Launaea taraxacifolia (Efo yanrin) aqueous extract was orally administered to albino rats with view to investigating the haematological, biochemical and histological difference on body organs. Fifteen (15) albino rats divided into five groups each of three rats were used. Group I was the control while groups II III, IV, and V were dosed with 500mg/kg, 1000mg/kg, 2000mg/kg and 3000mg/kg respectively. Rats treated with different doses of aqueous extracts had increase packed cell volume with a significant increase of 43% in groups II and V alongside with Haemoglobin of 14.3mg/dl increase compared with the control. Moreover, the differential leucocyte counts revealed moderate increase in the lymphocytes count of groups II and V when compared with normal value. The aqueous extract of L. taraxacifolia is safe and has immunostimulatory effect. However, the effect of the extract on the liver of rats has varying degrees of lesions ranging from mild to severe diffuse degeneration of hepatocytes with periportal cellular infiltration. There was presence of multiple foci of caseous necrosis of the hepatic cells. Animals to which aqueous extract was administered at graded doses showed presence of eosinophilic cast in degenerated tubules with cellular infiltration in the renal interstitium. The histological result showed that the aqueous extract of L. taraxacifolia, could be toxic to the liver and kidney and caution should therefore be exercised in its use for medicinal purpose.
| Published in | International Journal of Biochemistry, Biophysics & Molecular Biology (Volume 2, Issue 5) |
| DOI | 10.11648/j.ijbbmb.20170205.12 |
| Page(s) | 47-50 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Toxicity, Launaea taraxacifolia, Extract, Herbal, Rat
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APA Style
Florence Ifechukwude Aboderin, Joshua Seun Olajide, Adekunle Abiodun Adesiyan. (2017). Toxicity Effect of Launaea taraxacifolia Aqueous Extract on Vital Organs of Albino Rat. International Journal of Biochemistry, Biophysics & Molecular Biology, 2(5), 47-50. https://doi.org/10.11648/j.ijbbmb.20170205.12
ACS Style
Florence Ifechukwude Aboderin; Joshua Seun Olajide; Adekunle Abiodun Adesiyan. Toxicity Effect of Launaea taraxacifolia Aqueous Extract on Vital Organs of Albino Rat. Int. J. Biochem. Biophys. Mol. Biol. 2017, 2(5), 47-50. doi: 10.11648/j.ijbbmb.20170205.12
AMA Style
Florence Ifechukwude Aboderin, Joshua Seun Olajide, Adekunle Abiodun Adesiyan. Toxicity Effect of Launaea taraxacifolia Aqueous Extract on Vital Organs of Albino Rat. Int J Biochem Biophys Mol Biol. 2017;2(5):47-50. doi: 10.11648/j.ijbbmb.20170205.12
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Download@article{10.11648/j.ijbbmb.20170205.12,
author = {Florence Ifechukwude Aboderin and Joshua Seun Olajide and Adekunle Abiodun Adesiyan},
title = {Toxicity Effect of Launaea taraxacifolia Aqueous Extract on Vital Organs of Albino Rat},
journal = {International Journal of Biochemistry, Biophysics & Molecular Biology},
volume = {2},
number = {5},
pages = {47-50},
doi = {10.11648/j.ijbbmb.20170205.12},
url = {https://doi.org/10.11648/j.ijbbmb.20170205.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbbmb.20170205.12},
abstract = {Launaea taraxacifolia (Efo yanrin) aqueous extract was orally administered to albino rats with view to investigating the haematological, biochemical and histological difference on body organs. Fifteen (15) albino rats divided into five groups each of three rats were used. Group I was the control while groups II III, IV, and V were dosed with 500mg/kg, 1000mg/kg, 2000mg/kg and 3000mg/kg respectively. Rats treated with different doses of aqueous extracts had increase packed cell volume with a significant increase of 43% in groups II and V alongside with Haemoglobin of 14.3mg/dl increase compared with the control. Moreover, the differential leucocyte counts revealed moderate increase in the lymphocytes count of groups II and V when compared with normal value. The aqueous extract of L. taraxacifolia is safe and has immunostimulatory effect. However, the effect of the extract on the liver of rats has varying degrees of lesions ranging from mild to severe diffuse degeneration of hepatocytes with periportal cellular infiltration. There was presence of multiple foci of caseous necrosis of the hepatic cells. Animals to which aqueous extract was administered at graded doses showed presence of eosinophilic cast in degenerated tubules with cellular infiltration in the renal interstitium. The histological result showed that the aqueous extract of L. taraxacifolia, could be toxic to the liver and kidney and caution should therefore be exercised in its use for medicinal purpose.},
year = {2017}
}
TY - JOUR T1 - Toxicity Effect of Launaea taraxacifolia Aqueous Extract on Vital Organs of Albino Rat AU - Florence Ifechukwude Aboderin AU - Joshua Seun Olajide AU - Adekunle Abiodun Adesiyan Y1 - 2017/10/23 PY - 2017 N1 - https://doi.org/10.11648/j.ijbbmb.20170205.12 DO - 10.11648/j.ijbbmb.20170205.12 T2 - International Journal of Biochemistry, Biophysics & Molecular Biology JF - International Journal of Biochemistry, Biophysics & Molecular Biology JO - International Journal of Biochemistry, Biophysics & Molecular Biology SP - 47 EP - 50 PB - Science Publishing Group SN - 2575-5862 UR - https://doi.org/10.11648/j.ijbbmb.20170205.12 AB - Launaea taraxacifolia (Efo yanrin) aqueous extract was orally administered to albino rats with view to investigating the haematological, biochemical and histological difference on body organs. Fifteen (15) albino rats divided into five groups each of three rats were used. Group I was the control while groups II III, IV, and V were dosed with 500mg/kg, 1000mg/kg, 2000mg/kg and 3000mg/kg respectively. Rats treated with different doses of aqueous extracts had increase packed cell volume with a significant increase of 43% in groups II and V alongside with Haemoglobin of 14.3mg/dl increase compared with the control. Moreover, the differential leucocyte counts revealed moderate increase in the lymphocytes count of groups II and V when compared with normal value. The aqueous extract of L. taraxacifolia is safe and has immunostimulatory effect. However, the effect of the extract on the liver of rats has varying degrees of lesions ranging from mild to severe diffuse degeneration of hepatocytes with periportal cellular infiltration. There was presence of multiple foci of caseous necrosis of the hepatic cells. Animals to which aqueous extract was administered at graded doses showed presence of eosinophilic cast in degenerated tubules with cellular infiltration in the renal interstitium. The histological result showed that the aqueous extract of L. taraxacifolia, could be toxic to the liver and kidney and caution should therefore be exercised in its use for medicinal purpose. VL - 2 IS - 5 ER -
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