Background: During the last two decades, research about GATA-3, Ki-67, p53 expressions have been done, but it is still a debate on their use in predicting breast cancer patients’ prognosis and survival rate. Expressions of GATA-3 decreased with increasing of histopathology grading of breast cancer and increase with decrease of histopathology grading of breast cancer. The level expression of Ki-67 has a positive relation with breast cancer histopathology grading. p53 has no correlation with high grade differentiation of breast cancer. p53 is a transcription factor which is activated as a part of cellular stress response that can regulate genes’ cellular process, including apoptosis and senescence. Aim: To determine correlation between expressions of GATA 3, Ki-67 and p53 with histopathology grading of breast cancer in Makassar, Indonesia. Methods: Antibody monoclonal GATA 3, Ki-67 and p53 on the nucleus cell were detected with immunohistochemistry method. The positive and negative expressions of GATA 3, Ki-67 and p53 were assessed using scoring system according to the proportion of positive cell and coloring intensities. Results: There is no correlation between the higher positive expression ofp53 and higher expression of histopathology grading of breast cancer (P = 0.089). While Ki-67 had positive association with higher grade malignancy (P = 0.03). However, there was no association between GATA-3 expression and histopathology grading. Conclusion: In our research we found there is no correlation between higher expression of p53 and low expression of GATA-3 with higher histopathology grading of breast cancer. High expression of Ki-67 have significantly statistic analysis with high expression of histopathology grading of mammary cancer.
| Published in | Cancer Research Journal (Volume 4, Issue 3) |
| DOI | 10.11648/j.crj.20160403.11 |
| Page(s) | 43-47 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2016. Published by Science Publishing Group |
GATA-3, p53 and Ki-67, Histopathology Grading, Breast Cancer
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APA Style
Syarif Ibrahim, Rosdiana Natzir, Andi Asadul Islam, Tjakra Manuaba, A. Benyamin Fachruddin, et al. (2016). Correlation Between GATA-3, Ki67 and p53 Expressions to Histopathology Grading of Breast Cancer in Makassar, Indonesia. Cancer Research Journal, 4(3), 43-47. https://doi.org/10.11648/j.crj.20160403.11
ACS Style
Syarif Ibrahim; Rosdiana Natzir; Andi Asadul Islam; Tjakra Manuaba; A. Benyamin Fachruddin, et al. Correlation Between GATA-3, Ki67 and p53 Expressions to Histopathology Grading of Breast Cancer in Makassar, Indonesia. Cancer Res. J. 2016, 4(3), 43-47. doi: 10.11648/j.crj.20160403.11
AMA Style
Syarif Ibrahim, Rosdiana Natzir, Andi Asadul Islam, Tjakra Manuaba, A. Benyamin Fachruddin, et al. Correlation Between GATA-3, Ki67 and p53 Expressions to Histopathology Grading of Breast Cancer in Makassar, Indonesia. Cancer Res J. 2016;4(3):43-47. doi: 10.11648/j.crj.20160403.11
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Download@article{10.11648/j.crj.20160403.11,
author = {Syarif Ibrahim and Rosdiana Natzir and Andi Asadul Islam and Tjakra Manuaba and A. Benyamin Fachruddin and Burhanuddin Bahar and William Hamdani and Husni Cangara and Mochammad Hatta},
title = {Correlation Between GATA-3, Ki67 and p53 Expressions to Histopathology Grading of Breast Cancer in Makassar, Indonesia},
journal = {Cancer Research Journal},
volume = {4},
number = {3},
pages = {43-47},
doi = {10.11648/j.crj.20160403.11},
url = {https://doi.org/10.11648/j.crj.20160403.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20160403.11},
abstract = {Background: During the last two decades, research about GATA-3, Ki-67, p53 expressions have been done, but it is still a debate on their use in predicting breast cancer patients’ prognosis and survival rate. Expressions of GATA-3 decreased with increasing of histopathology grading of breast cancer and increase with decrease of histopathology grading of breast cancer. The level expression of Ki-67 has a positive relation with breast cancer histopathology grading. p53 has no correlation with high grade differentiation of breast cancer. p53 is a transcription factor which is activated as a part of cellular stress response that can regulate genes’ cellular process, including apoptosis and senescence. Aim: To determine correlation between expressions of GATA 3, Ki-67 and p53 with histopathology grading of breast cancer in Makassar, Indonesia. Methods: Antibody monoclonal GATA 3, Ki-67 and p53 on the nucleus cell were detected with immunohistochemistry method. The positive and negative expressions of GATA 3, Ki-67 and p53 were assessed using scoring system according to the proportion of positive cell and coloring intensities. Results: There is no correlation between the higher positive expression ofp53 and higher expression of histopathology grading of breast cancer (P = 0.089). While Ki-67 had positive association with higher grade malignancy (P = 0.03). However, there was no association between GATA-3 expression and histopathology grading. Conclusion: In our research we found there is no correlation between higher expression of p53 and low expression of GATA-3 with higher histopathology grading of breast cancer. High expression of Ki-67 have significantly statistic analysis with high expression of histopathology grading of mammary cancer.},
year = {2016}
}
TY - JOUR T1 - Correlation Between GATA-3, Ki67 and p53 Expressions to Histopathology Grading of Breast Cancer in Makassar, Indonesia AU - Syarif Ibrahim AU - Rosdiana Natzir AU - Andi Asadul Islam AU - Tjakra Manuaba AU - A. Benyamin Fachruddin AU - Burhanuddin Bahar AU - William Hamdani AU - Husni Cangara AU - Mochammad Hatta Y1 - 2016/04/01 PY - 2016 N1 - https://doi.org/10.11648/j.crj.20160403.11 DO - 10.11648/j.crj.20160403.11 T2 - Cancer Research Journal JF - Cancer Research Journal JO - Cancer Research Journal SP - 43 EP - 47 PB - Science Publishing Group SN - 2330-8214 UR - https://doi.org/10.11648/j.crj.20160403.11 AB - Background: During the last two decades, research about GATA-3, Ki-67, p53 expressions have been done, but it is still a debate on their use in predicting breast cancer patients’ prognosis and survival rate. Expressions of GATA-3 decreased with increasing of histopathology grading of breast cancer and increase with decrease of histopathology grading of breast cancer. The level expression of Ki-67 has a positive relation with breast cancer histopathology grading. p53 has no correlation with high grade differentiation of breast cancer. p53 is a transcription factor which is activated as a part of cellular stress response that can regulate genes’ cellular process, including apoptosis and senescence. Aim: To determine correlation between expressions of GATA 3, Ki-67 and p53 with histopathology grading of breast cancer in Makassar, Indonesia. Methods: Antibody monoclonal GATA 3, Ki-67 and p53 on the nucleus cell were detected with immunohistochemistry method. The positive and negative expressions of GATA 3, Ki-67 and p53 were assessed using scoring system according to the proportion of positive cell and coloring intensities. Results: There is no correlation between the higher positive expression ofp53 and higher expression of histopathology grading of breast cancer (P = 0.089). While Ki-67 had positive association with higher grade malignancy (P = 0.03). However, there was no association between GATA-3 expression and histopathology grading. Conclusion: In our research we found there is no correlation between higher expression of p53 and low expression of GATA-3 with higher histopathology grading of breast cancer. High expression of Ki-67 have significantly statistic analysis with high expression of histopathology grading of mammary cancer. VL - 4 IS - 3 ER -
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