Statistical Aspects of the Interrelation Between the Biological Activity of Chemical Compounds and Their Molecular Structure

Mukhomorov V. K.

doi:doi:10.11648/j.bsi.20160101.14

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Statistical Aspects of the Interrelation Between the Biological Activity of Chemical Compounds and Their Molecular Structure

Mukhomorov V. K.

Published in Biomedical Statistics and Informatics (Volume 1, Issue 1)

Received: 7 December 2016 Accepted: 27 December 2016 Published: 20 January 2017

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Abstract

An attempt was made to construct an adequate model of interrelation of radioprotective properties of biologically active chemical compounds with their electronic and information factors. Biological activity (radiation protective effects) of chemical compounds has been analyzed in relation to their electronic sign and the information function. Statistical comparison of qualitative indices has revealed that electronic and information signs the most informative characteristics of the molecules responsible for radiation protective action. Correlation equations are given for electronic and information dependent change in the antiradiation properties of the molecule. Quantitative estimates were made associating the protective efficiency of the chemical compounds under study with variations in the electronic parameters and dose of chemicals.

Published in	Biomedical Statistics and Informatics (Volume 1, Issue 1)
DOI	10.11648/j.bsi.20160101.14
Page(s)	24-34
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Bioactivity, Statistics, Molecular Structure, Electronic Sign, Information Function, Radioprotector, Statistical Criterion, Contingency, Correlation

References

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[3]	Veljkovič V., Lalovič D. (1973) General model pseudopotential for positive ions. Phys. Lett A. Vol. 45 (1): p. 59.
[4]	Sweeney T. R. (1979) A Survey of Compounds from the Antiradiation Drug Development Program. Washington.
[5]	Romantcev E. F. (1968) Radiation and chemical protection. Moscow. (in Russian).
[6]	Handbook of Applicable Mathematics. (1984). Vol. VI. Statistics. Part B. John Willey & Sons. Chichester-New York-Brisborne-Toronto-Singapore.
[7]	Pustyl'nik E. I. (1978) Statistical methods for the analysis and processing of observations. Moscow (in Russian).
[8]	Förster E., Rönz B. (1979) Methoden der Korrelations – und Regressionanalyse. Berlin.
[9]	Fleiss J. L. (1981) Statistical Methods for Rates and Proportions. Chichester-New York-Brisborne-Toronto-Singapore.
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[11]	Shannon C. (1948) A mathematical theory of communication. Bell. Techn. Journal. Vol. 27: p. 379.
[12]	Mukhomorov V. K. (2012) Modeling of chemical compounds bioactivity. Relationships of structure - bioactivity. Lambert Academic Publisher. Saarbrűcken. Germany. p. 165. ISBN: 978-3-659-19941-7. (in Russian).
[13]	Yaschunsky V. G. (1975) Progress in the search for chemical protective agents against radiation. Russian Chemical Reviews. Vol. 44 (3): p. 260.
[14]	Leo A., Hansch C., Elkins D. (1971) Partition coefficients and their uses. Chem. Reviews. Vol. 71 (6): p. 525.
[15]	Mukhomorov V. K. (2014) Bioactivity-structure. Interrelation of electronic and information factors of biologically activity of chemical compounds. Trends Journal of Sciences Research. Vol. 1 (1): p. 38.
[16]	Mukhomorov V. K. (2011) Entropy approach to the study of biological activity of chemical compounds: The other side of radioprotectors. Advances in Biological Chemistry. Vol. 1 (1): p. 1.

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Mukhomorov V. K. (2017). Statistical Aspects of the Interrelation Between the Biological Activity of Chemical Compounds and Their Molecular Structure. Biomedical Statistics and Informatics, 1(1), 24-34. https://doi.org/10.11648/j.bsi.20160101.14

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ACS Style

Mukhomorov V. K. Statistical Aspects of the Interrelation Between the Biological Activity of Chemical Compounds and Their Molecular Structure. Biomed. Stat. Inform. 2017, 1(1), 24-34. doi: 10.11648/j.bsi.20160101.14

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AMA Style

Mukhomorov V. K. Statistical Aspects of the Interrelation Between the Biological Activity of Chemical Compounds and Their Molecular Structure. Biomed Stat Inform. 2017;1(1):24-34. doi: 10.11648/j.bsi.20160101.14

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@article{10.11648/j.bsi.20160101.14,
  author = {Mukhomorov V. K.},
  title = {Statistical Aspects of the Interrelation Between the Biological Activity of Chemical Compounds and Their Molecular Structure},
  journal = {Biomedical Statistics and Informatics},
  volume = {1},
  number = {1},
  pages = {24-34},
  doi = {10.11648/j.bsi.20160101.14},
  url = {https://doi.org/10.11648/j.bsi.20160101.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bsi.20160101.14},
  abstract = {An attempt was made to construct an adequate model of interrelation of radioprotective properties of biologically active chemical compounds with their electronic and information factors. Biological activity (radiation protective effects) of chemical compounds has been analyzed in relation to their electronic sign and the information function. Statistical comparison of qualitative indices has revealed that electronic and information signs the most informative characteristics of the molecules responsible for radiation protective action. Correlation equations are given for electronic and information dependent change in the antiradiation properties of the molecule. Quantitative estimates were made associating the protective efficiency of the chemical compounds under study with variations in the electronic parameters and dose of chemicals.},
 year = {2017}
}

