New Targets in Advanced Thyroid Cancer Refractory Iodine

Lynda Marianela Vásconez Proaño

doi:doi:10.11648/j.crj.20190702.12

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New Targets in Advanced Thyroid Cancer Refractory Iodine

Lynda Marianela Vásconez Proaño

Published in Cancer Research Journal (Volume 7, Issue 2)

Received: 24 September 2018 Accepted: 12 October 2018 Published: 22 April 2019

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Abstract

The majority of deaths due to thyroid cancer occur in patients with advanced DTC refractory to radioactive iodine. The spectacular advances in molecular medicine of recent years have opened new therapeutic possibilities. Currently, there is general agreement that treatment with Tyrosine Kinase Inhibitors (TKI) should only be considered in patients with differentiated thyroid carcinoma refractory to radioactive iodine, with progressive and / or symptomatic metastatic disease that can not otherwise be treated locally. Most of these "new molecules" are multichannel inhibitors with varied action, which interact on different proteins such as RET, BRAF, cKIT, MET, EGFR, MAPK, PDGFR, etc. In addition, they have the additional advantage that they markedly prevent angiogenesis by acting on VEGFR 1, 2, and 3. TKI are associated with progression-free survival but not curative. Also, causes adverse effects that can affect the quality of life.The prolongation of progression-free survival has been demonstrated with sorafenib and lenvatinib compared with placebo in two phase III trials. These two drugs have been approved by the FDA and the European Medicines Agency for use in patients refractory to radioactive iodine with metastatic disease. Based on the Phase II Trials there are other Tyrosine Kinase Inhibitors (TKI) available such as sunitinib, axitinib or pazopanib that can produce some kind of clinical benefit and therefore need further investigation.

Published in	Cancer Research Journal (Volume 7, Issue 2)
DOI	10.11648/j.crj.20190702.12
Page(s)	39-44
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Target, Cancer, Thyroid

References

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[3]	Cabanillas Maria E, Amir Habra Mouhammed, Anti-tumour treatment, Lenvatinib : Role in thyroid cancer and other solid tumors, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Cancer Treatment Reviews, Elsevier, 42 (2016) 47-55, doi.org/10.1016/j.ctrv.2015.11.003.
[4]	Nair Abhilasha, Lemery Steven J., Yang Jun et al., FDA Approval Summary: Lenvatinib for Progressive, Radio-iodine–Refractory Differentiated Thyroid Cancer, Clinical Cancer Research, American Association for Cancer Research, 21 (23) December 1, 2015, doi: 10.1158/1078-0432.CCR-15-1377.
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[6]	Thornton Katherine, Kim Geoffrey, Maher V. Ellen et al., Vandetanib for the Treatment of Symptomatic or Progressive Medullary Thyroid Cancer in Patients with Unresectable Locally Advanced or Metastatic Disease: U.S. Food and Drug Administration Drug Approval Summary, CCR Perspectives in Drug Approval, American Association for Cancer Research, Clin Cancer Res; 18 (14) Jun 4, 2012, pages 3722-30 doi: 10.1158/1078-0432.CCR-12-0411.
[7]	Fallahi Poupak, Di Bari Flavia, Ferrari Silvia Martina et al., Selective use of vandetanib in the treatment of thyroid cancer, Drug Design, Development and Therapy, 2015:9 3459–3470, doi.org/10.2147/DDDT.S72495.
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[11]	Brose Marcia S, Nutting Christopher M, Jarzab Barbara et al., Sorafenib in radioactive iodine-refractory, locally advanced or metastatic diﬀerentiated thyroid cancer: a randomised, double-blind, phase 3 trial, www.thelancet.com, Jul 26, 2014, 384 (9940): pages 319-28, doi.org/10.1016/S0140 6736 (14) 60421-9
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APA Style

Lynda Marianela Vásconez Proaño. (2019). New Targets in Advanced Thyroid Cancer Refractory Iodine. Cancer Research Journal, 7(2), 39-44. https://doi.org/10.11648/j.crj.20190702.12

