Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells

Torricelli Piera; Ferorelli Pasquale; Shevchenko Anna; Antonelli Francesco; Siciliano Alberto; De Martino Angelo; Beninati Simone

doi:doi:10.11648/j.crj.20160405.11

Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells

Torricelli Piera, Ferorelli Pasquale, Shevchenko Anna, Antonelli Francesco, Siciliano Alberto, De Martino Angelo, Beninati Simone

Published in Cancer Research Journal (Volume 4, Issue 5)

Received: 4 August 2016 Accepted: 26 August 2016 Published: 21 September 2016

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Abstract

Administration of the chemotherapeutic agent by organ perfusion is more effective than the systemic administration. The active drug is reached by the tumor, to a higher concentration, and normal tissues are spared from major damages. The perfusion of various areas of the body is a recent goal of the experimental and clinical trials. Fatal malignancies observed in humans occur mainly in the abdominal area of the body, The development of a clinically applicable technique for the perfusion of this area is desirable. This report covers the laboratory studies, carried out in the development of a liver perfusion technique for chemotherapy. The results obtained have allowed us to highlight that, the potential anticancer activity of Citozym, a micronutrients supplement, is likely the result of the inhibition of oxidative stress. This work is the preliminary evidence, of the possible mechanism by which Citozym exerts its antineoplastic activity.

Published in	Cancer Research Journal (Volume 4, Issue 5)
DOI	10.11648/j.crj.20160405.11
Page(s)	69-72
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Antioxidants, Organ Perfusion, Oxidative Stress, Micronutrients, HCC, Hepatocarcinoma

References

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APA Style

Torricelli Piera, Ferorelli Pasquale, Shevchenko Anna, Antonelli Francesco, Siciliano Alberto, et al. (2016). Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells. Cancer Research Journal, 4(5), 69-72. https://doi.org/10.11648/j.crj.20160405.11

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ACS Style

Torricelli Piera; Ferorelli Pasquale; Shevchenko Anna; Antonelli Francesco; Siciliano Alberto, et al. Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells. Cancer Res. J. 2016, 4(5), 69-72. doi: 10.11648/j.crj.20160405.11

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AMA Style

Torricelli Piera, Ferorelli Pasquale, Shevchenko Anna, Antonelli Francesco, Siciliano Alberto, et al. Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells. Cancer Res J. 2016;4(5):69-72. doi: 10.11648/j.crj.20160405.11

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@article{10.11648/j.crj.20160405.11,
  author = {Torricelli Piera and Ferorelli Pasquale and Shevchenko Anna and Antonelli Francesco and Siciliano Alberto and De Martino Angelo and Beninati Simone},
  title = {Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells},
  journal = {Cancer Research Journal},
  volume = {4},
  number = {5},
  pages = {69-72},
  doi = {10.11648/j.crj.20160405.11},
  url = {https://doi.org/10.11648/j.crj.20160405.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20160405.11},
  abstract = {Administration of the chemotherapeutic agent by organ perfusion is more effective than the systemic administration. The active drug is reached by the tumor, to a higher concentration, and normal tissues are spared from major damages. The perfusion of various areas of the body is a recent goal of the experimental and clinical trials. Fatal malignancies observed in humans occur mainly in the abdominal area of the body, The development of a clinically applicable technique for the perfusion of this area is desirable. This report covers the laboratory studies, carried out in the development of a liver perfusion technique for chemotherapy. The results obtained have allowed us to highlight that, the potential anticancer activity of Citozym, a micronutrients supplement, is likely the result of the inhibition of oxidative stress. This work is the preliminary evidence, of the possible mechanism by which Citozym exerts its antineoplastic activity.},
 year = {2016}
}

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TY  - JOUR
T1  - Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells
AU  - Torricelli Piera
AU  - Ferorelli Pasquale
AU  - Shevchenko Anna
AU  - Antonelli Francesco
AU  - Siciliano Alberto
AU  - De Martino Angelo
AU  - Beninati Simone
Y1  - 2016/09/21
PY  - 2016
N1  - https://doi.org/10.11648/j.crj.20160405.11
DO  - 10.11648/j.crj.20160405.11
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 69
EP  - 72
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20160405.11
AB  - Administration of the chemotherapeutic agent by organ perfusion is more effective than the systemic administration. The active drug is reached by the tumor, to a higher concentration, and normal tissues are spared from major damages. The perfusion of various areas of the body is a recent goal of the experimental and clinical trials. Fatal malignancies observed in humans occur mainly in the abdominal area of the body, The development of a clinically applicable technique for the perfusion of this area is desirable. This report covers the laboratory studies, carried out in the development of a liver perfusion technique for chemotherapy. The results obtained have allowed us to highlight that, the potential anticancer activity of Citozym, a micronutrients supplement, is likely the result of the inhibition of oxidative stress. This work is the preliminary evidence, of the possible mechanism by which Citozym exerts its antineoplastic activity.
VL  - 4
IS  - 5
ER  -

