The Benefit of Locoregional Surgical Intervention in Metastatic Breast Cancer at Initial Presentation

Niveen A. Abo-Touk; Amir A. Fikry; El Yamani Fouda

doi:doi:10.11648/j.crj.20160402.12

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The Benefit of Locoregional Surgical Intervention in Metastatic Breast Cancer at Initial Presentation

Niveen A. Abo-Touk, Amir A. Fikry, El Yamani Fouda

Published in Cancer Research Journal (Volume 4, Issue 2)

Received: 19 February 2016 Accepted: 28 February 2016 Published: 12 March 2016

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Abstract

This study aims to determine the value of locoregional surgery compared with no surgery on the outcome of women with metastatic breast cancer at initial presentation. For that, fifty seven patients initially presented with stage IV breast cancer were prospectively randomized to undergo mastectomy in group I (27 patients) or no surgery in group II (30 patients). All patients received systemic treatment including chemotherapy, hormonal treatment in receptor positive patients and palliative radiotherapy for patients with bone metastases .The median overall survival (OS) was 18 and 11 months in group I and II, respectively; however the difference did not reach statistical significant (p=0.085). The 2-year OS was 46% in group I and 22% in group II. Tumor size, clinical lymph node stage, Eastern Cooperative Oncology Group Performance Status (ECOG- PS) and the number of metastatic sites were significant independent prognostic factors affecting the OS in univariate analysis, and bone metastases was highly statistically significant. In multivariate analysis ECOG- PS was a significant factor and both the number of metastatic sites and bone metastases were highly significant. Although, locoregional surgery tends to increase overall survival in patients presented with metastatic breast cancer and patients with better ECOG- PS and single bone metastasis are more likely to benefit from surgery, further studies are needed involving a large number of cases, multi-institutional trials and longer follow-up to verify these findings.

Published in	Cancer Research Journal (Volume 4, Issue 2)
DOI	10.11648/j.crj.20160402.12
Page(s)	32-36
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Breast Cancer, Metastasis, Locoregional Treatment, Surgery

References

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APA Style

Niveen A. Abo-Touk, Amir A. Fikry, El Yamani Fouda. (2016). The Benefit of Locoregional Surgical Intervention in Metastatic Breast Cancer at Initial Presentation. Cancer Research Journal, 4(2), 32-36. https://doi.org/10.11648/j.crj.20160402.12

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ACS Style

Niveen A. Abo-Touk; Amir A. Fikry; El Yamani Fouda. The Benefit of Locoregional Surgical Intervention in Metastatic Breast Cancer at Initial Presentation. Cancer Res. J. 2016, 4(2), 32-36. doi: 10.11648/j.crj.20160402.12

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AMA Style

Niveen A. Abo-Touk, Amir A. Fikry, El Yamani Fouda. The Benefit of Locoregional Surgical Intervention in Metastatic Breast Cancer at Initial Presentation. Cancer Res J. 2016;4(2):32-36. doi: 10.11648/j.crj.20160402.12

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@article{10.11648/j.crj.20160402.12,
  author = {Niveen A. Abo-Touk and Amir A. Fikry and El Yamani Fouda},
  title = {The Benefit of Locoregional Surgical Intervention in Metastatic Breast Cancer at Initial Presentation},
  journal = {Cancer Research Journal},
  volume = {4},
  number = {2},
  pages = {32-36},
  doi = {10.11648/j.crj.20160402.12},
  url = {https://doi.org/10.11648/j.crj.20160402.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20160402.12},
  abstract = {This study aims to determine the value of locoregional surgery compared with no surgery on the outcome of women with metastatic breast cancer at initial presentation. For that, fifty seven patients initially presented with stage IV breast cancer were prospectively randomized to undergo mastectomy in group I (27 patients) or no surgery in group II (30 patients). All patients received systemic treatment including chemotherapy, hormonal treatment in receptor positive patients and palliative radiotherapy for patients with bone metastases .The median overall survival (OS) was 18 and 11 months in group I and II, respectively; however the difference did not reach statistical significant (p=0.085). The 2-year OS was 46% in group I and 22% in group II. Tumor size, clinical lymph node stage, Eastern Cooperative Oncology Group Performance Status (ECOG- PS) and the number of metastatic sites were significant independent prognostic factors affecting the OS in univariate analysis, and bone metastases was highly statistically significant. In multivariate analysis ECOG- PS was a significant factor and both the number of metastatic sites and bone metastases were highly significant. Although, locoregional surgery tends to increase overall survival in patients presented with metastatic breast cancer and patients with better ECOG- PS and single bone metastasis are more likely to benefit from surgery, further studies are needed involving a large number of cases, multi-institutional trials and longer follow-up to verify these findings.},
 year = {2016}
}

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TY  - JOUR
T1  - The Benefit of Locoregional Surgical Intervention in Metastatic Breast Cancer at Initial Presentation
AU  - Niveen A. Abo-Touk
AU  - Amir A. Fikry
AU  - El Yamani Fouda
Y1  - 2016/03/12
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DO  - 10.11648/j.crj.20160402.12
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
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PB  - Science Publishing Group
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AB  - This study aims to determine the value of locoregional surgery compared with no surgery on the outcome of women with metastatic breast cancer at initial presentation. For that, fifty seven patients initially presented with stage IV breast cancer were prospectively randomized to undergo mastectomy in group I (27 patients) or no surgery in group II (30 patients). All patients received systemic treatment including chemotherapy, hormonal treatment in receptor positive patients and palliative radiotherapy for patients with bone metastases .The median overall survival (OS) was 18 and 11 months in group I and II, respectively; however the difference did not reach statistical significant (p=0.085). The 2-year OS was 46% in group I and 22% in group II. Tumor size, clinical lymph node stage, Eastern Cooperative Oncology Group Performance Status (ECOG- PS) and the number of metastatic sites were significant independent prognostic factors affecting the OS in univariate analysis, and bone metastases was highly statistically significant. In multivariate analysis ECOG- PS was a significant factor and both the number of metastatic sites and bone metastases were highly significant. Although, locoregional surgery tends to increase overall survival in patients presented with metastatic breast cancer and patients with better ECOG- PS and single bone metastasis are more likely to benefit from surgery, further studies are needed involving a large number of cases, multi-institutional trials and longer follow-up to verify these findings.
VL  - 4
IS  - 2
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Author Information