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ACS Style

Lynda Marianela Vásconez Proaño. New Targets in Advanced Thyroid Cancer Refractory Iodine. Cancer Res. J. 2019, 7(2), 39-44. doi: 10.11648/j.crj.20190702.12

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AMA Style

Lynda Marianela Vásconez Proaño. New Targets in Advanced Thyroid Cancer Refractory Iodine. Cancer Res J. 2019;7(2):39-44. doi: 10.11648/j.crj.20190702.12

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@article{10.11648/j.crj.20190702.12,
  author = {Lynda Marianela Vásconez Proaño},
  title = {New Targets in Advanced Thyroid Cancer Refractory Iodine},
  journal = {Cancer Research Journal},
  volume = {7},
  number = {2},
  pages = {39-44},
  doi = {10.11648/j.crj.20190702.12},
  url = {https://doi.org/10.11648/j.crj.20190702.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20190702.12},
  abstract = {The majority of deaths due to thyroid cancer occur in patients with advanced DTC refractory to radioactive iodine. The spectacular advances in molecular medicine of recent years have opened new therapeutic possibilities. Currently, there is general agreement that treatment with Tyrosine Kinase Inhibitors (TKI) should only be considered in patients with differentiated thyroid carcinoma refractory to radioactive iodine, with progressive and / or symptomatic metastatic disease that can not otherwise be treated locally. Most of these "new molecules" are multichannel inhibitors with varied action, which interact on different proteins such as RET, BRAF, cKIT, MET, EGFR, MAPK, PDGFR, etc. In addition, they have the additional advantage that they markedly prevent angiogenesis by acting on VEGFR 1, 2, and 3. TKI are associated with progression-free survival but not curative. Also, causes adverse effects that can affect the quality of life.The prolongation of progression-free survival has been demonstrated with sorafenib and lenvatinib compared with placebo in two phase III trials. These two drugs have been approved by the FDA and the European Medicines Agency for use in patients refractory to radioactive iodine with metastatic disease. Based on the Phase II Trials there are other Tyrosine Kinase Inhibitors (TKI) available such as sunitinib, axitinib or pazopanib that can produce some kind of clinical benefit and therefore need further investigation.},
 year = {2019}
}

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TY  - JOUR
T1  - New Targets in Advanced Thyroid Cancer Refractory Iodine
AU  - Lynda Marianela Vásconez Proaño
Y1  - 2019/04/22
PY  - 2019
N1  - https://doi.org/10.11648/j.crj.20190702.12
DO  - 10.11648/j.crj.20190702.12
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 39
EP  - 44
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20190702.12
AB  - The majority of deaths due to thyroid cancer occur in patients with advanced DTC refractory to radioactive iodine. The spectacular advances in molecular medicine of recent years have opened new therapeutic possibilities. Currently, there is general agreement that treatment with Tyrosine Kinase Inhibitors (TKI) should only be considered in patients with differentiated thyroid carcinoma refractory to radioactive iodine, with progressive and / or symptomatic metastatic disease that can not otherwise be treated locally. Most of these "new molecules" are multichannel inhibitors with varied action, which interact on different proteins such as RET, BRAF, cKIT, MET, EGFR, MAPK, PDGFR, etc. In addition, they have the additional advantage that they markedly prevent angiogenesis by acting on VEGFR 1, 2, and 3. TKI are associated with progression-free survival but not curative. Also, causes adverse effects that can affect the quality of life.The prolongation of progression-free survival has been demonstrated with sorafenib and lenvatinib compared with placebo in two phase III trials. These two drugs have been approved by the FDA and the European Medicines Agency for use in patients refractory to radioactive iodine with metastatic disease. Based on the Phase II Trials there are other Tyrosine Kinase Inhibitors (TKI) available such as sunitinib, axitinib or pazopanib that can produce some kind of clinical benefit and therefore need further investigation.
VL  - 7
IS  - 2
ER  -

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Lynda Marianela Vásconez Proaño

