.ijcoms.20251102.14

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    AMA Style

    Fajo IM, Lloret AM. Advantages of Customized Titanium Meshes in Oral Bone Regeneration: A Literature Review and Two Cases Presentation Using Customized Meshes. Int J Clin Oral Maxillofac Surg. 2025;11(2):82-88. doi: 10.11648/j.ijcoms.20251102.14

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  • @article{10.11648/j.ijcoms.20251102.14,
      author = {Iñaki Mayo Fajo and Antonio Macías Lloret},
      title = {Advantages of Customized Titanium Meshes in Oral Bone Regeneration: A Literature Review and Two Cases Presentation Using Customized Meshes},
      journal = {International Journal of Clinical Oral and Maxillofacial Surgery},
      volume = {11},
      number = {2},
      pages = {82-88},
      doi = {10.11648/j.ijcoms.20251102.14},
      url = {https://doi.org/10.11648/j.ijcoms.20251102.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcoms.20251102.14},
      abstract = {Bone grafting before dental implants are placed is one of the most common procedures nowadays in dentistry. The reality is that CBCT and also CAD-CAM technology have changed all what has to be related to it. Customized titanium meshes (CTMs) have become a reliable option for guided bone regeneration (GBR), allowing precise anatomical reconstruction of alveolar defects through CAD/CAM technology. Their rigidity, biocompatibility, and design flexibility provide superior mechanical stability and soft-tissue management compared with conventional collagen membranes or PTR membranes. This review analyzes the biological, technical, and clinical advantages of CTMs, summarizing current evidence on their predictability, technical considerations, and limitations. Additionally, it explores the role of digital planning and 3D printing in optimizing surgical outcomes, minimizing intraoperative adjustments, and improving patient-specific adaptation. CTMs have demonstrated high success rates in maintaining space for bone regeneration, reducing complications such as mesh exposure, and achieving satisfactory aesthetic and functional results. The review also discusses potential complications, handling protocols, and long-term clinical follow-up. Furthermore, it presents two cases in which Element® Customized Ti-Meshes were used, showing excellent integration and bone volume stability. After successful osteointegration of the bone graft, dental implants were placed, achieving predictable and stable restorative outcomes.},
     year = {2025}
    }
    

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    AU  - Iñaki Mayo Fajo
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    AB  - Bone grafting before dental implants are placed is one of the most common procedures nowadays in dentistry. The reality is that CBCT and also CAD-CAM technology have changed all what has to be related to it. Customized titanium meshes (CTMs) have become a reliable option for guided bone regeneration (GBR), allowing precise anatomical reconstruction of alveolar defects through CAD/CAM technology. Their rigidity, biocompatibility, and design flexibility provide superior mechanical stability and soft-tissue management compared with conventional collagen membranes or PTR membranes. This review analyzes the biological, technical, and clinical advantages of CTMs, summarizing current evidence on their predictability, technical considerations, and limitations. Additionally, it explores the role of digital planning and 3D printing in optimizing surgical outcomes, minimizing intraoperative adjustments, and improving patient-specific adaptation. CTMs have demonstrated high success rates in maintaining space for bone regeneration, reducing complications such as mesh exposure, and achieving satisfactory aesthetic and functional results. The review also discusses potential complications, handling protocols, and long-term clinical follow-up. Furthermore, it presents two cases in which Element® Customized Ti-Meshes were used, showing excellent integration and bone volume stability. After successful osteointegration of the bone graft, dental implants were placed, achieving predictable and stable restorative outcomes.
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