Niveen A. Abo-Touk

Department of Clinical Oncology & Nuclear Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Amir A. Fikry

Departement of General Surgery, Faculty of Medicine, Mansoura University, Mansoura, Egypt
El Yamani Fouda

Departement of General Surgery, Faculty of Medicine, Mansoura University, Mansoura, Egypt

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APA Style

Niveen A. Abo-Touk, Amir A. Fikry, El Yamani Fouda. (2016). The Benefit of Locoregional Surgical Intervention in Metastatic Breast Cancer at Initial Presentation. Cancer Research Journal, 4(2), 32-36. https://doi.org/10.11648/j.crj.20160402.12

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ACS Style

Niveen A. Abo-Touk; Amir A. Fikry; El Yamani Fouda. The Benefit of Locoregional Surgical Intervention in Metastatic Breast Cancer at Initial Presentation. Cancer Res. J. 2016, 4(2), 32-36. doi: 10.11648/j.crj.20160402.12

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AMA Style

Niveen A. Abo-Touk, Amir A. Fikry, El Yamani Fouda. The Benefit of Locoregional Surgical Intervention in Metastatic Breast Cancer at Initial Presentation. Cancer Res J. 2016;4(2):32-36. doi: 10.11648/j.crj.20160402.12

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@article{10.11648/j.crj.20160402.12,
  author = {Niveen A. Abo-Touk and Amir A. Fikry and El Yamani Fouda},
  title = {The Benefit of Locoregional Surgical Intervention in Metastatic Breast Cancer at Initial Presentation},
  journal = {Cancer Research Journal},
  volume = {4},
  number = {2},
  pages = {32-36},
  doi = {10.11648/j.crj.20160402.12},
  url = {https://doi.org/10.11648/j.crj.20160402.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20160402.12},
  abstract = {This study aims to determine the value of locoregional surgery compared with no surgery on the outcome of women with metastatic breast cancer at initial presentation. For that, fifty seven patients initially presented with stage IV breast cancer were prospectively randomized to undergo mastectomy in group I (27 patients) or no surgery in group II (30 patients). All patients received systemic treatment including chemotherapy, hormonal treatment in receptor positive patients and palliative radiotherapy for patients with bone metastases .The median overall survival (OS) was 18 and 11 months in group I and II, respectively; however the difference did not reach statistical significant (p=0.085). The 2-year OS was 46% in group I and 22% in group II. Tumor size, clinical lymph node stage, Eastern Cooperative Oncology Group Performance Status (ECOG- PS) and the number of metastatic sites were significant independent prognostic factors affecting the OS in univariate analysis, and bone metastases was highly statistically significant. In multivariate analysis ECOG- PS was a significant factor and both the number of metastatic sites and bone metastases were highly significant. Although, locoregional surgery tends to increase overall survival in patients presented with metastatic breast cancer and patients with better ECOG- PS and single bone metastasis are more likely to benefit from surgery, further studies are needed involving a large number of cases, multi-institutional trials and longer follow-up to verify these findings.},
 year = {2016}
}

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TY  - JOUR
T1  - The Benefit of Locoregional Surgical Intervention in Metastatic Breast Cancer at Initial Presentation
AU  - Niveen A. Abo-Touk
AU  - Amir A. Fikry
AU  - El Yamani Fouda
Y1  - 2016/03/12
PY  - 2016
N1  - https://doi.org/10.11648/j.crj.20160402.12
DO  - 10.11648/j.crj.20160402.12
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 32
EP  - 36
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20160402.12
AB  - This study aims to determine the value of locoregional surgery compared with no surgery on the outcome of women with metastatic breast cancer at initial presentation. For that, fifty seven patients initially presented with stage IV breast cancer were prospectively randomized to undergo mastectomy in group I (27 patients) or no surgery in group II (30 patients). All patients received systemic treatment including chemotherapy, hormonal treatment in receptor positive patients and palliative radiotherapy for patients with bone metastases .The median overall survival (OS) was 18 and 11 months in group I and II, respectively; however the difference did not reach statistical significant (p=0.085). The 2-year OS was 46% in group I and 22% in group II. Tumor size, clinical lymph node stage, Eastern Cooperative Oncology Group Performance Status (ECOG- PS) and the number of metastatic sites were significant independent prognostic factors affecting the OS in univariate analysis, and bone metastases was highly statistically significant. In multivariate analysis ECOG- PS was a significant factor and both the number of metastatic sites and bone metastases were highly significant. Although, locoregional surgery tends to increase overall survival in patients presented with metastatic breast cancer and patients with better ECOG- PS and single bone metastasis are more likely to benefit from surgery, further studies are needed involving a large number of cases, multi-institutional trials and longer follow-up to verify these findings.
VL  - 4
IS  - 2
ER  -

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