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Author Information

Torricelli Piera

Department SPES, University of Molise, Campobasso, Italy
Ferorelli Pasquale

University of Tor Vergata, Department of Biology, Rome, Italy
Shevchenko Anna

People’s Friendship University of Russia, Moscow, Russia
Antonelli Francesco

University of Tor Vergata, Department of Biology, Rome, Italy
Siciliano Alberto

University of Tor Vergata, Department of Biology, Rome, Italy
De Martino Angelo

University of Tor Vergata, Department of Biology, Rome, Italy
Beninati Simone

University of Tor Vergata, Department of Biology, Rome, Italy

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Plain Text BibTeX RIS

APA Style

Torricelli Piera, Ferorelli Pasquale, Shevchenko Anna, Antonelli Francesco, Siciliano Alberto, et al. (2016). Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells. Cancer Research Journal, 4(5), 69-72. https://doi.org/10.11648/j.crj.20160405.11

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ACS Style

Torricelli Piera; Ferorelli Pasquale; Shevchenko Anna; Antonelli Francesco; Siciliano Alberto, et al. Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells. Cancer Res. J. 2016, 4(5), 69-72. doi: 10.11648/j.crj.20160405.11

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AMA Style

Torricelli Piera, Ferorelli Pasquale, Shevchenko Anna, Antonelli Francesco, Siciliano Alberto, et al. Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells. Cancer Res J. 2016;4(5):69-72. doi: 10.11648/j.crj.20160405.11

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@article{10.11648/j.crj.20160405.11,
  author = {Torricelli Piera and Ferorelli Pasquale and Shevchenko Anna and Antonelli Francesco and Siciliano Alberto and De Martino Angelo and Beninati Simone},
  title = {Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells},
  journal = {Cancer Research Journal},
  volume = {4},
  number = {5},
  pages = {69-72},
  doi = {10.11648/j.crj.20160405.11},
  url = {https://doi.org/10.11648/j.crj.20160405.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20160405.11},
  abstract = {Administration of the chemotherapeutic agent by organ perfusion is more effective than the systemic administration. The active drug is reached by the tumor, to a higher concentration, and normal tissues are spared from major damages. The perfusion of various areas of the body is a recent goal of the experimental and clinical trials. Fatal malignancies observed in humans occur mainly in the abdominal area of the body, The development of a clinically applicable technique for the perfusion of this area is desirable. This report covers the laboratory studies, carried out in the development of a liver perfusion technique for chemotherapy. The results obtained have allowed us to highlight that, the potential anticancer activity of Citozym, a micronutrients supplement, is likely the result of the inhibition of oxidative stress. This work is the preliminary evidence, of the possible mechanism by which Citozym exerts its antineoplastic activity.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells
AU  - Torricelli Piera
AU  - Ferorelli Pasquale
AU  - Shevchenko Anna
AU  - Antonelli Francesco
AU  - Siciliano Alberto
AU  - De Martino Angelo
AU  - Beninati Simone
Y1  - 2016/09/21
PY  - 2016
N1  - https://doi.org/10.11648/j.crj.20160405.11
DO  - 10.11648/j.crj.20160405.11
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 69
EP  - 72
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20160405.11
AB  - Administration of the chemotherapeutic agent by organ perfusion is more effective than the systemic administration. The active drug is reached by the tumor, to a higher concentration, and normal tissues are spared from major damages. The perfusion of various areas of the body is a recent goal of the experimental and clinical trials. Fatal malignancies observed in humans occur mainly in the abdominal area of the body, The development of a clinically applicable technique for the perfusion of this area is desirable. This report covers the laboratory studies, carried out in the development of a liver perfusion technique for chemotherapy. The results obtained have allowed us to highlight that, the potential anticancer activity of Citozym, a micronutrients supplement, is likely the result of the inhibition of oxidative stress. This work is the preliminary evidence, of the possible mechanism by which Citozym exerts its antineoplastic activity.
VL  - 4
IS  - 5
ER  -

Copy | Download