,
Mirza Mohammad Nazmus Saquib,
Syed Golam Azam,
Md. Arif Ullah Bhuiyan,
Arif Ahmed Mohiuddin,
Md. Shadequl,
Chowdhury Mohammad Mosabber Rahman,
Musarat Jahan,
Nazneen Nawal
Background: Sternal wound infection (SWI) remains a serious postoperative complication following coronary artery bypass grafting (CABG), contributing to increased morbidity, prolonged hospitalization and healthcare costs. The use of topical vancomycin powder has emerged as a potential strategy to reduce surgical site infections in cardiac surgery. This study aimed to evaluate the effectiveness of topical vancomycin in preventing SWI among Bangladeshi patients undergoing isolated CABG. Methods: This prospective comparative study was conducted at the Department of Cardiac Surgery, United Hospital Limited, Dhaka, Bangladesh, from January 2025 to June 2025. A total of 400 patients undergoing isolated CABG were enrolled and divided into two equal groups: the control group (n = 200) received standard antibiotic prophylaxis, while the other group received vancomycin group (n = 200). Postoperative outcomes, including incidence and microbiology of SWI, ICU stay, hospital stay and 30-day morbidity and mortality, were analyzed. Results: The overall incidence of SWI was significantly lower in the vancomycin group (3.0%) compared to the control group (9.0%, p = 0.01). Staphylococcus aureus (both methicillin-sensitive and MRSA) was the predominant pathogen. The vancomycin group showed significantly shorter ICU (3.2 ± 1.6 vs. 3.8 ± 2.1 days, p = 0.01) and hospital stays (9.8 ± 4.3 vs. 12.4 ± 6.5 days, p < 0.001), with lower morbidity rates. Conclusion: Topical vancomycin application effectively reduces the incidence of sternal wound infection and shortens postoperative recovery time without increasing adverse outcomes among Bangladeshi CABG patients.
| Published in | Cardiology and Cardiovascular Research (Volume 9, Issue 4) |
| DOI | 10.11648/j.ccr.20250904.19 |
| Page(s) | 172-178 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2025. Published by Science Publishing Group |
Coronary Artery Bypass Grafting, Sternal Wound Infection, Topical Vancomycin, Postoperative Outcomes
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APA Style
Shanta, T. N., Saquib, M. M. N., Azam, S. G., Bhuiyan, M. A. U., Mohiuddin, A. A., et al. (2025). Role of Topical Vancomycin in Preventing Sternal Wound Infection Following Coronary Artery Bypass Grafting. Cardiology and Cardiovascular Research, 9(4), 172-178. https://doi.org/10.11648/j.ccr.20250904.19
ACS Style
Shanta, T. N.; Saquib, M. M. N.; Azam, S. G.; Bhuiyan, M. A. U.; Mohiuddin, A. A., et al. Role of Topical Vancomycin in Preventing Sternal Wound Infection Following Coronary Artery Bypass Grafting. Cardiol. Cardiovasc. Res. 2025, 9(4), 172-178. doi: 10.11648/j.ccr.20250904.19
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Download@article{10.11648/j.ccr.20250904.19,
author = {Tania Nusrat Shanta and Mirza Mohammad Nazmus Saquib and Syed Golam Azam and Md. Arif Ullah Bhuiyan and Arif Ahmed Mohiuddin and Md. Shadequl and Chowdhury Mohammad Mosabber Rahman and Musarat Jahan and Nazneen Nawal},
title = {Role of Topical Vancomycin in Preventing Sternal Wound Infection Following Coronary Artery Bypass Grafting},
journal = {Cardiology and Cardiovascular Research},
volume = {9},
number = {4},
pages = {172-178},
doi = {10.11648/j.ccr.20250904.19},
url = {https://doi.org/10.11648/j.ccr.20250904.19},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20250904.19},
