Ferroptosis is a new type of programmed cell death discovered in recent years. It is a regulatory cell death induced by iron dependent lipid peroxide injury. Ferroptosis plays a critical role in the development of glioma, affecting tumor proliferation, angiogenesis, tumor cell necrosis, and the formation of an immune-resistant tumor microenvironment. Glioma is the most common intracranial malignant tumor, with the characteristics of high incidence rate, high recurrence rate, high mortality rate and low cure rate. At present, the main standard treatment plan is tumor surgical resection, synchronous radiotherapy and chemotherapy, etc. Because of the extremely low 5-year survival rate and high recurrence rate of glioma patients, new effective treatment strategies are expected. With the extensive study of regulatory cell death in malignant tumors, there is increasing evidence that iron death is closely related to the development and outcome of glioma. Inducing iron death becomes an attractive strategy for glioma treatment. In this paper, we summarize the research on this aspect and summarize it in gelatin. The mechanism of action and therapeutic research value of tumor are expected to develop new therapeutic strategies and provide a certain theoretical basis for the in-depth research in this field.
| Published in | Cancer Research Journal (Volume 11, Issue 2) |
| DOI | 10.11648/j.crj.20231102.12 |
| Page(s) | 44-48 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2023. Published by Science Publishing Group |
Ferroptosis, Glioma, Therapeutic Target, Molecular Mechanism
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APA Style
Xiaohui Han, Shihua Liu, Sen Yang, Aixia Sui. (2023). Research Progress on the Mechanism and Treatment of Ferroptosis in Brain Glioma. Cancer Research Journal, 11(2), 44-48. https://doi.org/10.11648/j.crj.20231102.12
ACS Style
Xiaohui Han; Shihua Liu; Sen Yang; Aixia Sui. Research Progress on the Mechanism and Treatment of Ferroptosis in Brain Glioma. Cancer Res. J. 2023, 11(2), 44-48. doi: 10.11648/j.crj.20231102.12
AMA Style
Xiaohui Han, Shihua Liu, Sen Yang, Aixia Sui. Research Progress on the Mechanism and Treatment of Ferroptosis in Brain Glioma. Cancer Res J. 2023;11(2):44-48. doi: 10.11648/j.crj.20231102.12
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Download@article{10.11648/j.crj.20231102.12,
author = {Xiaohui Han and Shihua Liu and Sen Yang and Aixia Sui},
title = {Research Progress on the Mechanism and Treatment of Ferroptosis in Brain Glioma},
journal = {Cancer Research Journal},
volume = {11},
number = {2},
pages = {44-48},
doi = {10.11648/j.crj.20231102.12},
url = {https://doi.org/10.11648/j.crj.20231102.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20231102.12},
abstract = {Ferroptosis is a new type of programmed cell death discovered in recent years. It is a regulatory cell death induced by iron dependent lipid peroxide injury. Ferroptosis plays a critical role in the development of glioma, affecting tumor proliferation, angiogenesis, tumor cell necrosis, and the formation of an immune-resistant tumor microenvironment. Glioma is the most common intracranial malignant tumor, with the characteristics of high incidence rate, high recurrence rate, high mortality rate and low cure rate. At present, the main standard treatment plan is tumor surgical resection, synchronous radiotherapy and chemotherapy, etc. Because of the extremely low 5-year survival rate and high recurrence rate of glioma patients, new effective treatment strategies are expected. With the extensive study of regulatory cell death in malignant tumors, there is increasing evidence that iron death is closely related to the development and outcome of glioma. Inducing iron death becomes an attractive strategy for glioma treatment. In this paper, we summarize the research on this aspect and summarize it in gelatin. The mechanism of action and therapeutic research value of tumor are expected to develop new therapeutic strategies and provide a certain theoretical basis for the in-depth research in this field.},
year = {2023}
}
TY - JOUR T1 - Research Progress on the Mechanism and Treatment of Ferroptosis in Brain Glioma AU - Xiaohui Han AU - Shihua Liu AU - Sen Yang AU - Aixia Sui Y1 - 2023/05/10 PY - 2023 N1 - https://doi.org/10.11648/j.crj.20231102.12 DO - 10.11648/j.crj.20231102.12 T2 - Cancer Research Journal JF - Cancer Research Journal JO - Cancer Research Journal SP - 44 EP - 48 PB - Science Publishing Group SN - 2330-8214 UR - https://doi.org/10.11648/j.crj.20231102.12 AB - Ferroptosis is a new type of programmed cell death discovered in recent years. It is a regulatory cell death induced by iron dependent lipid peroxide injury. Ferroptosis plays a critical role in the development of glioma, affecting tumor proliferation, angiogenesis, tumor cell necrosis, and the formation of an immune-resistant tumor microenvironment. Glioma is the most common intracranial malignant tumor, with the characteristics of high incidence rate, high recurrence rate, high mortality rate and low cure rate. At present, the main standard treatment plan is tumor surgical resection, synchronous radiotherapy and chemotherapy, etc. Because of the extremely low 5-year survival rate and high recurrence rate of glioma patients, new effective treatment strategies are expected. With the extensive study of regulatory cell death in malignant tumors, there is increasing evidence that iron death is closely related to the development and outcome of glioma. Inducing iron death becomes an attractive strategy for glioma treatment. In this paper, we summarize the research on this aspect and summarize it in gelatin. The mechanism of action and therapeutic research value of tumor are expected to develop new therapeutic strategies and provide a certain theoretical basis for the in-depth research in this field. VL - 11 IS - 2 ER -
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