Cancer is a leading cause of human deaths worldwide. Besides inherited genetic disorders, a diverse range of physical, chemical and biological agents may induce cancer. About 15-20% of cancers are known to be originated due to pathogens. Viruses are considered to be the second (after smoking) most important risk factor in inducing human cancer. Viruses may either harbour a copy of oncogene or have an ability to alter the expression of cellular copy of the oncogenes. Both RNA and DNA viruses are can induce oncogenesis. Most of the DNA tumour viruses either integrate their genome (complete or part of it) into the host genome or express early genes that are required for early event of virus replication. These early genes are responsible for oncogenic transformation of host cells. Based upon the mechanism involved, oncogenic RNA viruses are divided into two groups-transforming and non-transforming RNA viruses. Transforming RNA viruses carry viral oncogenes that are homologous to the host oncogene, their expression in infected cells results in oncogenic transformation of the cell. Non-transforming RNA viruses induce oncogenesis similar to the DNA viruses. Contrary, oncolytic viruses selectively replicate in cancerous cells and induce cell death without any damage to the normal tissues. Typically, oncolytic viruses are nonpathogenic to humans that can naturally replicate in cancer cells by exploiting oncogenic cell signalling pathways. Pathogenic viruses can also be genetically manipulated which allow them to replicate in cancerous but not in normal cells. This review review describes the molecular mechanisms associated with virus induced oncogenesis and oncolysis.
| Published in | Cancer Research Journal (Volume 7, Issue 3) |
| DOI | 10.11648/j.crj.20190703.13 |
| Page(s) | 87-100 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2019. Published by Science Publishing Group |
Oncogenic, Oncolytic, Virus
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APA Style
Ram Kumar, Riyesh Thachamvally, Sunil Maherchandani, Bhupendra Nath Tripathi, Sanjay Barua, et al. (2019). Molecular Mechanisms Associated with Virus-induced Oncogenesis and Oncolysis. Cancer Research Journal, 7(3), 87-100. https://doi.org/10.11648/j.crj.20190703.13
ACS Style
Ram Kumar; Riyesh Thachamvally; Sunil Maherchandani; Bhupendra Nath Tripathi; Sanjay Barua, et al. Molecular Mechanisms Associated with Virus-induced Oncogenesis and Oncolysis. Cancer Res. J. 2019, 7(3), 87-100. doi: 10.11648/j.crj.20190703.13
AMA Style
Ram Kumar, Riyesh Thachamvally, Sunil Maherchandani, Bhupendra Nath Tripathi, Sanjay Barua, et al. Molecular Mechanisms Associated with Virus-induced Oncogenesis and Oncolysis. Cancer Res J. 2019;7(3):87-100. doi: 10.11648/j.crj.20190703.13
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Download@article{10.11648/j.crj.20190703.13,
author = {Ram Kumar and Riyesh Thachamvally and Sunil Maherchandani and Bhupendra Nath Tripathi and Sanjay Barua and Naveen Kumar},
title = {Molecular Mechanisms Associated with Virus-induced Oncogenesis and Oncolysis},
journal = {Cancer Research Journal},
volume = {7},
number = {3},
pages = {87-100},
doi = {10.11648/j.crj.20190703.13},
url = {https://doi.org/10.11648/j.crj.20190703.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20190703.13},
abstract = {Cancer is a leading cause of human deaths worldwide. Besides inherited genetic disorders, a diverse range of physical, chemical and biological agents may induce cancer. About 15-20% of cancers are known to be originated due to pathogens. Viruses are considered to be the second (after smoking) most important risk factor in inducing human cancer. Viruses may either harbour a copy of oncogene or have an ability to alter the expression of cellular copy of the oncogenes. Both RNA and DNA viruses are can induce oncogenesis. Most of the DNA tumour viruses either integrate their genome (complete or part of it) into the host genome or express early genes that are required for early event of virus replication. These early genes are responsible for oncogenic transformation of host cells. Based upon the mechanism involved, oncogenic RNA viruses are divided into two groups-transforming and non-transforming RNA viruses. Transforming RNA viruses carry viral oncogenes that are homologous to the host oncogene, their expression in infected cells results in oncogenic transformation of the cell. Non-transforming RNA viruses induce oncogenesis similar to the DNA viruses. Contrary, oncolytic viruses selectively replicate in cancerous cells and induce cell death without any damage to the normal tissues. Typically, oncolytic viruses are nonpathogenic to humans that can naturally replicate in cancer cells by exploiting oncogenic cell signalling pathways. Pathogenic viruses can also be genetically manipulated which allow them to replicate in cancerous but not in normal cells. This review review describes the molecular mechanisms associated with virus induced oncogenesis and oncolysis.},
year = {2019}
}
TY - JOUR T1 - Molecular Mechanisms Associated with Virus-induced Oncogenesis and Oncolysis AU - Ram Kumar AU - Riyesh Thachamvally AU - Sunil Maherchandani AU - Bhupendra Nath Tripathi AU - Sanjay Barua AU - Naveen Kumar Y1 - 2019/08/15 PY - 2019 N1 - https://doi.org/10.11648/j.crj.20190703.13 DO - 10.11648/j.crj.20190703.13 T2 - Cancer Research Journal JF - Cancer Research Journal JO - Cancer Research Journal SP - 87 EP - 100 PB - Science Publishing Group SN - 2330-8214 UR - https://doi.org/10.11648/j.crj.20190703.13 AB - Cancer is a leading cause of human deaths worldwide. Besides inherited genetic disorders, a diverse range of physical, chemical and biological agents may induce cancer. About 15-20% of cancers are known to be originated due to pathogens. Viruses are considered to be the second (after smoking) most important risk factor in inducing human cancer. Viruses may either harbour a copy of oncogene or have an ability to alter the expression of cellular copy of the oncogenes. Both RNA and DNA viruses are can induce oncogenesis. Most of the DNA tumour viruses either integrate their genome (complete or part of it) into the host genome or express early genes that are required for early event of virus replication. These early genes are responsible for oncogenic transformation of host cells. Based upon the mechanism involved, oncogenic RNA viruses are divided into two groups-transforming and non-transforming RNA viruses. Transforming RNA viruses carry viral oncogenes that are homologous to the host oncogene, their expression in infected cells results in oncogenic transformation of the cell. Non-transforming RNA viruses induce oncogenesis similar to the DNA viruses. Contrary, oncolytic viruses selectively replicate in cancerous cells and induce cell death without any damage to the normal tissues. Typically, oncolytic viruses are nonpathogenic to humans that can naturally replicate in cancer cells by exploiting oncogenic cell signalling pathways. Pathogenic viruses can also be genetically manipulated which allow them to replicate in cancerous but not in normal cells. This review review describes the molecular mechanisms associated with virus induced oncogenesis and oncolysis. VL - 7 IS - 3 ER -
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