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TY  - JOUR
T1  - Statistical Aspects of the Interrelation Between the Biological Activity of Chemical Compounds and Their Molecular Structure
AU  - Mukhomorov V. K.
Y1  - 2017/01/20
PY  - 2017
N1  - https://doi.org/10.11648/j.bsi.20160101.14
DO  - 10.11648/j.bsi.20160101.14
T2  - Biomedical Statistics and Informatics
JF  - Biomedical Statistics and Informatics
JO  - Biomedical Statistics and Informatics
SP  - 24
EP  - 34
PB  - Science Publishing Group
SN  - 2578-8728
UR  - https://doi.org/10.11648/j.bsi.20160101.14
AB  - An attempt was made to construct an adequate model of interrelation of radioprotective properties of biologically active chemical compounds with their electronic and information factors. Biological activity (radiation protective effects) of chemical compounds has been analyzed in relation to their electronic sign and the information function. Statistical comparison of qualitative indices has revealed that electronic and information signs the most informative characteristics of the molecules responsible for radiation protective action. Correlation equations are given for electronic and information dependent change in the antiradiation properties of the molecule. Quantitative estimates were made associating the protective efficiency of the chemical compounds under study with variations in the electronic parameters and dose of chemicals.
VL  - 1
IS  - 1
ER  -

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Author Information

Mukhomorov V. K.

Universita Degli Studi di Napoli “Federico II”, Via Cintia, Napoli, Italy

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APA Style

Mukhomorov V. K. (2017). Statistical Aspects of the Interrelation Between the Biological Activity of Chemical Compounds and Their Molecular Structure. Biomedical Statistics and Informatics, 1(1), 24-34. https://doi.org/10.11648/j.bsi.20160101.14

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ACS Style

Mukhomorov V. K. Statistical Aspects of the Interrelation Between the Biological Activity of Chemical Compounds and Their Molecular Structure. Biomed. Stat. Inform. 2017, 1(1), 24-34. doi: 10.11648/j.bsi.20160101.14

Copy | Download

AMA Style

Mukhomorov V. K. Statistical Aspects of the Interrelation Between the Biological Activity of Chemical Compounds and Their Molecular Structure. Biomed Stat Inform. 2017;1(1):24-34. doi: 10.11648/j.bsi.20160101.14

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@article{10.11648/j.bsi.20160101.14,
  author = {Mukhomorov V. K.},
  title = {Statistical Aspects of the Interrelation Between the Biological Activity of Chemical Compounds and Their Molecular Structure},
  journal = {Biomedical Statistics and Informatics},
  volume = {1},
  number = {1},
  pages = {24-34},
  doi = {10.11648/j.bsi.20160101.14},
  url = {https://doi.org/10.11648/j.bsi.20160101.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bsi.20160101.14},
  abstract = {An attempt was made to construct an adequate model of interrelation of radioprotective properties of biologically active chemical compounds with their electronic and information factors. Biological activity (radiation protective effects) of chemical compounds has been analyzed in relation to their electronic sign and the information function. Statistical comparison of qualitative indices has revealed that electronic and information signs the most informative characteristics of the molecules responsible for radiation protective action. Correlation equations are given for electronic and information dependent change in the antiradiation properties of the molecule. Quantitative estimates were made associating the protective efficiency of the chemical compounds under study with variations in the electronic parameters and dose of chemicals.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Statistical Aspects of the Interrelation Between the Biological Activity of Chemical Compounds and Their Molecular Structure
AU  - Mukhomorov V. K.
Y1  - 2017/01/20
PY  - 2017
N1  - https://doi.org/10.11648/j.bsi.20160101.14
DO  - 10.11648/j.bsi.20160101.14
T2  - Biomedical Statistics and Informatics
JF  - Biomedical Statistics and Informatics
JO  - Biomedical Statistics and Informatics
SP  - 24
EP  - 34
PB  - Science Publishing Group
SN  - 2578-8728
UR  - https://doi.org/10.11648/j.bsi.20160101.14
AB  - An attempt was made to construct an adequate model of interrelation of radioprotective properties of biologically active chemical compounds with their electronic and information factors. Biological activity (radiation protective effects) of chemical compounds has been analyzed in relation to their electronic sign and the information function. Statistical comparison of qualitative indices has revealed that electronic and information signs the most informative characteristics of the molecules responsible for radiation protective action. Correlation equations are given for electronic and information dependent change in the antiradiation properties of the molecule. Quantitative estimates were made associating the protective efficiency of the chemical compounds under study with variations in the electronic parameters and dose of chemicals.
VL  - 1
IS  - 1
ER  -

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