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APA Style

Lynda Marianela Vásconez Proaño. (2019). New Targets in Advanced Thyroid Cancer Refractory Iodine. Cancer Research Journal, 7(2), 39-44. https://doi.org/10.11648/j.crj.20190702.12

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ACS Style

Lynda Marianela Vásconez Proaño. New Targets in Advanced Thyroid Cancer Refractory Iodine. Cancer Res. J. 2019, 7(2), 39-44. doi: 10.11648/j.crj.20190702.12

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AMA Style

Lynda Marianela Vásconez Proaño. New Targets in Advanced Thyroid Cancer Refractory Iodine. Cancer Res J. 2019;7(2):39-44. doi: 10.11648/j.crj.20190702.12

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@article{10.11648/j.crj.20190702.12,
  author = {Lynda Marianela Vásconez Proaño},
  title = {New Targets in Advanced Thyroid Cancer Refractory Iodine},
  journal = {Cancer Research Journal},
  volume = {7},
  number = {2},
  pages = {39-44},
  doi = {10.11648/j.crj.20190702.12},
  url = {https://doi.org/10.11648/j.crj.20190702.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20190702.12},
  abstract = {The majority of deaths due to thyroid cancer occur in patients with advanced DTC refractory to radioactive iodine. The spectacular advances in molecular medicine of recent years have opened new therapeutic possibilities. Currently, there is general agreement that treatment with Tyrosine Kinase Inhibitors (TKI) should only be considered in patients with differentiated thyroid carcinoma refractory to radioactive iodine, with progressive and / or symptomatic metastatic disease that can not otherwise be treated locally. Most of these "new molecules" are multichannel inhibitors with varied action, which interact on different proteins such as RET, BRAF, cKIT, MET, EGFR, MAPK, PDGFR, etc. In addition, they have the additional advantage that they markedly prevent angiogenesis by acting on VEGFR 1, 2, and 3. TKI are associated with progression-free survival but not curative. Also, causes adverse effects that can affect the quality of life.The prolongation of progression-free survival has been demonstrated with sorafenib and lenvatinib compared with placebo in two phase III trials. These two drugs have been approved by the FDA and the European Medicines Agency for use in patients refractory to radioactive iodine with metastatic disease. Based on the Phase II Trials there are other Tyrosine Kinase Inhibitors (TKI) available such as sunitinib, axitinib or pazopanib that can produce some kind of clinical benefit and therefore need further investigation.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - New Targets in Advanced Thyroid Cancer Refractory Iodine
AU  - Lynda Marianela Vásconez Proaño
Y1  - 2019/04/22
PY  - 2019
N1  - https://doi.org/10.11648/j.crj.20190702.12
DO  - 10.11648/j.crj.20190702.12
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 39
EP  - 44
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20190702.12
AB  - The majority of deaths due to thyroid cancer occur in patients with advanced DTC refractory to radioactive iodine. The spectacular advances in molecular medicine of recent years have opened new therapeutic possibilities. Currently, there is general agreement that treatment with Tyrosine Kinase Inhibitors (TKI) should only be considered in patients with differentiated thyroid carcinoma refractory to radioactive iodine, with progressive and / or symptomatic metastatic disease that can not otherwise be treated locally. Most of these "new molecules" are multichannel inhibitors with varied action, which interact on different proteins such as RET, BRAF, cKIT, MET, EGFR, MAPK, PDGFR, etc. In addition, they have the additional advantage that they markedly prevent angiogenesis by acting on VEGFR 1, 2, and 3. TKI are associated with progression-free survival but not curative. Also, causes adverse effects that can affect the quality of life.The prolongation of progression-free survival has been demonstrated with sorafenib and lenvatinib compared with placebo in two phase III trials. These two drugs have been approved by the FDA and the European Medicines Agency for use in patients refractory to radioactive iodine with metastatic disease. Based on the Phase II Trials there are other Tyrosine Kinase Inhibitors (TKI) available such as sunitinib, axitinib or pazopanib that can produce some kind of clinical benefit and therefore need further investigation.
VL  - 7
IS  - 2
ER  -

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