abstract = {Background: Sternal wound infection (SWI) remains a serious postoperative complication following coronary artery bypass grafting (CABG), contributing to increased morbidity, prolonged hospitalization and healthcare costs. The use of topical vancomycin powder has emerged as a potential strategy to reduce surgical site infections in cardiac surgery. This study aimed to evaluate the effectiveness of topical vancomycin in preventing SWI among Bangladeshi patients undergoing isolated CABG. Methods: This prospective comparative study was conducted at the Department of Cardiac Surgery, United Hospital Limited, Dhaka, Bangladesh, from January 2025 to June 2025. A total of 400 patients undergoing isolated CABG were enrolled and divided into two equal groups: the control group (n = 200) received standard antibiotic prophylaxis, while the other group received vancomycin group (n = 200). Postoperative outcomes, including incidence and microbiology of SWI, ICU stay, hospital stay and 30-day morbidity and mortality, were analyzed. Results: The overall incidence of SWI was significantly lower in the vancomycin group (3.0%) compared to the control group (9.0%, p = 0.01). Staphylococcus aureus (both methicillin-sensitive and MRSA) was the predominant pathogen. The vancomycin group showed significantly shorter ICU (3.2 ± 1.6 vs. 3.8 ± 2.1 days, p = 0.01) and hospital stays (9.8 ± 4.3 vs. 12.4 ± 6.5 days, p Conclusion: Topical vancomycin application effectively reduces the incidence of sternal wound infection and shortens postoperative recovery time without increasing adverse outcomes among Bangladeshi CABG patients.},
year = {2025}
}
TY - JOUR T1 - Role of Topical Vancomycin in Preventing Sternal Wound Infection Following Coronary Artery Bypass Grafting AU - Tania Nusrat Shanta AU - Mirza Mohammad Nazmus Saquib AU - Syed Golam Azam AU - Md. Arif Ullah Bhuiyan AU - Arif Ahmed Mohiuddin AU - Md. Shadequl AU - Chowdhury Mohammad Mosabber Rahman AU - Musarat Jahan AU - Nazneen Nawal Y1 - 2025/12/17 PY - 2025 N1 - https://doi.org/10.11648/j.ccr.20250904.19 DO - 10.11648/j.ccr.20250904.19 T2 - Cardiology and Cardiovascular Research JF - Cardiology and Cardiovascular Research JO - Cardiology and Cardiovascular Research SP - 172 EP - 178 PB - Science Publishing Group SN - 2578-8914 UR - https://doi.org/10.11648/j.ccr.20250904.19 AB - Background: Sternal wound infection (SWI) remains a serious postoperative complication following coronary artery bypass grafting (CABG), contributing to increased morbidity, prolonged hospitalization and healthcare costs. The use of topical vancomycin powder has emerged as a potential strategy to reduce surgical site infections in cardiac surgery. This study aimed to evaluate the effectiveness of topical vancomycin in preventing SWI among Bangladeshi patients undergoing isolated CABG. Methods: This prospective comparative study was conducted at the Department of Cardiac Surgery, United Hospital Limited, Dhaka, Bangladesh, from January 2025 to June 2025. A total of 400 patients undergoing isolated CABG were enrolled and divided into two equal groups: the control group (n = 200) received standard antibiotic prophylaxis, while the other group received vancomycin group (n = 200). Postoperative outcomes, including incidence and microbiology of SWI, ICU stay, hospital stay and 30-day morbidity and mortality, were analyzed. Results: The overall incidence of SWI was significantly lower in the vancomycin group (3.0%) compared to the control group (9.0%, p = 0.01). Staphylococcus aureus (both methicillin-sensitive and MRSA) was the predominant pathogen. The vancomycin group showed significantly shorter ICU (3.2 ± 1.6 vs. 3.8 ± 2.1 days, p = 0.01) and hospital stays (9.8 ± 4.3 vs. 12.4 ± 6.5 days, p Conclusion: Topical vancomycin application effectively reduces the incidence of sternal wound infection and shortens postoperative recovery time without increasing adverse outcomes among Bangladeshi CABG patients. VL - 9 IS - 4 ER -
Department of Cardiac Surgery, United Hospital Limited, Dhaka, Bangladesh
Department of Cardiac Surgery, United Hospital Limited, Dhaka, Bangladesh
Department of Vascular Surgery, Sir Salimullah Medical College Hospital (Mitford Hospital), Dhaka, Bangladesh
Department of Cardiac Surgery, United Hospital Limited, Dhaka, Bangladesh
Department of Cardiac Surgery, United Hospital Limited, Dhaka, Bangladesh
Department of Cardiac Surgery, United Hospital Limited, Dhaka, Bangladesh
Department of Cardiac Surgery, Dhaka Medical College Hospital, Dhaka, Bangladesh
Department of Gynaecology & Obstetrics, 250-Bed Hospital, Narayanganj, Bangladesh
Department of NICU, Padma General Hospital, Dhaka, Bangladesh
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